data_2476 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; A Proton NMR and Nuclear Overhauser Effect (NOE) Study of Human Plasma Prealbumin, Including the Development and Application to Spectral Assignment of a Combined Ring Current Shift and NOE Prediction Program ; _BMRB_accession_number 2476 _BMRB_flat_file_name bmr2476.str _Entry_type update _Submission_date 1995-07-31 _Accession_date 1996-04-13 _Entry_origination BMRB _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details . loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Reid David G. . 2 Saunders Martin . . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 1 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 38 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 2010-06-17 revision BMRB 'Complete natural source information' 1999-06-14 revision BMRB 'Converted to BMRB NMR-STAR V 2.1 format' 1996-04-13 revision BMRB 'Link to the Protein Data Bank added' 1996-03-25 reformat BMRB 'Converted to the BMRB 1996-03-01 STAR flat-file format' 1995-07-31 original BMRB 'Last release in original BMRB flat-file format' stop_ save_ ############################# # Citation for this entry # ############################# save_entry_citation _Saveframe_category entry_citation _Citation_full ; Reid, David G., Saunders, Martin, "A Proton NMR and Nuclear Overhauser Effect (NOE) Study of Human Plasma Prealbumin, Including the Development and Application to Spectral Assignment of a Combined Ring Current Shift and NOE Prediction Program," J. Biol. Chem. 264 (4), 2003-2012 (1989). ; _Citation_title ; A Proton NMR and Nuclear Overhauser Effect (NOE) Study of Human Plasma Prealbumin, Including the Development and Application to Spectral Assignment of a Combined Ring Current Shift and NOE Prediction Program ; _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID ? loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Reid David G. . 2 Saunders Martin . . stop_ _Journal_abbreviation 'J. Biol. Chem.' _Journal_volume 264 _Journal_issue 4 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 2003 _Page_last 2012 _Year 1989 _Details . save_ ################################## # Molecular system description # ################################## save_system_pancreatic_polypeptide _Saveframe_category molecular_system _Mol_system_name 'pancreatic polypeptide' _Enzyme_commission_number . loop_ _Mol_system_component_name _Mol_label 'pancreatic polypeptide' $pancreatic_polypeptide stop_ _System_molecular_weight . _System_oligomer_state ? _System_paramagnetic ? _System_thiol_state . _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_pancreatic_polypeptide _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common 'pancreatic polypeptide' _Name_variant prealbumin _Molecular_mass . _Mol_thiol_state . _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 127 _Mol_residue_sequence ; GPTGTGESKCPLMVKVLDAV RGSPAINVAVHVFRKAADDT WEPFASGKTSESGELHGLTT EEEFVEGIYKVEIDTKSYWK ALGISPFHEHAEVVFTANDS GPRRYTIAALLSPYSYSTTA VVTNPKE ; loop_ _Residue_seq_code _Residue_label 1 GLY 2 PRO 3 THR 4 GLY 5 THR 6 GLY 7 GLU 8 SER 9 LYS 10 CYS 11 PRO 12 LEU 13 MET 14 VAL 15 LYS 16 VAL 17 LEU 18 ASP 19 ALA 20 VAL 21 ARG 22 GLY 23 SER 24 PRO 25 ALA 26 ILE 27 ASN 28 VAL 29 ALA 30 VAL 31 HIS 32 VAL 33 PHE 34 ARG 35 LYS 36 ALA 37 ALA 38 ASP 39 ASP 40 THR 41 TRP 42 GLU 43 PRO 44 PHE 45 ALA 46 SER 47 GLY 48 LYS 49 THR 50 SER 51 GLU 52 SER 53 GLY 54 GLU 55 LEU 56 HIS 57 GLY 58 LEU 59 THR 60 THR 61 GLU 62 GLU 63 GLU 64 PHE 65 VAL 66 GLU 67 GLY 68 ILE 69 TYR 70 LYS 71 VAL 72 GLU 73 ILE 74 ASP 75 THR 76 LYS 77 SER 78 TYR 79 TRP 80 LYS 81 ALA 82 LEU 83 GLY 84 ILE 85 SER 86 PRO 87 PHE 88 HIS 89 GLU 90 HIS 91 ALA 92 GLU 93 VAL 94 VAL 95 PHE 96 THR 97 ALA 98 ASN 99 ASP 100 SER 101 GLY 102 PRO 103 ARG 104 ARG 105 TYR 106 THR 107 ILE 108 ALA 109 ALA 110 LEU 111 LEU 112 SER 113 PRO 114 TYR 115 SER 116 TYR 117 SER 118 THR 119 THR 120 ALA 121 VAL 122 VAL 123 THR 124 ASN 125 PRO 126 LYS 127 GLU stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date 2015-11-25 loop_ _Database_name _Database_accession_code _Database_entry_mol_name _Sequence_query_to_submitted_percentage _Sequence_subject_length _Sequence_identity _Sequence_positive _Sequence_homology_expectation_value PDB 1BM7 "Human Transthyretin (Prealbumin) Complex With Flufenamic Acid (2-[[3-(Trifluoromethyl)phenyl]amino] Benzoic Acid)" 100.00 127 100.00 100.00 1.39e-86 PDB 1BMZ "Human Transthyretin (Prealbumin)" 100.00 127 100.00 100.00 1.39e-86 PDB 1BZ8 "Transthyretin (Del Val122)" 100.00 126 99.21 99.21 5.34e-84 PDB 1BZD "Tertiary Structures Of Three Amyloidogenic Transthyretin Variants And Implications For Amyloid Fibril Formation" 100.00 127 99.21 99.21 1.11e-85 PDB 1BZE "Tertiary Structures Of Three Amyloidogenic Transthyretin Variants And