data_26823 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; Backbone 1H, 13C, and 15N Chemical Shift Assignments, HNHA scalar coupling, and 15N backbone relaxation data for TDP-43 C-terminal domain wild type ; _BMRB_accession_number 26823 _BMRB_flat_file_name bmr26823.str _Entry_type original _Submission_date 2016-06-20 _Accession_date 2016-06-20 _Entry_origination author _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details . loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Conicella Alexander E. . 2 Fawzi Nicolas L. . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 2 coupling_constants 1 heteronucl_NOE 2 T1_relaxation 2 T2_relaxation 2 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 288 "13C chemical shifts" 660 "15N chemical shifts" 286 "coupling constants" 101 "T1 relaxation values" 222 "T2 relaxation values" 259 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 2016-10-25 update BMRB 'update entry citation' 2016-08-19 original author 'original release' stop_ loop_ _Related_BMRB_accession_number _Relationship 26826 'A321G mutant' 26827 'A321V mutant' 26828 'A326P mutant' 26829 'Q331K mutant' 26830 'M337V mutant' 26831 'M337P mutant' stop_ _Original_release_date 2016-08-19 save_ ############################# # Citation for this entry # ############################# save_entry_citation _Saveframe_category entry_citation _Citation_full . _Citation_title ; ALS Mutations Disrupt Phase Separation Mediated by alpha-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain ; _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID 27545621 loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Conicella Alexander E. . 2 Zerze Gul H. . 3 Mittal Jeetain . . 4 Fawzi Nicolas L. . stop_ _Journal_abbreviation 'Structure (Cambridge, MA, U.S.)' _Journal_volume 24 _Journal_issue 9 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 1537 _Page_last 1549 _Year 2016 _Details . loop_ _Keyword ALS IDP NMR TDP-43 'phase separation' 'ribonucleoprotein granule' stop_ save_ ################################## # Molecular system description # ################################## save_assembly _Saveframe_category molecular_system _Mol_system_name 'WT TDP-43_267-414 Monomer' _Enzyme_commission_number . loop_ _Mol_system_component_name _Mol_label 'WT TDP-43_267-414 Monomer' $WT_TDP-43_267-414 stop_ _System_molecular_weight . _System_physical_state 'intrinsically disordered' _System_oligomer_state ? _System_paramagnetic no _System_thiol_state . _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_WT_TDP-43_267-414 _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common WT_TDP-43_267-414 _Molecular_mass . _Mol_thiol_state 'not present' _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 151 _Mol_residue_sequence ; GHMNRQLERSGRFGGNPGGF GNQGGFGNSRGGGAGLGNNQ GSNMGGGMNFGAFSINPAMM AAAQAALQSSWGMMGMLASQ QNQSGPSGNNQNQGNMQREP NQAFGSGNNSYSGSNSGAAI GWGSASNAGSGSGFNGGFGS SMDSKSSGWGM ; loop_ _Residue_seq_code _Residue_author_seq_code _Residue_label 1 -3 GLY 2 -2 HIS 3 -1 MET 4 267 ASN 5 268 ARG 6 269 GLN 7 270 LEU 8 271 GLU 9 272 ARG 10 273 SER 11 274 GLY 12 275 ARG 13 276 PHE 14 277 GLY 15 278 GLY 16 279 ASN 17 280 PRO 18 281 GLY 19 282 GLY 20 283 PHE 21 284 GLY 22 285 ASN 23 286 GLN 24 287 GLY 25 288 GLY 26 289 PHE 27 290 GLY 28 291 ASN 29 292 SER 30 293 ARG 31 294 GLY 32 295 GLY 33 296 GLY 34 297 ALA 35 298 GLY 36 299 LEU 37 300 GLY 38 301 ASN 39 302 ASN 40 303 GLN 41 304 GLY 42 305 SER 43 306 ASN 44 307 MET 45 308 GLY 46 309 GLY 47 310 GLY 48 311 MET 49 312 ASN 50 313 PHE 51 314 GLY 52 315 ALA 53 316 PHE 54 317 SER 55 318 ILE 56 319 ASN 57 320 PRO 58 321 ALA 59 322 MET 60 323 MET 61 324 ALA 62 325 ALA 63 326 ALA 64 327 GLN 65 328 ALA 66 329 ALA 67 330 LEU 68 331 GLN 69 332 SER 70 333 SER 71 334 TRP 72 335 GLY 73 336 MET 74 337 MET 75 338 GLY 76 339 MET 77 340 LEU 78 341 ALA 79 342 SER 80 343 GLN 81 344 GLN 82 345 ASN 83 346 GLN 84 347 SER 85 348 GLY 86 349 PRO 87 350 SER 88 351 GLY 89 352 ASN 90 353 ASN 91 354 GLN 92 355 ASN 93 356 GLN 94 357 GLY 95 358 ASN 96 359 MET 97 360 GLN 98 361 ARG 99 362 GLU 100 363 PRO 101 364 ASN 102 365 GLN 103 366 ALA 104 367 PHE 105 368 GLY 106 369 SER 107 370 GLY 108 371 ASN 109 372 ASN 110 373 SER 111 374 TYR 112 375 SER 113 376 GLY 114 377 SER 115 378 ASN 116 379 SER 117 380 GLY 118 381 ALA 119 382 ALA 120 383 ILE 121 384 GLY 122 385 TRP 123 386 GLY 124 387 SER 125 388 ALA 126 389 SER 127 390 ASN 128 391 ALA 129 392 GLY 130 393 SER 131 394 GLY 132 395 SER 133 396 GLY 134 397 PHE 135 398 ASN 136 399 GLY 137 400 GLY 138 401 PHE 139 402 GLY 140 403 SER 141 404 SER 142 405 MET 143 406 ASP 144 407 SER 145 408 LYS 146 409 SER 147 410 SER 148 411 GLY 149 412 TRP 150 413 GLY 151 414 MET stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date . save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species $WT_TDP-43_267-414 Human 9606 Eukaryota Metazoa Homo sapiens stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $WT_TDP-43_267-414 'recombinant technology' . Escherichia coli . pJ411 stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample-1 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $WT_TDP-43_267-414 20 uM '[U-99% 13C; U-99% 15N]' MES 20 mM 'natural abundance' stop_ save_ save_sample-2 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $WT_TDP-43_267-414 20 uM '[U-99% 15N]' MES 20 mM 'natural abundance' stop_ save_ ############################ # Computer software used # ############################ save_NMRPipe _Saveframe_category software _Name NMRPipe _Version . loop_ _Vendor _Address _Electronic_address 'Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax' . . stop_ loop_ _Task processing stop_ _Details . save_ save_SPARKY _Saveframe_category software _Name SPARKY _Version . loop_ _Vendor _Address _Electronic_address Goddard . . stop_ loop_ _Task 'chemical shift assignment' 'peak picking' stop_ _Details . save_ save_TOPSPIN _Saveframe_category software _Name TOPSPIN _Version . loop_ _Vendor _Address _Electronic_address 'Bruker Biospin' . . stop_ loop_ _Task collection stop_ _Details . save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_Bruker_Avance_III_850_MHz_1H _Saveframe_category NMR_spectrometer _Manufacturer Bruker _Model Avance _Field_strength 850 _Details 'TCI cryoprobe' save_ save_Bruker_Avance_II_500_MHz_1H _Saveframe_category NMR_spectrometer _Manufacturer Bruker _Model Avance _Field_strength 500 _Details 'TCI cryoprobe' save_ ############################# # NMR applied experiments # ############################# save_2D_1H-15N_HSQC_1 _Saveframe_category NMR_applied_experiment _Experiment_name '2D 1H-15N HSQC' _Sample_label $sample-1 save_ save_3D_HNCACB_2 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCACB' _Sample_label $sample-1 save_ save_3D_CBCA(CO)NH_3 _Saveframe_category NMR_applied_experiment _Experiment_name '3D CBCA(CO)NH' _Sample_label $sample-1 save_ save_3D_HNCO_4 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCO' _Sample_label $sample-1 save_ save_3D_HN(CA)CO_5 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HN(CA)CO' _Sample_label $sample-1 save_ save_2D_1H-15N_HSQC_6 _Saveframe_category NMR_applied_experiment _Experiment_name '2D 1H-15N HSQC' _Sample_label $sample-1 save_ save_3D_HNCACB_7 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCACB' _Sample_label $sample-1 save_ save_3D_CBCA(CO)NH_8 _Saveframe_category NMR_applied_experiment _Experiment_name '3D CBCA(CO)NH' _Sample_label $sample-1 save_ save_hnhagp3d_9 _Saveframe_category NMR_applied_experiment _Experiment_name hnhagp3d _Sample_label $sample-2 save_ save_hsqct1etf3gpsitc3d.nlf_10 _Saveframe_category NMR_applied_experiment _Experiment_name hsqct1etf3gpsitc3d.nlf _Sample_label $sample-2 save_ save_hsqct2etf3gpsitc3d.ac_11 _Saveframe_category NMR_applied_experiment _Experiment_name hsqct2etf3gpsitc3d.ac _Sample_label $sample-2 save_ save_hsqcnoef3gpsi_12 _Saveframe_category NMR_applied_experiment _Experiment_name hsqcnoef3gpsi _Sample_label $sample-2 save_ save_hsqct1etf3gpsitc3d.nlf_13 _Saveframe_category NMR_applied_experiment _Experiment_name hsqct1etf3gpsitc3d.nlf _Sample_label $sample-2 save_ save_hsqct2etf3gpsitc3d.ac_14 _Saveframe_category NMR_applied_experiment _Experiment_name hsqct2etf3gpsitc3d.ac _Sample_label $sample-2 save_ save_hsqcnoef3gpsi_15 _Saveframe_category NMR_applied_experiment _Experiment_name hsqcnoef3gpsi _Sample_label $sample-2 save_ ####################### # Sample conditions # ####################### save_283_K _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units pH 6.1 . pH pressure 1 . atm temperature 283 . K stop_ save_ save_298_K _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units pH 6.1 . pH pressure 1 . atm temperature 298 . K stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chemical_shift_reference_1 _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis _Indirect_shift_ratio DSS C 13 'methyl protons' ppm 0.00 na indirect . . . 0.251449530 DSS H 1 'methyl protons' ppm 0.00 internal direct . . . 1.000000000 DSS N 15 'methyl protons' ppm 0.00 na indirect . . . 0.101329118 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_WT_TDP-43_267-414_298_K _Saveframe_category assigned_chemical_shifts _Details . loop_ _Experiment_label '2D 1H-15N HSQC' '3D HNCACB' '3D CBCA(CO)NH' '3D HNCO' '3D HN(CA)CO' stop_ loop_ _Sample_label $sample-1 stop_ _Sample_conditions_label $298_K _Chem_shift_reference_set_label $chemical_shift_reference_1 _Mol_system_component_name 'WT TDP-43_267-414 Monomer' _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 268 5 ARG C C 176.287 0.000 . 2 268 5 ARG CA C 56.405 0.000 . 3 268 5 ARG CB C 30.595 0.007 . 4 269 6 GLN H H 8.405 0.001 . 5 269 6 GLN C C 176.129 0.007 . 6 269 6 GLN CA C 56.249 0.061 . 7 269 6 GLN CB C 29.174 0.021 . 8 269 6 GLN N N 121.088 0.015 . 9 270 7 LEU H H 8.200 0.001 . 10 270 7 LEU C C 177.476 0.003 . 11 270 7 LEU CA C 55.359 0.061 . 12 270 7 LEU CB C 42.319 0.014 . 13 270 7 LEU N N 122.907 0.010 . 14 271 8 GLU H H 8.326 0.001 . 15 271 8 GLU C C 176.667 0.004 . 16 271 8 GLU CA C 56.767 0.065 . 17 271 8 GLU CB C 30.230 0.021 . 18 271 8 GLU N N 121.834 0.007 . 19 272 9 ARG H H 8.367 0.002 . 20 272 9 ARG C C 176.338 0.006 . 21 272 9 ARG CA C 56.369 0.082 . 22 272 9 ARG CB C 30.594 0.044 . 23 272 9 ARG N N 121.842 0.009 . 24 273 10 SER H H 8.278 0.003 . 25 273 10 SER C C 175.024 0.020 . 26 273 10 SER CA C 58.611 0.068 . 27 273 10 SER CB C 63.953 0.016 . 28 273 10 SER N N 116.310 0.025 . 29 274 11 GLY H H 8.379 0.001 . 30 274 11 GLY C C 174.112 0.015 . 31 274 11 GLY CA C 45.344 0.080 . 