data_4689 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; NMR Studies of the Backbone Flexibility and Structure of Human Growth Hormone: a Comparison of High and Low pH Conformations ; _BMRB_accession_number 4689 _BMRB_flat_file_name bmr4689.str _Entry_type original _Submission_date 2000-03-16 _Accession_date 2000-03-16 _Entry_origination author _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details . loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Kasimova Marina R. . 2 Kristensen Soren M. . 3 Howe Peter W.A. . 4 Christensen Thorkild . . 5 Matthiesen Finn . . 6 Petersen Jorgen . . 7 Sorensen Hans H. . 8 Led Jens J. . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 2 S2_parameters 2 T1_relaxation 2 T2_relaxation 2 heteronucl_NOE 2 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 502 "13C chemical shifts" 402 "15N chemical shifts" 245 "T1 relaxation values" 237 "T2 relaxation values" 237 "order parameters" 237 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 2002-04-01 original author . stop_ loop_ _Related_BMRB_accession_number _Relationship 25029 'assignments based on new series of NMR spectra' stop_ _Original_release_date 2002-04-01 save_ ############################# # Citation for this entry # ############################# save_entry_citation _Saveframe_category entry_citation _Citation_full . _Citation_title ; NMR Studies of the Backbone Flexibility and Structure of Human Growth Hormone: A Comparison of high and low pH Conformations ; _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code 22050830 _PubMed_ID 12054815 loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Kasimova Marina R. . 2 Kristensen Soren M. . 3 Howe Peter W.A. . 4 Christensen Thorkild . . 5 Matthiesen Finn . . 6 Petersen Jorgen . . 7 Sorensen Hans H. . 8 Led Jens J. . stop_ _Journal_abbreviation 'J. Mol. Biol.' _Journal_volume 318 _Journal_issue 3 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 679 _Page_last 695 _Year 2002 _Details . loop_ _Keyword 'backbone dynamics' 'amide proton exchange' 'human growth hormone' NMR 'secondary structure' 'protein folding' stop_ save_ ################################## # Molecular system description # ################################## save_system_hGH _Saveframe_category molecular_system _Mol_system_name 'Human Growth Hormone' _Abbreviation_common hGH _Enzyme_commission_number . loop_ _Mol_system_component_name _Mol_label hGH $hGH stop_ _System_molecular_weight . _System_physical_state native _System_oligomer_state monomer _System_paramagnetic no _System_thiol_state 'all disulfide bound' _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_hGH _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common 'Human Growth Hormone' _Abbreviation_common hGH _Molecular_mass . _Mol_thiol_state 'all disulfide bound' _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 191 _Mol_residue_sequence ; FPTIPLSRLFDNAMLRAHRL HQLAFDTYQEFEEAYIPKEQ KYSFLQNPQTSLCFSESIPT PSNREETQQKSNLELLRISL LLIQSWLEPVQFLRSVFANS LVYGASDSNVYDLLKDLEEG IQTLMGRLEDGSPRTGQIFK QTYSKFDTNSHNDDALLKNY GLLYCFRKDMDKVETFLRIV QCRSVEGSCGF ; loop_ _Residue_seq_code _Residue_label 1 PHE 2 PRO 3 THR 4 ILE 5 PRO 6 LEU 7 SER 8 ARG 9 LEU 10 PHE 11 ASP 12 ASN 13 ALA 14 MET 15 LEU 16 ARG 17 ALA 18 HIS 19 ARG 20 LEU 21 HIS 22 GLN 23 LEU 24 ALA 25 PHE 26 ASP 27 THR 28 TYR 29 GLN 30 GLU 31 PHE 32 GLU 33 GLU 34 ALA 35 TYR 36 ILE 37 PRO 38 LYS 39 GLU 40 GLN 41 LYS 42 TYR 43 SER 44 PHE 45 LEU 46 GLN 47 ASN 48 PRO 49 GLN 50 THR 51 SER 52 LEU 53 CYS 54 PHE 55 SER 56 GLU 57 SER 58 ILE 59 PRO 60 THR 61 PRO 62 SER 63 ASN 64 ARG 65 GLU 66 GLU 67 THR 68 GLN 69 GLN 70 LYS 71 SER 72 ASN 73 LEU 74 GLU 75 LEU 76 LEU 77 ARG 78 ILE 79 SER 80 LEU 81 LEU 82 LEU 83 ILE 84 GLN 85 SER 86 TRP 87 LEU 88 GLU 89 PRO 90 VAL 91 GLN 92 PHE 93 LEU 94 ARG 95 SER 96 VAL 97 PHE 98 ALA 99 ASN 100 SER 101 LEU 102 VAL 103 TYR 104 GLY 105 ALA 106 SER 107 ASP 108 SER 109 ASN 110 VAL 111 TYR 112 ASP 113 LEU 114 LEU 115 LYS 116 ASP 117 LEU 118 GLU 119 GLU 120 GLY 121 ILE 122 GLN 123 THR 124 LEU 125 MET 126 GLY 127 ARG 128 LEU 129 GLU 130 ASP 131 GLY 132 SER 133 PRO 134 ARG 135 THR 136 GLY 137 GLN 138 ILE 139 PHE 140 LYS 141 GLN 142 THR 143 TYR 144 SER 145 LYS 146 PHE 147 ASP 148 THR 149 ASN 150 SER 151 HIS 152 ASN 153 ASP 154 ASP 155 ALA 156 LEU 157 LEU 158 LYS 159 ASN 160 TYR 161 GLY 162 LEU 163 LEU 164 TYR 165 CYS 166 PHE 167 ARG 168 LYS 169 ASP 170 MET 171 ASP 172 LYS 173 VAL 174 GLU 175 THR 176 PHE 177 LEU 178 ARG 179 ILE 180 VAL 181 GLN 182 CYS 183 ARG 184 SER 185 VAL 186 GLU 187 GLY 188 SER 189 CYS 190 GLY 191 PHE stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date 2015-10-27 loop_ _Database_name _Database_accession_code _Database_entry_mol_name _Sequence_query_to_submitted_percentage _Sequence_subject_length _Sequence_identity _Sequence_positive _Sequence_homology_expectation_value BMRB 25029 hGH 100.00 191 100.00 100.00 1.29e-137 PDB 1A22 "Human Growth Hormone Bound To Single Receptor" 100.00 191 99.48 99.48 2.45e-136 PDB 1BP3 "The Xray Structure Of A Growth Hormone-Prolactin Receptor Complex" 100.00 191 99.48 99.48 2.45e-136 PDB 1HWG "1:2 Complex Of Human Growth Hormone With Its Soluble Binding Protein" 100.00 191 100.00 100.00 1.29e-137 PDB 1HWH "1:1 Complex Of Human Growth Hormone Mutant G120r With Its Soluble Binding Protein" 100.00 191 99.48 99.48 2.45e-136 PDB 3HHR "Human Growth Hormone And Extracellular Domain Of Its Receptor: Crystal Structure Of The Complex" 99.48 190 100.00 100.00 7.50e-137 DBJ BAJ21175 "growth hormone 1 [synthetic construct]" 100.00 217 100.00 100.00 2.57e-137 EMBL CAA23778 "unnamed protein product [Homo sapiens]" 100.00 217 99.48 99.48 3.99e-136 EMBL CAA23779 "growth hormone [Homo sapiens]" 100.00 217 99.48 99.48 3.39e-136 GB AAA52549 "growth hormone GH-1 [Homo sapiens]" 100.00 217 100.00 100.00 2.57e-137 GB AAA72260 "human growth hormone [synthetic construct]" 100.00 192 100.00 100.00 1.15e-137 GB AAA98618 "growth hormone [Homo sapiens]" 100.00 217 100.00 100.00 2.57e-137 GB AAC42099 "growth hormone [synthetic construct]" 100.00 192 100.00 100.00 1.15e-137 GB AAF23135 "recombinant ubiquitin-somatotropin fusion protein [synthetic construct]" 100.00 270 100.00 100.00 1.91e-137 PRF 1403262B "somatoliberin 20kD variant" 100.00 217 99.48 99.48 3.39e-136 REF NP_000506 "somatotropin isoform 1 precursor [Homo sapiens]" 100.00 217 100.00 100.00 2.57e-137 REF NP_001184093 "somatotropin precursor [Pan troglodytes]" 100.00 217 100.00 100.00 4.68e-137 REF NP_001277233 "growth hormone 1 precursor [Papio anubis]" 100.00 217 97.38 98.95 1.51e-133 REF XP_002827754 "PREDICTED: somatotropin isoform X7 [Pongo abelii]" 100.00 217 100.00 100.00 1.95e-137 REF XP_003262698 "PREDICTED: somatotropin isoform X1 [Nomascus leucogenys]" 65.97 252 98.41 99.21 4.47e-82 SP P01241 "RecName: Full=Somatotropin; AltName: Full=Growth hormone; Short=GH; Short=GH-N; AltName: Full=Growth hormone 1; AltName: Full=P" 100.00 217 100.00 100.00 2.57e-137 SP P58756 "RecName: Full=Somatotropin; AltName: Full=Growth hormone; Short=GH; Short=GH-N; AltName: Full=Growth hormone 1; AltName: Full=P" 100.00 217 100.00 100.00 4.68e-137 TPE CDW51387 "TPA: growth hormone B5 [Homo sapiens]" 100.00 217 100.00 100.00 2.57e-137 TPE CDW51389 "TPA: growth hormone B2 [Pan troglodytes]" 100.00 217 98.43 98.43 5.01e-134 TPE CDW51391 "TPA: growth hormone B2 [Gorilla gorilla]" 100.00 217 100.00 100.00 2.25e-137 TPE CDW51396 "TPA: growth hormone B4 [Pongo abelii]" 100.00 217 100.00 100.00 1.95e-137 TPE CDW51399 "TPA: growth hormone B2 [Nomascus leucogenys]" 100.00 217 98.95 99.48 5.13e-136 stop_ save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species $hGH human 9606 Eukaryota Metazoa Homo sapiens stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $hGH 'recombinant technology' 'E. coli' Escherichia coli . . stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $hGH 0.9 mM '[U-90% 15N; U-95% 13C]' H2O 10 % . D2O 90 % . stop_ save_ save_sample_2 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $hGH 0.9 mM '[U-90% 15N]' H2O 10 % . D2O 90 % . stop_ save_ save_sample_3 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $hGH 0.9 mM '[Leu-90% 15N]' H2O 10 % . D2O 90 % . 'Sodium phosphate' 10 mM . stop_ save_ save_sample_4 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $hGH 0.9 mM '[U-90% 15N; U-95% 13C]' H2O 0.04 % . D2O 99.96 % . stop_ save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_1 _Saveframe_category NMR_spectrometer _Manufacturer Bruker _Model AM500 _Field_strength 500 _Details . save_ save_spectrometer_2 _Saveframe_category NMR_spectrometer _Manufacturer Varian _Model UnityINOVA _Field_strength 500 _Details . save_ save_spectrometer_3 _Saveframe_category NMR_spectrometer _Manufacturer Varian _Model UnityINOVA _Field_strength 750 _Details . save_ save_spectrometer_4 _Saveframe_category NMR_spectrometer _Manufacturer Varian _Model UnityINOVA _Field_strength 800 _Details . save_ ####################### # Sample conditions # ####################### save_sample_conditions_one _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units pH 2.7 0.2 pH temperature 305 0.1 K pressure 1 . atm stop_ save_ save_sample_conditions_two _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units pH 7.0 0.2 pH temperature 305 0.1 K pressure 1 . atm stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chemical_shift_reference _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis _Indirect_shift_ratio H2O H 1 protons ppm 4.69 internal direct . . . 1.0 DSS N 15 'methyl protons' ppm 0.0 . indirect . . . 0.101329118 DSS C 13 'methyl protons' ppm 0.0 . indirect . . . 