data_25698 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; human CFTR NBD1 deltaRI F508del mutant chemical shift assignments ; _BMRB_accession_number 25698 _BMRB_flat_file_name bmr25698.str _Entry_type original _Submission_date 2015-07-09 _Accession_date 2015-07-09 _Entry_origination author _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details 'chemical shift assignments for a protein construct comprising residues 387-404 and 437-646 of human CFTR with F508del mutation' loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Hudson Rhea P. . 2 Chong Andrew . . 3 Forman-Kay Julie D. . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 1 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 185 "13C chemical shifts" 375 "15N chemical shifts" 186 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 2016-08-12 update BMRB 'update entry citation' 2015-08-12 original author 'original release' stop_ loop_ _Related_BMRB_accession_number _Relationship 25696 'hCFTR NBD1 deltaRI' 25697 'hCFTR NBD1 deltaRI I539T' stop_ _Original_release_date 2015-08-12 save_ ############################# # Citation for this entry # ############################# save_entry_citation _Saveframe_category entry_citation _Citation_full . _Citation_title ; Deletion of Phenylalanine-508 in the First Nucleotide Binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization ; _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID 26149808 loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Chong Andrew . . 2 Farber Patrick J. . 3 Vernon Robert M. . 4 Hudson Rhea P. . 5 Mittermaier Anthony K. . 6 Forman-Kay Julie D. . stop_ _Journal_abbreviation 'J. Biol. Chem.' _Journal_volume 290 _Journal_issue 38 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 22862 _Page_last 22878 _Year 2015 _Details . save_ ####################################### # Cited references within the entry # ####################################### save_reference_citation _Saveframe_category citation _Citation_full . _Citation_title ; Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator. ; _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID 22722932 loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Hudson Rhea P. . 2 Chong Andrew . . 3 Protasevich Irina . . 4 Vernon Robert M. . 5 Noy Efrat . . 6 Bihler Hermann . . 7 An 'Jian Li' . . 8 Kalid Ori . . 9 Sela-Culang Inbal . . 10 Mense Martin . . 11 Senderowitz Hanoch . . 12 Brouillette Chrisite . . 