32 274 11 GLY N N 110.444 0.009 . 33 275 12 ARG H H 8.067 0.002 . 34 275 12 ARG C C 176.105 0.001 . 35 275 12 ARG CA C 56.354 0.040 . 36 275 12 ARG CB C 30.688 0.036 . 37 275 12 ARG N N 120.341 0.014 . 38 276 13 PHE H H 8.315 0.002 . 39 276 13 PHE C C 176.219 0.011 . 40 276 13 PHE CA C 57.599 0.034 . 41 276 13 PHE CB C 39.471 0.023 . 42 276 13 PHE N N 120.864 0.020 . 43 277 14 GLY H H 8.269 0.002 . 44 277 14 GLY C C 174.355 0.022 . 45 277 14 GLY CA C 45.389 0.044 . 46 277 14 GLY N N 110.717 0.028 . 47 278 15 GLY H H 7.894 0.001 . 48 278 15 GLY C C 173.369 0.000 . 49 278 15 GLY CA C 44.967 0.058 . 50 278 15 GLY N N 107.819 0.018 . 51 279 16 ASN H H 8.336 0.001 . 52 279 16 ASN C C 173.539 0.000 . 53 279 16 ASN CA C 51.318 0.000 . 54 279 16 ASN CB C 38.871 0.000 . 55 279 16 ASN N N 119.017 0.007 . 56 280 17 PRO C C 177.435 0.001 . 57 280 17 PRO CA C 63.883 0.052 . 58 280 17 PRO CB C 31.909 0.013 . 59 281 18 GLY H H 8.385 0.001 . 60 281 18 GLY C C 174.494 0.015 . 61 281 18 GLY CA C 45.356 0.069 . 62 281 18 GLY N N 108.617 0.013 . 63 282 19 GLY H H 8.036 0.004 . 64 282 19 GLY C C 173.966 0.025 . 65 282 19 GLY CA C 45.160 0.013 . 66 282 19 GLY N N 108.134 0.019 . 67 283 20 PHE H H 8.138 0.002 . 68 283 20 PHE C C 176.465 0.006 . 69 283 20 PHE CA C 57.974 0.047 . 70 283 20 PHE CB C 39.549 0.018 . 71 283 20 PHE N N 119.700 0.018 . 72 284 21 GLY H H 8.393 0.002 . 73 284 21 GLY C C 173.949 0.009 . 74 284 21 GLY CA C 45.442 0.007 . 75 284 21 GLY N N 110.247 0.010 . 76 285 22 ASN H H 8.270 0.003 . 77 285 22 ASN C C 175.518 0.012 . 78 285 22 ASN CA C 53.302 0.043 . 79 285 22 ASN CB C 38.812 0.025 . 80 285 22 ASN N N 118.629 0.082 . 81 286 23 GLN H H 8.452 0.002 . 82 286 23 GLN C C 176.461 0.002 . 83 286 23 GLN CA C 56.213 0.031 . 84 286 23 GLN CB C 29.205 0.046 . 85 286 23 GLN N N 120.460 0.016 . 86 287 24 GLY H H 8.379 0.003 . 87 287 24 GLY C C 174.390 0.028 . 88 287 24 GLY CA C 45.459 0.033 . 89 287 24 GLY N N 109.388 0.035 . 90 288 25 GLY H H 8.031 0.002 . 91 288 25 GLY C C 173.964 0.030 . 92 288 25 GLY CA C 45.155 0.019 . 93 288 25 GLY N N 108.103 0.021 . 94 289 26 PHE H H 8.141 0.003 . 95 289 26 PHE C C 176.477 0.010 . 96 289 26 PHE CA C 57.970 0.044 . 97 289 26 PHE CB C 39.549 0.018 . 98 289 26 PHE N N 119.685 0.025 . 99 290 27 GLY H H 8.395 0.002 . 100 290 27 GLY C C 173.952 0.007 . 101 290 27 GLY CA C 45.442 0.007 . 102 290 27 GLY N N 110.247 0.008 . 103 291 28 ASN H H 8.273 0.001 . 104 291 28 ASN C C 175.510 0.009 . 105 291 28 ASN CA C 53.236 0.061 . 106 291 28 ASN CB C 38.916 0.071 . 107 291 28 ASN N N 118.573 0.028 . 108 292 29 SER H H 8.310 0.001 . 109 292 29 SER C C 174.708 0.008 . 110 292 29 SER CA C 58.706 0.003 . 111 292 29 SER CB C 63.782 0.031 . 112 292 29 SER N N 116.153 0.012 . 113 293 30 ARG H H 8.369 0.001 . 114 293 30 ARG C C 176.806 0.010 . 115 293 30 ARG CA C 56.312 0.038 . 116 293 30 ARG CB C 30.564 0.029 . 117 293 30 ARG N N 122.429 0.010 . 118 294 31 GLY H H 8.322 0.001 . 119 294 31 GLY C C 174.620 0.004 . 120 294 31 GLY CA C 45.339 0.002 . 121 294 31 GLY N N 109.460 0.014 . 122 295 32 GLY H H 8.260 0.006 . 123 295 32 GLY C C 174.702 0.004 . 124 295 32 GLY CA C 45.369 0.029 . 125 295 32 GLY N N 108.594 0.046 . 126 296 33 GLY H H 8.273 0.001 . 127 296 33 GLY C C 174.033 0.064 . 128 296 33 GLY CA C 45.262 0.055 . 129 296 33 GLY N N 108.510 0.009 . 130 297 34 ALA H H 8.232 0.001 . 131 297 34 ALA C C 178.230 0.000 . 132 297 34 ALA CA C 52.614 0.031 . 133 297 34 ALA CB C 19.270 0.014 . 134 297 34 ALA N N 123.624 0.003 . 135 298 35 GLY H H 8.355 0.001 . 136 298 35 GLY C C 174.222 0.007 . 137 298 35 GLY CA C 45.378 0.013 . 138 298 35 GLY N N 107.952 0.013 . 139 299 36 LEU H H 8.096 0.001 . 140 299 36 LEU C C 177.978 0.001 . 141 299 36 LEU CA C 55.248 0.019 . 142 299 36 LEU CB C 42.368 0.012 . 143 299 36 LEU N N 121.267 0.008 . 144 300 37 GLY H H 8.413 0.002 . 145 300 37 GLY C C 173.952 0.006 . 146 300 37 GLY CA C 45.453 0.014 . 147 300 37 GLY N N 109.107 0.026 . 148 301 38 ASN H H 8.272 0.001 . 149 301 38 ASN C C 175.087 0.047 . 150 301 38 ASN CA C 53.264 0.050 . 151 301 38 ASN CB C 38.817 0.008 . 152 301 38 ASN N N 118.553 0.020 . 153 302 39 ASN H H 8.459 0.001 . 154 302 39 ASN C C 175.259 0.026 . 155 302 39 ASN CA C 53.454 0.029 . 156 302 39 ASN CB C 38.721 0.020 . 157 302 39 ASN N N 119.004 0.010 . 158 303 40 GLN H H 8.336 0.001 . 159 303 40 GLN C C 176.476 0.025 . 160 303 40 GLN CA C 56.256 0.060 . 161 303 40 GLN CB C 29.242 0.005 . 162 303 40 GLN N N 120.366 0.014 . 163 304 41 GLY H H 8.387 0.006 . 164 304 41 GLY C C 174.207 0.024 . 165 304 41 GLY CA C 45.438 0.043 . 166 304 41 GLY N N 109.470 0.026 . 167 305 42 SER H H 8.176 0.003 . 168 305 42 SER C C 174.394 0.003 . 169 305 42 SER CA C 58.448 0.061 . 170 305 42 SER CB C 63.970 0.014 . 171 305 42 SER N N 115.406 0.077 . 172 306 43 ASN H H 8.493 0.002 . 173 306 43 ASN C C 175.312 0.013 . 174 306 43 ASN CA C 53.349 0.040 . 175 306 43 ASN CB C 38.557 0.016 . 176 306 43 ASN N N 120.415 0.010 . 177 307 44 MET H H 8.303 0.002 . 178 307 44 MET C C 176.781 0.002 . 179 307 44 MET CA C 55.671 0.041 . 180 307 44 MET CB C 32.557 0.104 . 181 307 44 MET N N 120.289 0.054 . 182 308 45 GLY H H 8.372 0.002 . 183 308 45 GLY C C 174.682 0.005 . 184 308 45 GLY CA C 45.492 0.000 . 185 308 45 GLY N N 109.539 0.031 . 186 309 46 GLY H H 8.233 0.001 . 187 309 46 GLY C C 174.717 0.017 . 188 309 46 GLY CA C 45.386 0.074 . 189 309 46 GLY N N 108.577 0.006 . 190 310 47 GLY H H 8.290 0.001 . 191 310 47 GLY C C 174.067 0.070 . 192 310 47 GLY CA C 45.267 0.012 . 193 310 47 GLY N N 108.753 0.016 . 194 311 48 MET H H 8.173 0.001 . 195 311 48 MET C C 175.633 0.003 . 196 311 48 MET CA C 55.462 0.056 . 197 311 48 MET CB C 32.803 0.005 . 198 311 48 MET N N 119.353 0.008 . 199 312 49 ASN H H 8.314 0.001 . 200 312 49 ASN C C 174.811 0.015 . 201 312 49 ASN CA C 53.006 0.097 . 202 312 49 ASN CB C 38.775 0.015 . 203 312 49 ASN N N 119.372 0.013 . 204 313 50 PHE H H 8.214 0.008 . 205 313 50 PHE C C 176.251 0.011 . 206 313 50 PHE CA C 58.153 0.050 . 207 313 50 PHE CB C 39.309 0.048 . 208 313 50 PHE N N 120.878 0.025 . 209 314 51 GLY H H 8.281 0.001 . 210 314 51 GLY C C 173.938 0.015 . 211 314 51 GLY CA C 45.483 0.026 . 212 314 51 GLY N N 109.861 0.014 . 213 315 52 ALA H H 7.994 0.002 . 214 315 52 ALA C C 177.387 0.002 . 215 315 52 ALA CA C 52.628 0.028 . 216 315 52 ALA CB C 19.029 0.022 . 217 315 52 ALA N N 123.571 0.008 . 218 316 53 PHE H H 8.025 0.002 . 219 316 53 PHE C C 175.552 0.006 . 220 316 53 PHE CA C 57.543 0.017 . 221 316 53 PHE CB C 39.482 0.031 . 222 316 53 PHE N N 118.141 0.012 . 223 317 54 SER H H 8.013 0.002 . 224 317 54 SER C C 173.932 0.018 . 225 317 54 SER CA C 58.254 0.081 . 226 317 54 SER CB C 63.968 0.039 . 227 317 54 SER N N 116.568 0.013 . 228 318 55 ILE H H 7.985 0.002 . 229 318 55 ILE C C 175.284 0.019 . 230 318 55 ILE CA C 60.858 0.045 . 231 318 55 ILE CB C 38.915 0.056 . 232 318 55 ILE N N 121.334 0.012 . 233 319 56 ASN H H 8.245 0.002 . 234 319 56 ASN C C 173.930 0.000 . 235 319 56 ASN CA C 51.157 0.000 . 236 319 56 ASN CB C 38.927 0.000 . 237 319 56 ASN N N 123.305 0.011 . 238 320 57 PRO C C 177.793 0.005 . 239 320 57 PRO CA C 64.661 0.084 . 240 320 57 PRO CB C 32.052 0.076 . 241 321 58 ALA H H 8.119 0.001 . 242 321 58 ALA C C 179.290 0.002 . 243 321 58 ALA CA C 53.851 0.026 . 244 321 58 ALA CB C 18.495 0.027 . 245 321 58 ALA N N 121.188 0.012 . 246 322 59 MET H H 7.950 0.002 . 247 322 59 MET C C 177.382 0.001 . 248 322 59 MET CA C 56.347 0.024 . 249 322 59 MET CB C 32.797 0.072 . 250 322 59 MET N N 118.030 0.009 . 251 323 60 MET H H 7.960 0.002 . 252 323 60 MET C C 177.001 0.020 . 253 323 60 MET CA C 56.863 0.059 . 254 323 60 MET CB C 32.656 0.050 . 255 323 60 MET N N 120.267 0.009 . 256 324 61 ALA H H 8.165 0.001 . 257 324 61 ALA C C 179.083 0.003 . 258 324 61 ALA CA C 53.776 0.021 . 259 324 61 ALA CB C 18.533 0.018 . 260 324 61 ALA N N 123.387 0.016 . 261 325 62 ALA H H 8.044 0.001 . 262 325 62 ALA C C 179.034 0.001 . 263 325 62 ALA CA C 53.761 0.009 . 264 325 62 ALA CB C 18.548 0.003 . 265 325 62 ALA N N 122.007 0.032 . 266 326 63 ALA H H 8.044 0.002 . 267 326 63 ALA C C 179.033 0.016 . 268 326 63 ALA CA C 53.722 0.040 . 269 326 63 ALA CB C 18.574 0.026 . 270 326 63 ALA N N 121.953 0.029 . 271 327 64 GLN H H 8.056 0.002 . 272 327 64 GLN C C 177.151 0.001 . 273 327 64 GLN CA C 57.320 0.048 . 274 327 64 GLN CB C 28.759 0.075 . 275 327 64 GLN N N 118.046 0.018 . 276 328 65 ALA H H 8.049 0.002 . 277 328 65 ALA C C 178.719 0.003 . 278 328 65 ALA CA C 53.748 0.023 . 279 328 65 ALA CB C 18.542 0.012 . 280 328 65 ALA N N 123.073 0.022 . 281 329 66 ALA H H 7.914 0.001 . 282 329 66 ALA C C 178.659 0.009 . 283 329 66 ALA CA C 53.379 0.063 . 284 329 66 ALA CB C 18.671 0.036 . 285 329 66 ALA N N 121.132 0.010 . 286 330 67 LEU H H 7.834 0.002 . 287 330 67 LEU C C 177.973 0.000 . 288 330 67 LEU CA C 55.993 0.032 . 289 330 67 LEU CB C 42.107 0.036 . 290 330 67 LEU N N 119.770 0.020 . 291 331 68 GLN H H 8.039 0.002 . 292 331 68 GLN C C 176.686 0.005 . 293 331 68 GLN CA C 56.569 0.036 . 294 331 68 GLN CB C 28.981 0.038 . 295 331 68 GLN N N 119.119 0.017 . 296 332 69 SER H H 8.104 0.002 . 297 332 69 SER C C 175.023 0.002 . 298 332 69 SER CA C 58.962 0.039 . 299 332 69 SER CB C 63.671 0.011 . 300 332 69 SER N N 115.416 0.017 . 301 333 70 SER H H 8.113 0.002 . 302 333 70 SER C C 174.745 0.004 . 303 333 70 SER CA C 58.994 0.083 . 304 333 70 SER CB C 63.623 0.052 . 305 333 70 SER N N 117.150 0.007 . 306 334 71 TRP H H 8.028 0.002 . 307 334 71 TRP C C 177.216 0.001 . 308 334 71 TRP CA C 57.937 0.063 . 309 334 71 TRP CB C 29.417 0.045 . 310 334 71 TRP N N 122.383 0.015 . 311 335 72 GLY H H 8.167 0.002 . 312 335 72 GLY C C 174.571 0.028 . 313 335 72 GLY CA C 45.756 0.040 . 314 335 72 GLY N N 109.230 0.018 . 315 336 73 MET H H 8.041 0.002 . 316 336 73 MET C C 176.708 0.029 . 317 336 73 MET CA C 56.029 0.017 . 318 336 73 MET CB C 32.710 0.079 . 319 336 73 MET N N 119.571 0.042 . 320 337 74 MET H H 8.260 0.002 . 321 337 74 MET C C 177.009 0.014 . 322 337 74 MET CA C 56.165 0.041 . 323 337 74 MET CB C 32.436 0.206 . 324 337 74 MET N N 119.686 0.014 . 325 338 75 GLY H H 8.257 0.002 . 326 338 75 GLY C C 174.439 0.009 . 327 338 75 GLY CA C 45.727 0.010 . 328 338 75 GLY N N 109.007 0.027 . 329 339 76 MET H H 8.041 0.002 . 330 339 76 MET C C 176.579 0.005 . 331 339 76 MET CA C 55.989 0.057 . 332 339 76 MET CB C 32.815 0.024 . 333 339 76 MET N N 119.635 0.026 . 334 340 77 LEU H H 8.147 0.001 . 335 340 77 LEU C C 177.585 0.007 . 336 340 77 LEU CA C 55.536 0.071 . 337 340 77 LEU CB C 42.237 0.028 . 338 340 77 LEU N N 122.258 0.009 . 