0.251449530 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_chemical_shift_assignment_one _Saveframe_category assigned_chemical_shifts _Details . loop_ _Sample_label $sample_1 $sample_2 $sample_3 $sample_4 stop_ _Sample_conditions_label $sample_conditions_one _Chem_shift_reference_set_label $chemical_shift_reference _Mol_system_component_name hGH _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 . 2 PRO HA H 4.57 0.02 1 2 . 2 PRO C C 176.4 0.1 1 3 . 2 PRO CA C 63.1 0.1 1 4 . 3 THR H H 8.34 0.02 1 5 . 3 THR HA H 4.30 0.02 1 6 . 3 THR C C 174.5 0.1 1 7 . 3 THR CA C 61.9 0.1 1 8 . 3 THR N N 116.8 0.15 1 9 . 4 ILE H H 8.42 0.02 1 10 . 4 ILE HA H 4.45 0.02 1 11 . 4 ILE C C 174.2 0.1 1 12 . 4 ILE CA C 58.7 0.1 1 13 . 4 ILE N N 126.8 0.15 1 14 . 5 PRO HA H 4.53 0.02 1 15 . 5 PRO C C 177.4 0.1 1 16 . 5 PRO CA C 62.9 0.1 1 17 . 5 PRO N N 140.0 0.15 1 18 . 6 LEU H H 8.85 0.02 1 19 . 6 LEU HA H 3.82 0.02 1 20 . 6 LEU C C 178.8 0.1 1 21 . 6 LEU CA C 58.2 0.1 1 22 . 6 LEU N N 124.8 0.15 1 23 . 7 SER H H 8.85 0.02 1 24 . 7 SER HA H 4.26 0.02 1 25 . 7 SER C C 176.8 0.1 1 26 . 7 SER CA C 60.8 0.1 1 27 . 7 SER N N 111.7 0.15 1 28 . 8 ARG H H 7.12 0.02 1 29 . 8 ARG HA H 4.23 0.02 1 30 . 8 ARG C C 178.3 0.1 1 31 . 8 ARG CA C 58.1 0.1 1 32 . 8 ARG N N 122.9 0.15 1 33 . 9 LEU H H 7.60 0.02 1 34 . 9 LEU HA H 4.07 0.02 1 35 . 9 LEU C C 181.3 0.1 1 36 . 9 LEU CA C 57.9 0.1 1 37 . 9 LEU N N 119.8 0.15 1 38 . 10 PHE H H 8.54 0.02 1 39 . 10 PHE HA H 4.12 0.02 1 40 . 10 PHE C C 177.9 0.1 1 41 . 10 PHE CA C 63.2 0.1 1 42 . 10 PHE N N 118.2 0.15 1 43 . 11 ASP H H 8.36 0.02 1 44 . 11 ASP HA H 4.41 0.02 1 45 . 11 ASP C C 178.1 0.1 1 46 . 11 ASP CA C 56.7 0.1 1 47 . 11 ASP N N 119.3 0.15 1 48 . 12 ASN H H 8.32 0.02 1 49 . 12 ASN HA H 4.46 0.02 1 50 . 12 ASN C C 177.4 0.1 1 51 . 12 ASN CA C 55.9 0.1 1 52 . 12 ASN N N 118.3 0.15 1 53 . 13 ALA H H 7.67 0.02 1 54 . 13 ALA HA H 4.18 0.02 1 55 . 13 ALA C C 179.1 0.1 1 56 . 13 ALA CA C 54.9 0.1 1 57 . 13 ALA N N 122.2 0.15 1 58 . 14 MET H H 8.82 0.02 1 59 . 14 MET HA H 4.39 0.02 1 60 . 14 MET C C 179.4 0.1 1 61 . 14 MET CA C 56.7 0.1 1 62 . 14 MET N N 116.8 0.15 1 63 . 15 LEU H H 8.10 0.02 1 64 . 15 LEU C C 180.5 0.1 1 65 . 15 LEU CA C 58.5 0.1 1 66 . 15 LEU N N 121.5 0.15 1 67 . 16 ARG H H 7.49 0.02 1 68 . 16 ARG HA H 4.03 0.02 1 69 . 16 ARG C C 178.3 0.1 1 70 . 16 ARG CA C 59.5 0.1 1 71 . 16 ARG N N 118.2 0.15 1 72 . 17 ALA H H 8.84 0.02 1 73 . 17 ALA HA H 4.02 0.02 1 74 . 17 ALA C C 179.6 0.1 1 75 . 17 ALA CA C 55.3 0.1 1 76 . 17 ALA N N 121.8 0.15 1 77 . 18 HIS H H 8.99 0.02 1 78 . 18 HIS HA H 4.44 0.02 1 79 . 18 HIS C C 177.5 0.1 1 80 . 18 HIS CA C 58.9 0.1 1 81 . 18 HIS N N 117.0 0.15 1 82 . 19 ARG H H 8.05 0.02 1 83 . 19 ARG HA H 4.03 0.02 1 84 . 19 ARG C C 179.4 0.1 1 85 . 19 ARG CA C 58.8 0.1 1 86 . 19 ARG N N 120.4 0.15 1 87 . 20 LEU H H 8.23 0.02 1 88 . 20 LEU HA H 3.88 0.02 1 89 . 20 LEU CA C 58.2 0.1 1 90 . 20 LEU N N 120.2 0.15 1 91 . 22 GLN HA H 3.83 0.02 1 92 . 22 GLN C C 177.9 0.1 1 93 . 23 LEU H H 8.56 0.02 1 94 . 23 LEU HA H 4.20 0.02 1 95 . 23 LEU C C 180.6 0.1 1 96 . 23 LEU CA C 58.1 0.1 1 97 . 23 LEU N N 119.8 0.15 1 98 . 24 ALA H H 8.64 0.02 1 99 . 24 ALA HA H 4.10 0.02 1 100 . 24 ALA CA C 55.4 0.1 1 101 . 24 ALA N N 123.6 0.15 1 102 . 25 PHE H H 8.42 0.02 1 103 . 25 PHE HA H 3.89 0.02 1 104 . 25 PHE C C 177.6 0.1 1 105 . 25 PHE CA C 62.1 0.1 1 106 . 25 PHE N N 119.0 0.15 1 107 . 26 ASP H H 9.11 0.02 1 108 . 26 ASP HA H 4.44 0.02 1 109 . 26 ASP CA C 56.2 0.1 1 110 . 26 ASP N N 119.2 0.15 1 111 . 30 GLU HA H 4.01 0.02 1 112 . 30 GLU C C 178.2 0.1 1 113 . 31 PHE H H 8.30 0.02 1 114 . 31 PHE HA H 4.13 0.02 1 115 . 31 PHE C C 177.3 0.1 1 116 . 31 PHE CA C 61.2 0.1 1 117 . 31 PHE N N 121.0 0.15 1 118 . 32 GLU H H 8.33 0.02 1 119 . 32 GLU HA H 3.71 0.02 1 120 . 32 GLU C C 177.8 0.1 1 121 . 32 GLU CA C 58.8 0.1 1 122 . 32 GLU N N 117.8 0.15 1 123 . 33 GLU H H 7.88 0.02 1 124 . 33 GLU HA H 3.96 0.02 1 125 . 33 GLU C C 177.5 0.1 1 126 . 33 GLU CA C 57.7 0.1 1 127 . 33 GLU N N 115.8 0.15 1 128 . 34 ALA H H 7.64 0.02 1 129 . 34 ALA HA H 4.05 0.02 1 130 . 34 ALA C C 178.9 0.1 1 131 . 34 ALA CA C 53.5 0.1 1 132 . 34 ALA N N 119.5 0.15 1 133 . 35 TYR H H 7.68 0.02 1 134 . 35 TYR HA H 4.49 0.02 1 135 . 35 TYR C C 175.9 0.1 1 136 . 35 TYR CA C 58.3 0.1 1 137 . 35 TYR N N 114.3 0.15 1 138 . 36 ILE H H 7.44 0.02 1 139 . 36 ILE HA H 4.26 0.02 1 140 . 36 ILE CA C 58.2 0.1 1 141 . 36 ILE N N 120.4 0.15 1 142 . 37 PRO C C 179.4 0.1 1 143 . 38 LYS HA H 4.07 0.02 1 144 . 38 LYS C C 177.6 0.1 1 145 . 38 LYS CA C 58.0 0.1 1 146 . 39 GLU H H 8.25 0.02 1 147 . 39 GLU HA H 4.25 0.02 1 148 . 39 GLU C C 176.5 0.1 1 149 . 39 GLU CA C 56.6 0.1 1 150 . 39 GLU N N 117.2 0.15 1 151 . 40 GLN H H 8.02 0.02 1 152 . 40 GLN HA H 4.27 0.02 1 153 . 40 GLN C C 176.3 0.1 1 154 . 40 GLN CA C 56.4 0.1 1 155 . 40 GLN N N 119.1 0.15 1 156 . 41 LYS H H 7.94 0.02 1 157 . 41 LYS HA H 4.06 0.02 1 158 . 41 LYS C C 176.8 0.1 1 159 . 41 LYS CA C 57.9 0.1 1 160 . 41 LYS N N 120.2 0.15 1 161 . 42 TYR H H 8.00 0.02 1 162 . 42 TYR HA H 4.49 0.02 1 163 . 42 TYR C C 176.6 0.1 1 164 . 42 TYR CA C 58.1 0.1 1 165 . 42 TYR N N 118.3 0.15 1 166 . 43 SER H H 8.05 0.02 1 167 . 43 SER HA H 4.27 0.02 1 168 . 43 SER C C 175.4 0.1 1 169 . 43 SER CA C 59.5 0.1 1 170 . 43 SER N N 116.4 0.15 1 171 . 44 PHE H H 7.89 0.02 1 172 . 44 PHE HA H 4.46 0.02 1 173 . 44 PHE C C 176.1 0.1 1 174 . 44 PHE CA C 58.7 0.1 1 175 . 44 PHE N N 120.9 0.15 1 176 . 45 LEU H H 7.64 0.02 1 177 . 45 LEU HA H 4.14 0.02 1 178 . 45 LEU C C 177.3 0.1 1 179 . 45 LEU CA C 55.6 0.1 1 180 . 45 LEU N N 120.1 0.15 1 181 . 46 GLN H H 7.73 0.02 1 182 . 46 GLN HA H 4.21 0.02 1 183 . 46 GLN C C 175.4 0.1 1 184 . 46 GLN CA C 55.8 0.1 1 185 . 46 GLN N N 117.9 0.15 1 186 . 47 ASN H H 7.91 0.02 1 187 . 47 ASN HA H 4.90 0.02 1 188 . 47 ASN CA C 51.3 0.1 1 189 . 47 ASN N N 119.0 0.15 1 190 . 48 PRO HA H 4.30 0.02 1 191 . 48 PRO C C 177.2 0.1 1 192 . 48 PRO CA C 63.8 0.1 1 193 . 49 GLN H H 8.26 0.02 1 194 . 49 GLN HA H 4.21 0.02 1 195 . 49 GLN C C 176.8 0.1 1 196 . 49 GLN CA C 56.4 0.1 1 197 . 49 GLN N N 118.6 0.15 1 198 . 50 THR H H 7.87 0.02 1 199 . 50 THR HA H 4.22 0.02 1 200 . 50 THR C C 175.0 0.1 1 201 . 50 THR CA C 62.7 0.1 1 202 . 50 THR N N 112.8 0.15 1 203 . 51 SER H H 7.84 0.02 1 204 . 51 SER HA H 4.43 0.02 1 205 . 51 SER C C 174.1 0.1 1 206 . 51 SER CA C 58.6 0.1 1 207 . 51 SER N N 116.7 0.15 1 208 . 52 LEU H H 7.44 0.02 1 209 . 52 LEU HA H 4.37 0.02 1 210 . 52 LEU C C 177.1 0.1 1 211 . 52 LEU CA C 55.3 0.1 1 212 . 52 LEU N N 122.9 0.15 1 213 . 53 CYS H H 8.03 0.02 1 214 . 53 CYS HA H 4.95 0.02 1 215 . 53 CYS CA C 53.1 0.1 1 216 . 53 CYS N N 118.4 0.15 1 217 . 55 SER C C 175.6 0.1 1 218 . 56 GLU H H 7.75 0.02 1 219 . 56 GLU HA H 4.31 0.02 1 220 . 56 GLU C C 176.2 0.1 1 221 . 56 GLU CA C 57.2 0.1 1 222 . 56 GLU N N 121.2 0.15 1 223 . 57 SER H H 7.75 0.02 1 224 . 57 SER HA H 4.37 0.02 1 225 . 57 SER C C 174.0 0.1 1 226 . 57 SER CA C 58.9 0.1 1 227 . 57 SER N N 113.2 0.15 1 228 . 58 ILE H H 7.53 0.02 1 229 . 58 ILE HA H 4.33 0.02 1 230 . 58 ILE CA C 58.5 0.1 1 231 . 58 ILE N N 123.8 0.15 1 232 . 59 PRO C C 174.2 0.1 1 233 . 60 THR H H 7.59 0.02 1 234 . 60 THR HA H 4.60 0.02 1 235 . 60 THR CA C 59.3 0.1 1 236 . 60 THR N N 119.4 0.15 1 237 . 76 LEU C C 177.7 0.1 1 238 . 77 ARG H H 8.56 0.02 1 239 . 77 ARG HA H 3.87 0.02 1 240 . 77 ARG C C 178.8 0.1 1 241 . 77 ARG CA C 60.0 0.1 1 242 . 77 ARG N N 120.8 0.15 1 243 . 78 ILE H H 8.41 0.02 1 244 . 78 ILE HA H 3.63 0.02 1 245 . 78 ILE C C 177.7 0.1 1 246 . 78 ILE CA C 65.5 0.1 1 247 . 78 ILE N N 118.4 0.15 1 248 . 79 SER H H 7.77 0.02 1 249 . 79 SER HA H 4.21 0.02 1 250 . 79 SER C C 174.9 0.1 1 251 . 79 SER CA C 64.0 0.1 1 252 . 79 SER N N 115.8 0.15 1 253 . 80 LEU H H 8.53 0.02 1 254 . 80 LEU HA H 3.96 0.02 1 255 . 80 LEU C C 178.2 0.1 1 256 . 80 LEU CA C 58.2 0.1 1 257 . 80 LEU N N 121.8 0.15 1 258 . 81 LEU H H 8.24 0.02 1 259 . 81 LEU HA H 4.12 0.02 1 260 . 81 LEU C C 180.7 0.1 1 261 . 81 LEU CA C 58.0 0.1 1 262 . 81 LEU N N 119.4 0.15 1 263 . 82 LEU H H 8.40 0.02 1 264 . 82 LEU HA H 4.37 0.02 1 265 . 82 LEU C C 179.3 0.1 1 266 . 82 LEU CA C 58.4 0.1 1 267 . 82 LEU N N 120.8 0.15 1 268 . 83 ILE H H 8.03 0.02 1 269 . 83 ILE HA H 3.82 0.02 1 270 . 83 ILE C C 178.3 0.1 1 271 . 83 ILE CA C 56.4 0.1 1 272 . 83 ILE N N 118.6 0.15 1 273 . 84 GLN H H 9.02 0.02 1 274 . 84 GLN HA H 3.89 0.02 1 275 . 84 GLN C C 179.5 0.1 1 276 . 84 GLN CA C 59.1 0.1 1 277 . 84 GLN N N 116.8 0.15 1 278 . 85 SER H H 8.13 0.02 1 279 . 85 SER HA H 4.16 0.02 1 280 . 85 SER CA C 61.5 0.1 1 281 . 85 SER N N 114.8 0.15 1 282 . 90 VAL HA H 4.45 0.02 1 283 . 90 VAL C C 177.0 0.1 1 284 . 91 GLN H H 8.40 0.02 1 285 . 91 GLN HA H 4.44 0.02 1 286 . 91 GLN C C 177.4 0.1 1 287 . 91 GLN CA C 58.6 0.1 1 288 . 91 GLN N N 116.2 0.15 1 289 . 92 PHE H H 8.31 0.02 1 290 . 92 PHE HA H 4.08 0.02 1 291 . 92 PHE C C 179.4 0.1 1 292 . 92 PHE CA C 58.2 0.1 1 293 . 92 PHE N N 120.2 0.15 1 294 . 93 LEU H H 8.23 0.02 1 295 . 93 LEU C C 178.3 0.1 1 296 . 93 LEU CA C 58.2 0.1 1 297 . 93 LEU N N 120.2 0.15 1 298 . 94 ARG H H 8.31 0.02 1 299 . 94 ARG HA H 4.08 0.02 1 300 . 94 ARG C C 178.1 0.1 1 301 . 94 ARG CA C 59.3 0.1 1 302 . 94 ARG N N 117.4 0.15 1 303 . 95 SER H H 8.22 0.02 1 304 . 95 SER HA H 4.32 0.02 1 305 . 95 SER C C 175.8 0.1 1 306 . 95 SER CA C 60.8 0.1 1 307 . 95 SER N N 113.0 0.15 1 308 . 96 VAL H H 7.49 0.02 1 309 . 96 VAL HA H 3.81 0.02 1 310 . 96 VAL C C 177.1 0.1 1 311 . 96 VAL CA C 64.4 0.1 1 312 . 96 VAL N N 120.4 0.15 1 313 . 97 PHE H H 7.50 0.02 1 314 . 97 PHE HA H 4.58 0.02 1 315 . 97 PHE C C 176.5 0.1 1 316 . 97 PHE CA C 58.7 0.1 1 317 . 97 PHE N N 116.8 0.15 1 318 . 98 ALA H H 7.82 0.02 1 319 . 98 ALA HA H 4.28 0.02 1 320 . 98 ALA C C 178.0 0.1 1 321 . 98 ALA CA C 53.8 0.1 1 322 . 98 ALA N N 122.1 0.15 1 323 . 99 ASN H H 8.10 0.02 1 324 . 99 ASN HA H 4.75 0.02 1 325 . 99 ASN C C 175.4 0.1 1 326 . 99 ASN CA C 61.8 0.1 1 327 . 99 ASN N N 115.8 0.15 1 328 . 100 SER H H 7.99 0.02 1 329 . 100 SER HA H 4.44 0.02 1 330 . 100 SER C C 174.8 0.1 1 331 . 