13 Forman-Kay Julie D. . stop_ _Journal_abbreviation 'J. Biol. Chem.' _Journal_name_full . _Journal_volume 287 _Journal_issue 34 _Journal_CSD . _Book_title . _Book_chapter_title . _Book_volume . _Book_series . _Book_publisher . _Book_publisher_city . _Book_ISBN . _Conference_title . _Conference_site . _Conference_state_province . _Conference_country . _Conference_start_date . _Conference_end_date . _Conference_abstract_number . _Thesis_institution . _Thesis_institution_city . _Thesis_institution_country . _Page_first 28480 _Page_last 28494 _Year 2012 _Details . save_ ################################## # Molecular system description # ################################## save_assembly _Saveframe_category molecular_system _Mol_system_name 'hCFTR NBD1 deltaRI F508del' _Enzyme_commission_number . loop_ _Mol_system_component_name _Mol_label 'hCFTR NBD1 delta RI F508del' $hCFTR_NBD1_delta_RI_F508del stop_ _System_molecular_weight . _System_physical_state native _System_oligomer_state ? _System_paramagnetic no _System_thiol_state . _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_hCFTR_NBD1_delta_RI_F508del _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common hCFTR_NBD1_delta_RI_F508del _Molecular_mass . _Mol_thiol_state 'not reported' _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 228 _Mol_residue_sequence ; SLTTTEVVMENVTAFWEEGG TPVLKDINFKIERGQLLAVA GSTGAGKTSLLMMIMGELEP SEGKIKHSGRISFCSQFSWI MPGTIKENIIGVSYDEYRYR SVIKACQLEEDISKFAEKDN IVLGEGGITLSGGQRARISL ARAVYKDADLYLLDSPFGYL DVLTEKEIFESCVCKLMANK TRILVTSKMEHLKKADKILI LHEGSSYFYGTFSELQNLQP DFSSKLMG ; loop_ _Residue_seq_code _Residue_author_seq_code _Residue_label 1 386 SER 2 387 LEU 3 388 THR 4 389 THR 5 390 THR 6 391 GLU 7 392 VAL 8 393 VAL 9 394 MET 10 395 GLU 11 396 ASN 12 397 VAL 13 398 THR 14 399 ALA 15 400 PHE 16 401 TRP 17 402 GLU 18 403 GLU 19 404 GLY 20 437 GLY 21 438 THR 22 439 PRO 23 440 VAL 24 441 LEU 25 442 LYS 26 443 ASP 27 444 ILE 28 445 ASN 29 446 PHE 30 447 LYS 31 448 ILE 32 449 GLU 33 450 ARG 34 451 GLY 35 452 GLN 36 453 LEU 37 454 LEU 38 455 ALA 39 456 VAL 40 457 ALA 41 458 GLY 42 459 SER 43 460 THR 44 461 GLY 45 462 ALA 46 463 GLY 47 464 LYS 48 465 THR 49 466 SER 50 467 LEU 51 468 LEU 52 469 MET 53 470 MET 54 471 ILE 55 472 MET 56 473 GLY 57 474 GLU 58 475 LEU 59 476 GLU 60 477 PRO 61 478 SER 62 479 GLU 63 480 GLY 64 481 LYS 65 482 ILE 66 483 LYS 67 484 HIS 68 485 SER 69 486 GLY 70 487 ARG 71 488 ILE 72 489 SER 73 490 PHE 74 491 CYS 75 492 SER 76 493 GLN 77 494 PHE 78 495 SER 79 496 TRP 80 497 ILE 81 498 MET 82 499 PRO 83 500 GLY 84 501 THR 85 502 ILE 86 503 LYS 87 504 GLU 88 505 ASN 89 506 ILE 90 507 ILE 91 508 GLY 92 509 VAL 93 510 SER 94 511 TYR 95 512 ASP 96 513 GLU 97 514 TYR 98 515 ARG 99 516 TYR 100 517 ARG 101 518 SER 102 519 VAL 103 520 ILE 104 521 LYS 105 522 ALA 106 523 CYS 107 524 GLN 108 525 LEU 109 526 GLU 110 527 GLU 111 528 ASP 112 529 ILE 113 530 SER 114 531 LYS 115 532 PHE 116 533 ALA 117 534 GLU 118 535 LYS 119 536 ASP 120 537 ASN 121 538 ILE 122 539 VAL 123 540 LEU 124 541 GLY 125 542 GLU 126 543 GLY 127 544 GLY 128 545 ILE 129 546 THR 130 547 LEU 131 548 SER 132 549 GLY 133 550 GLY 134 551 GLN 135 552 ARG 136 553 ALA 137 554 ARG 138 555 ILE 139 556 SER 140 557 LEU 141 558 