339 341 78 ALA H H 8.191 0.001 . 340 341 78 ALA C C 178.138 0.006 . 341 341 78 ALA CA C 53.141 0.065 . 342 341 78 ALA CB C 18.959 0.048 . 343 341 78 ALA N N 124.021 0.016 . 344 342 79 SER H H 8.079 0.001 . 345 342 79 SER C C 174.906 0.008 . 346 342 79 SER CA C 58.763 0.042 . 347 342 79 SER CB C 63.666 0.009 . 348 342 79 SER N N 113.746 0.006 . 349 343 80 GLN H H 8.194 0.001 . 350 343 80 GLN C C 176.129 0.006 . 351 343 80 GLN CA C 56.148 0.118 . 352 343 80 GLN CB C 29.290 0.032 . 353 343 80 GLN N N 121.388 0.013 . 354 344 81 GLN H H 8.228 0.001 . 355 344 81 GLN C C 175.807 0.010 . 356 344 81 GLN CA C 56.177 0.014 . 357 344 81 GLN CB C 29.325 0.021 . 358 344 81 GLN N N 120.283 0.007 . 359 345 82 ASN H H 8.396 0.004 . 360 345 82 ASN C C 175.198 0.014 . 361 345 82 ASN CA C 53.476 0.055 . 362 345 82 ASN CB C 38.797 0.057 . 363 345 82 ASN N N 119.228 0.010 . 364 346 83 GLN H H 8.352 0.001 . 365 346 83 GLN C C 175.932 0.007 . 366 346 83 GLN CA C 56.069 0.081 . 367 346 83 GLN CB C 29.409 0.037 . 368 346 83 GLN N N 120.631 0.011 . 369 347 84 SER H H 8.337 0.001 . 370 347 84 SER C C 174.510 0.000 . 371 347 84 SER CA C 58.450 0.034 . 372 347 84 SER CB C 64.052 0.004 . 373 347 84 SER N N 116.606 0.008 . 374 348 85 GLY H H 8.187 0.001 . 375 348 85 GLY C C 171.919 0.000 . 376 348 85 GLY CA C 44.705 0.000 . 377 348 85 GLY N N 110.451 0.011 . 378 349 86 PRO C C 177.399 0.008 . 379 349 86 PRO CA C 63.407 0.000 . 380 349 86 PRO CB C 32.037 0.004 . 381 350 87 SER H H 8.443 0.001 . 382 350 87 SER C C 175.118 0.007 . 383 350 87 SER CA C 58.539 0.084 . 384 350 87 SER CB C 63.968 0.028 . 385 350 87 SER N N 115.829 0.015 . 386 351 88 GLY H H 8.322 0.001 . 387 351 88 GLY C C 173.935 0.008 . 388 351 88 GLY CA C 45.459 0.023 . 389 351 88 GLY N N 110.352 0.014 . 390 352 89 ASN H H 8.281 0.009 . 391 352 89 ASN C C 175.133 0.005 . 392 352 89 ASN CA C 53.246 0.068 . 393 352 89 ASN CB C 38.827 0.001 . 394 352 89 ASN N N 118.509 0.038 . 395 353 90 ASN H H 8.432 0.002 . 396 353 90 ASN C C 175.326 0.020 . 397 353 90 ASN CA C 53.517 0.055 . 398 353 90 ASN CB C 38.664 0.053 . 399 353 90 ASN N N 119.058 0.010 . 400 354 91 GLN H H 8.362 0.002 . 401 354 91 GLN C C 175.856 0.007 . 402 354 91 GLN CA C 56.258 0.037 . 403 354 91 GLN CB C 29.160 0.031 . 404 354 91 GLN N N 120.017 0.012 . 405 355 92 ASN H H 8.426 0.003 . 406 355 92 ASN C C 175.279 0.009 . 407 355 92 ASN CA C 53.517 0.055 . 408 355 92 ASN CB C 38.664 0.053 . 409 355 92 ASN N N 119.027 0.016 . 410 356 93 GLN H H 8.358 0.004 . 411 356 93 GLN C C 176.497 0.033 . 412 356 93 GLN CA C 56.307 0.016 . 413 356 93 GLN CB C 29.222 0.045 . 414 356 93 GLN N N 120.037 0.018 . 415 357 94 GLY H H 8.408 0.002 . 416 357 94 GLY C C 173.955 0.007 . 417 357 94 GLY CA C 45.453 0.014 . 418 357 94 GLY N N 109.207 0.034 . 419 358 95 ASN H H 8.271 0.003 . 420 358 95 ASN C C 175.362 0.016 . 421 358 95 ASN CA C 53.304 0.016 . 422 358 95 ASN CB C 38.783 0.067 . 423 358 95 ASN N N 118.515 0.047 . 424 359 96 MET H H 8.284 0.007 . 425 359 96 MET C C 176.070 0.004 . 426 359 96 MET CA C 55.714 0.002 . 427 359 96 MET CB C 32.661 0.032 . 428 359 96 MET N N 120.373 0.041 . 429 360 97 GLN H H 8.329 0.001 . 430 360 97 GLN C C 175.625 0.005 . 431 360 97 GLN CA C 55.869 0.002 . 432 360 97 GLN CB C 29.261 0.028 . 433 360 97 GLN N N 121.215 0.013 . 434 361 98 ARG H H 8.286 0.001 . 435 361 98 ARG C C 175.908 0.004 . 436 361 98 ARG CA C 55.939 0.064 . 437 361 98 ARG CB C 31.092 0.037 . 438 361 98 ARG N N 122.319 0.005 . 439 362 99 GLU H H 8.416 0.001 . 440 362 99 GLU C C 174.776 0.000 . 441 362 99 GLU CA C 54.527 0.000 . 442 362 99 GLU CB C 29.595 0.000 . 443 362 99 GLU N N 123.155 0.011 . 444 363 100 PRO C C 176.745 0.007 . 445 363 100 PRO CA C 63.539 0.036 . 446 363 100 PRO CB C 31.994 0.005 . 447 364 101 ASN H H 8.470 0.002 . 448 364 101 ASN C C 175.259 0.014 . 449 364 101 ASN CA C 53.480 0.040 . 450 364 101 ASN CB C 38.598 0.020 . 451 364 101 ASN N N 117.837 0.014 . 452 365 102 GLN H H 8.209 0.002 . 453 365 102 GLN C C 175.542 0.004 . 454 365 102 GLN CA C 55.902 0.014 . 455 365 102 GLN CB C 29.458 0.018 . 456 365 102 GLN N N 120.584 0.008 . 457 366 103 ALA H H 8.222 0.001 . 458 366 103 ALA C C 177.423 0.007 . 459 366 103 ALA CA C 52.566 0.033 . 460 366 103 ALA CB C 19.100 0.052 . 461 366 103 ALA N N 124.736 0.022 . 462 367 104 PHE H H 8.141 0.001 . 463 367 104 PHE C C 176.377 0.004 . 464 367 104 PHE CA C 57.832 0.062 . 465 367 104 PHE CB C 39.524 0.012 . 466 367 104 PHE N N 119.285 0.013 . 467 368 105 GLY H H 8.253 0.005 . 468 368 105 GLY C C 174.143 0.008 . 469 368 105 GLY CA C 45.405 0.026 . 470 368 105 GLY N N 110.616 0.033 . 471 369 106 SER H H 8.214 0.004 . 472 369 106 SER C C 175.096 0.003 . 473 369 106 SER CA C 58.587 0.078 . 474 369 106 SER CB C 63.996 0.040 . 475 369 106 SER N N 115.508 0.007 . 476 370 107 GLY H H 8.460 0.002 . 477 370 107 GLY C C 173.948 0.015 . 478 370 107 GLY CA C 45.447 0.008 . 479 370 107 GLY N N 110.658 0.085 . 480 371 108 ASN H H 8.272 0.002 . 481 371 108 ASN C C 175.043 0.026 . 482 371 108 ASN CA C 53.255 0.060 . 483 371 108 ASN CB C 38.809 0.017 . 484 371 108 ASN N N 118.496 0.052 . 485 372 109 ASN H H 8.403 0.002 . 486 372 109 ASN C C 175.172 0.011 . 487 372 109 ASN CA C 53.395 0.103 . 488 372 109 ASN CB C 38.861 0.012 . 489 372 109 ASN N N 119.220 0.008 . 490 373 110 SER H H 8.190 0.001 . 491 373 110 SER C C 174.158 0.004 . 492 373 110 SER CA C 58.629 0.094 . 493 373 110 SER CB C 63.779 0.022 . 494 373 110 SER N N 115.678 0.011 . 495 374 111 TYR H H 8.179 0.001 . 496 374 111 TYR C C 175.894 0.001 . 497 374 111 TYR CA C 57.981 0.082 . 498 374 111 TYR CB C 38.623 0.044 . 499 374 111 TYR N N 121.963 0.009 . 500 375 112 SER H H 8.200 0.001 . 501 375 112 SER C C 174.782 0.006 . 502 375 112 SER CA C 58.299 0.017 . 503 375 112 SER CB C 63.919 0.029 . 504 375 112 SER N N 117.815 0.005 . 505 376 113 GLY H H 7.863 0.001 . 506 376 113 GLY C C 174.160 0.022 . 507 376 113 GLY CA C 45.407 0.021 . 508 376 113 GLY N N 110.348 0.005 . 509 377 114 SER H H 8.178 0.003 . 510 377 114 SER C C 174.443 0.052 . 511 377 114 SER CA C 58.460 0.049 . 512 377 114 SER CB C 63.947 0.037 . 513 377 114 SER N N 115.372 0.072 . 514 378 115 ASN H H 8.481 0.003 . 515 378 115 ASN C C 175.330 0.004 . 516 378 115 ASN CA C 53.280 0.040 . 517 378 115 ASN CB C 38.763 0.004 . 518 378 115 ASN N N 120.732 0.021 . 519 379 116 SER H H 8.263 0.001 . 520 379 116 SER C C 175.046 0.007 . 521 379 116 SER CA C 58.881 0.160 . 522 379 116 SER CB C 63.841 0.075 . 523 379 116 SER N N 116.008 0.012 . 524 380 117 GLY H H 8.365 0.002 . 525 380 117 GLY C C 173.848 0.003 . 526 380 117 GLY CA C 45.383 0.009 . 527 380 117 GLY N N 110.697 0.020 . 528 381 118 ALA H H 7.965 0.001 . 529 381 118 ALA C C 177.393 0.015 . 530 381 118 ALA CA C 52.413 0.038 . 531 381 118 ALA CB C 19.363 0.024 . 532 381 118 ALA N N 123.484 0.006 . 533 382 119 ALA H H 8.128 0.001 . 534 382 119 ALA C C 177.627 0.008 . 535 382 119 ALA CA C 52.408 0.005 . 536 382 119 ALA CB C 19.060 0.041 . 537 382 119 ALA N N 123.001 0.007 . 538 383 120 ILE H H 7.946 0.001 . 539 383 120 ILE C C 176.679 0.004 . 540 383 120 ILE CA C 61.301 0.038 . 541 383 120 ILE CB C 38.644 0.043 . 542 383 120 ILE N N 119.454 0.013 . 543 384 121 GLY H H 8.266 0.001 . 544 384 121 GLY C C 173.915 0.005 . 545 384 121 GLY CA C 45.257 0.008 . 546 384 121 GLY N N 112.230 0.008 . 547 385 122 TRP H H 8.025 0.002 . 548 385 122 TRP C C 176.801 0.007 . 549 385 122 TRP CA C 57.569 0.024 . 550 385 122 TRP CB C 29.635 0.020 . 551 385 122 TRP N N 121.152 0.011 . 552 386 123 GLY H H 8.266 0.002 . 553 386 123 GLY C C 174.136 0.008 . 554 386 123 GLY CA C 45.430 0.011 . 555 386 123 GLY N N 110.661 0.024 . 556 387 124 SER H H 8.081 0.002 . 557 387 124 SER C C 174.467 0.005 . 558 387 124 SER CA C 58.370 0.067 . 559 387 124 SER CB C 63.951 0.034 . 560 387 124 SER N N 115.578 0.006 . 561 388 125 ALA H H 8.353 0.001 . 562 388 125 ALA C C 177.847 0.003 . 563 388 125 ALA CA C 52.709 0.036 . 564 388 125 ALA CB C 19.161 0.044 . 565 388 125 ALA N N 125.668 0.012 . 566 389 126 SER H H 8.188 0.002 . 567 389 126 SER C C 174.392 0.012 . 568 389 126 SER CA C 58.578 0.066 . 569 389 126 SER CB C 63.760 0.012 . 570 389 126 SER N N 114.408 0.012 . 571 390 127 ASN H H 8.297 0.001 . 572 390 127 ASN C C 174.968 0.007 . 573 390 127 ASN CA C 53.251 0.066 . 574 390 127 ASN CB C 38.808 0.026 . 575 390 127 ASN N N 120.476 0.016 . 576 391 128 ALA H H 8.188 0.002 . 577 391 128 ALA C C 178.138 0.002 . 578 391 128 ALA CA C 52.970 0.084 . 579 391 128 ALA CB C 19.056 0.028 . 580 391 128 ALA N N 124.004 0.009 . 581 392 129 GLY H H 8.291 0.001 . 582 392 129 GLY C C 174.376 0.004 . 583 392 129 GLY CA C 45.364 0.016 . 584 392 129 GLY N N 107.838 0.012 . 585 393 130 SER H H 8.174 0.002 . 586 393 130 SER C C 175.163 0.002 . 587 393 130 SER CA C 58.561 0.057 . 588 393 130 SER CB C 63.972 0.032 . 589 393 130 SER N N 115.464 0.057 . 590 394 131 GLY H H 8.459 0.002 . 591 394 131 GLY C C 174.309 0.001 . 592 394 131 GLY CA C 45.412 0.034 . 593 394 131 GLY N N 110.853 0.049 . 594 395 132 SER H H 8.222 0.003 . 595 395 132 SER C C 175.013 0.008 . 596 395 132 SER CA C 58.615 0.084 . 597 395 132 SER CB C 63.942 0.004 . 598 395 132 SER N N 115.516 0.005 . 599 396 133 GLY H H 8.378 0.004 . 600 396 133 GLY C C 173.858 0.007 . 601 396 133 GLY CA C 45.283 0.073 . 602 396 133 GLY N N 110.472 0.077 . 603 397 134 PHE H H 8.110 0.002 . 604 397 134 PHE C C 175.751 0.004 . 605 397 134 PHE CA C 57.939 0.039 . 606 397 134 PHE CB C 39.505 0.028 . 607 397 134 PHE N N 120.223 0.024 . 608 398 135 ASN H H 8.415 0.002 . 609 398 135 ASN C C 175.350 0.005 . 610 398 135 ASN CA C 53.066 0.035 . 611 398 135 ASN CB C 38.794 0.020 . 612 398 135 ASN N N 121.471 0.017 . 613 399 136 GLY H H 7.788 0.001 . 614 399 136 GLY C C 174.416 0.063 . 615 399 136 GLY CA C 45.496 0.098 . 616 399 136 GLY N N 108.482 0.018 . 617 400 137 GLY H H 8.106 0.001 . 618 400 137 GLY C C 173.964 0.020 . 619 400 137 GLY CA C 45.098 0.090 . 620 400 137 GLY N N 108.272 0.005 . 621 401 138 PHE H H 8.117 0.001 . 622 401 138 PHE C C 176.416 0.003 . 623 401 138 PHE CA C 58.055 0.046 . 624 401 138 PHE CB C 39.573 0.082 . 625 401 138 PHE N N 119.905 0.017 . 626 402 139 GLY H H 8.371 0.002 . 627 402 139 GLY C C 174.064 0.009 . 628 402 139 GLY CA C 45.378 0.020 . 629 402 139 GLY N N 110.711 0.013 . 630 403 140 SER H H 8.173 0.002 . 631 403 140 SER C C 174.752 0.003 . 632 403 140 SER CA C 58.397 0.112 . 633 403 140 SER CB C 64.031 0.047 . 634 403 140 SER N N 115.498 0.042 . 635 404 141 SER H H 8.397 0.001 . 636 404 141 SER C C 174.740 0.011 . 637 404 141 SER CA C 58.640 0.071 . 638 404 141 SER CB C 63.769 0.054 . 