100 SER CA C 59.0 0.1 1 332 . 100 SER N N 115.4 0.15 1 333 . 101 LEU H H 8.17 0.02 1 334 . 101 LEU HA H 4.37 0.02 1 335 . 101 LEU C C 177.1 0.1 1 336 . 101 LEU CA C 55.7 0.1 1 337 . 101 LEU N N 123.0 0.15 1 338 . 102 VAL H H 7.76 0.02 1 339 . 102 VAL HA H 3.96 0.02 1 340 . 102 VAL C C 176.1 0.1 1 341 . 102 VAL CA C 62.6 0.1 1 342 . 102 VAL N N 118.7 0.15 1 343 . 103 TYR H H 8.07 0.02 1 344 . 103 TYR HA H 4.47 0.02 1 345 . 103 TYR C C 176.6 0.1 1 346 . 103 TYR CA C 58.5 0.1 1 347 . 103 TYR N N 123.0 0.15 1 348 . 104 GLY H H 8.12 0.02 1 349 . 104 GLY HA2 H 3.96 0.02 2 350 . 104 GLY HA3 H 3.74 0.02 2 351 . 104 GLY C C 174.2 0.1 1 352 . 104 GLY CA C 45.4 0.1 1 353 . 104 GLY N N 110.8 0.15 1 354 . 105 ALA H H 7.94 0.02 1 355 . 105 ALA HA H 4.30 0.02 1 356 . 105 ALA C C 177.7 0.1 1 357 . 105 ALA CA C 52.6 0.1 1 358 . 105 ALA N N 122.9 0.15 1 359 . 106 SER H H 8.12 0.02 1 360 . 106 SER HA H 4.42 0.02 1 361 . 106 SER C C 174.8 0.1 1 362 . 106 SER CA C 58.6 0.1 1 363 . 106 SER N N 114.1 0.15 1 364 . 107 ASP H H 8.46 0.02 1 365 . 107 ASP HA H 4.60 0.02 1 366 . 107 ASP C C 175.6 0.1 1 367 . 107 ASP CA C 54.1 0.1 1 368 . 107 ASP N N 120.0 0.15 1 369 . 108 SER H H 8.10 0.02 1 370 . 108 SER C C 174.4 0.1 1 371 . 108 SER CA C 59.1 0.1 1 372 . 108 SER N N 114.4 0.15 1 373 . 109 ASN H H 8.17 0.02 1 374 . 109 ASN HA H 4.18 0.02 1 375 . 109 ASN N N 123.0 0.15 1 376 . 110 VAL HA H 3.48 0.02 1 377 . 110 VAL C C 176.1 0.1 1 378 . 111 TYR H H 8.09 0.02 1 379 . 111 TYR HA H 3.99 0.02 1 380 . 111 TYR C C 176.4 0.1 1 381 . 111 TYR CA C 62.2 0.1 1 382 . 111 TYR N N 120.4 0.15 1 383 . 112 ASP H H 8.05 0.02 1 384 . 112 ASP HA H 4.19 0.02 1 385 . 112 ASP C C 177.9 0.1 1 386 . 112 ASP CA C 56.1 0.1 1 387 . 112 ASP N N 117.0 0.15 1 388 . 113 LEU H H 8.00 0.02 1 389 . 113 LEU HA H 4.08 0.02 1 390 . 113 LEU CA C 58.2 0.1 1 391 . 113 LEU N N 120.2 0.15 1 392 . 114 LEU HA H 4.20 0.02 1 393 . 114 LEU C C 178.7 0.1 1 394 . 115 LYS H H 8.34 0.02 1 395 . 115 LYS HA H 3.87 0.02 1 396 . 115 LYS C C 179.1 0.1 1 397 . 115 LYS CA C 58.7 0.1 1 398 . 115 LYS N N 119.7 0.15 1 399 . 116 ASP H H 8.52 0.02 1 400 . 116 ASP HA H 4.43 0.02 1 401 . 116 ASP C C 179.5 0.1 1 402 . 116 ASP CA C 55.8 0.1 1 403 . 116 ASP N N 118.7 0.15 1 404 . 117 LEU H H 8.49 0.02 1 405 . 117 LEU HA H 4.30 0.02 1 406 . 117 LEU C C 177.6 0.1 1 407 . 117 LEU CA C 57.6 0.1 1 408 . 117 LEU N N 123.8 0.15 1 409 . 118 GLU H H 8.91 0.02 1 410 . 118 GLU HA H 3.67 0.02 1 411 . 118 GLU C C 177.6 0.1 1 412 . 118 GLU CA C 60.0 0.1 1 413 . 118 GLU N N 120.4 0.15 1 414 . 119 GLU H H 8.12 0.02 1 415 . 119 GLU HA H 4.16 0.02 1 416 . 119 GLU C C 179.5 0.1 1 417 . 119 GLU CA C 58.1 0.1 1 418 . 119 GLU N N 117.2 0.15 1 419 . 120 GLY H H 8.32 0.02 1 420 . 120 GLY HA2 H 3.87 0.02 2 421 . 120 GLY C C 176.4 0.1 1 422 . 120 GLY CA C 47.3 0.1 1 423 . 120 GLY N N 109.4 0.15 1 424 . 121 ILE H H 8.85 0.02 1 425 . 121 ILE HA H 3.61 0.02 1 426 . 121 ILE C C 181.0 0.1 1 427 . 121 ILE CA C 65.9 0.1 1 428 . 121 ILE N N 122.6 0.15 1 429 . 122 GLN H H 8.45 0.02 1 430 . 122 GLN HA H 4.00 0.02 1 431 . 122 GLN C C 179.6 0.1 1 432 . 122 GLN CA C 60.1 0.1 1 433 . 122 GLN N N 120.2 0.15 1 434 . 123 THR H H 8.31 0.02 1 435 . 123 THR HA H 3.95 0.02 1 436 . 123 THR C C 177.0 0.1 1 437 . 123 THR CA C 66.7 0.1 1 438 . 123 THR N N 117.7 0.15 1 439 . 124 LEU H H 7.98 0.02 1 440 . 124 LEU HA H 3.62 0.02 1 441 . 124 LEU C C 178.2 0.1 1 442 . 124 LEU CA C 58.5 0.1 1 443 . 124 LEU N N 123.4 0.15 1 444 . 125 MET H H 8.62 0.02 1 445 . 125 MET HA H 3.67 0.02 1 446 . 125 MET C C 177.9 0.1 1 447 . 125 MET CA C 60.3 0.1 1 448 . 125 MET N N 117.1 0.15 1 449 . 126 GLY H H 7.81 0.02 1 450 . 126 GLY HA2 H 3.90 0.02 2 451 . 126 GLY C C 176.2 0.1 1 452 . 126 GLY CA C 46.9 0.1 1 453 . 126 GLY N N 103.9 0.15 1 454 . 127 ARG H H 7.61 0.02 1 455 . 127 ARG HA H 4.28 0.02 1 456 . 127 ARG C C 178.4 0.1 1 457 . 127 ARG CA C 56.1 0.1 1 458 . 127 ARG N N 118.9 0.15 1 459 . 128 LEU HA H 4.36 0.02 1 460 . 128 LEU C C 177.6 0.1 1 461 . 128 LEU CA C 56.2 0.1 1 462 . 129 GLU H H 7.81 0.02 1 463 . 129 GLU HA H 4.30 0.02 1 464 . 129 GLU C C 175.7 0.1 1 465 . 129 GLU CA C 56.2 0.1 1 466 . 129 GLU N N 117.8 0.15 1 467 . 130 ASP H H 8.13 0.02 1 468 . 130 ASP HA H 4.68 0.02 1 469 . 130 ASP C C 175.6 0.1 1 470 . 130 ASP CA C 53.5 0.1 1 471 . 130 ASP N N 119.0 0.15 1 472 . 131 GLY H H 8.36 0.02 1 473 . 131 GLY HA2 H 4.07 0.02 2 474 . 131 GLY HA3 H 3.92 0.02 2 475 . 131 GLY C C 173.8 0.1 1 476 . 131 GLY CA C 45.2 0.1 1 477 . 131 GLY N N 108.8 0.15 1 478 . 132 SER H H 8.02 0.02 1 479 . 132 SER HA H 4.75 0.02 1 480 . 132 SER C C 172.7 0.1 1 481 . 132 SER CA C 56.4 0.1 1 482 . 132 SER N N 116.5 0.15 1 483 . 133 PRO HA H 4.44 0.02 1 484 . 133 PRO C C 177.0 0.1 1 485 . 133 PRO CA C 63.1 0.1 1 486 . 133 PRO N N 137.6 0.15 1 487 . 134 ARG H H 8.37 0.02 1 488 . 134 ARG HA H 4.33 0.02 1 489 . 134 ARG C C 176.5 0.1 1 490 . 134 ARG CA C 55.9 0.1 1 491 . 134 ARG N N 121.4 0.15 1 492 . 135 THR H H 8.01 0.02 1 493 . 135 THR HA H 4.32 0.02 1 494 . 135 THR C C 175.0 0.1 1 495 . 135 THR CA C 61.7 0.1 1 496 . 135 THR N N 114.5 0.15 1 497 . 136 GLY H H 8.35 0.02 1 498 . 136 GLY HA2 H 3.96 0.02 2 499 . 136 GLY C C 173.9 0.1 1 500 . 136 GLY CA C 45.2 0.1 1 501 . 136 GLY N N 110.7 0.15 1 502 . 137 GLN H H 8.21 0.02 1 503 . 137 GLN HA H 4.23 0.02 1 504 . 137 GLN C C 175.9 0.1 1 505 . 137 GLN CA C 56.0 0.1 1 506 . 137 GLN N N 120.5 0.15 1 507 . 138 ILE H H 8.09 0.02 1 508 . 138 ILE HA H 4.09 0.02 1 509 . 138 ILE C C 175.7 0.1 1 510 . 138 ILE CA C 58.5 0.1 1 511 . 138 ILE N N 121.6 0.15 1 512 . 139 PHE H H 8.14 0.02 1 513 . 139 PHE HA H 4.58 0.02 1 514 . 139 PHE C C 175.2 0.1 1 515 . 139 PHE CA C 57.6 0.1 1 516 . 139 PHE N N 124.0 0.15 1 517 . 140 LYS H H 8.10 0.02 1 518 . 140 LYS C C 175.7 0.1 1 519 . 140 LYS CA C 56.0 0.1 1 520 . 140 LYS N N 123.2 0.15 1 521 . 141 GLN H H 7.91 0.02 1 522 . 141 GLN HA H 4.28 0.02 1 523 . 141 GLN C C 175.8 0.1 1 524 . 141 GLN CA C 55.7 0.1 1 525 . 141 GLN N N 121.6 0.15 1 526 . 142 THR H H 8.10 0.02 1 527 . 142 THR HA H 4.26 0.02 1 528 . 142 THR C C 174.0 0.1 1 529 . 142 THR CA C 61.6 0.1 1 530 . 142 THR N N 115.8 0.15 1 531 . 143 TYR H H 8.18 0.02 1 532 . 143 TYR HA H 4.48 0.02 1 533 . 143 TYR C C 175.7 0.1 1 534 . 143 TYR CA C 57.7 0.1 1 535 . 143 TYR N N 122.4 0.15 1 536 . 144 SER H H 8.10 0.02 1 537 . 144 SER HA H 4.30 0.02 1 538 . 144 SER CA C 58.3 0.1 1 539 . 144 SER N N 116.8 0.15 1 540 . 149 ASN HA H 4.20 0.02 1 541 . 149 ASN C C 175.3 0.1 1 542 . 150 SER H H 8.02 0.02 1 543 . 150 SER HA H 4.32 0.02 1 544 . 150 SER C C 174.5 0.1 1 545 . 150 SER CA C 58.5 0.1 1 546 . 150 SER N N 115.8 0.15 1 547 . 151 HIS H H 8.53 0.02 1 548 . 151 HIS HA H 4.63 0.02 1 549 . 151 HIS C C 174.2 0.1 1 550 . 151 HIS CA C 55.6 0.1 1 551 . 151 HIS N N 119.6 0.15 1 552 . 152 ASN H H 8.14 0.02 1 553 . 152 ASN HA H 4.68 0.02 1 554 . 152 ASN CA C 53.2 0.1 1 555 . 152 ASN N N 118.4 0.15 1 556 . 153 ASP C C 175.5 0.1 1 557 . 153 ASP CA C 54.0 0.1 1 558 . 154 ASP H H 8.30 0.02 1 559 . 154 ASP HA H 4.62 0.02 1 560 . 154 ASP C C 175.9 0.1 1 561 . 154 ASP CA C 53.8 0.1 1 562 . 154 ASP N N 119.0 0.15 1 563 . 155 ALA H H 8.17 0.02 1 564 . 155 ALA HA H 4.11 0.02 1 565 . 155 ALA C C 178.8 0.1 1 566 . 155 ALA CA C 54.8 0.1 1 567 . 155 ALA N N 124.7 0.15 1 568 . 156 LEU H H 7.98 0.02 1 569 . 156 LEU HA H 4.19 0.02 1 570 . 156 LEU C C 178.6 0.1 1 571 . 156 LEU CA C 58.0 0.1 1 572 . 156 LEU N N 118.6 0.15 1 573 . 157 LEU H H 7.69 0.02 1 574 . 157 LEU HA H 4.18 0.02 1 575 . 157 LEU C C 179.6 0.1 1 576 . 157 LEU CA C 57.1 0.1 1 577 . 157 LEU N N 117.8 0.15 1 578 . 158 LYS H H 8.02 0.02 1 579 . 158 LYS CA C 58.7 0.1 1 580 . 158 LYS N N 120.6 0.15 1 581 . 160 TYR HA H 3.97 0.02 1 582 . 160 TYR C C 177.3 0.1 1 583 . 160 TYR CA C 59.8 0.1 1 584 . 161 GLY H H 8.18 0.02 1 585 . 161 GLY HA2 H 3.95 0.02 2 586 . 161 GLY HA3 H 3.73 0.02 2 587 . 161 GLY C C 176.4 0.1 1 588 . 161 GLY CA C 47.4 0.1 1 589 . 161 GLY N N 105.5 0.15 1 590 . 162 LEU H H 8.06 0.02 1 591 . 162 LEU HA H 4.09 0.02 1 592 . 162 LEU CA C 58.3 0.1 1 593 . 162 LEU N N 122.1 0.15 1 594 . 170 MET HA H 4.45 0.02 1 595 . 170 MET C C 179.4 0.1 1 596 . 170 MET CA C 56.0 0.1 1 597 . 171 ASP H H 7.84 0.02 1 598 . 171 ASP HA H 4.02 0.02 1 599 . 171 ASP C C 178.2 0.1 1 600 . 171 ASP CA C 56.5 0.1 1 601 . 171 ASP N N 120.2 0.15 1 602 . 172 LYS H H 7.63 0.02 1 603 . 172 LYS HA H 3.50 0.02 1 604 . 172 LYS C C 176.8 0.1 1 605 . 172 LYS CA C 59.1 0.1 1 606 . 172 LYS N N 121.5 0.15 1 607 . 173 VAL H H 7.90 0.02 1 608 . 173 VAL HA H 3.49 0.02 1 609 . 173 VAL C C 177.0 0.1 1 610 . 173 VAL CA C 67.2 0.1 1 611 . 173 VAL N N 117.6 0.15 1 612 . 174 GLU H H 7.74 0.02 1 613 . 174 GLU HA H 3.68 0.02 1 614 . 174 GLU C C 177.3 0.1 1 615 . 174 GLU CA C 60.2 0.1 1 616 . 174 GLU N N 116.9 0.15 1 617 . 175 THR H H 7.84 0.02 1 618 . 175 THR HA H 4.09 0.02 1 619 . 175 THR C C 175.7 0.1 1 620 . 175 THR CA C 66.7 0.1 1 621 . 175 THR N N 115.2 0.15 1 622 . 176 PHE H H 8.14 0.02 1 623 . 176 PHE HA H 4.57 0.02 1 624 . 176 PHE C C 178.2 0.1 1 625 . 176 PHE CA C 57.6 0.1 1 626 . 176 PHE N N 129.2 0.15 1 627 . 177 LEU H H 8.56 0.02 1 628 . 177 LEU HA H 3.97 0.02 1 629 . 177 LEU C C 178.2 0.1 1 630 . 177 LEU CA C 58.2 0.1 1 631 . 177 LEU N N 118.5 0.15 1 632 . 178 ARG H H 7.98 0.02 1 633 . 178 ARG HA H 4.04 0.02 1 634 . 178 ARG C C 178.4 0.1 1 635 . 178 ARG CA C 58.8 0.1 1 636 . 178 ARG N N 119.3 0.15 1 637 . 179 ILE H H 7.90 0.02 1 638 . 179 ILE HA H 4.36 0.02 1 639 . 179 ILE C C 178.4 0.1 1 640 . 179 ILE CA C 65.3 0.1 1 641 . 179 ILE N N 119.5 0.15 1 642 . 180 VAL H H 7.77 0.02 1 643 . 180 VAL HA H 3.47 0.02 1 644 . 180 VAL C C 178.6 0.1 1 645 . 180 VAL CA C 66.6 0.1 1 646 . 180 VAL N N 118.3 0.15 1 647 . 181 GLN H H 8.76 0.02 1 648 . 181 GLN HA H 4.42 0.02 1 649 . 181 GLN C C 177.6 0.1 1 650 . 181 GLN CA C 59.6 0.1 1 651 . 181 GLN N N 123.9 0.15 1 652 . 182 CYS H H 8.44 0.02 1 653 . 