ALA 142 559 ARG 143 560 ALA 144 561 VAL 145 562 TYR 146 563 LYS 147 564 ASP 148 565 ALA 149 566 ASP 150 567 LEU 151 568 TYR 152 569 LEU 153 570 LEU 154 571 ASP 155 572 SER 156 573 PRO 157 574 PHE 158 575 GLY 159 576 TYR 160 577 LEU 161 578 ASP 162 579 VAL 163 580 LEU 164 581 THR 165 582 GLU 166 583 LYS 167 584 GLU 168 585 ILE 169 586 PHE 170 587 GLU 171 588 SER 172 589 CYS 173 590 VAL 174 591 CYS 175 592 LYS 176 593 LEU 177 594 MET 178 595 ALA 179 596 ASN 180 597 LYS 181 598 THR 182 599 ARG 183 600 ILE 184 601 LEU 185 602 VAL 186 603 THR 187 604 SER 188 605 LYS 189 606 MET 190 607 GLU 191 608 HIS 192 609 LEU 193 610 LYS 194 611 LYS 195 612 ALA 196 613 ASP 197 614 LYS 198 615 ILE 199 616 LEU 200 617 ILE 201 618 LEU 202 619 HIS 203 620 GLU 204 621 GLY 205 622 SER 206 623 SER 207 624 TYR 208 625 PHE 209 626 TYR 210 627 GLY 211 628 THR 212 629 PHE 213 630 SER 214 631 GLU 215 632 LEU 216 633 GLN 217 634 ASN 218 635 LEU 219 636 GLN 220 637 PRO 221 638 ASP 222 639 PHE 223 640 SER 224 641 SER 225 642 LYS 226 643 LEU 227 644 MET 228 645 GLY stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date . save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species $hCFTR_NBD1_delta_RI_F508del human 9606 Eukaryota Metazoa Homo sapiens stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $hCFTR_NBD1_delta_RI_F508del 'recombinant technology' . Escherichia coli . 'pET-SUMO hNBD1 deltaRI F508del' stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $hCFTR_NBD1_delta_RI_F508del 1 mM '[U-99% 13C; U-99% 15N; 50%D20]' 'sodium phosphate' 50 mM 'natural abundance' 'sodium chloride' 150 mM 'natural abundance' glycerol 274 mM 'natural abundance' 'magnesium chloride' 5 mM 'natural abundance' 'sodium azide' .08 mM 'natural abundance' DTT 5 mM 'natural abundance' 'adenosine triphosphate' 5 mM 'natural abundance' H2O 90 % 'natural abundance' D2O 10 % 'natural abundance' stop_ save_ ############################ # Computer software used # ############################ save_NMRView _Saveframe_category software _Name NMRView _Version 5.2.2 loop_ _Vendor _Address _Electronic_address 'Johnson, One Moon Scientific' . . stop_ loop_ _Task 'chemical shift assignment' stop_ _Details . save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_1 _Saveframe_category NMR_spectrometer _Manufacturer Varian _Model INOVA _Field_strength 600 _Details 'with cyroprobe' save_ ############################# # NMR applied experiments # ############################# save_2D_1H-15N_HSQC_1 _Saveframe_category NMR_applied_experiment _Experiment_name '2D 1H-15N HSQC' _Sample_label $sample_1 save_ save_3D_HNCO_2 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCO' _Sample_label $sample_1 save_ save_3D_HNCA_3 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCA' _Sample_label $sample_1 save_ save_3D_HN(CO)CA_4 