639 404 141 SER N N 117.557 0.011 . 640 405 142 MET H H 8.351 0.001 . 641 405 142 MET C C 175.975 0.007 . 642 405 142 MET CA C 55.791 0.058 . 643 405 142 MET CB C 32.640 0.045 . 644 405 142 MET N N 121.706 0.019 . 645 406 143 ASP H H 8.200 0.001 . 646 406 143 ASP C C 176.425 0.011 . 647 406 143 ASP CA C 54.356 0.060 . 648 406 143 ASP CB C 41.290 0.027 . 649 406 143 ASP N N 120.945 0.018 . 650 407 144 SER H H 8.209 0.001 . 651 407 144 SER C C 174.895 0.005 . 652 407 144 SER CA C 58.968 0.090 . 653 407 144 SER CB C 63.615 0.025 . 654 407 144 SER N N 116.564 0.005 . 655 408 145 LYS H H 8.280 0.002 . 656 408 145 LYS C C 176.935 0.001 . 657 408 145 LYS CA C 56.568 0.025 . 658 408 145 LYS CB C 32.625 0.015 . 659 408 145 LYS N N 122.508 0.007 . 660 409 146 SER H H 8.173 0.001 . 661 409 146 SER C C 174.713 0.001 . 662 409 146 SER CA C 58.534 0.087 . 663 409 146 SER CB C 63.829 0.000 . 664 409 146 SER N N 116.070 0.020 . 665 410 147 SER H H 8.255 0.001 . 666 410 147 SER C C 174.849 0.014 . 667 410 147 SER CA C 58.772 0.075 . 668 410 147 SER CB C 63.826 0.015 . 669 410 147 SER N N 117.426 0.005 . 670 411 148 GLY H H 8.270 0.002 . 671 411 148 GLY C C 173.831 0.011 . 672 411 148 GLY CA C 45.352 0.012 . 673 411 148 GLY N N 110.234 0.016 . 674 412 149 TRP H H 8.002 0.001 . 675 412 149 TRP C C 176.679 0.009 . 676 412 149 TRP CA C 57.605 0.032 . 677 412 149 TRP CB C 29.539 0.017 . 678 412 149 TRP N N 120.858 0.010 . 679 413 150 GLY H H 8.226 0.001 . 680 413 150 GLY C C 173.097 0.000 . 681 413 150 GLY CA C 45.504 0.010 . 682 413 150 GLY N N 111.395 0.010 . 683 414 151 MET H H 7.635 0.002 . 684 414 151 MET C C 173.340 0.000 . 685 414 151 MET CA C 56.907 0.000 . 686 414 151 MET CB C 33.739 0.000 . 687 414 151 MET N N 124.562 0.012 . stop_ save_ save_WT_TDP-43_267-414_283_K _Saveframe_category assigned_chemical_shifts _Details . loop_ _Experiment_label '2D 1H-15N HSQC' '3D HNCACB' '3D CBCA(CO)NH' stop_ loop_ _Sample_label $sample-1 stop_ _Sample_conditions_label $283_K _Chem_shift_reference_set_label $chemical_shift_reference_1 _Mol_system_component_name 'WT TDP-43_267-414 Monomer' _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 267 4 ASN H H 8.677 0.001 . 2 267 4 ASN CA C 53.305 0.067 . 3 267 4 ASN CB C 38.598 0.024 . 4 267 4 ASN N N 120.920 0.011 . 5 268 5 ARG H H 8.469 0.002 . 6 268 5 ARG CA C 56.499 0.026 . 7 268 5 ARG CB C 30.559 0.049 . 8 268 5 ARG N N 122.124 0.007 . 9 269 6 GLN H H 8.486 0.001 . 10 269 6 GLN CA C 56.266 0.075 . 11 269 6 GLN CB C 29.100 0.011 . 12 269 6 GLN N N 121.272 0.003 . 13 270 7 LEU H H 8.291 0.000 . 14 270 7 LEU CA C 55.346 0.019 . 15 270 7 LEU CB C 42.233 0.028 . 16 270 7 LEU N N 123.077 0.013 . 17 271 8 GLU H H 8.397 0.001 . 18 271 8 GLU CA C 56.726 0.039 . 19 271 8 GLU CB C 30.150 0.000 . 20 271 8 GLU N N 122.001 0.017 . 21 272 9 ARG H H 8.463 0.002 . 22 272 9 ARG CA C 56.400 0.081 . 23 272 9 ARG CB C 30.552 0.032 . 24 272 9 ARG N N 122.123 0.017 . 25 273 10 SER H H 8.367 0.002 . 26 273 10 SER CA C 58.642 0.092 . 27 273 10 SER CB C 63.936 0.031 . 28 273 10 SER N N 116.530 0.015 . 29 274 11 GLY H H 8.461 0.001 . 30 274 11 GLY CA C 45.285 0.031 . 31 274 11 GLY N N 110.627 0.020 . 32 275 12 ARG H H 8.140 0.002 . 33 275 12 ARG CA C 56.296 0.028 . 34 275 12 ARG CB C 30.614 0.007 . 35 275 12 ARG N N 120.454 0.009 . 36 276 13 PHE H H 8.421 0.001 . 37 276 13 PHE CA C 57.692 0.000 . 38 276 13 PHE CB C 39.320 0.000 . 39 276 13 PHE N N 121.051 0.008 . 40 277 14 GLY H H 8.340 0.004 . 41 277 14 GLY CA C 45.283 0.000 . 42 277 14 GLY N N 110.915 0.026 . 43 278 15 GLY H H 7.950 0.001 . 44 278 15 GLY CA C 44.916 0.045 . 45 278 15 GLY N N 107.863 0.003 . 46 279 16 ASN H H 8.424 0.001 . 47 279 16 ASN CA C 51.341 0.000 . 48 279 16 ASN CB C 38.690 0.000 . 49 279 16 ASN N N 119.085 0.009 . 50 280 17 PRO CA C 63.859 0.080 . 51 280 17 PRO CB C 31.895 0.012 . 52 281 18 GLY H H 8.482 0.002 . 53 281 18 GLY CA C 45.223 0.021 . 54 281 18 GLY N N 108.860 0.012 . 55 282 19 GLY H H 8.097 0.001 . 56 282 19 GLY CA C 45.115 0.029 . 57 282 19 GLY N N 108.246 0.013 . 58 283 20 PHE H H 8.225 0.001 . 59 283 20 PHE CA C 58.025 0.025 . 60 283 20 PHE CB C 39.519 0.014 . 61 283 20 PHE N N 119.812 0.026 . 62 284 21 GLY H H 8.483 0.001 . 63 284 21 GLY CA C 45.407 0.030 . 64 284 21 GLY N N 110.447 0.004 . 65 285 22 ASN H H 8.334 0.001 . 66 285 22 ASN CA C 53.259 0.041 . 67 285 22 ASN CB C 38.755 0.029 . 68 285 22 ASN N N 118.811 0.000 . 69 286 23 GLN H H 8.544 0.001 . 70 286 23 GLN CA C 55.960 0.194 . 71 286 23 GLN CB C 29.126 0.017 . 72 286 23 GLN N N 120.595 0.003 . 73 287 24 GLY H H 8.456 0.001 . 74 287 24 GLY CA C 45.468 0.039 . 75 287 24 GLY N N 109.508 0.000 . 76 288 25 GLY H H 8.074 0.001 . 77 288 25 GLY CA C 45.039 0.014 . 78 288 25 GLY N N 108.150 0.017 . 79 289 26 PHE H H 8.235 0.000 . 80 289 26 PHE CA C 58.011 0.019 . 81 289 26 PHE CB C 39.528 0.018 . 82 289 26 PHE N N 119.754 0.001 . 83 290 27 GLY H H 8.483 0.001 . 84 290 27 GLY CA C 45.389 0.029 . 85 290 27 GLY N N 110.441 0.024 . 86 291 28 ASN H H 8.339 0.001 . 87 291 28 ASN CA C 53.145 0.080 . 88 291 28 ASN CB C 38.856 0.054 . 89 291 28 ASN N N 118.679 0.015 . 90 292 29 SER H H 8.390 0.001 . 91 292 29 SER CA C 58.772 0.033 . 92 292 29 SER CB C 63.682 0.015 . 93 292 29 SER N N 116.321 0.016 . 94 293 30 ARG H H 8.452 0.001 . 95 293 30 ARG CA C 56.334 0.039 . 96 293 30 ARG CB C 30.483 0.023 . 97 293 30 ARG N N 122.574 0.012 . 98 294 31 GLY H H 8.395 0.001 . 99 294 31 GLY CA C 45.282 0.011 . 100 294 31 GLY N N 109.585 0.013 . 101 295 32 GLY H H 8.332 0.001 . 102 295 32 GLY CA C 45.308 0.021 . 103 295 32 GLY N N 108.710 0.008 . 104 296 33 GLY H H 8.348 0.001 . 105 296 33 GLY CA C 45.186 0.051 . 106 296 33 GLY N N 108.635 0.012 . 107 297 34 ALA H H 8.322 0.001 . 108 297 34 ALA CA C 52.634 0.024 . 109 297 34 ALA CB C 19.213 0.021 . 110 297 34 ALA N N 123.691 0.006 . 111 298 35 GLY H H 8.435 0.001 . 112 298 35 GLY CA C 45.285 0.014 . 113 298 35 GLY N N 108.106 0.009 . 114 299 36 LEU H H 8.188 0.001 . 115 299 36 LEU CA C 55.234 0.032 . 116 299 36 LEU CB C 42.327 0.022 . 117 299 36 LEU N N 121.312 0.007 . 118 300 37 GLY H H 8.503 0.001 . 119 300 37 GLY CA C 45.376 0.028 . 120 300 37 GLY N N 109.288 0.031 . 121 301 38 ASN H H 8.341 0.003 . 122 301 38 ASN CA C 53.172 0.093 . 123 301 38 ASN CB C 38.742 0.012 . 124 301 38 ASN N N 118.665 0.015 . 125 302 39 ASN H H 8.539 0.001 . 126 302 39 ASN CA C 53.457 0.049 . 127 302 39 ASN CB C 38.632 0.016 . 128 302 39 ASN N N 119.113 0.005 . 129 303 40 GLN H H 8.417 0.001 . 130 303 40 GLN CA C 56.263 0.063 . 131 303 40 GLN CB C 29.191 0.017 . 132 303 40 GLN N N 120.449 0.010 . 133 304 41 GLY H H 8.466 0.001 . 134 304 41 GLY CA C 45.403 0.000 . 135 304 41 GLY N N 109.631 0.034 . 136 305 42 SER H H 8.247 0.000 . 137 305 42 SER CA C 58.393 0.013 . 138 305 42 SER CB C 63.880 0.052 . 139 305 42 SER N N 115.627 0.000 . 140 306 43 ASN H H 8.570 0.002 . 141 306 43 ASN CA C 53.397 0.065 . 142 306 43 ASN CB C 38.531 0.030 . 143 306 43 ASN N N 120.571 0.033 . 144 307 44 MET H H 8.383 0.001 . 145 307 44 MET CA C 55.687 0.073 . 146 307 44 MET CB C 32.363 0.081 . 147 307 44 MET N N 120.382 0.010 . 148 308 45 GLY H H 8.453 0.002 . 149 308 45 GLY CA C 45.431 0.022 . 150 308 45 GLY N N 109.696 0.009 . 151 309 46 GLY H H 8.308 0.001 . 152 309 46 GLY CA C 45.331 0.058 . 153 309 46 GLY N N 108.693 0.008 . 154 310 47 GLY H H 8.366 0.001 . 155 310 47 GLY CA C 45.200 0.006 . 156 310 47 GLY N N 108.865 0.010 . 157 311 48 MET H H 8.254 0.000 . 158 311 48 MET CA C 55.398 0.044 . 159 311 48 MET CB C 32.735 0.100 . 160 311 48 MET N N 119.427 0.006 . 161 312 49 ASN H H 8.396 0.002 . 162 312 49 ASN CA C 52.986 0.041 . 163 312 49 ASN CB C 38.661 0.020 . 164 312 49 ASN N N 119.472 0.015 . 165 313 50 PHE H H 8.304 0.003 . 166 313 50 PHE CA C 58.178 0.081 . 167 313 50 PHE CB C 39.255 0.089 . 168 313 50 PHE N N 121.044 0.015 . 169 314 51 GLY H H 8.361 0.001 . 170 314 51 GLY CA C 45.393 0.039 . 171 314 51 GLY N N 110.050 0.010 . 172 315 52 ALA H H 8.079 0.002 . 173 315 52 ALA CA C 52.729 0.123 . 174 315 52 ALA CB C 19.040 0.005 . 175 315 52 ALA N N 123.667 0.012 . 176 316 53 PHE H H 8.124 0.003 . 177 316 53 PHE CA C 57.572 0.075 . 178 316 53 PHE CB C 39.499 0.033 . 179 316 53 PHE N N 118.364 0.028 . 180 317 54 SER H H 8.067 0.002 . 181 317 54 SER CA C 58.155 0.083 . 182 317 54 SER CB C 63.993 0.069 . 183 317 54 SER N N 116.798 0.014 . 184 318 55 ILE H H 8.094 0.002 . 185 318 55 ILE CA C 60.843 0.101 . 186 318 55 ILE CB C 38.856 0.062 . 187 318 55 ILE N N 121.574 0.025 . 188 319 56 ASN H H 8.321 0.002 . 189 319 56 ASN CA C 52.680 0.000 . 190 319 56 ASN N N 123.675 0.027 . 191 320 57 PRO CA C 64.698 0.041 . 192 320 57 PRO CB C 31.977 0.000 . 193 321 58 ALA H H 8.190 0.002 . 194 321 58 ALA CA C 53.917 0.058 . 195 321 58 ALA CB C 18.338 0.008 . 196 321 58 ALA N N 121.384 0.041 . 197 322 59 MET H H 8.025 0.002 . 198 322 59 MET CA C 56.611 0.021 . 199 322 59 MET CB C 32.592 0.000 . 200 322 59 MET N N 118.550 0.030 . 201 323 60 MET H H 8.053 0.003 . 202 323 60 MET CA C 56.966 0.009 . 203 323 60 MET CB C 32.617 0.000 . 204 323 60 MET N N 120.604 0.031 . 205 324 61 ALA H H 8.257 0.002 . 206 324 61 ALA CA C 53.932 0.044 . 207 324 61 ALA CB C 18.306 0.006 . 208 324 61 ALA N N 123.412 0.014 . 209 325 62 ALA H H 8.120 0.006 . 210 325 62 ALA CA C 53.969 0.013 . 211 325 62 ALA CB C 18.323 0.009 . 212 325 62 ALA N N 122.190 0.028 . 213 326 63 ALA H H 8.098 0.004 . 214 326 63 ALA CA C 53.956 0.018 . 215 326 63 ALA CB C 18.639 0.163 . 216 326 63 ALA N N 122.164 0.016 . 217 327 64 GLN H H 8.110 0.004 . 218 327 64 GLN CA C 57.500 0.064 . 219 327 64 GLN CB C 28.630 0.046 . 220 327 64 GLN N N 118.325 0.018 . 221 328 65 ALA H H 8.101 0.004 . 222 328 65 ALA CA C 53.895 0.020 . 223 328 65 ALA CB C 18.300 0.022 . 224 328 65 ALA N N 122.998 0.045 . 225 329 66 ALA H H 7.938 0.002 . 226 329 66 ALA HB H 1.403 0.000 . 227 329 66 ALA CA C 53.544 0.153 . 228 329 66 ALA CB C 18.501 0.016 . 229 329 66 ALA N N 121.145 0.013 . 230 330 67 LEU H H 7.851 0.004 . 231 330 67 LEU CA C 56.201 0.024 . 232 330 67 LEU CB C 42.035 0.007 . 233 330 67 LEU N N 119.916 0.008 . 234 331 68 GLN H H 8.075 0.002 . 235 331 68 GLN CA C 56.662 0.033 . 236 331 68 GLN CB C 28.752 0.017 . 237 331 68 GLN N N 119.089 0.023 . 238 332 69 SER H H 8.155 0.002 . 239 332 69 SER CA C 58.859 0.308 . 240 332 69 SER CB C 63.710 0.162 . 241 332 69 SER N N 115.465 0.029 . 242 333 70 SER H H 8.151 0.002 . 243 333 70 SER CA C 59.150 0.059 . 244 333 70 SER CB C 63.523 0.006 . 245 333 70 SER N N 117.338 0.019 . 246 334 71 TRP H H 8.080 0.004 . 247 334 71 TRP CA C 58.002 0.021 . 