Implications For Amyloid Fibril Formation" 100.00 127 99.21 99.21 7.39e-86 PDB 1DVQ "Crystal Structure Of Human Transthyretin" 97.64 124 99.19 100.00 8.45e-84 PDB 1DVS "Crystal Structure Of Human Transthyretin In Complex With Resveratrol" 97.64 124 99.19 100.00 8.45e-84 PDB 1DVT "Crystal Structure Of Human Transthyretin In Complex With Flurbiprofen" 97.64 124 99.19 100.00 8.45e-84 PDB 1DVU "Crystal Structure Of Human Transthyretin In Complex With Dibenzofuran- 4,6-Dicarboxylic Acid" 97.64 124 99.19 100.00 8.45e-84 PDB 1DVX "Crystal Structure Of Human Transthyretin In Complex With Diclofenac" 97.64 124 99.19 100.00 8.45e-84 PDB 1DVY "Crystal Structure Of Transthyretin In Complex With N-(M- Trifluoromethylphenyl) Phenoxazine-4,6-Dicarboxylic Acid" 97.64 124 99.19 100.00 8.45e-84 PDB 1DVZ "Crystal Structure Of Human Transthyretin In Complex With O- Trifluoromethylphenyl Anthranilic Acid" 97.64 124 99.19 100.00 8.45e-84 PDB 1E3F "Structure Of Human Transthyretin Complexed With Bromophenols: A New Mode Of Binding" 100.00 127 100.00 100.00 1.39e-86 PDB 1E4H "Structure Of Human Transthyretin Complexed With Bromophenols: A New Mode Of Binding" 100.00 127 100.00 100.00 1.39e-86 PDB 1E5A "Structure Of Human Transthyretin Complexed With Bromophenols: A New Mode Of Binding" 100.00 127 100.00 100.00 1.39e-86 PDB 1ETA "The X-Ray Crystal Structure Refinements Of Normal Human Transthyretin And The Amyloidogenic Val 30-->met Variant To 1.7 Angstro" 100.79 128 99.22 99.22 8.71e-85 PDB 1ETB "The X-Ray Crystal Structure Refinements Of Normal Human Transthyretin And The Amyloidogenic Val 30-->met Variant To 1.7 Angstro" 100.00 127 99.21 99.21 8.24e-86 PDB 1F41 "Crystal Structure Of Human Transthyretin At 1.5a Resolution" 100.00 127 100.00 100.00 1.39e-86 PDB 1F86 "Transthyretin Thr119met Protein Stabilisation" 90.55 115 99.13 99.13 1.10e-76 PDB 1FH2 "Transthyretin Stability As A Key Factor In Amyloidogenesis" 91.34 116 98.28 98.28 6.27e-73 PDB 1FHN "Transthyretin Stability As A Key Factor In Amyloidogenesis" 100.00 127 99.21 99.21 7.39e-86 PDB 1G1O "Crystal Structure Of The Highly Amyloidogenic Transthyretin Mutant Ttr G53sE54DL55S" 100.00 127 97.64 98.43 4.63e-84 PDB 1GKO "An Engineered Transthyretin Monomer That Is Non-Amyloidogenic - Unless Partially Denatured" 100.00 127 98.43 99.21 1.39e-85 PDB 1ICT "Monoclinic Form Of Human Transthyretin Complexed With Thyroxine (T4)" 100.00 127 100.00 100.00 1.39e-86 PDB 1III "Crystal Structure Of The Transthyretin Mutant Ttr Y114c-data Collected At Room Temperature" 100.00 127 99.21 99.21 3.76e-85 PDB 1IIK "Crystal Structure Of The Transthyretin Mutant Ttr Y114c-Data Collected At Cryo Temperature" 100.00 127 99.21 99.21 3.76e-85 PDB 1IJN "Crystal Structure Of The Transthyretin Mutant Ttr C10aY114C" 100.00 127 98.43 98.43 9.95e-84 PDB 1QAB "The Structure Of Human Retinol Binding Protein With Its Carrier Protein Transthyretin Reveals Interaction With The Carboxy Term" 100.00 127 99.21 100.00 2.68e-86 PDB 1QWH "A Covalent Dimer Of Transthyretin That Affects The Amyloid Pathway" 92.13 117 100.00 100.00 2.77e-78 PDB 1RLB "Retinol Binding Protein Complexed With Transthyretin" 100.00 127 99.21 100.00 2.68e-86 PDB 1SOK "Crystal Structure Of The Transthyretin Mutant A108yL110E SOLVED IN Space Group P21212" 100.00 127 98.43 98.43 2.16e-84 PDB 1SOQ "Crystal Structure Of The Transthyretin Mutant A108yL110E SOLVED IN Space Group C2" 100.00 127 98.43 98.43 2.16e-84 PDB 1THA "Mechanism Of Molecular Recognition. Structural Aspects Of 3, 3'-Diiodo-L-Thyronine Binding To Human Serum Transthyretin" 100.00 127 99.21 100.00 2.68e-86 PDB 1THC "Crystal Structure Determination At 2.3a Of Human Transthyretin-3',5'- Dibromo-2',4,4',6-Tetra-Hydroxyaurone Complex" 100.00 127 99.21 100.00 2.68e-86 PDB 1TLM "Structural Aspects Of Inotropic Bipyridine Binding: Crystal Structure Determination To 1.9 Angstroms Of The Human Serum Transth" 100.00 127 99.21 100.00 2.68e-86 PDB 1TSH "Tertiary Structures Of Three Amyloidogenic Transthyretin Variants And Implications For Amyloid Fibril Formation" 100.00 127 99.21 99.21 7.07e-86 PDB 1TT6 "The Orthorhombic Crystal Structure Of Transthyretin In Complex With Diethylstilbestrol" 100.00 127 100.00 100.00 1.39e-86 PDB 1TTA "The X-Ray Crystal Structure Refinements Of Normal Human Transthyretin And The Amyloidogenic Val30met Variant To 1.7 Angstroms R" 100.00 127 100.00 100.00 1.39e-86 PDB 1TTB "The X-Ray Crystal Structure Refinements Of Normal Human Transthyretin And The Amyloidogenic Val30met Variant To 1.7 Angstroms R" 100.00 127 99.21 99.21 8.24e-86 PDB 1TTC "The X-Ray Crystal Structure Refinements Of Normal Human Transthyretin And The Amyloidogenic Val30met Variant To 1.7 Angstroms R" 100.00 127 99.21 100.00 4.01e-86 PDB 1TTR "Transthyretin-V122I CARDIOMYOPATHIC MUTANT" 100.00 127 99.21 100.00 2.59e-86 PDB 1TYR "Transthyretin Complex With Retinoic Acid" 100.00 127 100.00 100.00 1.39e-86 PDB 1TZ8 "The Monoclinic Crystal Struture Of Transthyretin In Complex With Diethylstilbestrol" 100.00 127 100.00 100.00 1.39e-86 PDB 1U21 "Transthyretin With Tethered Inhibitor On One Monomer." 