182 CYS HA H 4.30 0.02 1 654 . 182 CYS C C 176.9 0.1 1 655 . 182 CYS CA C 57.7 0.1 1 656 . 182 CYS N N 116.0 0.15 1 657 . 183 ARG H H 7.83 0.02 1 658 . 183 ARG HA H 4.26 0.02 1 659 . 183 ARG C C 177.9 0.1 1 660 . 183 ARG CA C 58.0 0.1 1 661 . 183 ARG N N 116.2 0.15 1 662 . 184 SER H H 7.81 0.02 1 663 . 184 SER HA H 4.46 0.02 1 664 . 184 SER C C 174.0 0.1 1 665 . 184 SER CA C 60.7 0.1 1 666 . 184 SER N N 113.5 0.15 1 667 . 185 VAL H H 7.90 0.02 1 668 . 185 VAL HA H 4.28 0.02 1 669 . 185 VAL C C 175.7 0.1 1 670 . 185 VAL CA C 65.3 0.1 1 671 . 185 VAL N N 119.7 0.15 1 672 . 186 GLU H H 8.31 0.02 1 673 . 186 GLU HA H 4.26 0.02 1 674 . 186 GLU C C 177.0 0.1 1 675 . 186 GLU CA C 57.2 0.1 1 676 . 186 GLU N N 124.4 0.15 1 677 . 187 GLY H H 8.56 0.02 1 678 . 187 GLY HA2 H 4.05 0.02 2 679 . 187 GLY HA3 H 3.82 0.02 2 680 . 187 GLY C C 174.6 0.1 1 681 . 187 GLY CA C 45.5 0.1 1 682 . 187 GLY N N 111.2 0.15 1 683 . 188 SER H H 8.01 0.02 1 684 . 188 SER HA H 4.31 0.02 1 685 . 188 SER C C 175.0 0.1 1 686 . 188 SER CA C 59.0 0.1 1 687 . 188 SER N N 115.1 0.15 1 688 . 189 CYS H H 8.45 0.02 1 689 . 189 CYS HA H 4.58 0.02 1 690 . 189 CYS C C 174.4 0.1 1 691 . 189 CYS CA C 55.4 0.1 1 692 . 189 CYS N N 119.8 0.15 1 693 . 190 GLY H H 8.14 0.02 1 694 . 190 GLY HA2 H 3.82 0.02 2 695 . 190 GLY C C 173.0 0.1 1 696 . 190 GLY CA C 45.2 0.1 1 697 . 190 GLY N N 109.4 0.15 1 698 . 191 PHE H H 7.73 0.02 1 699 . 191 PHE HA H 4.52 0.02 1 700 . 191 PHE C C 178.8 0.1 1 701 . 191 PHE CA C 57.6 0.1 1 702 . 191 PHE N N 121.9 0.15 1 stop_ save_ save_chemical_shift_assignment_two _Saveframe_category assigned_chemical_shifts _Details . loop_ _Sample_label $sample_1 $sample_2 stop_ _Sample_conditions_label $sample_conditions_two _Chem_shift_reference_set_label $chemical_shift_reference _Mol_system_component_name hGH _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 . 2 PRO HA H 4.58 0.02 1 2 . 2 PRO CA C 63.20 0.10 1 3 . 3 THR H H 8.27 0.02 1 4 . 3 THR HA H 4.26 0.02 1 5 . 3 THR CA C 61.90 0.10 1 6 . 3 THR N N 115.80 0.15 1 7 . 4 ILE H H 8.31 0.02 1 8 . 4 ILE HA H 4.43 0.02 1 9 . 4 ILE CA C 58.80 0.10 1 10 . 4 ILE N N 126.20 0.15 1 11 . 5 PRO HA H 4.49 0.02 1 12 . 5 PRO CA C 63.00 0.10 1 13 . 6 LEU H H 8.85 0.02 1 14 . 6 LEU HA H 3.93 0.02 1 15 . 6 LEU CA C 58.30 0.10 1 16 . 6 LEU N N 124.90 0.15 1 17 . 7 SER H H 8.86 0.02 1 18 . 7 SER HA H 4.25 0.02 1 19 . 7 SER CA C 61.20 0.10 1 20 . 7 SER N N 111.90 0.15 1 21 . 8 ARG H H 7.06 0.02 1 22 . 8 ARG HA H 4.29 0.02 1 23 . 8 ARG CA C 58.00 0.10 1 24 . 8 ARG N N 122.90 0.15 1 25 . 9 LEU H H 7.59 0.02 1 26 . 9 LEU HA H 4.09 0.02 1 27 . 9 LEU CA C 57.90 0.10 1 28 . 9 LEU N N 119.80 0.15 1 29 . 10 PHE H H 8.47 0.02 1 30 . 10 PHE HA H 4.15 0.02 1 31 . 10 PHE CA C 63.50 0.10 1 32 . 10 PHE N N 118.50 0.15 1 33 . 11 ASP H H 8.33 0.02 1 34 . 11 ASP HA H 4.40 0.02 1 35 . 11 ASP N N 121.00 0.15 1 36 . 12 ASN H H 8.18 0.02 1 37 . 12 ASN HA H 4.41 0.02 1 38 . 12 ASN N N 117.50 0.15 1 39 . 13 ALA H H 7.68 0.02 1 40 . 13 ALA HA H 4.13 0.02 1 41 . 13 ALA N N 122.30 0.15 1 42 . 14 MET H H 8.95 0.02 1 43 . 14 MET HA H 4.38 0.02 1 44 . 14 MET N N 117.30 0.15 1 45 . 15 LEU H H 8.14 0.02 1 46 . 15 LEU HA H 4.20 0.02 1 47 . 15 LEU CA C 58.50 0.10 1 48 . 15 LEU N N 121.30 0.15 1 49 . 16 ARG H H 7.33 0.02 1 50 . 16 ARG HA H 4.06 0.02 1 51 . 16 ARG CA C 59.30 0.10 1 52 . 16 ARG N N 118.50 0.15 1 53 . 17 ALA H H 8.86 0.02 1 54 . 17 ALA HA H 3.97 0.02 1 55 . 17 ALA CA C 55.40 0.10 1 56 . 17 ALA N N 122.30 0.15 1 57 . 18 HIS H H 9.00 0.02 1 58 . 18 HIS CA C 59.30 0.10 1 59 . 18 HIS N N 116.80 0.15 1 60 . 22 GLN HA H 3.65 0.02 1 61 . 22 GLN CA C 59.00 0.10 1 62 . 23 LEU H H 8.38 0.02 1 63 . 23 LEU HA H 4.22 0.02 1 64 . 23 LEU CA C 58.20 0.10 1 65 . 23 LEU N N 119.40 0.15 1 66 . 24 ALA H H 8.47 0.02 1 67 . 24 ALA HA H 4.09 0.02 1 68 . 24 ALA CA C 55.60 0.10 1 69 . 24 ALA N N 124.10 0.15 1 70 . 25 PHE H H 8.82 0.02 1 71 . 25 PHE HA H 3.84 0.02 1 72 . 25 PHE CA C 62.30 0.10 1 73 . 25 PHE N N 119.40 0.15 1 74 . 26 ASP H H 9.39 0.02 1 75 . 26 ASP HA H 4.47 0.02 1 76 . 26 ASP CA C 57.80 0.10 1 77 . 26 ASP N N 121.00 0.15 1 78 . 27 THR H H 8.60 0.02 1 79 . 27 THR HA H 4.12 0.02 1 80 . 27 THR CA C 67.10 0.10 1 81 . 27 THR N N 116.30 0.15 1 82 . 28 TYR H H 8.18 0.02 1 83 . 28 TYR HA H 4.17 0.02 1 84 . 28 TYR CA C 62.80 0.10 1 85 . 28 TYR N N 123.20 0.15 1 86 . 29 GLN H H 8.13 0.02 1 87 . 29 GLN HA H 3.86 0.02 1 88 . 29 GLN CA C 59.30 0.10 1 89 . 29 GLN N N 117.80 0.15 1 90 . 31 PHE HA H 4.11 0.02 1 91 . 31 PHE CA C 61.10 0.10 1 92 . 32 GLU H H 8.76 0.02 1 93 . 32 GLU HA H 3.49 0.02 1 94 . 32 GLU CA C 59.40 0.10 1 95 . 32 GLU N N 119.10 0.15 1 96 . 33 GLU H H 7.87 0.02 1 97 . 33 GLU HA H 3.85 0.02 1 98 . 33 GLU CA C 58.60 0.10 1 99 . 33 GLU N N 115.60 0.15 1 100 . 34 ALA H H 7.61 0.02 1 101 . 34 ALA HA H 3.89 0.02 1 102 . 34 ALA CA C 54.40 0.10 1 103 . 34 ALA N N 119.10 0.15 1 104 . 35 TYR H H 7.59 0.02 1 105 . 35 TYR HA H 4.61 0.02 1 106 . 35 TYR CA C 58.20 0.10 1 107 . 35 TYR N N 111.30 0.15 1 108 . 36 ILE H H 7.28 0.02 1 109 . 44 PHE CA C 58.90 0.10 1 110 . 45 LEU H H 7.69 0.02 1 111 . 45 LEU HA H 4.18 0.02 1 112 . 45 LEU CA C 55.70 0.10 1 113 . 45 LEU N N 119.20 0.15 1 114 . 46 GLN H H 7.71 0.02 1 115 . 46 GLN HA H 4.21 0.02 1 116 . 46 GLN CA C 56.10 0.10 1 117 . 46 GLN N N 117.20 0.15 1 118 . 47 ASN H H 7.87 0.02 1 119 . 47 ASN HA H 4.97 0.02 1 120 . 47 ASN CA C 51.30 0.10 1 121 . 47 ASN N N 118.70 0.15 1 122 . 48 PRO HA H 4.38 0.02 1 123 . 48 PRO CA C 63.90 0.10 1 124 . 49 GLN H H 8.34 0.02 1 125 . 49 GLN HA H 4.26 0.02 1 126 . 49 GLN CA C 56.60 0.10 1 127 . 49 GLN N N 118.20 0.15 1 128 . 50 THR H H 7.85 0.02 1 129 . 50 THR HA H 4.27 0.02 1 130 . 50 THR CA C 62.50 0.10 1 131 . 50 THR N N 112.50 0.15 1 132 . 51 SER H H 8.09 0.02 1 133 . 51 SER HA H 4.37 0.02 1 134 . 51 SER CA C 58.60 0.10 1 135 . 51 SER N N 116.90 0.15 1 136 . 52 LEU H H 7.95 0.02 1 137 . 52 LEU HA H 4.37 0.02 1 138 . 52 LEU CA C 55.90 0.10 1 139 . 52 LEU N N 123.80 0.15 1 140 . 53 CYS H H 8.48 0.02 1 141 . 53 CYS HA H 5.02 0.02 1 142 . 53 CYS CA C 53.40 0.10 1 143 . 53 CYS N N 119.10 0.15 1 144 . 56 GLU H H 7.79 0.02 1 145 . 56 GLU HA H 4.17 0.02 1 146 . 56 GLU CA C 58.30 0.10 1 147 . 56 GLU N N 122.50 0.15 1 148 . 57 SER H H 7.43 0.02 1 149 . 57 SER HA H 4.27 0.02 1 150 . 57 SER CA C 59.40 0.10 1 151 . 57 SER N N 111.50 0.15 1 152 . 58 ILE H H 7.78 0.02 1 153 . 58 ILE HA H 4.24 0.02 1 154 . 58 ILE CA C 58.80 0.10 1 155 . 58 ILE N N 125.20 0.15 1 156 . 61 PRO CA C 62.50 0.10 1 157 . 62 SER H H 9.03 0.02 1 158 . 62 SER HA H 4.46 0.02 1 159 . 62 SER CA C 59.50 0.10 1 160 . 62 SER N N 117.20 0.15 1 161 . 63 ASN H H 7.49 0.02 1 162 . 63 ASN HA H 4.77 0.02 1 163 . 63 ASN CA C 52.00 0.10 1 164 . 63 ASN N N 115.50 0.15 1 165 . 77 ARG CA C 59.30 0.10 1 166 . 78 ILE H H 8.37 0.02 1 167 . 78 ILE CA C 66.00 0.10 1 168 . 79 SER H H 7.70 0.02 1 169 . 79 SER HA H 4.21 0.02 1 170 . 79 SER CA C 64.00 0.10 1 171 . 79 SER N N 115.10 0.15 1 172 . 80 LEU H H 8.69 0.02 1 173 . 80 LEU HA H 3.93 0.02 1 174 . 80 LEU CA C 58.20 0.10 1 175 . 80 LEU N N 121.50 0.15 1 176 . 81 LEU HA H 4.18 0.02 1 177 . 81 LEU CA C 57.80 0.10 1 178 . 82 LEU H H 8.45 0.02 1 179 . 82 LEU CA C 58.90 0.10 1 180 . 82 LEU N N 122.50 0.15 1 181 . 83 ILE H H 7.92 0.02 1 182 . 83 ILE HA H 3.84 0.02 1 183 . 83 ILE CA C 63.40 0.10 1 184 . 83 ILE N N 118.50 0.15 1 185 . 84 GLN H H 9.08 0.02 1 186 . 84 GLN HA H 3.81 0.02 1 187 . 84 GLN CA C 59.20 0.10 1 188 . 84 GLN N N 116.60 0.15 1 189 . 85 SER H H 8.18 0.02 1 190 . 85 SER HA H 4.22 0.02 1 191 . 85 SER CA C 61.70 0.10 1 192 . 85 SER N N 114.30 0.15 1 193 . 89 PRO HA H 4.37 0.02 1 194 . 89 PRO CA C 62.60 0.10 1 195 . 90 VAL H H 8.63 0.02 1 196 . 90 VAL HA H 3.71 0.02 1 197 . 90 VAL CA C 60.30 0.10 1 198 . 90 VAL N N 122.20 0.15 1 199 . 91 GLN H H 9.15 0.02 1 200 . 91 GLN HA H 4.03 0.02 1 201 . 91 GLN CA C 58.80 0.10 1 202 . 91 GLN N N 115.80 0.15 1 203 . 94 ARG CA C 60.60 0.10 1 204 . 95 SER H H 8.52 0.02 1 205 . 95 SER HA H 4.24 0.02 1 206 . 95 SER CA C 61.20 0.10 1 207 . 95 SER N N 113.30 0.15 1 208 . 96 VAL H H 7.25 0.02 1 209 . 96 VAL HA H 3.79 0.02 1 210 . 96 VAL CA C 65.20 0.10 1 211 . 96 VAL N N 122.70 0.15 1 212 . 97 PHE HA H 4.62 0.02 1 213 . 97 PHE CA C 60.10 0.10 1 214 . 98 ALA H H 8.15 0.02 1 215 . 98 ALA HA H 4.21 0.02 1 216 . 98 ALA CA C 54.60 0.10 1 217 . 98 ALA N N 119.00 0.15 1 218 . 99 ASN H H 7.41 0.02 1 219 . 99 ASN HA H 4.82 0.02 1 220 . 99 ASN CA C 53.10 0.10 1 221 . 99 ASN N N 113.80 0.15 1 222 . 100 SER H H 7.42 0.02 1 223 . 100 SER HA H 4.68 0.02 1 224 . 100 SER CA C 58.10 0.10 1 225 . 100 SER N N 115.80 0.15 1 226 . 103 TYR HA H 4.29 0.02 1 227 . 103 TYR CA C 60.20 0.10 1 228 . 104 GLY H H 8.32 0.02 1 229 . 104 GLY HA2 H 3.87 0.02 2 230 . 104 GLY CA C 45.90 0.10 1 231 . 104 GLY N N 112.40 0.15 1 232 . 105 ALA H H 7.87 0.02 1 233 . 105 ALA HA H 4.22 0.02 1 234 . 105 ALA CA C 53.70 0.10 1 235 . 105 ALA N N 123.40 0.15 1 236 . 106 SER H H 8.04 0.02 1 237 . 106 SER HA H 4.39 0.02 1 238 . 106 SER CA C 59.30 0.10 1 239 . 106 SER N N 113.20 0.15 1 240 . 107 ASP H H 8.09 0.02 1 241 . 107 ASP CA C 54.80 0.10 1 242 . 107 ASP N N 120.50 0.15 1 243 . 108 SER H H 7.74 0.02 1 244 . 108 SER HA H 4.46 0.02 1 245 . 108 SER CA C 58.50 0.10 1 246 . 108 SER N N 114.10 0.15 1 247 . 116 ASP HA H 4.52 0.02 1 248 . 116 ASP CA C 57.00 0.10 1 249 . 117 LEU H H 8.24 0.02 1 250 . 117 LEU HA H 4.28 0.02 1 251 . 117 LEU CA C 57.60 0.10 1 252 . 117 LEU N N 123.20 0.15 1 253 . 118 GLU H H 8.91 0.02 1 254 . 118 GLU HA H 3.63 0.02 1 255 . 118 GLU CA C 60.50 0.10 1 256 . 118 GLU N N 122.90 0.15 1 257 . 119 GLU H H 7.80 0.02 1 258 . 119 GLU HA H 4.11 0.02 1 259 . 119 GLU CA C 59.30 0.10 1 260 . 119 GLU N N 117.80 0.15 1 261 . 120 GLY H H 8.39 0.02 1 262 . 120 GLY CA C 47.50 0.10 1 263 . 120 GLY N N 109.50 0.15 1 264 . 121 ILE H H 9.04 0.02 1 265 . 