248 334 71 TRP CB C 29.403 0.048 . 249 334 71 TRP N N 122.566 0.011 . 250 335 72 GLY H H 8.232 0.003 . 251 335 72 GLY CA C 45.693 0.074 . 252 335 72 GLY N N 109.322 0.047 . 253 336 73 MET H H 8.105 0.002 . 254 336 73 MET CA C 56.070 0.090 . 255 336 73 MET CB C 32.481 0.203 . 256 336 73 MET N N 119.669 0.026 . 257 337 74 MET H H 8.335 0.003 . 258 337 74 MET CA C 56.209 0.025 . 259 337 74 MET CB C 32.281 0.094 . 260 337 74 MET N N 119.747 0.039 . 261 338 75 GLY H H 8.315 0.002 . 262 338 75 GLY CA C 45.655 0.028 . 263 338 75 GLY N N 109.163 0.031 . 264 339 76 MET H H 8.103 0.001 . 265 339 76 MET CA C 56.093 0.077 . 266 339 76 MET CB C 32.676 0.013 . 267 339 76 MET N N 119.775 0.032 . 268 340 77 LEU H H 8.240 0.002 . 269 340 77 LEU CA C 55.518 0.088 . 270 340 77 LEU CB C 42.139 0.049 . 271 340 77 LEU N N 122.406 0.030 . 272 341 78 ALA H H 8.285 0.009 . 273 341 78 ALA HB H 1.365 0.000 . 274 341 78 ALA CA C 53.248 0.071 . 275 341 78 ALA CB C 18.859 0.014 . 276 341 78 ALA N N 124.174 0.035 . 277 342 79 SER H H 8.153 0.001 . 278 342 79 SER CA C 58.839 0.039 . 279 342 79 SER CB C 63.544 0.016 . 280 342 79 SER N N 113.847 0.010 . 281 343 80 GLN H H 8.237 0.001 . 282 343 80 GLN CA C 56.136 0.049 . 283 343 80 GLN CB C 29.224 0.003 . 284 343 80 GLN N N 121.477 0.018 . 285 344 81 GLN H H 8.271 0.001 . 286 344 81 GLN CA C 56.125 0.067 . 287 344 81 GLN CB C 29.290 0.041 . 288 344 81 GLN N N 120.359 0.009 . 289 345 82 ASN H H 8.473 0.003 . 290 345 82 ASN CA C 53.467 0.038 . 291 345 82 ASN CB C 38.723 0.041 . 292 345 82 ASN N N 119.328 0.022 . 293 346 83 GLN H H 8.433 0.002 . 294 346 83 GLN CA C 56.009 0.063 . 295 346 83 GLN CB C 29.354 0.036 . 296 346 83 GLN N N 120.760 0.014 . 297 347 84 SER H H 8.415 0.001 . 298 347 84 SER CA C 58.501 0.079 . 299 347 84 SER CB C 64.030 0.038 . 300 347 84 SER N N 116.749 0.007 . 301 348 85 GLY H H 8.260 0.002 . 302 348 85 GLY CA C 44.716 0.000 . 303 348 85 GLY N N 110.554 0.020 . 304 349 86 PRO CA C 63.381 0.000 . 305 349 86 PRO CB C 32.060 0.027 . 306 350 87 SER H H 8.546 0.001 . 307 350 87 SER CA C 58.607 0.084 . 308 350 87 SER CB C 63.893 0.075 . 309 350 87 SER N N 116.032 0.005 . 310 351 88 GLY H H 8.393 0.003 . 311 351 88 GLY CA C 45.357 0.050 . 312 351 88 GLY N N 110.499 0.009 . 313 352 89 ASN H H 8.353 0.001 . 314 352 89 ASN CA C 53.160 0.046 . 315 352 89 ASN CB C 38.768 0.022 . 316 352 89 ASN N N 118.548 0.019 . 317 353 90 ASN H H 8.512 0.002 . 318 353 90 ASN CA C 53.506 0.000 . 319 353 90 ASN CB C 38.620 0.000 . 320 353 90 ASN N N 119.164 0.014 . 321 354 91 GLN H H 8.438 0.002 . 322 354 91 GLN CA C 56.250 0.039 . 323 354 91 GLN CB C 29.084 0.009 . 324 354 91 GLN N N 120.087 0.004 . 325 355 92 ASN H H 8.504 0.001 . 326 355 92 ASN CA C 53.485 0.000 . 327 355 92 ASN CB C 38.638 0.000 . 328 355 92 ASN N N 119.088 0.013 . 329 356 93 GLN H H 8.431 0.004 . 330 356 93 GLN CA C 56.300 0.041 . 331 356 93 GLN CB C 29.203 0.010 . 332 356 93 GLN N N 120.098 0.002 . 333 357 94 GLY H H 8.482 0.002 . 334 357 94 GLY CA C 45.388 0.062 . 335 357 94 GLY N N 109.393 0.026 . 336 358 95 ASN H H 8.348 0.006 . 337 358 95 ASN CA C 53.227 0.027 . 338 358 95 ASN CB C 38.710 0.070 . 339 358 95 ASN N N 118.601 0.051 . 340 359 96 MET H H 8.357 0.002 . 341 359 96 MET CA C 55.618 0.050 . 342 359 96 MET CB C 32.530 0.067 . 343 359 96 MET N N 120.485 0.006 . 344 360 97 GLN H H 8.404 0.002 . 345 360 97 GLN CA C 55.852 0.047 . 346 360 97 GLN CB C 29.225 0.031 . 347 360 97 GLN N N 121.334 0.023 . 348 361 98 ARG H H 8.377 0.001 . 349 361 98 ARG CA C 55.929 0.098 . 350 361 98 ARG CB C 31.041 0.032 . 351 361 98 ARG N N 122.555 0.023 . 352 362 99 GLU H H 8.504 0.001 . 353 362 99 GLU CA C 54.398 0.000 . 354 362 99 GLU CB C 29.513 0.000 . 355 362 99 GLU N N 123.370 0.022 . 356 363 100 PRO CA C 63.498 0.099 . 357 363 100 PRO CB C 32.047 0.001 . 358 364 101 ASN H H 8.579 0.001 . 359 364 101 ASN CA C 53.438 0.080 . 360 364 101 ASN CB C 38.556 0.076 . 361 364 101 ASN N N 118.040 0.010 . 362 365 102 GLN H H 8.293 0.002 . 363 365 102 GLN CA C 55.877 0.090 . 364 365 102 GLN CB C 29.421 0.024 . 365 365 102 GLN N N 120.787 0.026 . 366 366 103 ALA H H 8.317 0.001 . 367 366 103 ALA CA C 52.542 0.025 . 368 366 103 ALA CB C 19.053 0.040 . 369 366 103 ALA N N 124.967 0.018 . 370 367 104 PHE H H 8.256 0.001 . 371 367 104 PHE CA C 57.824 0.093 . 372 367 104 PHE CB C 39.432 0.046 . 373 367 104 PHE N N 119.583 0.009 . 374 368 105 GLY H H 8.330 0.003 . 375 368 105 GLY CA C 45.259 0.013 . 376 368 105 GLY N N 110.900 0.014 . 377 369 106 SER H H 8.284 0.001 . 378 369 106 SER CA C 58.602 0.092 . 379 369 106 SER CB C 63.929 0.026 . 380 369 106 SER N N 115.626 0.005 . 381 370 107 GLY H H 8.543 0.001 . 382 370 107 GLY CA C 45.399 0.036 . 383 370 107 GLY N N 110.767 0.000 . 384 371 108 ASN H H 8.329 0.002 . 385 371 108 ASN CA C 53.172 0.046 . 386 371 108 ASN CB C 38.702 0.026 . 387 371 108 ASN N N 118.516 0.001 . 388 372 109 ASN H H 8.481 0.002 . 389 372 109 ASN CA C 53.320 0.071 . 390 372 109 ASN CB C 38.784 0.033 . 391 372 109 ASN N N 119.354 0.004 . 392 373 110 SER H H 8.261 0.001 . 393 373 110 SER CA C 58.615 0.038 . 394 373 110 SER CB C 63.748 0.038 . 395 373 110 SER N N 115.803 0.013 . 396 374 111 TYR H H 8.261 0.001 . 397 374 111 TYR CA C 58.049 0.085 . 398 374 111 TYR CB C 38.595 0.014 . 399 374 111 TYR N N 122.121 0.017 . 400 375 112 SER H H 8.283 0.001 . 401 375 112 SER CA C 58.307 0.091 . 402 375 112 SER CB C 63.875 0.019 . 403 375 112 SER N N 118.053 0.010 . 404 376 113 GLY H H 7.894 0.001 . 405 376 113 GLY CA C 45.324 0.021 . 406 376 113 GLY N N 110.480 0.012 . 407 377 114 SER H H 8.254 0.002 . 408 377 114 SER CA C 58.497 0.060 . 409 377 114 SER CB C 63.862 0.034 . 410 377 114 SER N N 115.377 0.002 . 411 378 115 ASN H H 8.559 0.002 . 412 378 115 ASN CA C 53.247 0.077 . 413 378 115 ASN CB C 38.671 0.028 . 414 378 115 ASN N N 120.864 0.023 . 415 379 116 SER H H 8.336 0.001 . 416 379 116 SER CA C 58.856 0.056 . 417 379 116 SER CB C 63.741 0.009 . 418 379 116 SER N N 116.171 0.014 . 419 380 117 GLY H H 8.437 0.002 . 420 380 117 GLY CA C 45.284 0.017 . 421 380 117 GLY N N 110.859 0.007 . 422 381 118 ALA H H 8.028 0.000 . 423 381 118 ALA CA C 52.406 0.037 . 424 381 118 ALA CB C 19.273 0.036 . 425 381 118 ALA N N 123.569 0.006 . 426 382 119 ALA H H 8.217 0.001 . 427 382 119 ALA CA C 52.410 0.045 . 428 382 119 ALA CB C 18.982 0.056 . 429 382 119 ALA N N 123.170 0.006 . 430 383 120 ILE H H 8.062 0.001 . 431 383 120 ILE CA C 61.338 0.058 . 432 383 120 ILE CB C 38.641 0.054 . 433 383 120 ILE N N 119.801 0.008 . 434 384 121 GLY H H 8.365 0.003 . 435 384 121 GLY CA C 45.157 0.014 . 436 384 121 GLY N N 112.521 0.009 . 437 385 122 TRP H H 8.120 0.001 . 438 385 122 TRP CA C 57.672 0.054 . 439 385 122 TRP CB C 29.584 0.015 . 440 385 122 TRP N N 121.334 0.010 . 441 386 123 GLY H H 8.339 0.002 . 442 386 123 GLY CA C 45.328 0.009 . 443 386 123 GLY N N 110.915 0.019 . 444 387 124 SER H H 8.154 0.001 . 445 387 124 SER CA C 58.441 0.092 . 446 387 124 SER CB C 63.932 0.014 . 447 387 124 SER N N 115.700 0.012 . 448 388 125 ALA H H 8.445 0.001 . 449 388 125 ALA CA C 52.740 0.019 . 450 388 125 ALA CB C 19.067 0.020 . 451 388 125 ALA N N 125.794 0.011 . 452 389 126 SER H H 8.265 0.000 . 453 389 126 SER CA C 58.581 0.102 . 454 389 126 SER CB C 63.742 0.063 . 455 389 126 SER N N 114.570 0.010 . 456 390 127 ASN H H 8.361 0.002 . 457 390 127 ASN CA C 53.127 0.067 . 458 390 127 ASN CB C 38.741 0.008 . 459 390 127 ASN N N 120.607 0.016 . 460 391 128 ALA H H 8.261 0.001 . 461 391 128 ALA CA C 52.977 0.049 . 462 391 128 ALA CB C 19.041 0.018 . 463 391 128 ALA N N 124.110 0.011 . 464 392 129 GLY H H 8.365 0.001 . 465 392 129 GLY CA C 45.295 0.022 . 466 392 129 GLY N N 107.975 0.006 . 467 393 130 SER H H 8.255 0.002 . 468 393 130 SER CA C 58.578 0.071 . 469 393 130 SER CB C 63.907 0.031 . 470 393 130 SER N N 115.505 0.014 . 471 394 131 GLY H H 8.540 0.001 . 472 394 131 GLY CA C 45.359 0.022 . 473 394 131 GLY N N 111.055 0.000 . 474 395 132 SER H H 8.306 0.001 . 475 395 132 SER CA C 58.629 0.112 . 476 395 132 SER CB C 63.925 0.026 . 477 395 132 SER N N 115.654 0.004 . 478 396 133 GLY H H 8.461 0.001 . 479 396 133 GLY CA C 45.158 0.060 . 480 396 133 GLY N N 110.627 0.024 . 481 397 134 PHE H H 8.188 0.001 . 482 397 134 PHE CA C 57.993 0.037 . 483 397 134 PHE CB C 39.514 0.011 . 484 397 134 PHE N N 120.357 0.019 . 485 398 135 ASN H H 8.510 0.001 . 486 398 135 ASN CA C 52.989 0.061 . 487 398 135 ASN CB C 38.716 0.040 . 488 398 135 ASN N N 121.697 0.006 . 489 399 136 GLY H H 7.845 0.001 . 490 399 136 GLY CA C 45.460 0.109 . 491 399 136 GLY N N 108.512 0.024 . 492 400 137 GLY H H 8.173 0.001 . 493 400 137 GLY CA C 45.019 0.085 . 494 400 137 GLY N N 108.362 0.012 . 495 401 138 PHE H H 8.199 0.002 . 496 401 138 PHE CA C 58.095 0.022 . 497 401 138 PHE CB C 39.508 0.026 . 498 401 138 PHE N N 120.016 0.007 . 499 402 139 GLY H H 8.457 0.001 . 500 402 139 GLY CA C 45.273 0.004 . 501 402 139 GLY N N 110.928 0.022 . 502 403 140 SER H H 8.249 0.001 . 503 403 140 SER CA C 58.400 0.150 . 504 403 140 SER CB C 64.020 0.070 . 505 403 140 SER N N 115.600 0.027 . 506 404 141 SER H H 8.488 0.000 . 507 404 141 SER CA C 58.660 0.039 . 508 404 141 SER CB C 63.700 0.055 . 509 404 141 SER N N 117.762 0.004 . 510 405 142 MET H H 8.424 0.002 . 511 405 142 MET CA C 55.745 0.086 . 512 405 142 MET CB C 32.513 0.064 . 513 405 142 MET N N 121.820 0.010 . 514 406 143 ASP H H 8.252 0.001 . 515 406 143 ASP CA C 54.349 0.073 . 516 406 143 ASP CB C 41.152 0.037 . 517 406 143 ASP N N 121.065 0.006 . 518 407 144 SER H H 8.278 0.001 . 519 407 144 SER CA C 58.956 0.045 . 520 407 144 SER CB C 63.513 0.022 . 521 407 144 SER N N 116.766 0.008 . 522 408 145 LYS H H 8.348 0.001 . 523 408 145 LYS CA C 56.563 0.028 . 524 408 145 LYS CB C 32.564 0.023 . 525 408 145 LYS N N 122.611 0.025 . 526 409 146 SER H H 8.235 0.001 . 527 409 146 SER CA C 58.526 0.064 . 528 409 146 SER CB C 63.796 0.029 . 529 409 146 SER N N 116.248 0.014 . 530 410 147 SER H H 8.348 0.001 . 531 410 147 SER CA C 58.789 0.032 . 532 410 147 SER CB C 63.742 0.023 . 533 410 147 SER N N 117.674 0.004 . 534 411 148 GLY H H 8.351 0.002 . 535 411 148 GLY CA C 45.268 0.020 . 536 411 148 GLY N N 110.412 0.015 . 537 412 149 TRP H H 8.065 0.001 . 538 412 149 TRP CA C 57.714 0.040 . 539 412 149 TRP CB C 29.470 0.005 . 540 412 149 TRP N N 121.047 0.011 . 541 413 150 GLY H H 8.305 0.001 . 542 413 150 GLY CA C 45.436 0.020 . 543 413 150 GLY N N 111.722 0.020 . 544 414 151 MET H H 7.696 0.003 . 545 414 151 MET CA C 56.779 0.000 . 546 414 151 MET CB C 33.554 0.000 . 