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HN(CO)CA' _Sample_label $sample_1 save_ save_2D_1H-13C_HSQC_5 _Saveframe_category NMR_applied_experiment _Experiment_name '2D 1H-13C HSQC' _Sample_label $sample_1 save_ ####################### # Sample conditions # ####################### save_sample_conditions_1 _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units 'ionic strength' 0.89 . M pH 7.6 . pH pressure 1 . atm temperature 293.15 . K stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chemical_shift_reference_1 _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis _Indirect_shift_ratio DSS C 13 'methyl protons' ppm 0.0 external indirect . . . 0.25148 DSS H 1 'methyl protons' ppm 0.0 external direct . . . 1 DSS N 15 'methyl protons' ppm 0.0 external indirect . . . 0.10134 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_assigned_chem_shift_list_1 _Saveframe_category assigned_chemical_shifts _Details . loop_ _Software_label $NMRView stop_ loop_ _Experiment_label '2D 1H-15N HSQC' '3D HNCO' '3D HNCA' '3D HN(CO)CA' stop_ loop_ _Sample_label $sample_1 stop_ _Sample_conditions_label $sample_conditions_1 _Chem_shift_reference_set_label $chemical_shift_reference_1 _Mol_system_component_name 'hCFTR NBD1 delta RI F508del' _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 386 1 SER N N 120.00 . . 2 387 2 LEU C C 177.31 . . 3 387 2 LEU CA C 55.118 . . 4 388 3 THR H H 8.267 . . 5 388 3 THR C C 174.06 . . 6 388 3 THR CA C 61.305 . . 7 388 3 THR N N 115.20 . . 8 389 4 THR H H 8.250 . . 9 389 4 THR N N 115.86 . . 10 392 7 VAL C C 173.76 . . 11 392 7 VAL CA C 60.897 . . 12 393 8 VAL H H 8.699 . . 13 393 8 VAL C C 174.10 . . 14 393 8 VAL CA C 60.663 . . 15 393 8 VAL N N 125.71 . . 16 394 9 MET H H 8.289 . . 17 394 9 MET C C 174.21 . . 18 394 9 MET CA C 55.761 . . 19 394 9 MET N N 123.85 . . 20 395 10 GLU H H 8.910 . . 21 395 10 GLU C C 173.23 . . 22 395 10 GLU CA C 54.126 . . 23 395 10 GLU N N 125.06 . . 24 396 11 ASN H H 8.876 . . 25 396 11 ASN C C 174.17 . . 26 396 11 ASN CA C 54.010 . . 27 396 11 ASN N N 123.58 . . 28 397 12 VAL H H 8.349 . . 29 397 12 VAL C C 176.09 . . 30 397 12 VAL CA C 63.546 . . 31 397 12 VAL N N 120.00 . . 32 398 13 THR H H 7.800 . . 33 398 13 THR C C 172.57 . . 34 398 13 THR CA C 60.575 . . 35 398 13 THR N N 123.28 . . 36 399 14 ALA H H 8.789 . . 37 399 14 ALA C C 173.55 . . 38 399 14 ALA CA C 51.150 . . 39 399 14 ALA N N 127.06 . . 40 400 15 PHE H H 9.237 . . 41 400 15 PHE C C 174.83 . . 42 400 15 PHE CA C 56.519 . . 43 400 15 PHE N N 118.81 . . 44 401 16 TRP H H 8.916 . . 45 401 16 TRP C C 176.92 . . 46 401 16 TRP CA C 59.146 . . 47 401 16 TRP N N 121.49 . . 48 402 17 GLU H H 7.939 . . 49 402 17 GLU C C 175.28 . . 50 402 17 GLU CA C 54.418 . . 51 402 17 GLU N N 117.72 . . 52 403 18 GLU H H 8.784 . . 53 403 18 GLU C C 177.45 . . 54 403 18 GLU CA C 57.628 . . 55 403 18 GLU N N 125.56 . . 