121 ILE HA H 3.61 0.02 1 266 . 121 ILE CA C 66.00 0.10 1 267 . 121 ILE N N 122.90 0.15 1 268 . 122 GLN H H 8.35 0.02 1 269 . 122 GLN HA H 4.05 0.02 1 270 . 122 GLN CA C 60.20 0.10 1 271 . 122 GLN N N 120.40 0.15 1 272 . 123 THR H H 8.54 0.02 1 273 . 124 LEU H H 7.96 0.02 1 274 . 124 LEU HA H 3.63 0.02 1 275 . 124 LEU CA C 58.60 0.10 1 276 . 125 MET H H 8.55 0.02 1 277 . 125 MET HA H 3.70 0.02 1 278 . 125 MET CA C 60.30 0.10 1 279 . 125 MET N N 117.10 0.15 1 280 . 126 GLY H H 7.73 0.02 1 281 . 126 GLY CA C 46.80 0.10 1 282 . 126 GLY N N 104.40 0.15 1 283 . 127 ARG H H 7.57 0.02 1 284 . 127 ARG HA H 4.31 0.02 1 285 . 127 ARG CA C 55.90 0.10 1 286 . 127 ARG N N 119.10 0.15 1 287 . 128 LEU H H 7.73 0.02 1 288 . 128 LEU HA H 4.42 0.02 1 289 . 128 LEU CA C 55.20 0.10 1 290 . 128 LEU N N 119.50 0.15 1 291 . 129 GLU H H 7.35 0.02 1 292 . 129 GLU HA H 4.07 0.02 1 293 . 129 GLU CA C 57.90 0.10 1 294 . 129 GLU N N 121.00 0.15 1 295 . 130 ASP H H 7.88 0.02 1 296 . 130 ASP HA H 4.78 0.02 1 297 . 130 ASP CA C 53.40 0.10 1 298 . 130 ASP N N 124.40 0.15 1 299 . 131 GLY H H 9.07 0.02 1 300 . 131 GLY HA2 H 4.08 0.02 2 301 . 131 GLY CA C 45.60 0.10 1 302 . 131 GLY N N 110.70 0.15 1 303 . 132 SER H H 8.12 0.02 1 304 . 132 SER HA H 4.61 0.02 1 305 . 132 SER CA C 57.40 0.10 1 306 . 132 SER N N 117.70 0.15 1 307 . 133 PRO HA H 4.37 0.02 1 308 . 133 PRO CA C 63.40 0.10 1 309 . 134 ARG H H 8.22 0.02 1 310 . 134 ARG N N 123.20 0.15 1 311 . 135 THR HA H 4.35 0.02 1 312 . 135 THR CA C 61.50 0.10 1 313 . 136 GLY H H 8.45 0.02 1 314 . 136 GLY CA C 45.30 0.10 1 315 . 136 GLY N N 110.10 0.15 1 316 . 137 GLN H H 8.29 0.02 1 317 . 137 GLN CA C 56.70 0.10 1 318 . 137 GLN N N 116.80 0.15 1 319 . 146 PHE HA H 4.31 0.02 1 320 . 146 PHE CA C 56.90 0.10 1 321 . 147 ASP H H 8.06 0.02 1 322 . 147 ASP HA H 4.50 0.02 1 323 . 147 ASP CA C 53.30 0.10 1 324 . 147 ASP N N 125.20 0.15 1 325 . 148 THR H H 7.93 0.02 1 326 . 148 THR HA H 3.86 0.02 1 327 . 148 THR CA C 62.40 0.10 1 328 . 148 THR N N 115.80 0.15 1 329 . 149 ASN H H 8.30 0.02 1 330 . 149 ASN HA H 4.64 0.02 1 331 . 149 ASN CA C 53.60 0.10 1 332 . 149 ASN N N 120.20 0.15 1 333 . 150 SER H H 7.83 0.02 1 334 . 150 SER HA H 4.30 0.02 1 335 . 150 SER CA C 58.70 0.10 1 336 . 150 SER N N 115.50 0.15 1 337 . 153 ASP H H 8.40 0.02 1 338 . 153 ASP HA H 4.59 0.02 1 339 . 153 ASP CA C 54.80 0.10 1 340 . 153 ASP N N 120.00 0.15 1 341 . 154 ASP H H 8.05 0.02 1 342 . 154 ASP HA H 4.62 0.02 1 343 . 154 ASP CA C 54.00 0.10 1 344 . 154 ASP N N 120.70 0.15 1 345 . 155 ALA H H 8.40 0.02 1 346 . 155 ALA HA H 4.03 0.02 1 347 . 155 ALA CA C 55.20 0.10 1 348 . 155 ALA N N 126.00 0.15 1 349 . 156 LEU H H 8.01 0.02 1 350 . 156 LEU HA H 4.22 0.02 1 351 . 156 LEU CA C 58.80 0.10 1 352 . 156 LEU N N 119.30 0.15 1 353 . 157 LEU H H 7.82 0.02 1 354 . 157 LEU N N 117.20 0.15 1 355 . 159 ASN H H 8.25 0.02 1 356 . 159 ASN HA H 4.46 0.02 1 357 . 159 ASN CA C 56.00 0.10 1 358 . 159 ASN N N 119.60 0.15 1 359 . 160 TYR H H 8.44 0.02 1 360 . 160 TYR HA H 4.28 0.02 1 361 . 160 TYR CA C 58.20 0.10 1 362 . 160 TYR N N 121.30 0.15 1 363 . 161 GLY H H 8.29 0.02 1 364 . 161 GLY HA2 H 3.96 0.02 2 365 . 161 GLY CA C 47.30 0.10 1 366 . 161 GLY N N 104.10 0.15 1 367 . 162 LEU H H 8.15 0.02 1 368 . 162 LEU HA H 4.37 0.02 1 369 . 162 LEU CA C 58.50 0.10 1 370 . 162 LEU N N 122.90 0.15 1 371 . 163 LEU H H 8.49 0.02 1 372 . 163 LEU HA H 4.20 0.02 1 373 . 163 LEU CA C 58.10 0.10 1 374 . 163 LEU N N 120.00 0.15 1 375 . 169 ASP H H 8.72 0.02 1 376 . 170 MET H H 8.28 0.02 1 377 . 170 MET N N 117.50 0.15 1 378 . 171 ASP H H 7.56 0.02 1 379 . 171 ASP HA H 3.49 0.02 1 380 . 171 ASP CA C 56.90 0.10 1 381 . 171 ASP N N 120.20 0.15 1 382 . 172 LYS H H 7.25 0.02 1 383 . 172 LYS HA H 3.78 0.02 1 384 . 172 LYS CA C 59.60 0.10 1 385 . 172 LYS N N 120.40 0.15 1 386 . 173 VAL H H 7.77 0.02 1 387 . 173 VAL HA H 3.44 0.02 1 388 . 173 VAL CA C 67.10 0.10 1 389 . 173 VAL N N 117.00 0.15 1 390 . 174 GLU H H 7.85 0.02 1 391 . 174 GLU CA C 60.70 0.10 1 392 . 174 GLU N N 117.70 0.15 1 393 . 175 THR H H 7.90 0.02 1 394 . 175 THR HA H 3.73 0.02 1 395 . 175 THR CA C 66.90 0.10 1 396 . 175 THR N N 114.80 0.15 1 397 . 176 PHE H H 8.71 0.02 1 398 . 176 PHE HA H 4.51 0.02 1 399 . 176 PHE CA C 58.10 0.10 1 400 . 176 PHE N N 120.90 0.15 1 401 . 177 LEU H H 8.53 0.02 1 402 . 177 LEU HA H 3.99 0.02 1 403 . 177 LEU CA C 58.50 0.10 1 404 . 177 LEU N N 118.80 0.15 1 405 . 178 ARG H H 8.13 0.02 1 406 . 178 ARG HA H 4.05 0.02 1 407 . 178 ARG CA C 59.00 0.10 1 408 . 178 ARG N N 119.20 0.15 1 409 . 179 ILE H H 7.89 0.02 1 410 . 179 ILE HA H 4.21 0.02 1 411 . 179 ILE CA C 65.20 0.10 1 412 . 179 ILE N N 119.50 0.15 1 413 . 180 VAL H H 7.78 0.02 1 414 . 180 VAL HA H 3.49 0.02 1 415 . 180 VAL CA C 66.70 0.10 1 416 . 180 VAL N N 118.70 0.15 1 417 . 181 GLN H H 8.76 0.02 1 418 . 181 GLN CA C 59.70 0.10 1 419 . 181 GLN N N 123.70 0.15 1 420 . 182 CYS H H 8.44 0.02 1 421 . 182 CYS CA C 58.00 0.10 1 422 . 182 CYS N N 116.30 0.15 1 423 . 183 ARG H H 7.91 0.02 1 424 . 183 ARG HA H 4.27 0.02 1 425 . 183 ARG CA C 58.90 0.10 1 426 . 183 ARG N N 116.30 0.15 1 427 . 184 SER H H 7.82 0.02 1 428 . 184 SER HA H 4.46 0.02 1 429 . 184 SER CA C 60.90 0.10 1 430 . 184 SER N N 113.30 0.15 1 431 . 185 VAL CA C 61.50 0.10 1 432 . 186 GLU H H 8.35 0.02 1 433 . 186 GLU HA H 4.22 0.02 1 434 . 186 GLU CA C 57.70 0.10 1 435 . 186 GLU N N 124.90 0.15 1 436 . 187 GLY H H 8.53 0.02 1 437 . 187 GLY CA C 45.70 0.10 1 438 . 187 GLY N N 110.90 0.15 1 439 . 188 SER H H 8.03 0.02 1 440 . 188 SER N N 115.10 0.15 1 441 . 189 CYS HA H 4.61 0.02 1 442 . 190 GLY H H 8.23 0.02 1 443 . 190 GLY CA C 45.60 0.10 1 444 . 190 GLY N N 109.60 0.15 1 445 . 191 PHE H H 7.41 0.02 1 446 . 191 PHE CA C 58.80 0.10 1 447 . 191 PHE N N 123.90 0.15 1 stop_ save_ save_T1_one _Saveframe_category T1_relaxation _Details . loop_ _Sample_label $sample_2 stop_ _Sample_conditions_label $sample_conditions_one _Spectrometer_frequency_1H 499.98 _T1_coherence_type Nz _T1_value_units s-1 _Mol_system_component_name hGH _Text_data_format . _Text_data . loop_ _T1_ID _Residue_seq_code _Residue_label _Atom_name _T1_value _T1_value_error 1 3 THR N 1.051 0.009 2 4 ILE N 1.207 0.031 3 6 LEU N 1.171 0.035 4 7 SER N 1.174 0.027 5 8 ARG N 1.192 0.033 6 9 LEU N 1.343 0.029 7 10 PHE N 1.263 0.027 8 11 ASP N 1.268 0.018 9 12 ASN N 1.315 0.014 10 13 ALA N 1.258 0.028 11 14 MET N 1.261 0.031 12 15 LEU N 1.415 0.013 13 16 ARG N 1.241 0.048 14 17 ALA N 1.301 0.042 15 18 HIS N 1.304 0.037 16 19 ARG N 1.312 0.018 17 20 LEU N 1.416 0.010 18 23 LEU N 1.315 0.034 19 24 ALA N 1.199 0.047 20 25 PHE N 1.325 0.034 21 26 ASP N 1.366 0.047 22 31 PHE N 1.397 0.040 23 32 GLU N 1.327 0.018 24 33 GLU N 1.239 0.031 25 34 ALA N 1.257 0.022 26 35 TYR N 1.278 0.067 27 36 ILE N 1.406 0.035 28 39 GLU N 1.419 0.022 29 40 GLN N 1.396 0.016 30 41 LYS N 1.271 0.044 31 42 TYR N 1.384 0.014 32 43 SER N 1.421 0.014 33 44 PHE N 1.558 0.024 34 45 LEU N 1.424 0.026 35 46 GLN N 1.472 0.022 36 47 ASN N 1.378 0.014 37 49 GLN N 1.459 0.017 38 50 THR N 1.509 0.028 39 51 SER N 1.489 0.028 40 52 LEU N 1.339 0.027 41 53 CYS N 1.328 0.030 42 56 GLU N 1.440 0.060 43 57 SER N 1.335 0.044 44 58 ILE N 1.181 0.049 45 60 THR N 1.298 0.029 46 77 ARG N 1.369 0.031 47 78 ILE N 1.297 0.022 48 79 SER N 1.240 0.043 49 80 LEU N 1.335 0.043 50 81 LEU N 1.378 0.026 51 82 LEU N 1.341 0.029 52 83 ILE N 1.304 0.025 53 84 GLN N 1.397 0.041 54 85 SER N 1.367 0.029 55 86 TRP N 1.161 0.203 56 91 GLN N 1.347 0.021 57 92 PHE N 1.346 0.014 58 93 LEU N 1.395 0.014 59 94 ARG N 1.238 0.027 60 95 SER N 1.452 0.099 61 96 VAL N 1.326 0.036 62 97 PHE N 1.543 0.073 63 98 ALA N 1.488 0.036 64 99 ASN N 1.366 0.021 65 100 SER N 1.437 0.021 66 101 LEU N 1.470 0.024 67 102 VAL N 1.430 0.032 68 103 TYR N 1.400 0.051 69 104 GLY N 1.501 0.042 70 105 ALA N 1.472 0.029 71 106 SER N 1.378 0.018 72 107 ASP N 1.378 0.013 73 108 SER N 1.416 0.016 74 109 ASN N 1.453 0.036 75 111 TYR N 1.310 0.025 76 112 ASP N 1.340 0.023 77 113 LEU N 1.288 0.017 78 114 LEU N 1.345 0.057 79 115 LYS N 1.349 0.019 80 116 ASP N 1.290 0.026 81 117 LEU N 1.334 0.040 82 118 GLU N 1.362 0.037 83 119 GLU N 1.314 0.030 84 120 GLY N 1.313 0.031 85 121 ILE N 1.385 0.048 86 122 GLN N 1.365 0.024 87 123 THR N 1.185 0.022 88 124 LEU N 1.360 0.017 89 125 MET N 1.245 0.036 90 126 GLY N 1.354 0.039 91 127 ARG N 1.275 0.025 92 129 GLU N 1.420 0.022 93 130 ASP N 1.477 0.021 94 131 GLY N 1.437 0.020 95 132 SER N 1.407 0.013 96 134 ARG N 1.455 0.016 97 135 THR N 1.424 0.011 98 136 GLY N 1.494 0.014 99 137 GLN N 1.429 0.013 100 138 ILE N 1.454 0.020 101 139 PHE N 1.553 0.027 102 140 LYS N 1.486 0.015 103 141 GLN N 1.434 0.047 104 142 THR N 1.384 0.028 105 143 TYR N 1.469 0.020 106 144 SER N 1.409 0.019 107 150 SER N 1.445 0.012 108 151 HIS N 1.438 0.023 109 152 ASN N 1.445 0.029 110 154 ASP N 1.404 0.022 111 155 ALA N 1.410 0.042 112 156 LEU N 1.341 0.020 113 157 LEU N 1.420 0.028 114 158 LYS N 1.311 0.034 115 161 GLY N 1.370 0.099 116 162 LEU N 1.392 0.034 117 171 ASP N 1.459 0.022 118 172 LYS N 1.340 0.042 119 173 VAL N 1.365 0.039 120 174 GLU N 1.267 0.043 121 175 THR N 1.287 0.042 122 176 PHE N 1.349 0.041 123 177 LEU N 1.258 0.022 124 178 ARG N 1.329 0.021 125 179 ILE N 1.291 0.022 126 180 VAL N 1.313 0.039 127 181 GLN N 1.246 0.042 128 182 CYS N 1.298 0.030 129 183 ARG N 1.342 0.047 130 184 SER N 1.325 0.032 131 185 VAL N 1.297 0.036 132 186 GLU N 1.335 0.027 133 187 GLY N 1.299 0.027 134 188 SER N 1.344 0.015 135 189 CYS N 1.386 0.044 136 190 GLY N 1.379 0.015 137 191 PHE N 1.220 0.010 stop_ save_ save_T1_two _Saveframe_category T1_relaxation _Details . loop_ _Sample_label $sample_2 stop_ _Sample_conditions_label $sample_conditions_two _Spectrometer_frequency_1H 499.98 _T1_coherence_type Nz _T1_value_units s-1 _Mol_system_component_name hGH _Text_data_format . _Text_data . loop_ _T1_ID _Residue_seq_code _Residue_label _Atom_name _T1_value _T1_value_error 1 3 THR N 1.233 0.071 2 4 ILE N 1.382 0.211 3 6 LEU N 1.169 0.331 4 7 SER N 1.282 0.106 5 8 ARG N 1.412 0.073 6 9 LEU N 1.338 0.050 7 10 PHE N 1.257 0.043 8 11 ASP N 1.221 0.045 9 12 ASN N 1.258 0.033 10 13 ALA N 1.238 0.039 11 14 MET N 1.273 0.056 12 15 LEU N 1.269 0.039 13 16 ARG N 1.259 0.037 14 17 ALA N 1.339 0.060 15 18 HIS N 1.208 0.061 16 23 LEU N 1.311 0.061 17 24 ALA N 1.148 0.059 18 25 PHE N 1.355 0.092 19 26 ASP N 1.219 0.062 20 27 THR N 1.082 0.070 21 28 TYR N 1.360 0.060 22 29 GLN N 1.529 0.076 23 32 GLU N 1.159 0.075 24 33 GLU N 1.201 0.049 25 34 ALA N 1.222 0.032 26 35 TYR N 1.114 0.052 27 46 GLN N 1.475 0.082 28 47 ASN N 1.517 0.106 29 49 GLN N 1.495 0.057 30 50 THR N 1.212 0.196 31 51 SER N 1.553 0.195 32 52 LEU N 1.447 0.063 33 53 CYS N 1.351 0.049 34 56 GLU N 1.379 0.083 35 57 SER N 1.369 0.307 36 58 ILE N 1.416 0.110 37 63 ASN N 1.472 0.110 38 79 SER N 1.380 0.079 39 82 LEU N 1.342 0.080 40 83 ILE N 1.346 0.056 41 84 GLN N 1.373 0.076 42 85 SER N 1.404 0.130 43 86 TRP N 1.332 0.094 44 90 VAL N 1.422 0.092 45 91 GLN N 1.356 0.060 46 95 SER N 1.380 0.113 47 96 VAL N 1.296 0.067 48 98 ALA N 1.358 0.030 49 99 ASN N 1.605 0.103 50 100 SER N 1.468 0.068 51 104 GLY N 1.410 0.199 52 105 ALA N 1.503 0.053 53 106 SER N 1.640 0.209 54 107 ASP N 1.625 0.061 55 108 SER N 1.493 0.056 56 117 LEU N 1.254 0.039 57 118 GLU N 1.201 0.041 58 119 GLU N 1.320 0.025 59 120 GLY N 1.261 0.056 60 121 ILE N 1.309 0.053 61 122 GLN N 1.389 0.041 62 125 MET N 1.293 0.065 63 126 GLY N 1.307 0.068 64 127 ARG N 1.237 0.028 65 128 LEU N 1.292 0.037 66 129 GLU N 1.536 0.075 67 130 ASP N 1.638 0.125 68 131 GLY N 1.296 0.288 69 132 SER N 1.274 0.057 70 137 GLN N 1.642 0.250 71 147 ASP N 1.887 0.485 72 148 THR N 1.653 0.236 73 149 ASN N 1.366 0.126 74 150 SER N 1.148 0.172 75 153 ASP N 1.370 0.042 76 154 ASP N 1.499 0.042 77 155 ALA N 1.378 0.185 78 156 LEU N 1.400 0.041 79 159 ASN N 1.245 0.051 80 160 TYR N 1.242 0.049 81 161 GLY N 1.354 0.118 82 162 LEU N 1.213 0.068 83 163 LEU N 1.300 0.116 84 171 ASP N 1.273 0.085 85 173 VAL N 1.420 0.053 86 174 GLU N 1.218 0.026 87 175 THR N 1.371 0.094 88 176 PHE N 1.294 0.039 89 177 LEU N 1.260 0.043 90 178 ARG N 1.312 0.043 91 179 ILE N 1.254 0.030 92 180 VAL N 1.398 0.046 93 181 GLN N 1.256 0.103 94 182 CYS N 1.337 0.068 95 183 ARG N 1.289 0.076 96 184 SER N 1.160 0.069 97 186 GLU N 1.525 0.263 98 187 GLY N 1.643 0.322 99 188 SER N 1.433 0.074 100 191 PHE N 1.277 0.017 stop_ save_ save_T2_one _Saveframe_category T2_relaxation _Details . loop_ _Sample_label $sample_2 stop_ _Sample_conditions_label $sample_conditions_one _Spectrometer_frequency_1H 499.98 _T2_coherence_type Nx _T2_value_units s-1 _Mol_system_component_name hGH _Text_data_format . _Text_data . loop_ _T2_ID _Residue_seq_code _Residue_label _Atom_name _T2_value _T2_value_error _Rex_value _Rex_error 1 3 THR N 4.355 . . . 2 4 ILE N 7.713 . . . 3 6 LEU N 14.264 . . . 4 7 SER N 15.090 . . . 5 8 ARG N 15.938 . . . 6 9 LEU N 16.074 . . . 7 10 PHE N 17.643 . . . 8 11 ASP N 15.779 . . . 9 12 ASN N 16.320 . . . 10 13 ALA N 15.980 . . . 11 14 MET N 16.489 . . . 12 15 LEU N 9.439 . . . 13 16 ARG N 17.417 . . . 14 17 ALA N 17.092 . . . 15 18 HIS N 16.285 . . . 16 19 ARG N 13.989 . . . 17 20 LEU N 9.884 . . . 18 23 LEU N 15.154 . . . 19 24 ALA N 19.692 . . . 20 25 PHE N 15.997 . . . 21 26 ASP N 18.528 . . . 22 31 PHE N 17.502 . . . 23 32 GLU N 16.730 . . . 24 33 GLU N 14.805 . . . 25 34 ALA N 16.951 . . . 26 35 TYR N 20.125 . . . 27 36 ILE N 18.736 . . . 28 39 GLU N 11.251 . . . 29 40 GLN N 11.290 . . . 30 41 LYS N 17.554 . . . 31 42 TYR N 12.509 . . . 32 43 SER N 9.915 . . . 33 44 PHE N 11.287 . . . 34 45 LEU N 13.219 . . . 35 46 GLN N 11.558 . . . 36 47 ASN N 11.042 . . . 37 49 GLN N 11.126 . . . 38 50 THR N 10.623 . . . 39 51 SER N 11.626 . . . 40 52 LEU N 7.335 . . . 41 53 CYS N 15.652 . . . 42 56 GLU N 22.675 . . . 43 57 SER N 15.582 . . . 44 58 ILE N 16.050 . . . 45 60 THR N 17.000 . . . 46 77 ARG N 16.526 . . . 47 78 ILE N 16.116 . . . 48 79 SER N 16.102 . . . 49 80 LEU N 16.437 . . . 50 81 LEU N 18.342 . . . 51 82 LEU N 14.996 . . . 52 83 ILE N 15.665 . . . 53 84 GLN N 15.983 . . . 54 85 SER N 15.029 . . . 55 86 TRP N 23.987 . . . 56 91 GLN N 10.854 . . . 57 92 PHE N 14.972 . . . 58 93 LEU N 10.005 . . . 59 94 ARG N 16.389 . . . 60 95 SER N 16.575 . . . 61 96 VAL N 17.942 . . . 62 97 PHE N 17.107 . . . 63 98 ALA N 15.307 . . . 64 99 ASN N 9.802 . . . 65 100 SER N 12.142 . . . 66 101 LEU N 12.902 . . . 67 102 VAL N 16.704 . . . 68 103 TYR N 12.524 . . . 69 104 GLY N 12.557 . . . 70 105 ALA N 13.280 . . . 71 106 SER N 10.142 . . . 72 107 ASP N 10.936 . . . 73 108 SER N 10.694 . . . 74 109 ASN N 11.139 . . . 75 111 TYR N 14.791 . . . 76 112 ASP N 14.098 . . . 77 113 LEU N 15.027 . . . 78 114 LEU N 18.651 . . . 79 115 LYS N 14.839 . . . 80 116 ASP N 16.588 . . . 81 117 LEU N 15.807 . . . 82 118 GLU N 15.294 . . . 83 119 GLU N 14.713 . . . 84 120 GLY N 15.421 . . . 85 121 ILE N 16.261 . . . 86 122 GLN N 14.198 . . . 87 123 THR N 9.892 . . . 88 124 LEU N 10.514 . . . 89 125 MET N 11.329 . . . 90 126 GLY N 15.383 . . . 91 127 ARG N 15.552 . . . 92 129 GLU N 13.161 . . . 93 130 ASP N 8.814 . . . 94 131 GLY N 5.205 . . . 95 132 SER N 5.945 . . . 96 134 ARG N 5.957 . . . 97 135 THR N 6.537 . . . 98 136 GLY N 4.634 . . . 99 137 GLN N 7.781 . . . 100 138 ILE N 8.415 . . . 101 139 PHE N 10.204 . . . 102 140 LYS N 9.491 . . . 103 141 GLN N 9.690 . . . 104 142 THR N 10.026 . . . 105 143 TYR N 13.086 . . . 106 144 SER N 12.379 . . . 107 150 SER N 8.162 . . . 108 151 HIS N 10.668 . . . 109 152 ASN N 9.940 . . . 110 154 ASP N 11.268 . . . 111 155 ALA N 14.009 . . . 112 156 LEU N 14.518 . . . 113 157 LEU N 12.235 . . . 114 158 LYS N 17.432 . . . 115 161 GLY N 25.896 . . . 116 162 LEU N 15.996 . . . 117 171 ASP N 10.250 . . . 118 172 LYS N 9.248 . . . 119 173 VAL N 18.289 . . . 120 174 GLU N 18.168 . . . 121 175 THR N 16.535 . . . 122 176 PHE N 17.807 . . . 123 177 LEU N 17.118 . . . 124 178 ARG N 16.027 . . . 125 179 ILE N 15.469 . . . 126 180 VAL N 17.118 . . . 127 181 GLN N 17.909 . . . 128 182 CYS N 14.722 . . . 129 183 ARG N 17.302 . . . 130 184 SER N 16.014 . . . 131 185 VAL N 16.496 . . . 132 186 GLU N 13.414 . . . 133 187 GLY N 9.374 . . . 134 188 SER N 11.149 . . . 135 189 CYS N 17.782 . . . 136 190 GLY N 5.566 . . . 137 191 PHE N 3.750 . . . stop_ save_ save_T2_two _Saveframe_category T2_relaxation _Details . loop_ _Sample_label $sample_2 stop_ _Sample_conditions_label $sample_conditions_two _Spectrometer_frequency_1H 499.98 _T2_coherence_type Nx _T2_value_units s-1 _Mol_system_component_name hGH _Text_data_format . _Text_data . loop_ _T2_ID _Residue_seq_code _Residue_label _Atom_name _T2_value _T2_value_error _Rex_value _Rex_error 1 3 THR N 15.537 . . . 2 4 ILE N 16.916 . . . 3 6 LEU N 27.383 . . . 4 7 SER N 22.153 . . . 5 8 ARG N 20.739 . . . 6 9 LEU N 20.361 . . . 7 10 PHE N 19.227 . . . 8 11 ASP N 18.801 . . . 9 12 ASN N 19.395 . . . 10 13 ALA N 19.922 . . . 11 14 MET N 20.389 . . . 12 15 LEU N 18.301 . . . 13 16 ARG N 18.320 . . . 14 17 ALA N 20.415 . . . 15 18 HIS N 19.837 . . . 16 23 LEU N 21.080 . . . 17 24 ALA N 19.937 . . . 18 25 PHE N 20.742 . . . 19 26 ASP N 18.474 . . . 20 27 THR N 21.680 . . . 21 28 TYR N 20.161 . . . 22 29 GLN N 17.395 . . . 23 32 GLU N 20.322 . . . 24 33 GLU N 18.713 . . . 25 34 ALA N 19.061 . . . 26 35 TYR N 16.386 . . . 27 46 GLN N 19.504 . . . 28 47 ASN N 20.562 . . . 29 49 GLN N 20.360 . . . 30 50 THR N 25.500 . . . 31 51 SER N 17.061 . . . 32 52 LEU N 16.607 . . . 33 53 CYS N 19.744 . . . 34 56 GLU N 23.436 . . . 35 57 SER N 13.709 . . . 36 58 ILE N 18.229 . . . 37 63 ASN N 20.956 . . . 38 79 SER N 18.910 . . . 39 82 LEU N 21.744 . . . 40 83 ILE N 19.291 . . . 41 84 GLN N 18.231 . . . 42 85 SER N 20.720 . . . 43 86 TRP N 15.075 . . . 44 90 VAL N 20.809 . . . 45 91 GLN N 18.945 . . . 46 95 SER N 16.576 . . . 47 96 VAL N 18.752 . . . 48 98 ALA N 18.257 . . . 49 99 ASN N 18.478 . . . 50 100 SER N 19.256 . . . 51 104 GLY N 24.869 . . . 52 105 ALA N 18.764 . . . 53 106 SER N 20.224 . . . 54 107 ASP N 18.306 . . . 55 108 SER N 16.810 . . . 56 117 LEU N 19.467 . . . 57 118 GLU N 18.550 . . . 58 119 GLU N 18.730 . . . 59 120 GLY N 15.620 . . . 60 121 ILE N 17.680 . . . 61 122 GLN N 17.653 . . . 62 125 MET N 19.180 . . . 63 126 GLY N 16.972 . . . 64 127 ARG N 19.300 . . . 65 128 LEU N 18.502 . . . 66 129 GLU N 20.018 . . . 67 130 ASP N 15.695 . . . 68 131 GLY N 15.273 . . . 69 132 SER N 19.565 . . . 70 137 GLN N 24.033 . . . 71 147 ASP N 19.767 . . . 72 148 THR N 18.589 . . . 73 149 ASN N 18.918 . . . 74 150 SER N 19.005 . . . 75 153 ASP N 18.581 . . . 76 154 ASP N 16.004 . . . 77 155 ALA N 22.989 . . . 78 156 LEU N 19.383 . . . 79 159 ASN N 20.505 . . . 80 160 TYR N 19.920 . . . 81 161 GLY N 20.669 . . . 82 162 LEU N 19.678 . . . 83 163 LEU N 20.334 . . . 84 171 ASP N 19.405 . . . 85 173 VAL N 19.771 . . . 86 174 GLU N 18.526 . . . 87 175 THR N 22.155 . . . 88 176 PHE N 19.021 . . . 89 177 LEU N 19.825 . . . 90 178 ARG N 20.877 . . . 91 179 ILE N 19.367 . . . 92 180 VAL N 20.480 . . . 93 181 GLN N 22.651 . . . 94 182 CYS N 19.831 . . . 95 183 ARG N 23.024 . . . 96 184 SER N 19.494 . . . 97 186 GLU N 23.545 . . . 98 187 GLY N 20.287 . . . 99 188 SER N 19.885 . . . 100 191 PHE N 10.190 . . . stop_ save_ save_Heteronuclear_NOE_one _Saveframe_category heteronuclear_NOE _Details . loop_ _Sample_label $sample_2 stop_ _Sample_conditions_label $sample_conditions_one _Spectrometer_frequency_1H 499.98 _Mol_system_component_name hGH _Atom_one_atom_name N _Atom_two_atom_name H _Heteronuclear_NOE_value_type NOE/NONOE _NOE_reference_value . _NOE_reference_description . _Text_data_format . _Text_data . loop_ _Residue_seq_code _Residue_label _Heteronuclear_NOE_value _Heteronuclear_NOE_value_error 3 THR -0.513 . 