100.00 127 100.00 100.00 1.39e-86 PDB 1X7S "The X-Ray Crystallographic Structure Of The Amyloidogenic Variant Ttr Tyr78phe" 100.00 127 99.21 100.00 5.44e-86 PDB 1X7T "Structure Of Ttr R104h: A Non-Amyloidogenic Variant With Protective Clinical Effects" 100.00 127 99.21 99.21 1.83e-85 PDB 1Y1D "Crystal Structure Of Transthyretin In Complex With Iododiflunisal" 100.00 127 100.00 100.00 1.39e-86 PDB 1Z7J "Human Transthyretin (Also Called Prealbumin) Complex With 3, 3',5,5'- Tetraiodothyroacetic Acid (T4ac)" 100.00 127 100.00 100.00 1.39e-86 PDB 1ZCR "Crystal Structure Of Human Transthyretin With Bound Iodide" 100.00 128 100.00 100.00 1.32e-86 PDB 1ZD6 "Crystal Structure Of Human Transthyretin With Bound Chloride" 100.00 128 100.00 100.00 1.32e-86 PDB 2B14 "The Crystal Structure Of 2,4-Dinitrophenol In Complex With The Amyloidogenic Variant Transthyretin Leu 55 Pro" 100.00 127 99.21 99.21 3.76e-85 PDB 2B15 "The Crystal Structure Of 2,4-Dinitrophenol In Complex With Human Transthyretin" 100.00 127 100.00 100.00 1.39e-86 PDB 2B16 "The Crystal Structure Of 2,4-Dinitrophenol In Complex With The Amyloidogenic Variant Transthyretin Tyr78phe" 100.00 127 99.21 100.00 5.44e-86 PDB 2B77 "Human Transthyretin (ttr) Complexed With Diflunisal Analogues- Ttr.2', 4'-dichloro-4-hydroxy-1,1'-biphenyl-3-carboxylic Acid" 100.00 127 100.00 100.00 1.39e-86 PDB 2B9A "Human Transthyretin (ttr) Complexed With Diflunisal Analogues- Ttr.3', 5'-difluorobiphenyl-4-carboxylic Acid" 100.00 127 100.00 100.00 1.39e-86 PDB 2F7I "Human Transthyretin (Ttr) Complexed With Diflunisal Analogues- Ttr. 2',6'-Difluorobiphenyl-4-Carboxylic Acid" 100.00 127 100.00 100.00 1.39e-86 PDB 2F8I "Human Transthyretin (Ttr) Complexed With Benzoxazole" 100.00 127 100.00 100.00 1.39e-86 PDB 2FBR "Human Transthyretin (Ttr) Complexed With Bivalant Amyloid Inhibitor (4 Carbon Linker)" 100.00 127 100.00 100.00 1.39e-86 PDB 2FLM "Human Transthyretin (Ttr) Complexed With Bivalant Amyloid Inhibitor (6 Carbon Linker)" 100.00 127 100.00 100.00 1.39e-86 PDB 2G3X "Crystal Structure Of Transthyretin Mutant I84s At Acidic Ph" 100.00 127 99.21 99.21 1.60e-85 PDB 2G3Z "Crystal Structure Of Transthyretin Mutant I84a At Low Ph" 100.00 127 99.21 99.21 1.09e-85 PDB 2G4E "Crystal Structure Of Transthyretin Mutant I84a At Neutral Ph" 100.00 127 99.21 99.21 1.09e-85 PDB 2G4G "Crystal Structure Of Human Transthyretin At Ph 4.6" 100.00 127 100.00 100.00 1.39e-86 PDB 2G5U "Human Transthyretin (Ttr) Complexed With Hydroxylated Polychlorinated Biphenyl-4,4'-Dihydroxy-3,3',5,5'-Tetrachlorobiphenyl" 100.00 127 100.00 100.00 1.39e-86 PDB 2G9K "Human Transthyretin (Ttr) Complexed With Hydroxylated Polychlorinated Biphenyl-4-Hydroxy-2',3,3',4',5-Pentachlorobiphenyl" 100.00 127 100.00 100.00 1.39e-86 PDB 2GAB "Human Transthyretin (Ttr) Complexed With Hydroxylated Polychlorinated Biphenyl-4-Hydroxy-3,3',5,4'-Tetrachlorobiphenyl" 100.00 127 100.00 100.00 1.39e-86 PDB 2H4E "Crystal Structure Of Cys10 Sulfonated Transthyretin" 100.00 127 99.21 99.21 5.88e-85 PDB 2NOY "Crystal Structure Of Transthyretin Mutant I84s At Ph 7.5" 100.00 127 99.21 99.21 1.60e-85 PDB 2PAB "Structure Of Prealbumin, Secondary, Tertiary And Quaternary Interactions Determined By Fourier Refinement At 1.8 Angstroms" 100.00 127 99.21 100.00 2.68e-86 PDB 2QEL "Crystal Structure Of The Highly Amyloidogenic Transthyretin Mutant Ttr G53s/e54d/l55s- Heated Protein" 100.00 127 97.64 98.43 4.63e-84 PDB 2QGB "Human Transthyretin (Ttr) In Apo-Form" 100.00 127 100.00 100.00 1.39e-86 PDB 2QGC "Human Transthyretin (Ttr) Complexed With 2-(3,5-Dimethyl-4- Hydroxyphenyl)benzoxazole" 100.00 127 100.00 100.00 1.39e-86 PDB 2QGD "Human Transthyretin (Ttr) Complexed With 2-(3,5-Dibromo-4- Hydroxyphenyl)benzoxazole" 100.00 127 100.00 100.00 1.39e-86 PDB 2QGE "Human Transthyretin (Ttr) Complexed With 2-(3,5-Dimethylphenyl) Benzoxazole" 100.00 127 100.00 100.00 1.39e-86 PDB 2ROX "Transthyretin (Also Called Prealbumin) Complex With Thyroxine (T4)" 100.00 127 100.00 100.00 1.39e-86 PDB 2ROY "Transthyretin (Also Called Prealbumin) Complex With 3',5'-Dinitro-N- Acetyl-L-Thyronine" 100.00 127 100.00 100.00 1.39e-86 PDB 2TRH "Tertiary Structures Of Three Amyloidogenic Transthyretin Variants And Implications For Amyloid Fibril Formation" 100.00 127 99.21 99.21 1.07e-84 PDB 2TRY "Tertiary Structures Of Three Amyloidogenic Transthyretin Variants And Implications For Amyloid Fibril Formation" 100.00 127 99.21 99.21 1.62e-85 PDB 2WQA "Complex Of Ttr And Rbp4 And Oleic