56 437 20 GLY H H 7.959 . . 57 437 20 GLY C C 173.32 . . 58 437 20 GLY CA C 44.262 . . 59 437 20 GLY N N 108.29 . . 60 438 21 THR H H 8.568 . . 61 438 21 THR N N 117.99 . . 62 439 22 PRO C C 176.33 . . 63 439 22 PRO CA C 63.465 . . 64 440 23 VAL H H 8.248 . . 65 440 23 VAL C C 172.66 . . 66 440 23 VAL CA C 61.247 . . 67 440 23 VAL N N 122.70 . . 68 441 24 LEU H H 6.837 . . 69 441 24 LEU C C 175.24 . . 70 441 24 LEU CA C 52.788 . . 71 441 24 LEU N N 119.54 . . 72 442 25 LYS H H 8.508 . . 73 442 25 LYS C C 173.10 . . 74 442 25 LYS CA C 54.710 . . 75 442 25 LYS N N 121.80 . . 76 443 26 ASP H H 7.887 . . 77 443 26 ASP C C 173.14 . . 78 443 26 ASP CA C 54.768 . . 79 443 26 ASP N N 125.32 . . 80 444 27 ILE H H 9.222 . . 81 444 27 ILE C C 175.69 . . 82 444 27 ILE CA C 59.438 . . 83 444 27 ILE N N 119.38 . . 84 445 28 ASN H H 7.674 . . 85 445 28 ASN C C 173.94 . . 86 445 28 ASN CA C 52.083 . . 87 445 28 ASN N N 122.74 . . 88 446 29 PHE H H 8.269 . . 89 446 29 PHE C C 172.02 . . 90 446 29 PHE CA C 57.095 . . 91 446 29 PHE N N 114.50 . . 92 447 30 LYS H H 7.834 . . 93 447 30 LYS C C 174.60 . . 94 447 30 LYS N N 118.63 . . 95 448 31 ILE H H 9.151 . . 96 448 31 ILE C C 174.62 . . 97 448 31 ILE CA C 59.648 . . 98 448 31 ILE N N 122.17 . . 99 449 32 GLU H H 8.313 . . 100 449 32 GLU CA C 54.602 . . 101 449 32 GLU N N 125.09 . . 102 450 33 ARG H H 8.568 . . 103 450 33 ARG C C 177.97 . . 104 450 33 ARG N N 119.40 . . 105 451 34 GLY H H 9.112 . . 106 451 34 GLY C C 173.62 . . 107 451 34 GLY CA C 44.559 . . 108 451 34 GLY N N 113.74 . . 109 452 35 GLN H H 7.804 . . 110 452 35 GLN C C 173.35 . . 111 452 35 GLN CA C 56.111 . . 112 452 35 GLN N N 118.63 . . 113 453 36 LEU H H 9.541 . . 114 453 36 LEU C C 175.19 . . 115 453 36 LEU CA C 53.251 . . 116 453 36 LEU N N 120.84 . . 117 454 37 LEU H H 9.027 . . 118 454 37 LEU C C 174.26 . . 119 454 37 LEU CA C 52.492 . . 120 454 37 LEU N N 130.02 . . 121 455 38 ALA H H 8.731 . . 122 455 38 ALA C C 174.92 . . 123 455 38 ALA CA C 49.340 . . 124 455 38 ALA N N 129.29 . . 125 456 39 VAL H H 9.071 . . 126 456 39 VAL C C 173.14 . . 127 456 39 VAL CA C 60.546 . . 128 456 39 VAL N N 123.61 . . 129 457 40 ALA H H 9.033 . . 130 457 40 ALA C C 175.74 . . 131 457 40 ALA CA C 49.515 . . 132 457 40 ALA N N 128.29 . . 133 458 41 GLY H H 8.240 . . 134 458 41 GLY C C 174.08 . . 135 458 41 GLY CA C 44.904 . . 136 458 41 GLY N N 106.09 . . 137 459 42 SER H H 9.216 . . 138 459 42 SER C C 173.92 . . 139 459 42 SER CA C 58.212 . . 140 459 42 SER N N 119.03 . . 141 460 43 THR H H 8.610 . . 142 460 43 THR C C 175.63 . . 143 460 43 THR CA C 63.271 . . 144 460 43 THR N N 117.12 . . 145 461 44 GLY H H 8.036 . . 146 461 44 GLY C C 174.26 . . 147 461 44 GLY CA C 45.857 . . 148 461 44 GLY N N 114.45 . . 149 462 45 ALA H H 8.102 . . 150 462 45 ALA C C 175.99 . . 151 462 45 ALA CA C 55.045 . . 