4 ILE 0.209 . 6 LEU 0.634 . 7 SER 0.878 . 8 ARG 0.865 . 9 LEU 0.732 . 10 PHE 0.757 . 11 ASP 0.563 . 12 ASN 0.745 . 13 ALA 0.730 . 14 MET 0.744 . 15 LEU 0.406 . 16 ARG 0.948 . 17 ALA 0.852 . 18 HIS 0.647 . 19 ARG 0.606 . 20 LEU 0.310 . 23 LEU 0.562 . 24 ALA 0.665 . 25 PHE 0.687 . 26 ASP 0.625 . 31 PHE 0.455 . 32 GLU 0.794 . 33 GLU 0.953 . 34 ALA 0.714 . 35 TYR 0.400 . 36 ILE 0.707 . 39 GLU 0.333 . 40 GLN 0.392 . 41 LYS 0.113 . 42 TYR 0.520 . 43 SER 0.421 . 44 PHE 0.440 . 45 LEU 0.338 . 46 GLN 0.441 . 47 ASN 0.479 . 49 GLN 0.472 . 50 THR 0.397 . 51 SER 0.299 . 52 LEU 0.362 . 53 CYS 0.569 . 56 GLU 0.512 . 57 SER 0.570 . 58 ILE 0.626 . 60 THR 0.831 . 77 ARG 0.651 . 78 ILE 0.645 . 79 SER 0.889 . 80 LEU 0.782 . 81 LEU 0.607 . 82 LEU 0.480 . 83 ILE 0.614 . 84 GLN 0.429 . 85 SER 0.590 . 86 TRP 0.411 . 91 GLN 0.466 . 92 PHE 0.537 . 93 LEU 0.111 . 94 ARG 0.727 . 95 SER 0.672 . 96 VAL 0.503 . 97 PHE 0.540 . 98 ALA 0.511 . 99 ASN -0.000 . 100 SER 0.403 . 101 LEU 0.137 . 102 VAL 0.573 . 103 TYR 0.344 . 104 GLY 0.532 . 105 ALA 0.695 . 106 SER 0.345 . 107 ASP 0.213 . 108 SER 0.374 . 109 ASN 0.100 . 111 TYR 0.588 . 112 ASP 0.536 . 113 LEU 0.651 . 114 LEU 0.894 . 115 LYS 0.431 . 116 ASP 0.833 . 117 LEU 0.898 . 118 GLU 0.918 . 119 GLU 0.451 . 120 GLY 0.680 . 121 ILE 0.634 . 122 GLN 0.615 . 123 THR 0.229 . 124 LEU 0.523 . 125 MET 0.280 . 126 GLY 0.768 . 127 ARG 0.633 . 129 GLU 0.649 . 130 ASP 0.321 . 131 GLY 0.177 . 132 SER 0.238 . 134 ARG 0.129 . 135 THR 0.035 . 136 GLY 0.118 . 137 GLN 0.188 . 138 ILE 0.362 . 139 PHE 0.033 . 140 LYS 0.304 . 141 GLN 0.182 . 142 THR 0.170 . 143 TYR 0.275 . 144 SER 0.437 . 150 SER 0.281 . 151 HIS 0.257 . 152 ASN 0.362 . 154 ASP 0.364 . 155 ALA 0.504 . 156 LEU 0.456 . 157 LEU 0.518 . 158 LYS 0.604 . 161 GLY 0.503 . 162 LEU 0.511 . 171 ASP 0.606 . 172 LYS 0.694 . 173 VAL 0.590 . 174 GLU 0.641 . 175 THR 0.907 . 176 PHE 0.851 . 177 LEU 0.845 . 178 ARG 0.625 . 179 ILE 0.705 . 180 VAL 0.740 . 181 GLN 0.861 . 182 CYS 0.555 . 183 ARG 0.766 . 184 SER 0.718 . 185 VAL 0.751 . 186 GLU 0.654 . 187 GLY 0.297 . 188 SER 0.461 . 189 CYS 0.445 . 190 GLY 0.055 . 191 PHE -0.187 . stop_ save_ save_Heteronuclear_NOE_two _Saveframe_category heteronuclear_NOE _Details . loop_ _Sample_label $sample_2 stop_ _Sample_conditions_label $sample_conditions_two _Spectrometer_frequency_1H 499.98 _Mol_system_component_name hGH _Atom_one_atom_name N _Atom_two_atom_name H _Heteronuclear_NOE_value_type NOE/NONOE _NOE_reference_value . _NOE_reference_description . _Text_data_format . _Text_data . loop_ _Residue_seq_code _Residue_label _Heteronuclear_NOE_value _Heteronuclear_NOE_value_error 3 THR 0.495 . 4 ILE 0.346 . 6 LEU 0.423 . 7 SER 0.791 . 8 ARG 0.861 . 9 LEU 0.755 . 10 PHE 0.642 . 11 ASP 0.751 . 12 ASN 0.679 . 13 ALA 0.652 . 14 MET 0.811 . 15 LEU 0.605 . 16 ARG 0.774 . 17 ALA 0.742 . 18 HIS 0.651 . 23 LEU 0.739 . 24 ALA 0.709 . 25 PHE 0.685 . 26 ASP 0.816 . 27 THR 0.798 . 28 TYR 0.575 . 29 GLN 0.501 . 32 GLU 0.766 . 33 GLU 0.722 . 34 ALA 0.790 . 35 TYR 0.670 . 46 GLN 0.306 . 47 ASN 0.555 . 49 GLN 0.356 . 50 THR 0.455 . 51 SER 0.315 . 52 LEU 0.546 . 53 CYS 0.738 . 56 GLU 0.797 . 57 SER 0.177 . 58 ILE 0.591 . 63 ASN 0.683 . 79 SER 0.716 . 82 LEU 0.809 . 83 ILE 0.796 . 84 GLN 0.715 . 85 SER 0.618 . 86 TRP 0.924 . 90 VAL 0.685 . 91 GLN 0.727 . 95 SER 0.929 . 96 VAL 0.674 . 98 ALA 0.737 . 99 ASN 0.717 . 100 SER 0.630 . 104 GLY 0.772 . 105 ALA 0.672 . 106 SER 0.554 . 107 ASP 0.558 . 108 SER 0.524 . 117 LEU 0.690 . 118 GLU 0.861 . 119 GLU 0.751 . 120 GLY 0.706 . 121 ILE 0.724 . 122 GLN 0.703 . 125 MET 0.756 . 126 GLY 0.883 . 127 ARG 0.806 . 128 LEU 0.719 . 129 GLU 0.820 . 130 ASP 0.322 . 131 GLY 0.590 . 132 SER 0.786 . 137 GLN 0.666 . 147 ASP 0.358 . 148 THR 0.379 . 149 ASN 0.473 . 150 SER 0.344 . 153 ASP 0.632 . 154 ASP 0.468 . 155 ALA 0.443 . 156 LEU 0.648 . 159 ASN 0.731 . 160 TYR 0.672 . 161 GLY 0.664 . 162 LEU 0.657 . 163 LEU 0.761 . 171 ASP 0.801 . 173 VAL 0.711 . 174 GLU 0.771 . 175 THR 0.665 . 176 PHE 0.677 . 177 LEU 0.741 . 178 ARG 0.764 . 179 ILE 0.756 . 180 VAL 0.781 . 181 GLN 0.778 . 182 CYS 0.767 . 183 ARG 0.800 . 184 SER 0.632 . 186 GLU 0.411 . 187 GLY 0.520 . 188 SER 0.700 . 191 PHE -0.022 . stop_ save_ save_S2_one _Saveframe_category S2_parameters _Details . loop_ _Sample_label $sample_2 stop_ _Sample_conditions_label $sample_conditions_one _Mol_system_component_name hGH _Tau_e_value_units ps _Tau_s_value_units . _Text_data_format . _Text_data . loop_ _Residue_seq_code _Residue_label _Atom_name _Model_fit _S2_value _S2_value_fit_error _Tau_e_value _Tau_e_value_fit_error _S2f_value _S2f_value_fit_error _S2s_value _S2s_value_fit_error _Tau_s_value _Tau_s_value_fit_error _S2H_value _S2H_value_fit_error _S2N_value _S2N_value_fit_error 3 THR N S2,te,S2f 0.136 0.004 772.20 18.10 0.62 0.01 . . . . . . . . 4 ILE N S2,te,S2f 0.330 0.019 941.50 96.80 0.71 0.02 . . . . . . . . 6 LEU N S2 0.834 0.021 . . . . . . . . . . . . 7 SER N S2 0.851 0.016 . . . . . . . . . . . . 8 ARG N S2 0.865 0.020 . . . . . . . . . . . . 9 LEU N S2 0.952 0.016 . . . . . . . . . . . . 10 PHE N S2,Rex 0.907 0.022 . . . . . . . . . . . . 11 ASP N S2,te 0.874 0.013 96.00 19.60 . . . . . . . . . . 12 ASN N S2 0.939 0.010 . . . . . . . . . . . . 13 ALA N S2 0.911 0.018 . . . . . . . . . . . . 14 MET N S2 0.915 0.020 . . . . . . . . . . . . 15 LEU N S2,te,S2f 0.400 0.014 1449.80 91.70 0.79 0.01 . . . . . . . . 16 ARG N S2 0.932 0.027 . . . . . . . . . . . . 17 ALA N S2 0.951 0.025 . . . . . . . . . . . . 18 HIS N S2 0.926 0.024 . . . . . . . . . . . . 19 ARG N S2,te,S2f 0.727 0.034 893.70 220.30 0.90 0.02 . . . . . . . . 20 LEU N S2,te,S2f 0.429 0.010 1249.80 34.60 0.83 0.01 . . . . . . . . 23 LEU N S2,te 0.881 0.021 125.90 46.60 . . . . . . . . . . 24 ALA N S2,Rex 0.869 0.035 . . . . . . . . . . . . 25 PHE N S2 0.946 0.022 . . . . . . . . . . . . 26 ASP N S2,Rex 0.973 0.031 . . . . . . . . . . . . 31 PHE N S2,te 0.909 0.026 430.70 253.60 . . . . . . . . . . 32 GLU N S2 0.954 0.011 . . . . . . . . . . . . 33 GLU N S2 0.875 0.020 . . . . . . . . . . . . 34 ALA N S2,Rex 0.856 0.015 . . . . . . . . . . . . 35 TYR N S2,te,Rex 0.835 0.052 153.80 84.80 . . . . . . . . . . 36 ILE N S2,Rex 0.939 0.025 . . . . . . . . . . . . 39 GLU N S2,te,S2f 0.606 0.030 829.20 102.70 0.89 0.02 . . . . . . . . 40 GLN N S2,te,S2f 0.617 0.022 764.90 106.30 0.87 0.01 . . . . . . . . 41 LYS N S2,te,Rex 0.703 0.025 139.70 22.40 . . . . . . . . . . 42 TYR N S2,te,S2f 0.646 0.019 1087.50 114.00 0.88 0.01 . . . . . . . . 43 SER N S2,te,S2f 0.473 0.017 1275.50 94.40 0.82 0.01 . . . . . . . . 44 PHE N S2,te,S2f 0.637 0.031 1115.50 132.20 0.92 0.02 . . . . . . . . 45 LEU N S2,te 0.825 0.016 193.60 37.70 . . . . . . . . . . 46 GLN N S2,te,S2f 0.613 0.029 1109.50 136.60 0.90 0.02 . . . . . . . . 47 ASN N S2,te,S2f 0.580 0.020 976.40 94.80 0.84 0.01 . . . . . . . . 49 GLN N S2,te,S2f 0.554 0.020 1310.60 108.20 0.86 0.01 . . . . . . . . 50 THR N S2,te,S2f 0.561 0.031 1148.10 132.30 0.88 0.02 . . . . . . . . 51 SER N S2,te,S2f 0.686 0.034 659.40 113.70 0.93 0.02 . . . . . . . . 52 LEU N S2,te,S2f 0.271 0.047 1505.70 180.60 0.70 0.03 . . . . . . . . 53 CYS N S2,te,Rex 0.840 0.023 86.20 23.80 . . . . . . . . . . 56 GLU N S2,te,Rex 0.876 0.065 757.10 426.00 . . . . . . . . . . 57 SER N S2,te,Rex 0.832 0.032 81.40 26.30 . . . . . . . . . . 58 ILE N S2 0.838 0.029 . . . . . . . . . . . . 60 THR N S2 0.913 0.019 . . . . . . . . . . . . 77 ARG N S2 0.937 0.019 . . . . . . . . . . . . 78 ILE N S2,te,Rex 0.839 0.020 55.50 19.10 . . . . . . . . . . 79 SER N S2 0.903 0.024 . . . . . . . . . . . . 80 LEU N S2 0.935 0.025 . . . . . . . . . . . . 81 LEU N S2,te,Rex 0.880 0.024 102.90 34.60 . . . . . . . . . . 82 LEU N S2,te 0.869 0.019 144.20 34.90 . . . . . . . . . . 83 ILE N S2 0.926 0.016 . . . . . . . . . . . . 84 GLN N S2,te 0.894 0.031 247.00 144.20 . . . . . . . . . . 85 SER N S2,te 0.886 0.019 97.60 31.70 . . . . . . . . . . 86 TRP N S2 0.888 0.130 . . . . . . . . . . . . 91 GLN N S2,te,S2f 0.526 0.024 1147.50 129.90 0.82 0.01 . . . . . . . . 92 PHE N S2,te,Rex 0.864 0.011 123.70 16.00 . . . . . . . . . . 93 LEU N S2,te,S2f 0.465 0.024 933.40 76.30 0.86 0.01 . . . . . . . . 94 ARG N S2,Rex 0.788 0.017 . . . . . . . . . . . . 95 SER N S2 0.975 0.051 . . . . . . . . . . . . 96 VAL N S2,te,Rex 0.844 0.031 118.20 39.40 . . . . . . . . . . 97 PHE N S2,te,Rex 0.907 0.050 396.10 375.70 . . . . . . . . . . 98 ALA N S2,te,Rex 0.878 0.030 188.40 77.40 . . . . . . . . . . 99 ASN N S2,te,S2f 0.533 0.025 549.50 62.40 0.88 0.01 . . . . . . . . 100 SER N S2,te,S2f 0.677 0.029 793.10 105.80 0.91 0.01 . . . . . . . . 101 LEU N S2,te 0.784 0.011 350.90 66.20 . . . . . . . . . . 102 VAL N S2,te,Rex 0.880 0.024 129.00 46.70 . . . . . . . . . . 103 TYR N S2,te 0.801 0.027 150.40 53.60 . . . . . . . . . . 104 GLY N S2,te,S2f 0.689 0.060 1214.50 416.60 0.92 0.03 . . . . . . . . 105 ALA N S2,te 0.865 0.024 241.20 93.60 . . . . . . . . . . 106 SER N S2,te,S2f 0.461 0.019 1177.30 82.50 0.82 0.01 . . . . . . . . 107 ASP N S2,te,S2f 0.519 0.011 946.60 29.00 0.87 0.01 . . . . . . . . 108 SER N S2,te,S2f 0.502 0.019 1203.00 91.50 0.85 0.01 . . . . . . . . 109 ASN N S2,te,S2f 0.561 0.045 855.80 85.40 0.93 0.03 . . . . . . . . 111 TYR N S2,te 0.872 0.013 98.00 21.30 . . . . . . . . . . 112 ASP N S2,te 0.860 0.014 131.10 25.20 . . . . . . . . . . 113 LEU N S2,te 0.882 0.011 84.30 17.50 . . . . . . . . . . 114 LEU N S2 0.989 0.032 . . . . . . . . . . . . 115 LYS N S2,te,Rex 0.841 0.014 155.70 21.70 . . . . . . . . . . 116 ASP N S2 0.934 0.015 . . . . . . . . . . . . 117 LEU N S2 0.946 0.025 . . . . . . . . . . . . 118 GLU N S2 0.936 0.022 . . . . . . . . . . . . 119 GLU N S2,te,Rex 0.815 0.022 114.50 20.40 . . . . . . . . . . 120 GLY N S2 0.925 0.019 . . . . . . . . . . . . 