Acid" 100.00 129 100.00 100.00 2.08e-86 PDB 3A4D "Crystal Structure Of Human Transthyretin (Wild-Type)" 100.00 127 100.00 100.00 1.39e-86 PDB 3A4E "Crystal Structure Of Human Transthyretin (e54g)" 100.00 127 99.21 99.21 2.11e-85 PDB 3A4F "Crystal Structure Of Human Transthyretin (e54k)" 100.00 127 99.21 100.00 5.21e-86 PDB 3B56 "Crystal Structure Of Transthyretin In Complex With 3,5- Diiodosalicylic Acid" 100.00 127 100.00 100.00 1.39e-86 PDB 3BSZ "Crystal Structure Of The Transthyretin-retinol Binding Protein-fab Complex" 100.00 127 100.00 100.00 1.39e-86 PDB 3BT0 "Crystal Structure Of Transthyretin Variant V20s" 100.00 127 99.21 99.21 1.07e-85 PDB 3CBR "Crystal Structure Of Human Transthyretin (Ttr) At Ph3.5" 100.00 127 100.00 100.00 1.39e-86 PDB 3CFM "Crystal Structure Of The Apo Form Of Human Wild-Type Transthyretin" 92.91 118 100.00 100.00 8.23e-80 PDB 3CFN "Crystal Structure Of Human Transthyretin In Complex With 1-Anilino-8- Naphthalene Sulfonate" 92.91 118 100.00 100.00 8.23e-80 PDB 3CFQ "Crystal Structure Of Human Wild-Type Transthyretin In Complex With Diclofenac" 92.91 118 100.00 100.00 8.23e-80 PDB 3CFT "Crystal Structure Of Human Transthyretin In Complex With 1- Amino-5-Naphthalene Sulfonate" 92.91 118 100.00 100.00 8.23e-80 PDB 3CN0 "Human Transthyretin (Ttr) In Complex With 3,5-Dimethyl-4- Hydroxystilbene" 100.00 127 100.00 100.00 1.39e-86 PDB 3CN1 "Human Transthyretin (Ttr) In Complex With 3,5-Dibromo-4- Hydroxystilbene" 100.00 127 100.00 100.00 1.39e-86 PDB 3CN2 "Human Transthyretin (Ttr) In Complex With 3,5-Dibromo-4- Hydroxybiphenyl" 100.00 127 100.00 100.00 1.39e-86 PDB 3CN3 "Human Transthyretin (Ttr) In Complex With 1,3-Dibromo-2- Hydroxy-5-Phenoxybenzene" 100.00 127 100.00 100.00 1.39e-86 PDB 3CN4 "Human Transthyretin (Ttr) In Complex With N-(3,5-Dibromo-4- Hydroxyphenyl)benzamide" 100.00 127 100.00 100.00 1.39e-86 PDB 3CXF "Crystal Structure Of Transthyretin Variant Y114h" 100.00 127 99.21 100.00 1.09e-85 PDB 3D2T "Human Transthyretin (ttr) Complexed With Diflunisal" 100.00 127 100.00 100.00 1.39e-86 PDB 3D7P "Crystal Structure Of Human Transthyretin (Ttr) At Ph 4.0" 100.00 127 100.00 100.00 1.39e-86 PDB 3DGD "Crystal Structure Of The F87mL110M MUTANT OF HUMAN TRANSTHYRETIN AT Ph 4.6" 100.00 127 98.43 99.21 1.39e-85 PDB 3DID "Crystal Structure Of The F87mL110M MUTANT OF HUMAN TRANSTHYRETIN AT Ph 4.6 Soaked" 100.00 127 98.43 99.21 1.39e-85 PDB 3DJR "Crystal Structure Of Transthyretin Variant L58h At Neutral Ph" 100.00 127 99.21 99.21 2.89e-85 PDB 3DJS "Crystal Structure Of Transthyretin Variant L58h At Acidic Ph" 100.00 127 99.21 99.21 2.89e-85 PDB 3DJT "Crystal Structure Of Transthyretin Variant V30m At Acidic Ph" 100.00 127 99.21 100.00 4.01e-86 PDB 3DJZ "Crystal Structure Of Transthyretin Variant L55p At Neutral Ph" 100.00 127 99.21 99.21 3.76e-85 PDB 3DK0 "Crystal Structure Of Transthyretin Variant L55p At Acidic Ph" 100.00 127 99.21 99.21 3.76e-85 PDB 3DK2 "Crystal Structure Of Transthyretin Variant Y114h At Acidic Ph" 100.00 127 99.21 100.00 1.09e-85 PDB 3DO4 "Crystal Structure Of Transthyretin Variant T60a At Acidic Ph" 100.00 127 99.21 99.21 7.07e-86 PDB 3ESN "Human Transthyretin (Ttr) Complexed With N-(3,5-Dibromo-4- Hydroxyphenyl)-2,6-Dimethylbenzamide" 100.00 127 100.00 100.00 1.39e-86 PDB 3ESO "Human Transthyretin (Ttr) Complexed With N-(3,5-Dibromo-4- Hydroxyphenyl)-2,5-Dichlorobenzamide" 100.00 127 100.00 100.00 1.39e-86 PDB 3ESP "Human Transthyretin (Ttr) Complexed With N-(3,5-Dibromo-4- Hydroxyphenyl)-3,5-Dimethyl-4-Hydroxybenzamide" 100.00 127 100.00 100.00 1.39e-86 PDB 3FC8 "Crystal Structure Of Transthyretin In Complex With Iododiflunisal-Betaalaome" 97.64 124 100.00 100.00 4.25e-84 PDB 3FCB "Crystal Structure Of Transthyretin In Complex With Iododiflunisal-Betaalaoh" 97.64 124 100.00 100.00 4.25e-84 PDB 3GLZ "Human Transthyretin (Ttr) Complexed With(E)-3-(2- (Trifluoromethyl)benzylideneaminooxy)propanoic Acid (Inhibitor 11)" 100.00 127 100.00 100.00 1.39e-86 PDB 3GPS "Crystal Structure Of The F87mL110M MUTANT OF HUMAN TRANSTHYRETIN AT Ph 5.5" 100.00 127 98.43 99.21 1.39e-85 PDB 3GRB "Crystal Structure Of The F87mL110M MUTANT OF HUMAN TRANSTHYRETIN AT Ph 6.5" 100.00 127 98.43 99.21 1.39e-85 PDB 3GRG "Crystal Structure Of The F87mL110M MUTANT OF HUMAN TRANSTHYRETIN AT Ph 7.5" 100.00 127 98.43 99.21 1.39e-85 PDB 3GS0 "Human Transthyretin (Ttr) Complexed With (S)-3-(9h-Fluoren- 9-Ylideneaminooxy)-2-Methylpropanoic Acid (Inhibitor 16)" 100.00 127 100.00 100.00 1.39e-86 PDB 3GS4 "Human Transthyretin (Ttr) Complexed With 3-(9h-Fluoren-9- Ylideneaminooxy)propanoic Acid (Inhibitor 15)" 100.00 127 100.00 100.00 1.39e-86 PDB 3GS7 "Human Transthyretin (Ttr) Complexed With (E)-3-(2- Methoxybenzylideneaminooxy)propanoic Acid (Inhibitor 13)" 100.00 127 100.00 100.00 1.39e-86 