547 414 151 MET N N 124.542 0.007 . stop_ save_ ######################## # Coupling constants # ######################## save_WT_TDP-43_267-414_3JHNHA _Saveframe_category coupling_constants _Details . loop_ _Experiment_label hnhagp3d stop_ _Sample_conditions_label $283_K _Spectrometer_frequency_1H 500 _Mol_system_component_name 'WT TDP-43_267-414 Monomer' _Text_data_format . _Text_data . loop_ _Coupling_constant_ID _Coupling_constant_code _Atom_one_residue_seq_code _Atom_one_residue_label _Atom_one_name _Atom_two_residue_seq_code _Atom_two_residue_label _Atom_two_name _Coupling_constant_value _Coupling_constant_min_value _Coupling_constant_max_value _Coupling_constant_value_error 1 3JHNHA 4 ASN HN 4 ASN HA 6.738680695295079 . . 0.323965482474291 2 3JHNHA 6 GLN HN 6 GLN HA 6.232835536425143 . . 0.14588656130236544 3 3JHNHA 7 LEU HN 7 LEU HA 5.959418397714929 . . 0.1365240939780632 4 3JHNHA 8 GLU HN 8 GLU HA 5.836791379204779 . . 0.13871824720965265 5 3JHNHA 9 ARG HN 9 ARG HA 6.041617027482297 . . 0.1248027286614759 6 3JHNHA 10 SER HN 10 SER HA 6.297896872862946 . . 0.19804676686144518 7 3JHNHA 12 ARG HN 12 ARG HA 5.777744677037054 . . 0.2496687795949919 8 3JHNHA 13 PHE HN 13 PHE HA 6.092331589727809 . . 0.17208266660638483 9 3JHNHA 15 GLY HN 15 GLY HA 6.0367819479179445 . . 0.18145006201121028 10 3JHNHA 16 ASN HN 16 ASN HA 6.883785251331518 . . 0.20606991529258156 11 3JHNHA 18 GLY HN 18 GLY HA 6.63035596312576 . . 0.19342846937687064 12 3JHNHA 19 GLY HN 19 GLY HA 6.906270454474759 . . 0.09802213542972815 13 3JHNHA 20 PHE HN 20 PHE HA 6.69133762210868 . . 0.07359144828202524 14 3JHNHA 23 GLN HN 23 GLN HA 6.1208519076572365 . . 0.16352490091303995 15 3JHNHA 24 GLY HN 24 GLY HA 6.7370501386801696 . . 0.06571578124583777 16 3JHNHA 25 GLY HN 25 GLY HA 6.906270454474759 . . 0.09802213542972815 17 3JHNHA 26 PHE HN 26 PHE HA 6.69133762210868 . . 0.07359144828202524 18 3JHNHA 29 SER HN 29 SER HA 6.334797302768379 . . 0.21614053146117485 19 3JHNHA 30 ARG HN 30 ARG HA 6.449842294140592 . . 0.21434264734393516 20 3JHNHA 31 GLY HN 31 GLY HA 6.5769851298230515 . . 0.19464171152347376 21 3JHNHA 32 GLY HN 32 GLY HA 6.9520276908093965 . . 0.07935935436477237 22 3JHNHA 33 GLY HN 33 GLY HA 6.9520276908093965 . . 0.07935935436477237 23 3JHNHA 35 GLY HN 35 GLY HA 6.215716075977772 . . 0.12685896598185753 24 3JHNHA 37 GLY HN 37 GLY HA 6.8485518608867615 . . 0.08804087987032894 25 3JHNHA 39 ASN HN 39 ASN HA 7.189224368201021 . . 0.14901087615020714 26 3JHNHA 40 GLN HN 40 GLN HA 6.249841050161914 . . 0.1265713343268562 27 3JHNHA 43 ASN HN 43 ASN HA 6.779557744126025 . . 0.17065361308391402 28 3JHNHA 44 MET HN 44 MET HA 6.671065801703927 . . 0.13128103771594368 29 3JHNHA 46 GLY HN 46 GLY HA 7.302589758711017 . . 0.0984228036404291 30 3JHNHA 47 GLY HN 47 GLY HA 6.995971643996182 . . 0.08601632272852822 31 3JHNHA 49 ASN HN 49 ASN HA 7.417389367112703 . . 0.15965996795213577 32 3JHNHA 50 PHE HN 50 PHE HA 5.301233620078299 . . 0.15841657640125284 33 3JHNHA 51 GLY HN 51 GLY HA 6.174367124709805 . . 0.21763925993470767 34 3JHNHA 52 ALA HN 52 ALA HA 4.921762223905936 . . 0.20788280746785137 35 3JHNHA 54 SER HN 54 SER HA 6.2600995245816105 . . 0.20689259438930474 36 3JHNHA 55 ILE HN 55 ILE HA 6.4561340663348465 . . 0.23913350645808684 37 3JHNHA 59 MET HN 59 MET HA 6.275939099574368 . . 0.25847548605423576 38 3JHNHA 60 MET HN 60 MET HA 5.607202191228632 . . 0.3805230566014801 39 3JHNHA 61 ALA HN 61 ALA HA 4.412897492910162 . . 0.34908369177263054 40 3JHNHA 62 ALA HN 62 ALA HA 4.115647954693262 . . 0.34956733757594627 41 3JHNHA 63 ALA HN 63 ALA HA 4.350546118698568 . . 0.3062274798701443 42 3JHNHA 65 ALA HN 65 ALA HA 4.019334901390134 . . 0.43370019382112623 43 3JHNHA 66 ALA HN 66 ALA HA 4.3636424139443815 . . 0.35845083331563465 44 3JHNHA 67 LEU HN 67 LEU HA 5.227007116454231 . . 0.38707867991877176 45 3JHNHA 68 GLN HN 68 GLN HA 5.371061986502133 . . 0.32730328539183073 46 3JHNHA 69 SER HN 69 SER HA 6.056789264387468 . . 0.11652852334467934 47 3JHNHA 70 SER HN 70 SER HA 6.068515975763524 . . 0.37975057075008234 48 3JHNHA 71 TRP HN 71 TRP HA 5.599661801644494 . . 0.3227834847541846 49 3JHNHA 72 GLY HN 72 GLY HA 6.186228623164322 . . 0.31590200968318705 50 3JHNHA 74 MET HN 74 MET HA 5.67355353996234 . . 0.2528537956911334 51 3JHNHA 75 GLY HN 75 GLY HA 6.497181488744955 . . 0.27596190304578183 52 3JHNHA 77 LEU HN 77 LEU HA 5.553501412564796 . . 0.21645942853424227 53 3JHNHA 78 ALA HN 78 ALA HA 4.906482985812706 . . 0.19131474820292915 54 3JHNHA 79 SER HN 79 SER HA 5.500154288702432 . . 0.17742588452289265 55 3JHNHA 80 GLN HN 80 GLN HA 6.43782041182689 . . 0.18726546150476775 56 3JHNHA 81 GLN HN 81 GLN HA 5.9190122066685475 . . 0.17331555723756953 57 3JHNHA 83 GLN HN 83 GLN HA 6.043385361352049 . . 0.13597761437138622 58 3JHNHA 84 SER HN 84 SER HA 6.689061278393214 . . 0.13918550845759636 59 3JHNHA 85 GLY HN 85 GLY HA 6.241760261748357 . . 0.11155493683227835 60 3JHNHA 87 SER HN 87 SER HA 6.479810289580052 . . 0.14862765134414424 61 3JHNHA 88 GLY HN 88 GLY HA 6.68519552267811 . . 0.15224424554120208 62 3JHNHA 94 GLY HN 94 GLY HA 6.8398988890720105 . . 0.0891262222477458 63 3JHNHA 97 GLN HN 97 GLN HA 6.1123772876630404 . . 0.13292916944547883 64 3JHNHA 98 ARG HN 98 ARG HA 6.611212376153457 . . 0.13999114173438887 65 3JHNHA 99 GLU HN 99 GLU HA 5.631160602792137 . . 0.17613215173197982 66 3JHNHA 101 ASN HN 101 ASN HA 6.414709126437652 . . 0.16045192919942153 67 3JHNHA 102 GLN HN 102 GLN HA 5.561297995290166 . . 0.15007190209319798 68 3JHNHA 103 ALA HN 103 ALA HA 5.408431493141168 . . 0.1501816678510659 69 3JHNHA 107 GLY HN 107 GLY HA 6.799661775045777 . . 0.13549410680126872 70 3JHNHA 111 TYR HN 111 TYR HA 6.5919873847598 . . 0.14817558573732992 71 3JHNHA 112 SER HN 112 SER HA 6.376923904911911 . . 0.1728399283984583 72 3JHNHA 113 GLY HN 113 GLY HA 5.622465541695763 . . 0.22536496695657693 73 3JHNHA 115 ASN HN 115 ASN HA 6.415771889578592 . . 0.1903233509805773 74 3JHNHA 116 SER HN 116 SER HA 6.1170229144892145 . . 0.18371052094616402 75 3JHNHA 118 ALA HN 118 ALA HA 5.2671620553985825 . . 0.1255126895438039 76 3JHNHA 119 ALA HN 119 ALA HA 5.207894602663525 . . 0.1200977490825057 77 3JHNHA 120 ILE HN 120 ILE HA 6.147719472820888 . . 0.11498607414195039 78 3JHNHA 121 GLY HN 121 GLY HA 6.373836391952245 . . 0.1503362213287467 79 3JHNHA 122 TRP HN 122 TRP HA 6.26385847919089 . . 0.13618163451798093 80 3JHNHA 124 SER HN 124 SER HA 7.16221539914492 . . 0.15094817766602908 81 3JHNHA 125 ALA HN 125 ALA HA 5.330540588262757 . . 0.16587280123154802 82 3JHNHA 126 SER HN 126 SER HA 6.182006110913993 . . 0.1344728442610954 83 3JHNHA 128 ALA HN 128 ALA HA 5.164719749556014 . . 0.14332776041280226 84 3JHNHA 129 GLY HN 129 GLY HA 6.364516408139793 . . 0.13152691021446117 85 3JHNHA 131 GLY HN 131 GLY HA 6.59968429364606 . . 0.10748638669359067 86 3JHNHA 134 PHE HN 134 PHE HA 6.444766145190015 . . 0.120013528474189 87 3JHNHA 135 ASN HN 135 ASN HA 7.084598729265385 . . 0.15348315865375906 88 3JHNHA 136 GLY HN 136 GLY HA 5.9661339756692735 . . 0.1783213749509862 89 3JHNHA 137 GLY HN 137 GLY HA 6.336188455395706 . . 0.15022289675517797 90 3JHNHA 138 PHE HN 138 PHE HA 6.628161025277162 . . 0.10670611279254683 91 3JHNHA 141 SER HN 141 SER HA 6.214430891014504 . . 0.1777946954190961 92 3JHNHA 142 MET HN 142 MET HA 6.236588723527479 . . 0.1346776205474285 93 3JHNHA 143 ASP HN 143 ASP HA 6.461672571151699 . . 0.11615816155780312 94 3JHNHA 144 SER HN 144 SER HA 5.547445564308838 . . 0.15264450073779745 95 3JHNHA 145 LYS HN 145 LYS HA 6.5097109846122745 . . 0.11932171455031249 96 3JHNHA 146 SER HN 146 SER HA 6.034022348681859 . . 0.1402885007799206 97 3JHNHA 147 SER HN 147 SER HA 5.7605985733653755 . . 0.15789749848369894 98 3JHNHA 148 GLY HN 148 GLY HA 6.320635611257508 . . 0.1425809412846064 99 3JHNHA 149 TRP HN 149 TRP HA 6.020061740778649 . . 0.0968880835942123 100 3JHNHA 150 GLY HN 150 GLY HA 6.114397340219857 . . 0.12650731696830864 101 3JHNHA 151 MET HN 151 MET HA 8.643508423904233 . . 0.06569694427419392 stop_ save_ save_WT_TDP-43_267-414_850_MHz_R1 _Saveframe_category T1_relaxation _Details . loop_ _Sample_label $sample-2 stop_ _Sample_conditions_label $283_K _Spectrometer_frequency_1H 850 _T1_coherence_type Sz _T1_value_units s-1 _Mol_system_component_name 'WT TDP-43_267-414 Monomer' _Text_data_format . _Text_data . loop_ _T1_ID _Residue_seq_code _Residue_label _Atom_name _T1_value _T1_value_error 1 4 ASN N 1.643756 0.139889 2 6 GLN N 1.906251 0.084273 3 7 LEU N 1.946772 0.083161 4 8 GLU N 1.904645 0.071111 5 9 ARG N 1.874355 0.059859 6 10 SER N 1.784131 0.107354 7 12 ARG N 2.076283 0.123465 8 13 PHE N 1.937482 0.123276 9 15 GLY N 1.817710 0.117478 10 16 ASN N 1.884308 0.102922 11 18 GLY N 1.734372 0.100145 12 19 GLY N 1.744289 0.099576 13 20 PHE N 1.812473 0.081369 14 22 ASN N 1.731116 0.103218 15 23 GLN N 1.718108 0.095711 16 24 GLY N 1.884905 0.086578 17 25 GLY N 1.902495 0.097372 18 26 PHE N 1.680522 0.072368 19 29 SER N 1.844319 0.108489 20 30 ARG N 1.962740 0.104282 21 31 GLY N 1.791579 0.101491 22 32 GLY N 1.796315 0.077946 23 33 GLY N 1.625957 0.071170 24 35 GLY N 1.496004 0.063833 25 37 GLY N 1.666274 0.067946 26 39 ASN N 1.852404 0.098190 27 40 GLN N 1.694545 0.072087 28 41 GLY N 1.776205 0.078268 29 43 ASN N 1.711990 0.105124 30 44 MET N 1.751689 0.078438 31 45 GLY N 1.722285 0.080912 32 46 GLY N 1.645106 0.077161 33 47 GLY N 1.681080 0.073420 34 48 MET N 1.622423 0.072610 35 49 ASN N 1.511716 0.086820 36 50 PHE N 1.632131 0.085940 37 51 GLY N 1.836306 0.095558 38 52 ALA N 1.962877 0.100762 39 53 PHE N 1.560904 0.088684 40 54 SER N 1.668131 0.114423 41 55 ILE N 1.623472 0.137366 42 59 MET N 1.527431 0.121742 43 60 MET N 1.804409 0.161152 44 61 ALA N 1.380971 0.136510 45 62 ALA N 1.513009 0.123691 46 63 ALA N 1.668303 0.109379 47 65 ALA N 1.912272 0.178929 48 66 ALA N 1.612066 0.125928 49 67 LEU N 1.403220 0.125428 50 68 GLN N 1.320050 0.122331 51 69 SER N 1.668136 0.168773 52 70 SER N 1.489534 0.153400 53 71 TRP N 1.676671 0.158283 54 72 GLY N 1.434404 0.158464 55 73 MET N 1.867662 0.127631 56 74 MET N 1.649338 0.119569 57 75 GLY N 1.735064 0.135935 58 76 MET N 1.706775 0.112519 59 77 LEU N 1.704286 0.098692 60 78 ALA N 1.829600 0.092550 61 79 SER N 1.539192 0.086204 62 80 GLN N 1.873917 0.104331 63 81 GLN N 1.710619 0.093760 64 83 GLN N 1.581460 0.074408 65 84 SER N 1.666636 0.070555 66 85 GLY N 1.629258 0.066018 67 87 SER N 1.519928 0.071859 68 88 GLY N 1.900192 0.084247 69 94 GLY N 1.663118 0.076209 70 96 MET N 1.779450 0.071094 71 97 GLN N 1.592842 0.070977 72 98 ARG N 1.639429 0.082067 73 99 GLU N 1.742877 0.091194 74 101 ASN N 1.663433 0.085799 75 102 GLN N 1.733036 