121 ILE N S2 0.976 0.030 . . . . . . . . . . . . 122 GLN N S2,te 0.874 0.014 103.70 25.40 . . . . . . . . . . 123 THR N S2,te,S2f 0.434 0.027 800.60 119.70 0.77 0.02 . . . . . . . . 124 LEU N S2,te,S2f 0.444 0.020 1637.10 162.10 0.79 0.01 . . . . . . . . 125 MET N S2,te 0.716 0.021 111.20 17.80 . . . . . . . . . . 126 GLY N S2 0.919 0.024 . . . . . . . . . . . . 127 ARG N S2,te 0.885 0.019 78.20 31.00 . . . . . . . . . . 129 GLU N S2,te,S2f 0.718 0.054 1266.10 497.50 0.90 0.03 . . . . . . . . 130 ASP N S2,te,S2f 0.379 0.017 1361.10 85.90 0.81 0.01 . . . . . . . . 131 GLY N S2,te,S2f 0.165 0.010 1430.20 73.70 0.69 0.01 . . . . . . . . 132 SER N S2,te,S2f 0.220 0.007 1401.60 47.50 0.70 0.01 . . . . . . . . 134 ARG N S2,te,S2f 0.200 0.009 1331.30 46.90 0.73 0.01 . . . . . . . . 135 THR N S2,te,S2f 0.278 0.009 1072.60 27.20 0.77 0.01 . . . . . . . . 136 GLY N S2,te,S2f 0.142 0.006 1400.30 33.10 0.70 0.01 . . . . . . . . 137 GLN N S2,te,S2f 0.349 0.010 1131.50 30.40 0.79 0.01 . . . . . . . . 138 ILE N S2,te,S2f 0.332 0.022 1509.00 198.70 0.77 0.02 . . . . . . . . 139 PHE N S2,te,S2f 0.596 0.032 709.10 73.50 0.95 0.02 . . . . . . . . 140 LYS N S2,te,S2f 0.481 0.017 1102.90 59.30 0.85 0.01 . . . . . . . . 141 GLN N S2,te,S2f 0.508 0.058 849.40 162.70 0.86 0.03 . . . . . . . . 142 THR N S2,te,S2f 0.516 0.023 785.80 58.50 0.86 0.01 . . . . . . . . 143 TYR N S2,te 0.821 0.012 304.50 56.70 . . . . . . . . . . 144 SER N S2,te,S2f 0.689 0.022 732.40 98.30 0.91 0.01 . . . . . . . . 150 SER N S2,te,S2f 0.361 0.010 1262.10 44.30 0.79 0.01 . . . . . . . . 151 HIS N S2,te,S2f 0.567 0.017 863.50 57.10 0.89 0.01 . . . . . . . . 152 ASN N S2,te,S2f 0.493 0.029 1153.00 144.70 0.84 0.02 . . . . . . . . 154 ASP N S2,te,S2f 0.607 0.020 815.70 80.70 0.88 0.01 . . . . . . . . 155 ALA N S2,te 0.851 0.032 576.50 222.00 . . . . . . . . . . 156 LEU N S2,te 0.859 0.013 188.50 30.80 . . . . . . . . . . 157 LEU N S2,te,S2f 0.628 0.035 1213.20 210.70 0.88 0.02 . . . . . . . . 158 LYS N S2,te,Rex 0.878 0.025 97.90 33.00 . . . . . . . . . . 161 GLY N S2,Rex 0.935 0.071 . . . . . . . . . . . . 162 LEU N S2,te 0.912 0.022 283.20 180.30 . . . . . . . . . . 171 ASP N S2,te,S2f 0.434 0.026 2153.70 454.10 0.79 0.02 . . . . . . . . 172 LYS N S2 0.756 0.022 . . . . . . . . . . . . 173 VAL N S2,te,Rex 0.918 0.029 194.20 128.60 . . . . . . . . . . 174 GLU N S2,te,Rex 0.880 0.033 76.50 39.80 . . . . . . . . . . 175 THR N S2 0.918 0.027 . . . . . . . . . . . . 176 PHE N S2 0.965 0.026 . . . . . . . . . . . . 177 LEU N S2,Rex 0.898 0.015 . . . . . . . . . . . . 178 ARG N S2,te 0.918 0.015 142.20 38.80 . . . . . . . . . . 179 ILE N S2 0.908 0.013 . . . . . . . . . . . . 180 VAL N S2,Rex 0.906 0.025 . . . . . . . . . . . . 181 GLN N S2 0.925 0.029 . . . . . . . . . . . . 182 CYS N S2,te 0.859 0.022 101.00 31.10 . . . . . . . . . . 183 ARG N S2,Rex 0.901 0.032 . . . . . . . . . . . . 184 SER N S2 0.945 0.020 . . . . . . . . . . . . 185 VAL N S2 0.943 0.018 . . . . . . . . . . . . 186 GLU N S2,te,S2f 0.688 0.047 1255.00 700.20 0.88 0.03 . . . . . . . . 187 GLY N S2,te,S2f 0.452 0.028 887.50 113.10 0.79 0.02 . . . . . . . . 188 SER N S2,te,S2f 0.579 0.018 883.60 87.40 0.84 0.01 . . . . . . . . 189 CYS N S2,te,Rex 0.863 0.030 192.80 83.20 . . . . . . . . . . 190 GLY N S2,te,S2f 0.197 0.009 1204.90 35.60 0.71 0.01 . . . . . . . . 191 PHE N S2,te,S2f 0.103 0.004 1085.10 18.90 0.62 0.01 . . . . . . . . stop_ save_ save_S2_two _Saveframe_category S2_parameters _Details . loop_ _Sample_label $sample_2 stop_ _Sample_conditions_label $sample_conditions_two _Mol_system_component_name hGH _Tau_e_value_units ps _Tau_s_value_units . _Text_data_format . _Text_data . loop_ _Residue_seq_code _Residue_label _Atom_name _Model_fit _S2_value _S2_value_fit_error _Tau_e_value _Tau_e_value_fit_error _S2f_value _S2f_value_fit_error _S2s_value _S2s_value_fit_error _Tau_s_value _Tau_s_value_fit_error _S2H_value _S2H_value_fit_error _S2N_value _S2N_value_fit_error 3 THR N S2,te 0.847 0.026 115.90 45.70 . . . . . . . . . . 4 ILE N S2,te 0.871 0.037 369.40 307.30 . . . . . . . . . . 6 LEU N S2,te 0.910 0.119 340.40 752.70 . . . . . . . . . . 7 SER N S2,Rex 1.021 0.088 . . . . . . . . . . . . 8 ARG N S2,te 1.101 0.088 19.00 1906.50 . . . . . . . . . . 9 LEU N S2,Rex 1.063 0.042 . . . . . . . . . . . . 10 PHE N S2,te 0.961 0.017 353.80 406.30 . . . . . . . . . . 11 ASP N S2 0.975 0.026 . . . . . . . . . . . . 12 ASN N S2,te 0.969 0.014 346.00 367.60 . . . . . . . . . . 13 ALA N S2,te,Rex 0.946 0.030 191.70 170.00 . . . . . . . . . . 14 MET N S2 1.041 0.028 . . . . . . . . . . . . 15 LEU N S2,te 0.943 0.019 381.60 317.20 . . . . . . . . . . 16 ARG N S2 0.974 0.018 . . . . . . . . . . . . 17 ALA N S2,te 0.963 0.048 2479.80 3152.50 . . . . . . . . . . 18 HIS N S2 0.996 0.037 . . . . . . . . . . . . 23 LEU N S2,Rex 1.035 0.045 . . . . . . . . . . . . 24 ALA N S2 0.969 0.036 . . . . . . . . . . . . 25 PHE N S2,te,Rex 0.912 0.084 1434.70 1024.30 . . . . . . . . . . 26 ASP N S2 0.965 0.035 . . . . . . . . . . . . 27 THR N S2,Rex 0.857 0.056 . . . . . . . . . . . . 28 TYR N S2,te,Rex 0.877 0.033 1075.00 298.00 . . . . . . . . . . 29 GLN N S2,te,Rex 0.762 0.038 1418.30 166.60 . . . . . . . . . . 32 GLU N S2,Rex 0.923 0.057 . . . . . . . . . . . . 33 GLU N S2 0.967 0.026 . . . . . . . . . . . . 34 ALA N S2,Rex 0.938 0.025 . . . . . . . . . . . . 35 TYR N S2 0.868 0.028 . . . . . . . . . . . . 46 GLN N S2,te,Rex 0.755 0.062 905.80 208.80 . . . . . . . . . . 47 ASN N S2,te,Rex 0.824 0.067 1296.90 431.40 . . . . . . . . . . 49 GLN N S2,te,Rex 0.744 0.038 1057.90 129.80 . . . . . . . . . . 50 THR N S2,Rex 0.917 0.146 . . . . . . . . . . . . 51 SER N S2,te,Rex 0.720 0.107 1026.60 473.50 . . . . . . . . . . 52 LEU N S2,te 0.857 0.023 1132.40 232.00 . . . . . . . . . . 53 CYS N S2,te,Rex 0.962 0.054 1059.50 494.50 . . . . . . . . . . 56 GLU N S2,Rex 1.092 0.067 . . . . . . . . . . . . 57 SER N S2,te 0.741 0.082 730.30 434.70 . . . . . . . . . . 58 ILE N S2,te 0.939 0.038 589.00 653.20 . . . . . . . . . . 63 ASN N S2,te,Rex 0.880 0.067 1762.90 1022.90 . . . . . . . . . . 79 SER N S2,te 0.933 0.043 1893.00 2029.60 . . . . . . . . . . 82 LEU N S2 1.089 0.051 . . . . . . . . . . . . 83 ILE N S2,te 0.972 0.044 4505.60 2883.30 . . . . . . . . . . 84 GLN N S2,te 0.947 0.040 1353.10 1209.90 . . . . . . . . . . 85 SER N S2,te,Rex 0.897 0.055 1067.80 747.40 . . . . . . . . . . 86 TRP N S2 0.902 0.049 . . . . . . . . . . . . 90 VAL N S2,te,Rex 0.884 0.059 1766.90 1012.80 . . . . . . . . . . 91 GLN N S2 1.031 0.028 . . . . . . . . . . . . 95 SER N S2 0.967 0.050 . . . . . . . . . . . . 96 VAL N S2,te 0.968 0.027 363.30 609.20 . . . . . . . . . . 98 ALA N S2,te,Rex 0.975 0.033 561.80 235.40 . . . . . . . . . . 99 ASN N S2,te 0.926 0.072 4046.70 6956.40 . . . . . . . . . . 100 SER N S2,te,Rex 0.866 0.046 1432.30 493.00 . . . . . . . . . . 104 GLY N S2,Rex 1.070 0.148 . . . . . . . . . . . . 105 ALA N S2,te,Rex 0.867 0.033 1758.90 440.30 . . . . . . . . . . 106 SER N S2,te,Rex 0.737 0.109 1724.90 658.70 . . . . . . . . . . 107 ASP N S2,te,Rex 0.738 0.035 1752.00 217.40 . . . . . . . . . . 108 SER N S2,te 0.838 0.024 1252.10 226.30 . . . . . . . . . . 117 LEU N S2,te 0.973 0.016 350.20 451.70 . . . . . . . . . . 118 GLU N S2 0.949 0.026 . . . . . . . . . . . . 119 GLU N S2 1.009 0.015 . . . . . . . . . . . . 120 GLY N S2 0.900 0.027 . . . . . . . . . . . . 121 ILE N S2 0.979 0.029 . . . . . . . . . . . . 122 GLN N S2,te 0.933 0.023 1364.40 497.40 . . . . . . . . . . 125 MET N S2,Rex 0.991 0.050 . . . . . . . . . . . . 126 GLY N S2 0.963 0.038 . . . . . . . . . . . . 127 ARG N S2 0.992 0.018 . . . . . . . . . . . . 128 LEU N S2 0.993 0.018 . . . . . . . . . . . . 129 GLU N S2,te 0.912 0.068 5367.30 6950.20 . . . . . . . . . . 130 ASP N S2,te 0.748 0.051 1064.70 239.60 . . . . . . . . . . 131 GLY N S2 0.834 0.058 . . . . . . . . . . . . 132 SER N S2,Rex 0.943 0.044 . . . . . . . . . . . . 137 GLN N S2,te,Rex 0.803 0.137 2178.70 1616.00 . . . . . . . . . . 147 ASP N S2,te,Rex 0.536 0.246 1545.20 646.80 . . . . . . . . . . 148 THR N S2,te 0.880 0.056 489.70 486.70 . . . . . . . . . . 149 ASN N S2,te 0.913 0.039 396.60 448.20 . . . . . . . . . . 150 SER N S2 0.932 0.104 . . . . . . . . . . . . 153 ASP N S2,te,Rex 0.920 0.026 896.50 412.20 . . . . . . . . . . 154 ASP N S2,te 0.813 0.022 1087.00 122.40 . . . . . . . . . . 155 ALA N S2,te,Rex 0.838 0.082 864.40 624.00 . . . . . . . . . . 156 LEU N S2,te,Rex 0.881 0.026 1459.60 260.90 . . . . . . . . . . 159 ASN N S2,Rex 0.990 0.040 . . . . . . . . . . . . 160 TYR N S2,te 0.971 0.021 336.00 488.50 . . . . . . . . . . 161 GLY N S2,te 0.960 0.051 558.40 795.90 . . . . . . . . . . 162 LEU N S2,Rex 0.947 0.051 . . . . . . . . . . . . 163 LEU N S2 1.052 0.049 . . . . . . . . . . . . 171 ASP N S2 1.013 0.038 . . . . . . . . . . . . 173 VAL N S2,te,Rex 0.899 0.098 1900.70 1408.40 . . . . . . . . . . 174 GLU N S2 0.966 0.013 . . . . . . . . . . . . 175 THR N S2,te,Rex 0.906 0.058 1319.40 931.20 . . . . . . . . . . 176 PHE N S2,te 0.968 0.016 403.10 417.40 . . . . . . . . . . 177 LEU N S2,Rex 0.992 0.035 . . . . . . . . . . . . 178 ARG N S2,Rex 1.048 0.036 . . . . . . . . . . . . 179 ILE N S2,Rex 0.985 0.025 . . . . . . . . . . . . 180 VAL N S2,te 1.088 0.076 0.00 2746.60 . . . . . . . . . . 181 GLN N S2,te,Rex 0.988 0.090 624.20 452.50 . . . . . . . . . . 182 CYS N S2 1.048 0.040 . . . . . . . . . . . . 183 ARG N S2,Rex 0.983 0.061 . . . . . . . . . . . . 184 SER N S2,te,Rex 0.883 0.048 76.60 58.50 . . . . . . . . . . 186 GLU N S2,te,Rex 0.742 0.129 1201.10 661.60 . . . . . . . . . . 187 GLY N S2,te 0.926 0.083 437.00 773.40 . . . . . . . . . . 188 SER N S2,te,Rex 0.917 0.070 1479.40 1071.80 . . . . . . . . . . 191 PHE N S2,te,S2f 0.440 0.013 804.00 24.40 0.84 0.01 . . . . . . . . stop_ save_