PDB 3HJ0 "Transthyretin In Complex With A Covalent Small Molecule Kinetic Stabilizer" 100.00 127 99.21 99.21 5.88e-85 PDB 3I9A "Crystal Structure Of Human Transthyretin Variant A25t - #1" 100.00 127 99.21 99.21 8.24e-86 PDB 3I9I "Crystal Structure Of Human Transthyretin Variant A25t - #2" 91.34 116 99.14 99.14 1.20e-77 PDB 3I9P "Crystal Structure Of Human Transthyretin - Wild Type" 91.34 116 100.00 100.00 2.80e-78 PDB 3IMR "Transthyretin In Complex With (E)-2,6-Dibromo-4-(2,6- Dichlorostyryl)phenol" 100.00 127 100.00 100.00 1.39e-86 PDB 3IMS "Transthyretin In Complex With 2,6-Dibromo-4-(2,6- Dichlorophenethyl)phenol" 100.00 127 100.00 100.00 1.39e-86 PDB 3IMT "Transthyretin In Complex With (E)-4-(4-Aminostyryl)-2,6- Dibromophenol" 100.00 127 100.00 100.00 1.39e-86 PDB 3IMU "Transthyretin In Complex With (E)-4-(3-Aminostyryl)-2,6- Dibromoaniline" 100.00 127 100.00 100.00 1.39e-86 PDB 3IMV "Transthyretin In Complex With (E)-4-(4-Aminostyryl)-2,6- Dibromoaniline" 100.00 127 100.00 100.00 1.39e-86 PDB 3IMW "Transthyretin In Complex With (E)-2,6-Dibromo-4-(2,6- Dimethoxystyryl)aniline" 100.00 127 100.00 100.00 1.39e-86 PDB 3IPB "Human Transthyretin (Ttr) Complexed With A Palindromic Bivalent Amyloid Inhibitor (11 Carbon Linker)." 100.00 127 100.00 100.00 1.39e-86 PDB 3IPE "Human Transthyretin (Ttr) Complexed With A Palindromic Bivalent Amyloid Inhibitor (7 Carbon Linker)." 100.00 127 100.00 100.00 1.39e-86 PDB 3KGS "V30m Mutant Human Transthyretin (Ttr) (Apov30m) Ph 7.5" 100.00 127 99.21 100.00 4.01e-86 PDB 3KGT "V30m Mutant Human Transthyretin (Ttr) Complexed With Geniste (V30m:gen) Ph 7.5" 100.00 127 99.21 100.00 4.01e-86 PDB 3KGU "Wild Type Human Transthyretin (Ttr) Complexed With Genistein (Ttrwt:gen) Ph 7.5" 100.00 127 100.00 100.00 1.39e-86 PDB 3M1O "Human Transthyretin (Ttr) Complexed With 2-((3,5-Dichloro-4- Hydroxyphenyl)amino)benzoic Acid" 100.00 127 100.00 100.00 1.39e-86 PDB 3NEE "Wild Type Human Transthyretin (Ttr) Complexed With Gc-1 (Ttrwt:gc-1)" 91.34 116 100.00 100.00 2.80e-78 PDB 3NEO "Wild Type Human Transthyretin (Ttr) Complexed With Gc-24 (Ttrwt:gc-24)" 91.34 116 100.00 100.00 2.80e-78 PDB 3NES "V30m Mutant Human Transthyretin (Ttr) Complexed With Gc-1 (V30m:gc-1)" 91.34 116 99.14 100.00 6.93e-78 PDB 3NEX "V30m Mutant Human Transthyretin (Ttr) Complexed With Gc-24 (V30m:gc- 24)" 91.34 116 99.14 100.00 6.93e-78 PDB 3NG5 "Crystal Structure Of V30m Transthyretin Complexed With (-)- Epigallocatechin Gallate (Egcg)" 100.00 127 99.21 100.00 4.01e-86 PDB 3OZK "Crystal Structure Of Human Transthyretin Variant A25t In Complex With Thyroxine (T4)" 100.00 127 99.21 99.21 8.24e-86 PDB 3OZL "Crystal Structure Of Human Transthyretin Variant A25t In Complex With Flufenamic Acid" 100.00 127 99.21 99.21 8.24e-86 PDB 3P3R "Transthyretin In Complex With (3,4-Dihydroxy-5-Nitrophenyl)(2- Fluorophenyl)methanone" 100.00 127 100.00 100.00 1.39e-86 PDB 3P3S "Human Transthyretin (Ttr) Complexed With (Z)-5-(3,5-Dibromo-4- Hydroxybenzylidene)-Imino-1-Methylimidazolidin-4-One" 100.00 127 100.00 100.00 1.39e-86 PDB 3P3T "Human Transthyretin (Ttr) Complexed With 4-(3-(2-Flourophenoxy) Propyl)-3,5-Dimethyl-1h-Pyrazole" 100.00 127 100.00 100.00 1.39e-86 PDB 3P3U "Human Transthyretin (Ttr) Complexed With 5-(2-Ethoxyphenyl)-3- (Pyridin-4-Yl)-1,2,4-Oxadiazole" 100.00 127 100.00 100.00 1.39e-86 PDB 3SSG "Structure Of Transthyretin L55p In Complex With Zn" 100.00 127 99.21 99.21 3.76e-85 PDB 3TCT "Structure Of Wild-Type Ttr In Complex With Tafamidis" 100.00 127 100.00 100.00 1.39e-86 PDB 3TFB "Transthyretin Natural Mutant A25t" 91.34 116 99.14 99.14 1.20e-77 PDB 3U2I "X-Ray Crystal Structure Of Human Transthyretin At Room Temperature" 91.34 117 100.00 100.00 2.15e-77 PDB 3U2J "Neutron Crystal Structure Of Human Transthyretin" 91.34 117 100.00 100.00 2.15e-77 PDB 3W3B "Crystal Structure Of Wild-type Human Transthyretin" 100.00 127 100.00 100.00 1.39e-86 PDB 4ABQ "Crystal Structure Of Transthyretin In Complex With Ligand C-1" 97.64 124 100.00 100.00 4.25e-84 PDB 4ABU "Crystal Structure Of Transthyretin In Complex With Ligand C-2" 97.64 124 100.00 100.00 4.25e-84 PDB 4ABV "Crystal Structure Of Transthyretin In Complex With Ligand C-3" 97.64 124 100.00 100.00 4.25e-84 PDB 4ABW "Crystal Structure Of Transthyretin In Complex With Ligand C-6" 97.64 124 100.00 100.00 4.25e-84 PDB 4AC2 "Crystal Structure Of Transthyretin In Complex With Ligand C-7" 97.64 124 100.00 100.00 4.25e-84 PDB 4AC4 "Crystal Structure Of Transthyretin In Complex With Ligand C-18" 100.00 127 100.00 100.00 1.39e-86 PDB 4ACT "Crystal Structure Of Transthyretin In Complex With Ligand C-17" 100.00 127 100.00 100.00 1.39e-86 PDB 4ANK "Crystallographic Study Of Novel Transthyretin Ligands Exhibiting Negative-Cooperativity Between Two T4 Binding Sites." 