0.081736 76 103 ALA N 1.685009 0.073605 77 104 PHE N 1.635237 0.070731 78 106 SER N 1.711243 0.070247 79 107 GLY N 1.777846 0.080566 80 108 ASN N 1.892524 0.079674 81 110 SER N 1.730360 0.076792 82 111 TYR N 1.939299 0.095572 83 112 SER N 1.683823 0.092901 84 113 GLY N 1.763996 0.102754 85 114 SER N 1.835818 0.075617 86 115 ASN N 1.772880 0.129052 87 116 SER N 1.691726 0.074556 88 117 GLY N 1.777993 0.073385 89 118 ALA N 1.773759 0.059466 90 119 ALA N 1.543834 0.052628 91 120 ILE N 1.465072 0.061208 92 121 GLY N 1.833215 0.084428 93 122 TRP N 1.691272 0.071689 94 124 SER N 1.664514 0.077147 95 125 ALA N 1.723841 0.071152 96 126 SER N 1.658012 0.062829 97 127 ASN N 1.884076 0.089366 98 128 ALA N 1.745877 0.063563 99 129 GLY N 1.524297 0.070242 100 130 SER N 1.803192 0.082744 101 131 GLY N 1.696845 0.071463 102 132 SER N 1.628242 0.069995 103 134 PHE N 1.658757 0.076249 104 135 ASN N 1.822269 0.104690 105 136 GLY N 1.818828 0.102563 106 137 GLY N 1.730341 0.098335 107 138 PHE N 1.964013 0.086537 108 139 GLY N 1.821304 0.079200 109 141 SER N 1.785590 0.077821 110 142 MET N 1.817993 0.073144 111 143 ASP N 1.866186 0.069373 112 144 SER N 1.786143 0.077178 113 145 LYS N 1.878321 0.076828 114 146 SER N 1.789959 0.078450 115 147 SER N 1.758957 0.068186 116 148 GLY N 1.658891 0.067702 117 149 TRP N 1.728562 0.056780 118 150 GLY N 1.600088 0.052920 119 151 MET N 1.305728 0.043001 stop_ save_ save_WT_TDP-43_267-414_500_MHz_R1 _Saveframe_category T1_relaxation _Details . loop_ _Sample_label $sample-2 stop_ _Sample_conditions_label $283_K _Spectrometer_frequency_1H 500 _T1_coherence_type Sz _T1_value_units s-1 _Mol_system_component_name 'WT TDP-43_267-414 Monomer' _Text_data_format . _Text_data . loop_ _T1_ID _Residue_seq_code _Residue_label _Atom_name _T1_value _T1_value_error 1 4 ASN N 1.315402 0.135542 2 6 GLN N 1.832864 0.098354 3 7 LEU N 1.913918 0.097998 4 8 GLU N 1.806658 0.085383 5 9 ARG N 1.801776 0.066805 6 10 SER N 2.065485 0.159093 7 12 ARG N 1.815731 0.133107 8 13 PHE N 2.024115 0.145555 9 15 GLY N 1.546285 0.095822 10 16 ASN N 1.456103 0.115350 11 18 GLY N 1.944336 0.119871 12 19 GLY N 1.967048 0.087401 13 23 GLN N 1.777382 0.106584 14 24 GLY N 1.858598 0.094016 15 25 GLY N 1.798772 0.077293 16 29 SER N 1.403928 0.121849 17 30 ARG N 1.861277 0.151129 18 31 GLY N 1.604585 0.106327 19 33 GLY N 1.537260 0.068760 20 34 ALA N 1.703973 0.048212 21 35 GLY N 1.560095 0.071358 22 37 GLY N 1.644902 0.068045 23 40 GLN N 1.898837 0.089026 24 43 ASN N 1.836371 0.108205 25 44 MET N 1.893301 0.097393 26 47 GLY N 1.432162 0.073205 27 48 MET N 1.723996 0.081540 28 49 ASN N 1.665135 0.109666 29 50 PHE N 1.820306 0.102294 30 51 GLY N 2.079013 0.137522 31 52 ALA N 1.967601 0.103445 32 54 SER N 1.911907 0.143983 33 55 ILE N 1.966364 0.143800 34 59 MET N 2.299285 0.179905 35 60 MET N 2.076883 0.173051 36 61 ALA N 1.953179 0.155395 37 62 ALA N 1.966280 0.154635 38 63 ALA N 2.146976 0.156783 39 65 ALA N 2.167048 0.190294 40 66 ALA N 1.911500 0.137600 41 67 LEU N 1.901883 0.175272 42 68 GLN N 2.162631 0.215655 43 69 SER N 1.987769 0.173502 44 70 SER N 2.309069 0.225592 45 71 TRP N 2.313532 0.180288 46 72 GLY N 1.972678 0.169882 47 73 MET N 2.007360 0.114331 48 74 MET N 1.886889 0.140318 49 75 GLY N 1.969433 0.143637 50 76 MET N 1.934116 0.107688 51 77 LEU N 1.701518 0.116904 52 78 ALA N 1.903283 0.106397 53 79 SER N 2.106473 0.112729 54 80 GLN N 2.051176 0.132556 55 81 GLN N 1.958993 0.107265 56 83 GLN N 1.737197 0.094162 57 84 SER N 1.731580 0.086198 58 85 GLY N 1.560652 0.060415 59 87 SER N 1.456776 0.079503 60 88 GLY N 1.617954 0.092599 61 94 GLY N 1.667657 0.077075 62 97 GLN N 1.879195 0.094311 63 98 ARG N 2.103757 0.114101 64 99 GLU N 1.849125 0.100767 65 101 ASN N 1.904252 0.096334 66 102 GLN N 1.785624 0.100091 67 103 ALA N 1.882319 0.084045 68 104 PHE N 1.836932 0.085493 69 107 GLY N 1.636927 0.078886 70 111 TYR N 1.809020 0.105244 71 112 SER N 1.773780 0.115598 72 113 GLY N 1.722324 0.092640 73 115 ASN N 1.635075 0.144112 74 116 SER N 1.629574 0.106980 75 117 GLY N 1.897122 0.066063 76 118 ALA N 1.815409 0.059839 77 119 ALA N 1.606472 0.064472 78 120 ILE N 1.664167 0.067693 79 121 GLY N 1.668037 0.088023 80 122 TRP N 1.948637 0.086300 81 124 SER N 1.752803 0.084090 82 125 ALA N 1.595716 0.072807 83 126 SER N 1.666742 0.079289 84 128 ALA N 1.603469 0.068966 85 129 GLY N 1.611768 0.077570 86 131 GLY N 1.546143 0.081269 87 134 PHE N 1.774136 0.077654 88 135 ASN N 1.739493 0.121891 89 136 GLY N 1.787707 0.086807 90 137 GLY N 1.794322 0.096921 91 138 PHE N 1.702909 0.079613 92 139 GLY N 1.935610 0.071428 93 141 SER N 1.725481 0.092701 94 142 MET N 1.704476 0.076693 95 143 ASP N 1.816866 0.083614 96 144 SER N 1.730688 0.091049 97 145 LYS N 2.018381 0.092849 98 146 SER N 1.723801 0.094409 99 147 SER N 1.554027 0.079353 100 148 GLY N 1.616664 0.074308 101 149 TRP N 1.577662 0.052792 102 150 GLY N 1.369591 0.054466 103 151 MET N 1.166751 0.039671 stop_ save_ save_WT_TDP-43_267-414_850_MHz_R2 _Saveframe_category T2_relaxation _Details . loop_ _Sample_label $sample-2 stop_ _Sample_conditions_label $283_K _Spectrometer_frequency_1H 850 _T2_coherence_type S(+,-) _T2_value_units s-1 _Mol_system_component_name 'WT TDP-43_267-414 Monomer' _Text_data_format . _Text_data . loop_ _T2_ID _Residue_seq_code _Residue_label _Atom_name _T2_value _T2_value_error _Rex_value _Rex_error 1 4 ASN N 3.831561 0.288092 . . 2 6 GLN N 4.601263 0.178668 . . 3 7 LEU N 5.036656 0.202131 . . 4 8 GLU N 4.746953 0.178375 . . 5 9 ARG N 4.258404 0.129765 . . 6 10 SER N 5.505041 0.223734 . . 7 12 ARG N 5.298316 0.268369 . . 8 13 PHE N 5.171424 0.265137 . . 9 15 GLY N 4.750573 0.276795 . . 10 16 ASN N 5.194536 0.232164 . . 11 18 GLY N 5.447266 0.271521 . . 12 19 GLY N 4.892603 0.245437 . . 13 20 PHE N 4.842996 0.197987 . . 14 22 ASN N 4.954947 0.226998 . . 15 23 GLN N 4.689877 0.213256 . . 16 24 GLY N 4.842211 0.210075 . . 17 25 GLY N 5.251481 0.244647 . . 18 26 PHE N 4.808777 0.180036 . . 19 29 SER N 4.754047 0.205110 . . 20 30 ARG N 4.535234 0.215450 . . 21 31 GLY N 4.352797 0.198727 . . 22 32 GLY N 4.279364 0.167910 . . 23 33 GLY N 5.450999 0.184385 . . 24 35 GLY N 4.339420 0.154936 . . 25 37 GLY N 4.427695 0.164408 . . 26 39 ASN N 4.901340 0.210742 . . 27 40 GLN N 4.670675 0.176924 . . 28 41 GLY N 4.562878 0.177355 . . 29 43 ASN N 4.734872 0.224274 . . 30 44 MET N 4.409211 0.168107 . . 31 45 GLY N 5.021190 0.181352 . . 32 46 GLY N 5.025215 0.185304 . . 33 47 GLY N 4.030348 0.157937 . . 34 48 MET N 5.246692 0.186953 . . 35 49 ASN N 5.464837 0.249718 . . 36 50 PHE N 6.230649 0.263693 . . 37 51 GLY N 6.822883 0.305873 . . 38 52 ALA N 7.572751 0.309142 . . 39 53 PHE N 6.937473 0.344457 . . 40 54 SER N 6.956615 0.384146 . . 41 55 ILE N 7.485034 0.501644 . . 42 59 MET N 11.368037 0.816307 . . 43 60 MET N 12.012062 1.026616 . . 44 61 ALA N 12.563340 0.927744 . . 45 62 ALA N 12.410994 0.975445 . . 46 63 ALA N 11.944430 0.706880 . . 47 65 ALA N 11.764102 1.082594 . . 48 66 ALA N 12.015812 0.911209 . . 49 67 LEU N 12.437492 0.968448 . . 50 68 GLN N 11.470109 1.111069 . . 51 69 SER N 11.283166 0.857419 . . 52 70 SER N 9.358244 0.679818 . . 53 71 TRP N 10.509848 0.759979 . . 54 72 GLY N 11.368195 0.974007 . . 55 73 MET N 7.900932 0.490216 . . 56 74 MET N 8.297774 0.517907 . . 57 75 GLY N 9.601757 0.542991 . . 58 76 MET N 8.537466 0.449511 . . 59 77 LEU N 7.517006 0.396387 . . 60 78 ALA N 8.092596 0.353163 . . 61 79 SER N 6.810232 0.284805 . . 62 80 GLN N 6.514472 0.310202 . . 63 81 GLN N 6.147266 0.261306 . . 64 83 GLN N 5.164646 0.194385 . . 65 84 SER N 4.495455 0.161817 . . 66 85 GLY N 4.250543 0.150267 . . 67 87 SER N 4.212252 0.168353 . . 68 88 GLY N 3.990508 0.172662 . . 69 94 GLY N 5.172788 0.201263 . . 70 96 MET N 5.099679 0.177684 . . 71 97 GLN N 5.818995 0.199456 . . 72 98 ARG N 5.404216 0.244113 . . 73 99 GLU N 5.982504 0.255710 . . 74 101 ASN N 5.927530 0.264497 . . 75 102 GLN N 5.527274 0.219386 . . 76 103 ALA N 5.983797 0.224653 . . 77 104 PHE N 4.960800 0.197841 . . 78 106 SER N 4.560582 0.169867 . . 79 107 GLY N 4.391205 0.172812 . . 80 108 ASN N 5.088044 0.182333 . . 81 110 SER N 5.225346 0.188154 . . 82 111 TYR N 5.707347 0.223204 . . 83 112 SER N 5.032231 0.233933 . . 84 113 GLY N 4.657240 0.259305 . . 85 114 SER N 4.558227 0.159572 . . 86 115 ASN N 4.537689 0.257539 . . 87 116 SER N 4.510412 0.166330 . . 88 117 GLY N 4.225346 0.168784 . . 89 118 ALA N 5.209535 0.162701 . . 90 119 ALA N 4.894908 0.157550 . . 91 120 ILE N 5.394330 0.193244 . . 92 121 GLY N 5.491786 0.203915 . . 93 122 TRP N 5.582422 0.204278 . . 94 124 SER N 5.478006 0.189834 . . 95 125 ALA N 5.279431 0.173656 . . 96 126 SER N 4.301821 0.152968 . . 97 127 ASN N 4.483661 0.187144 . . 98 128 ALA N 4.687023 0.150488 . . 99 129 GLY N 4.414448 0.159262 . . 100 130 SER N 5.085932 0.178839 . . 101 131 GLY N 3.712896 0.163223 . . 102 132 SER N 4.251651 0.158524 . . 103 134 PHE N 4.472059 0.163910 . . 104 135 ASN N 5.066860 0.234177 . . 105 136 GLY N 5.442364 0.266548 . . 106 137 GLY N 5.228105 0.237751 . . 107 138 PHE N 4.535710 0.170082 . . 108 139 GLY N 4.187797 0.166875 . . 109 141 SER N 4.859149 0.178261 . . 110 142 MET N 4.500384 0.163466 . . 111 143 ASP N 4.369528 0.154555 . . 112 144 SER N 4.285399 0.159208 . . 113 145 LYS N 4.147933 0.158341 . . 114 146 SER N 4.652602 0.171712 . . 115 147 SER N 4.130048 0.151243 . . 116 148 GLY N 4.559282 0.158440 . . 117 149 TRP N 4.203185 0.130609 . . 118 150 GLY N 3.433935 0.122410 . . 119 151 MET N 3.530867 0.117529 . . stop_ save_ save_WT_TDP-43_267-414_500_MHz_R2 _Saveframe_category T2_relaxation _Details . loop_ _Sample_label $sample-2 stop_ _Sample_conditions_label $283_K _Spectrometer_frequency_1H 500 _T2_coherence_type S(+,-) _T2_value_units s-1 _Mol_system_component_name 'WT TDP-43_267-414 Monomer' _Text_data_format . _Text_data . loop_ _T2_ID _Residue_seq_code _Residue_label _Atom_name _T2_value _T2_value_error _Rex_value _Rex_error 1 4 ASN N 2.716074 0.407890 . . 2 6 GLN N 3.326811 0.280407 . . 3 7 LEU N 3.547734 0.303798 . . 4 8 GLU N 3.515088 0.309003 . . 5 9 ARG N 3.679347 0.213290 . . 6 10 SER N 4.249262 0.436117 . . 7 11 GLY N 3.323153 0.170000 . . 8 12 ARG N 4.084885 0.437173 . . 9 13 PHE N 3.537533 0.397188 . . 10 14 GLY N 3.545315 0.144363 . . 11 15 GLY N 3.069859 0.287205 . . 12 16 ASN N 3.840966 0.414479 . . 13 18 GLY N 3.394946 0.333492 . . 14 19 GLY N 3.446585 0.268170 . . 15 20 PHE N 3.447164 0.224591 . . 16 21 GLY N 3.299547 0.192697 . . 17 22 ASN N 3.511996 0.331397 . . 18 23 GLN N 4.060672 0.325613 . . 19 24 GLY N 3.393900 0.292390 . . 20 25 GLY N 3.221464 0.239661 . . 