100.00 147 100.00 100.00 1.09e-86 PDB 4DER "Crystal Structure Of The Wild Type Ttr Binding Apigenin (Ttrwt:api)" 91.34 116 100.00 100.00 2.80e-78 PDB 4DES "Crystal Structure Of The Wild Type Ttr Binding Chrysin (Ttrwt:chr)" 91.34 116 100.00 100.00 2.80e-78 PDB 4DET "Crystal Structure Of The Wild Type Ttr Binding Kaempferol (Ttrwt:kae)" 91.34 116 100.00 100.00 2.80e-78 PDB 4DEU "Crystal Structure Of The Wild Type Ttr Binding Naringenin (Ttrwt:nar)" 91.34 117 100.00 100.00 2.57e-78 PDB 4DEW "Crystal Structure Of The Wild Type Ttr Binding Luteolin (Ttrwt:lut)" 100.00 147 100.00 100.00 1.09e-86 PDB 4FI6 "Kinetic Stabilization Of Transthyretin Through Covalent Modification Of K15 By 3-(5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl)-" 100.00 127 100.00 100.00 1.39e-86 PDB 4FI7 "Kinetic Stabilization Of Transthyretin Through Covalent Modification Of K15 By 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadia" 100.00 127 100.00 100.00 1.39e-86 PDB 4FI8 "Kinetic Stabilization Of Transthyretin Through Covalent Modification Of K15 By 4-bromo-3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3," 100.00 127 100.00 100.00 1.39e-86 PDB 4HIQ "The Structure Of V122i Mutant Transthyretin In Complex With Ag10" 100.00 127 99.21 100.00 2.59e-86 PDB 4HIS "The Structure Of V122i Mutant Transthyretin In Complex With Tafamidis" 100.00 127 99.21 100.00 2.59e-86 PDB 4HJS "Kinetic Stabilization Of Transthyretin Through Covalent Modification Of K15 By (e)-n-(4-(4-hydroxy-3,5-dimethylstyryl)ethanesul" 91.34 116 100.00 100.00 2.80e-78 PDB 4HJT "Kinetic Stabilization Of Transthyretin Through Covalent Modification Of K15 By (e)-n-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)pr" 100.00 127 100.00 100.00 1.39e-86 PDB 4HJU "Transthyretin In Complex With (e)-n-(3-(4-hydroxy-3,5-dimethylstyryl) Phenyl)acrylamide" 100.00 127 100.00 100.00 1.39e-86 PDB 4I85 "Crystal Structure Of Transthyretin In Complex With Chf5074 At Neutral Ph" 100.00 127 100.00 100.00 1.39e-86 PDB 4I87 "Crystal Structure Of Ttr Variant I84s In Complex With Chf5074 At Acidic Ph" 100.00 127 99.21 99.21 1.60e-85 PDB 4I89 "Crystal Structure Of Transthyretin In Complex With Diflunisal At Acidic Ph" 100.00 127 99.21 99.21 1.60e-85 PDB 4IIZ "Crystal Structure Of Wild-type Human Transthyretin In Complex With Lumiracoxib" 100.00 127 100.00 100.00 1.39e-86 PDB 4IK6 "Crystal Structure Of Human Transthyretin In Complex With Lumiracoxib" 100.00 127 100.00 100.00 1.39e-86 PDB 4IK7 "Crystal Structure Of Human Transthyretin In Complex With Indomethacin" 100.00 127 100.00 100.00 1.39e-86 PDB 4IKI "Crystal Structure Of Wild-type Human Transthyretin In Complex With Indomethacin" 100.00 127 100.00 100.00 1.39e-86 PDB 4IKJ "Crystal Structure Of Wild-type Human Transthyretin In Complex With Sulindac" 100.00 127 100.00 100.00 1.39e-86 PDB 4IKK "Crystal Structure Of Wild-type Human Transthyretin In Complex With Sulindac" 100.00 127 100.00 100.00 1.39e-86 PDB 4IKL "Crystal Structure Of Wild-type Human Transthyretin In Complex With Sulindac" 100.00 127 100.00 100.00 1.39e-86 PDB 4KY2 "Transthyretin In Complex With The Fluorescent Folding Sensor (e)-7- Hydroxy-3-(4-hydroxy-3,5-dimethylstyryl)-4-methyl-2h-chrome" 100.00 127 100.00 100.00 1.39e-86 PDB 4L1S "Covalent Modification Of Transthyretin K15 By Yielding The Fluorescent Conjugate (e)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethy" 100.00 127 100.00 100.00 1.39e-86 PDB 4L1T "Transthyretin In Complex With (e)-3-(dimethylamino)-5-(4-hydroxy-3,5- Dimethylstyryl)benzoic Acid" 100.00 127 100.00 100.00 1.39e-86 PDB 4MAS "High Resolution Structure Of Wild Type Human Transthyretin In Complex With 3,3',5,5'-tetrachloro-[1,1'-biphenyl]-4,4'diol" 100.00 127 100.00 100.00 1.39e-86 PDB 4MRB "Wild Type Human Transthyretin Ph 7.5" 100.00 127 100.00 100.00 1.39e-86 PDB 4MRC "Human Transthyretin Ser52pro Mutant" 99.21 126 99.21 99.21 1.05e-84 PDB 4N85 "Crystal Structure Of Human Transthyretin" 100.00 159 100.00 100.00 2.09e-86 PDB 4N86 "Crystal Structure Of Human Transthyretin Complexed With Glabridin" 100.00 159 100.00 100.00 2.09e-86 PDB 4N87 "Crystal Structure Of V30m Mutant Human Transthyretin Complexed With Glabridin" 100.00 159 99.21 100.00 4.53e-86 PDB 4PM1 "Human Transthyretin (ttr) Complexed With 16-alpha-bromo-estradiol" 100.00 127 100.00 100.00 1.39e-86 PDB 4PME "Human Transthyretin (ttr) Complexed With Ferulic Acid And Curcumin" 92.91 118 100.00 100.00 6.62e-80 PDB 4PMF "Human Transthyretin (ttr) Complexed With Curcumin" 92.13 117 100.00 100.00 4.99e-79 PDB 4PVL "X-ray Structure Of Human Transthyretin (ttr) At Room Temperature To 1.9a Resolution" 100.00 130 100.00 100.00 1.69e-86 PDB 4PVM "Neutron Structure Of Human Transthyretin (ttr) At Room Temperature To 2.0a Resolution (laue)" 100.00 130 100.00 100.00 1.69e-86 PDB 4PVN "Neutron