21 26 PHE N 3.447164 0.224591 . . 22 27 GLY N 3.299547 0.192697 . . 23 28 ASN N 3.620938 0.178789 . . 24 29 SER N 3.476921 0.399076 . . 25 30 ARG N 3.751361 0.379458 . . 26 31 GLY N 2.882554 0.308116 . . 27 32 GLY N 2.992095 0.201691 . . 28 33 GLY N 2.971849 0.217786 . . 29 34 ALA N 3.445612 0.176906 . . 30 35 GLY N 2.786391 0.221818 . . 31 36 LEU N 3.598403 0.194734 . . 32 37 GLY N 2.869656 0.208176 . . 33 38 ASN N 3.620938 0.178789 . . 34 39 ASN N 3.770228 0.334914 . . 35 40 GLN N 3.856054 0.287774 . . 36 41 GLY N 3.161175 0.184540 . . 37 42 SER N 3.303671 0.148318 . . 38 43 ASN N 3.798112 0.350831 . . 39 44 MET N 3.564112 0.311995 . . 40 45 GLY N 3.161175 0.184540 . . 41 46 GLY N 3.192674 0.222032 . . 42 47 GLY N 2.762835 0.236698 . . 43 48 MET N 3.746244 0.288552 . . 44 49 ASN N 4.592744 0.443946 . . 45 50 PHE N 4.455644 0.424074 . . 46 51 GLY N 4.147468 0.430691 . . 47 52 ALA N 4.754437 0.420643 . . 48 53 PHE N 5.816085 0.420818 . . 49 54 SER N 5.074230 0.543216 . . 50 55 ILE N 5.585775 0.709812 . . 51 59 MET N 8.944357 1.308961 . . 52 60 MET N 6.748418 1.053771 . . 53 61 ALA N 8.951216 1.491299 . . 54 62 ALA N 9.268563 1.233060 . . 55 63 ALA N 8.213275 1.150189 . . 56 65 ALA N 7.954871 1.348824 . . 57 66 ALA N 8.412336 1.199760 . . 58 67 LEU N 7.647171 1.177486 . . 59 68 GLN N 9.573326 1.606793 . . 60 69 SER N 7.217259 1.061973 . . 61 70 SER N 7.917795 1.172829 . . 62 71 TRP N 8.465268 1.074594 . . 63 72 GLY N 7.660161 1.298822 . . 64 73 MET N 6.241262 0.614384 . . 65 74 MET N 6.639701 0.781811 . . 66 75 GLY N 5.122459 0.632440 . . 67 76 MET N 5.693701 0.502692 . . 68 77 LEU N 5.499435 0.607209 . . 69 78 ALA N 4.869075 0.441517 . . 70 79 SER N 4.735056 0.418291 . . 71 80 GLN N 4.472838 0.474421 . . 72 81 GLN N 4.571534 0.433422 . . 73 82 ASN N 3.740773 0.205719 . . 74 83 GLN N 3.360106 0.320035 . . 75 84 SER N 3.235206 0.287458 . . 76 85 GLY N 2.876210 0.215601 . . 77 87 SER N 3.231139 0.269299 . . 78 88 GLY N 2.792580 0.262478 . . 79 89 ASN N 3.464552 0.171799 . . 80 90 ASN N 3.411009 0.205729 . . 81 91 GLN N 3.469224 0.165012 . . 82 92 ASN N 3.411009 0.205729 . . 83 93 GLN N 3.469224 0.165012 . . 84 94 GLY N 3.217970 0.241807 . . 85 95 ASN N 3.464552 0.171799 . . 86 96 MET N 3.728883 0.261696 . . 87 97 GLN N 3.882993 0.328573 . . 88 98 ARG N 4.452746 0.398785 . . 89 99 GLU N 3.997002 0.369529 . . 90 101 ASN N 4.466019 0.360101 . . 91 102 GLN N 4.513463 0.380042 . . 92 103 ALA N 3.606449 0.299044 . . 93 104 PHE N 3.485194 0.288395 . . 94 105 GLY N 3.545315 0.144363 . . 95 106 SER N 3.381476 0.195953 . . 96 107 GLY N 3.408384 0.254761 . . 97 108 ASN N 3.631298 0.278871 . . 98 109 ASN N 3.740773 0.205719 . . 99 110 SER N 3.966417 0.303027 . . 100 111 TYR N 3.697846 0.347047 . . 101 112 SER N 4.151567 0.405785 . . 102 113 GLY N 3.316830 0.302224 . . 103 114 SER N 3.706207 0.285227 . . 104 115 ASN N 3.527936 0.407500 . . 105 116 SER N 3.135768 0.292911 . . 106 117 GLY N 3.568564 0.219016 . . 107 118 ALA N 3.388847 0.200413 . . 108 119 ALA N 3.362537 0.225703 . . 109 120 ILE N 3.490387 0.256842 . . 110 121 GLY N 3.477937 0.331457 . . 111 122 TRP N 4.101423 0.316413 . . 112 123 GLY N 3.545315 0.144363 . . 113 124 SER N 3.698051 0.285909 . . 114 125 ALA N 3.471569 0.264705 . . 115 126 SER N 3.556314 0.270955 . . 116 127 ASN N 3.728883 0.261696 . . 117 128 ALA N 3.080190 0.224673 . . 118 129 GLY N 2.830433 0.246387 . . 119 130 SER N 3.540247 0.223500 . . 120 131 GLY N 2.976899 0.245456 . . 121 132 SER N 3.381476 0.195953 . . 122 133 GLY N 3.323153 0.170000 . . 123 134 PHE N 3.248298 0.260334 . . 124 135 ASN N 3.217301 0.369147 . . 125 136 GLY N 3.459501 0.277126 . . 126 137 GLY N 3.099353 0.281447 . . 127 138 PHE N 3.214366 0.264253 . . 128 139 GLY N 3.478282 0.222859 . . 129 140 SER N 3.303671 0.148318 . . 130 141 SER N 2.999275 0.282560 . . 131 142 MET N 3.421754 0.282222 . . 132 143 ASP N 3.436406 0.265548 . . 133 144 SER N 3.333611 0.282181 . . 134 145 LYS N 3.137765 0.269141 . . 135 146 SER N 3.020623 0.260695 . . 136 147 SER N 2.922365 0.256165 . . 137 148 GLY N 3.013229 0.248535 . . 138 149 TRP N 3.013808 0.189125 . . 139 150 GLY N 2.576797 0.206976 . . 140 151 MET N 2.158540 0.161303 . . stop_ save_ save_WT_TDP-43_267-414_850_MHz_HetNOE _Saveframe_category heteronuclear_NOE _Details . loop_ _Experiment_label hsqcnoef3gpsi stop_ loop_ _Sample_label $sample-2 stop_ _Sample_conditions_label $283_K _Spectrometer_frequency_1H 850 _Mol_system_component_name 'WT TDP-43_267-414 Monomer' _Atom_one_atom_name N _Atom_two_atom_name H _Heteronuclear_NOE_value_type 'relative intensities' _NOE_reference_value 0 _NOE_reference_description . _Text_data_format . _Text_data . loop_ _Residue_seq_code _Residue_label _Heteronuclear_NOE_value _Heteronuclear_NOE_value_error 4 ASN 0.188852 0.0758604 6 GLN 0.514044 0.0601132 7 LEU 0.575106 0.0692789 8 GLU 0.394885 0.0605043 9 ARG 0.483474 0.0446668 10 SER 0.386435 0.0696266 12 ARG 0.516201 0.0870248 13 PHE 0.513953 0.101402 15 GLY 0.299744 0.0753746 16 ASN 0.502433 0.0804647 18 GLY 0.491919 0.069849 19 GLY 0.575168 0.0859521 23 GLN 0.371797 0.0637635 25 GLY 0.51997 0.0862134 29 SER 0.347559 0.0651948 30 ARG 0.404744 0.0645383 31 GLY 0.394205 0.0749063 32 GLY 0.519047 0.0712058 33 GLY 0.44402 0.0617978 35 GLY 0.306768 0.0618717 37 GLY 0.470653 0.062503 39 ASN 0.593028 0.0757453 40 GLN 0.344025 0.0601344 43 ASN 0.302564 0.0722713 44 MET 0.400126 0.07004 46 GLY 0.434888 0.0683052 47 GLY 0.327083 0.0566703 49 ASN 0.532276 0.0774309 50 PHE 0.477075 0.08295 51 GLY 0.515052 0.0761301 52 ALA 0.402808 0.073381 53 PHE 0.422217 0.0792579 54 SER 0.444621 0.0899658 55 ILE 0.695943 0.148871 59 MET 0.614691 0.121594 60 MET 0.531823 0.126355 61 ALA 0.542782 0.0926515 62 ALA 0.480579 0.121545 63 ALA 0.56095 0.126054 65 ALA 0.640515 0.143806 66 ALA 0.607199 0.142004 67 LEU 0.586993 0.149025 68 GLN 0.63452 0.165584 70 SER 0.493455 0.113208 71 TRP 0.61286 0.123139 72 GLY 0.803407 0.141225 74 MET 0.447243 0.0951196 75 GLY 0.445976 0.0836087 77 LEU 0.630765 0.101301 78 ALA 0.425894 0.0726438 79 SER 0.400793 0.077929 80 GLN 0.482165 0.0871307 81 GLN 0.685286 0.102481 83 GLN 0.451996 0.0696964 84 SER 0.331183 0.0585697 85 GLY 0.406481 0.0634637 87 SER 0.389205 0.0675562 88 GLY 0.306445 0.0683419 94 GLY 0.557017 0.0697017 97 GLN 0.280008 0.0612859 98 ARG 0.406346 0.0732784 99 GLU 0.603224 0.0811291 101 ASN 0.592197 0.0896042 102 GLN 0.543345 0.0941813 103 ALA 0.485361 0.0677657 106 SER 0.484621 0.0631196 107 GLY 0.452329 0.0669372 111 TYR 0.462553 0.0693787 112 SER 0.527576 0.0706071 113 GLY 0.434792 0.0751619 115 ASN 0.347115 0.0767125 116 SER 0.395521 0.0574733 117 GLY 0.415417 0.0637843 118 ALA 0.40644 0.0520911 119 ALA 0.397051 0.0585936 120 ILE 0.36131 0.076061 121 GLY 0.419854 0.0684464 122 TRP 0.488485 0.0668248 125 ALA 0.498195 0.0625662 126 SER 0.361587 0.052366 128 ALA 0.547023 0.0549715 129 GLY 0.237256 0.0604244 131 GLY 0.277433 0.0555496 132 SER 0.433508 0.0656465 134 PHE 0.468916 0.0649474 135 ASN 0.439071 0.0721847 136 GLY 0.399477 0.0873428 137 GLY 0.503667 0.0749303 138 PHE 0.454453 0.0691381 139 GLY 0.38494 0.0667549 141 SER 0.510756 0.0742006 142 MET 0.295745 0.0559548 143 ASP 0.664845 0.0727225 144 SER 0.56463 0.0659788 145 LYS 0.451872 0.0621829 146 SER 0.388399 0.0610915 147 SER 0.436769 0.0599626 148 GLY 0.443209 0.0725889 149 TRP 0.517553 0.0607119 150 GLY 0.249187 0.0520062 151 MET -0.06942 -0.0558437 stop_ save_ save_WT_TDP-43_267-414_500_MHz_HetNOE _Saveframe_category heteronuclear_NOE _Details . loop_ _Experiment_label hsqcnoef3gpsi stop_ loop_ _Sample_label $sample-2 stop_ _Sample_conditions_label $283_K _Spectrometer_frequency_1H 500 _Mol_system_component_name 'WT TDP-43_267-414 Monomer' _Atom_one_atom_name N _Atom_two_atom_name H _Heteronuclear_NOE_value_type 'relative intensities' _NOE_reference_value 0 _NOE_reference_description . _Text_data_format . _Text_data . loop_ _Residue_seq_code _Residue_label _Heteronuclear_NOE_value _Heteronuclear_NOE_value_error 4 ASN -0.278665 -0.0726276 6 GLN -0.114276 -0.0499826 7 LEU 0.132665 0.0532943 8 GLU 0.0441663 0.0478331 9 ARG -0.11795 -0.0336161 10 SER 0.107516 0.070118 12 ARG 0.0596667 0.0621432 13 PHE -0.0584987 -0.0586101 15 GLY 0.0957489 0.0536538 16 ASN 0.0647521 0.071111 18 GLY -0.0407116 -0.0585816 19 GLY -0.0114028 -0.0502069 24 GLY -0.0476029 -0.0481187 25 GLY -0.0830472 -0.0423866 29 SER -0.0815668 -0.0625779 30 ARG -0.159565 -0.0595899 31 GLY -0.0900238 -0.0592944 32 GLY -0.0411096 -0.0376607 33 GLY -0.00161925 -0.039585 35 GLY -0.326614 -0.048951 39 ASN -0.0815799 -0.0525593 40 GLN -0.0457644 -0.0488399 43 ASN 0.13407 0.05067 44 MET 0.0272984 0.049521 47 GLY -0.199847 -0.0465001 49 ASN -0.0149801 -0.0592266 50 PHE 0.165371 0.0555907 51 GLY 0.0634536 0.0681491 52 ALA 0.175216 0.0532865 54 SER 0.18282 0.0609654 55 ILE 0.273472 0.0929514 59 MET 0.200434 0.0774497 60 MET 0.285033 0.0820178 61 ALA 0.359714 0.0904104 62 ALA 0.443495 0.0795038 63 ALA 0.301364 0.0662799 65 ALA 0.426949 0.122544 66 ALA 0.30008 0.083367 67 LEU 0.338858 0.0930419 68 GLN 0.427766 0.114114 69 SER 0.272129 0.0812925 70 SER 0.16531 0.0835546 71 TRP 0.289252 0.0843439 72 GLY 0.347582 0.0983563 74 MET 0.207299 0.0898607 75 GLY 0.278359 0.0850987 77 LEU 0.253642 0.0733668 78 ALA 0.185974 0.0551664 79 SER 0.0728879 0.0527656 80 GLN 0.0862225 0.0677233 81 GLN 0.181226 0.0616184 83 GLN -0.174252 -0.0555087 84 SER -0.057892 -0.0521336 85 GLY -0.0463624 -0.044898 87 SER -0.227628 -0.0519521 88 GLY -0.125714 -0.0549637 97 GLN 0.0157173 0.0565827 98 ARG 0.0210391 0.0548681 99 GLU 0.182015 0.061228 101 ASN 0.144425 0.0586447 102 GLN 0.197161 0.0582068 103 ALA 0.151554 0.0492733 107 GLY -0.0654063 -0.0468143 111 TYR 0.152848 0.0633206 112 SER 0.0796614 0.0640166 113 GLY 0.107715 0.0563569 115 ASN -0.0607393 -0.0745022 116 SER -0.00862987 -0.0525073 118 ALA 0.0275187 0.0396949 119 ALA -0.043187 -0.0422147 120 ILE -0.173476 -0.0541975 121 GLY 0.0244579 0.0547312 122 TRP 0.0406394 0.0474 124 SER 0.0225841 0.0461973 125 ALA -0.099581 -0.0464356 126 SER -0.0352558 -0.0422195 128 ALA 0.0582783 0.040181 129 GLY -0.184461 -0.0481064 131 GLY -0.200239 -0.0454458 134 PHE -0.0339831 -0.0476002 135 ASN -0.0713105 -0.061702 136 GLY 0.0404198 0.0539173 137 GLY 0.110709 0.0484596 138 PHE 0.0588025 0.0508824 141 SER -0.124518 -0.0521386 142 MET -0.0706366 -0.0471489 143 ASP 0.111065 0.0480418 144 SER 0.0677448 0.0446901 145 LYS 0.0489498 0.051747 146 SER -0.0717365 -0.044999 147 SER -0.157156 -0.0477221 148 GLY -0.212951 -0.0499073 149 TRP -0.369653 -0.0415239 150 GLY -0.342151 -0.0454907 151 MET -0.745793 -0.0516545 stop_ save_