Structure Of Human Transthyretin (ttr) At Room Temperature To 2.3a Resolution (monochromatic)" 100.00 130 100.00 100.00 1.69e-86 PDB 4PWE "Crystal Structure Of V30m Mutant Human Transthyretin" 100.00 159 99.21 100.00 4.53e-86 PDB 4PWF "Crystal Structure Of V30m Mutant Human Transthyretin Complexed With Ferulic Acid Phenethyl Ester" 100.00 159 99.21 100.00 4.53e-86 PDB 4PWG "Crystal Structure Of V30m Mutant Human Transthyretin Complexed With Caffeic Acid Ethyl Ester" 100.00 159 99.21 100.00 4.53e-86 PDB 4PWH "Crystal Structure Of V30m Mutant Human Transthyretin Complexed With Caffeic Acid 1,1-dimethylallyl Ester" 100.00 159 99.21 100.00 4.53e-86 PDB 4PWI "Crystal Structure Of V30m Mutant Human Transthyretin Complexed With Rosmarinic Acid" 100.00 159 99.21 100.00 4.53e-86 PDB 4PWJ "Crystal Structure Of V30m Mutant Human Transthyretin Complexed With Nordihydroguaiaretic Acid" 100.00 159 99.21 100.00 4.53e-86 PDB 4PWK "Crystal Structure Of V30m Mutant Human Transthyretin Complexed With Dihydroguaiaretic Acid" 100.00 159 99.21 100.00 4.53e-86 PDB 4QRF "Crystal Structure Of V30m Mutant Human Transthyretin Complexed With Caffeic Acid Phenethyl Ester" 100.00 159 99.21 100.00 4.53e-86 PDB 4QXV "Crystal Structure Of Human Transthyretin In Complex With Luteolin At 1.1 A Resolution" 100.00 127 100.00 100.00 1.39e-86 PDB 4QYA "Crystal Structure Of Human Transthyretin Variant V30m In Complex With Luteolin" 100.00 127 99.21 100.00 4.01e-86 PDB 4TKW "Crystal Sructure Of Human Transthyretin Leu55pro Mutant" 93.70 125 99.16 99.16 5.30e-79 PDB 4TL4 "Crystal Structure Of Human Transthyretin Val30met Mutant" 93.70 125 99.16 100.00 6.74e-80 PDB 4TL5 "Crystal Structure Of Human Transthyretin Ser85pro Mutant" 93.70 125 99.16 99.16 2.44e-79 PDB 4TLK "Crystal Structure Of Human Transthyretin Ser85pro/glu92pro Mutant" 93.70 125 98.32 98.32 2.55e-78 PDB 4TLS "Crystal Structure Of Human Transthyretin Glu92pro Mutant" 93.70 125 99.16 99.16 3.46e-79 PDB 4TLT "Crystal Structure Of Human Transthyretin" 93.70 125 99.16 99.16 1.07e-78 PDB 4TM9 "Crystal Structure Of Human Transthyretin Thr119trp Mutant" 93.70 125 99.16 99.16 4.03e-79 PDB 4TNE "Crystal Structure Of Human Transthyretin Thr119tyr Mutant" 93.70 125 99.16 99.16 2.26e-79 PDB 4TQ8 "Dual Binding Mode For 3-(9h-fluoren-9-ylideneaminooxy)propanoic Acid Binding To Human Transthyretin (ttr)" 100.00 127 100.00 100.00 1.39e-86 PDB 4TQH "Human Transthyretin (ttr) Complexed With 3-(9h-fluoren-9- Ylideneaminooxy)ethanoic Acid" 100.00 127 100.00 100.00 1.39e-86 PDB 4TQI "Human Transthyretin (ttr) Complexed With 3-(9h-fluoren-9- Ylideneaminooxy)propanoic Acid In A Dual Binding Mode" 100.00 127 100.00 100.00 1.39e-86 PDB 4TQP "Human Transthyretin (ttr) Complexed With (r)-3-(9h-fluoren-9- Ylideneaminooxy)-2-methyl-n-(methylsulfonyl) Propionamide In A Du" 100.00 127 100.00 100.00 1.39e-86 PDB 4WNJ "Crystal Structure Of Transthyretin-quercetin Complex" 100.00 127 100.00 100.00 1.39e-86 PDB 4WNS "Crystal Structure Of Transthyretin Complexed With Pterostilbene" 100.00 127 100.00 100.00 1.39e-86 PDB 4WO0 "Crystal Structure Of Transthyretin In Complex With Apigenin" 100.00 127 100.00 100.00 1.39e-86 PDB 4Y9B "Crystal Structure Of V30m Mutated Transthyretin In Complex With Alpha- Mangostin" 100.00 159 99.21 100.00 4.53e-86 PDB 4Y9C "Crystal Structure Of V30m Mutated Transthyretin With Bromide In Complex With Alpha-mangostin" 100.00 159 99.21 100.00 4.53e-86 PDB 4Y9E "Crystal Structure Of V30m Mutated Transthyretin In Complex With Gamma- Mangostin" 100.00 159 99.21 100.00 4.53e-86 PDB 4Y9F "Crystal Structure Of V30m Mutated Transthyretin With Bromide In Complex With Gamma-mangostin" 100.00 159 99.21 100.00 4.53e-86 PDB 4Y9G "Crystal Structure Of V30m Mutated Transthyretin In Complex With 3- Isomangostin" 100.00 159 99.21 100.00 4.53e-86 PDB 4YDM "High Resolution Crystal Structure Of Human Transthyretin Bound To Ligand And Conjugates Of 3-(5-(3,5-dichloro-4-hydroxyphenyl)-" 100.00 127 99.21 99.21 1.50e-85 PDB 4YDN "High Resolution Crystal Structure Of Human Transthyretin Bound To Ligand And Conjugates Of 4-(5-(3,5-dichloro-4-hydroxyphenyl)-" 100.00 127 99.21 99.21 1.50e-85 PDB 5AKS "Transthyretin Binding Heterogeneity And Anti-amyloidogenic Activity Of Natural Polyphenols And Their Metabolites: Resveratrol-3" 100.00 127 100.00 100.00 1.39e-86 PDB 5AKT "Transthyretin Binding Heterogeneity And Anti-amyloidogenic Activity Of Natural Polyphenols And Their Metabolites: Resveratrol-4" 100.00 127 100.00 100.00 1.39e-86 PDB 5AKV "Transthyretin Binding Heterogeneity And Anti-amyloidogenic Activity Of Natural Polyphenols And Their Metabolites: Genistein-7-o" 100.00 127 100.00 100.00 1.39e-86 PDB 5AL0 "Transthyretin Binding Heterogeneity And Anti-amyloidogenic Activity Of Natural Polyphenols And Their Metabolites: Resveratrol-3" 100.00 127 100.00 100.00 1.39e-86 PDB 5AL8 "Transthyretin Binding Heterogeneity And Anti-amyloidogenic Activity Of Natural Polyphenols And Their Metabolites: Daidzein-7-o-" 100.00 127 100.00 100.00 1.39e-86 PDB 5BOJ "Crystal Structure Of Human Transthyretin In Complex With Gemfibrozil" 100.00 127 100.00 100.00 1.39e-86 PDB 5CR1 "Crystal Structure Of Ttr/resveratrol/t4 Complex" 91.34 116 99.14 99.14 3.02e-77 PDB 5TTR "Leu 55 Pro Transthyretin Crystal Structure" 100.00 127 99.21 99.21 3.76e-85 DBJ BAA00059 "prealbumin [Homo sapiens]" 100.00 147 99.21 100.00 2.35e-86 DBJ BAF62350 "transthyretin [Pan troglodytes verus]" 100.00 147 97.64 99.21 4.43e-84 DBJ BAG34987 "unnamed protein product [Homo sapiens]" 100.00 147 100.00 100.00 1.09e-86 EMBL CAA42087 "transthyretin [Homo sapiens]" 100.00 147 100.00 100.00 1.09e-86 EMBL CAG33189 "TTR [Homo sapiens]" 100.00 147 99.21 100.00 3.71e-86 GB AAA60011 "prealbumin [Homo sapiens]" 100.00 147 100.00 100.00 1.09e-86 GB AAA60012 "prealbumin [Homo sapiens]" 100.00 147 100.00 100.00 1.09e-86 GB AAA60013 "prealbumin precursor, partial [Homo sapiens]" 100.00 147 100.00 100.00 1.09e-86 GB AAA60018 "prealbumin [Homo sapiens]" 100.00 147 99.21 100.00 2.35e-86 GB AAA61181 "transthyretin, partial [Homo sapiens]" 92.13 117 100.00 100.00 2.77e-78 PRF 0908191A "prealbumin,thyroxine binding" 100.00 127 100.00 100.00 1.39e-86 PRF 1008142A "prealbumin variant" 100.00 127 98.43 99.21 1.57e-84 PRF 1101213A "protein,amyloid fibril" 100.00 127 100.00 100.00 1.39e-86 PRF 1709210A transthyretin 100.00 147 100.00 100.00 1.09e-86 REF NP_000362 "transthyretin precursor [Homo sapiens]" 100.00 147 100.00 100.00 1.09e-86 REF NP_001009137 "transthyretin precursor [Pan troglodytes]" 100.00 147 97.64 99.21 4.43e-84 REF XP_003830303 "PREDICTED: transthyretin [Pan paniscus]" 100.00 148 97.64 99.21 5.10e-84 SP P02766 "RecName: Full=Transthyretin; AltName: Full=ATTR; AltName: Full=Prealbumin; AltName: Full=TBPA; Flags: Precursor" 100.00 147 100.00 100.00 1.09e-86 SP Q5U7I5 "RecName: Full=Transthyretin; AltName: Full=Prealbumin; Flags: Precursor" 100.00 147 97.64 99.21 4.43e-84 stop_ save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species _Strain $pancreatic_polypeptide human 9606 Eukaryota Metazoa Homo sapiens generic stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $pancreatic_polypeptide 'not available' . . . . . stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_one _Saveframe_category sample _Sample_type solution _Details . save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_list _Saveframe_category NMR_spectrometer _Manufacturer unknown _Model unknown _Field_strength 0 _Details 'spectrometer information not available' save_ ############################# # NMR applied experiments # ############################# save__1 _Saveframe_category NMR_applied_experiment _Sample_label $sample_one save_ ####################### # Sample conditions # ####################### save_sample_condition_set_one _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units pH 7.4 . na temperature 353 . K stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chem_shift_reference_par_set_one _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis _Indirect_shift_ratio_citation_label _Correction_value_citation_label DSS H . . ppm 0 . . . . . $entry_citation $entry_citation stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_chemical_shift_assignment_data_set_one _Saveframe_category assigned_chemical_shifts _Details . loop_ _Sample_label $sample_one stop_ _Sample_conditions_label $sample_condition_set_one _Chem_shift_reference_set_label $chem_shift_reference_par_set_one _Mol_system_component_name 'pancreatic polypeptide' _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 . 22 GLY HA2 H 4.15 . 1 2 . 22 GLY HA3 H 4.15 . 1 3 . 33 PHE HA H 5.23 . 1 4 . 33 PHE HD1 H 7.6 . 1 5 . 33 PHE HD2 H 7.6 . 1 6 . 33 PHE HE1 H 7.6 . 1 7 . 33 PHE HE2 H 7.6 . 1 8 . 41 TRP HE3 H 7.6 . 1 9 . 41 TRP HH2 H 7.22 . 1 10 . 64 PHE HA H 4.86 . 1 11 . 64 PHE HD1 H 7.22 . 1 12 . 64 PHE HD2 H 7.22 . 1 13 . 64 PHE HE1 H 6.72 . 1 14 . 64 PHE HE2 H 6.72 . 1 15 . 75 THR HG2 H 1.06 . 1 16 . 78 TYR HD1 H 5.63 . 1 17 . 78 TYR HD2 H 5.63 . 1 18 . 78 TYR HE1 H 6.43 . 1 19 . 78 TYR HE2 H 6.43 . 1 20 . 79 TRP HZ2 H 7.46 . 1 21 . 79 TRP HH2 H 7.12 . 1 22 . 87 PHE HD1 H 6.83 . 1 23 . 87 PHE HD2 H 6.83 . 1 24 . 87 PHE HE1 H 7.22 . 1 25 . 87 PHE HE2 H 7.22 . 1 26 . 105 TYR HD1 H 7.12 . 1 27 . 105 TYR HD2 H 7.12 . 1 28 . 105 TYR HE1 H 7.22 . 1 29 . 105 TYR HE2 H 7.22 . 1 30 . 111 LEU HD1 H .28 . 1 31 . 111 LEU HD2 H .28 . 1 32 . 112 SER HA H 5.23 . 1 33 . 114 TYR HD1 H 6.83 . 1 34 . 114 TYR HD2 H 6.83 . 1 35 . 120 ALA HA H 4.03 . 1 36 . 120 ALA HB H .18 . 1 37 . 122 VAL HG1 H .34 . 1 38 . 122 VAL HG2 H .34 . 1 stop_ save_