152 462 45 ALA N N 122.52 . . 153 463 46 GLY H H 7.964 . . 154 463 46 GLY C C 173.39 . . 155 463 46 GLY CA C 44.563 . . 156 463 46 GLY N N 99.630 . . 157 464 47 LYS H H 9.129 . . 158 464 47 LYS C C 177.36 . . 159 464 47 LYS CA C 59.768 . . 160 464 47 LYS N N 122.95 . . 161 465 48 THR H H 9.395 . . 162 465 48 THR C C 177.48 . . 163 465 48 THR CA C 67.450 . . 164 465 48 THR N N 117.31 . . 165 466 49 SER H H 8.349 . . 166 466 49 SER C C 173.75 . . 167 466 49 SER CA C 64.683 . . 168 466 49 SER N N 118.82 . . 169 467 50 LEU H H 8.175 . . 170 467 50 LEU C C 178.37 . . 171 467 50 LEU CA C 58.966 . . 172 467 50 LEU N N 123.21 . . 173 468 51 LEU H H 7.327 . . 174 468 51 LEU C C 178.94 . . 175 468 51 LEU CA C 58.211 . . 176 468 51 LEU N N 117.84 . . 177 469 52 MET H H 8.659 . . 178 469 52 MET C C 178.72 . . 179 469 52 MET CA C 57.054 . . 180 469 52 MET N N 117.49 . . 181 470 53 MET H H 8.026 . . 182 470 53 MET C C 179.73 . . 183 470 53 MET CA C 58.143 . . 184 470 53 MET N N 120.49 . . 185 471 54 ILE H H 7.482 . . 186 471 54 ILE C C 175.69 . . 187 471 54 ILE CA C 65.098 . . 188 471 54 ILE N N 122.36 . . 189 472 55 MET H H 7.434 . . 190 472 55 MET C C 175.75 . . 191 472 55 MET CA C 56.059 . . 192 472 55 MET N N 113.27 . . 193 473 56 GLY H H 7.474 . . 194 473 56 GLY C C 174.04 . . 195 473 56 GLY CA C 45.001 . . 196 473 56 GLY N N 106.52 . . 197 474 57 GLU H H 7.846 . . 198 474 57 GLU C C 174.01 . . 199 474 57 GLU CA C 56.649 . . 200 474 57 GLU N N 118.22 . . 201 475 58 LEU H H 6.452 . . 202 475 58 LEU C C 174.01 . . 203 475 58 LEU CA C 52.818 . . 204 475 58 LEU N N 119.55 . . 205 476 59 GLU H H 8.628 . . 206 476 59 GLU N N 127.23 . . 207 477 60 PRO C C 176.75 . . 208 477 60 PRO CA C 62.519 . . 209 478 61 SER H H 9.195 . . 210 478 61 SER C C 174.07 . . 211 478 61 SER CA C 59.918 . . 212 478 61 SER N N 119.56 . . 213 479 62 GLU H H 7.828 . . 214 479 62 GLU C C 174.26 . . 215 479 62 GLU CA C 54.903 . . 216 479 62 GLU N N 119.59 . . 217 480 63 GLY H H 8.330 . . 218 480 63 GLY C C 173.51 . . 219 480 63 GLY CA C 44.731 . . 220 480 63 GLY N N 107.88 . . 221 481 64 LYS H H 8.234 . . 222 481 64 LYS C C 173.72 . . 223 481 64 LYS CA C 54.660 . . 224 481 64 LYS N N 116.58 . . 225 482 65 ILE H H 8.484 . . 226 482 65 ILE C C 174.68 . . 227 482 65 ILE CA C 59.144 . . 228 482 65 ILE N N 121.80 . . 229 483 66 LYS H H 8.955 . . 230 483 66 LYS C C 174.53 . . 231 483 66 LYS CA C 54.906 . . 232 483 66 LYS N N 127.05 . . 233 484 67 HIS H H 8.043 . . 234 484 67 HIS C C 173.79 . . 235 484 67 HIS CA C 56.025 . . 236 484 67 HIS N N 119.08 . . 237 485 68 SER H H 8.706 . . 238 485 68 SER C C 174.65 . . 239 485 68 SER CA C 58.015 . . 240 485 68 SER N N 116.11 . . 241 486 69 GLY C C 173.48 . . 242 486 69 GLY CA C 44.866 . . 243 487 70 ARG H H 8.962 . . 244 487 70 ARG C C 176.05 . . 245 487 70 ARG CA C 55.572 . . 246 487 70 ARG N N 121.51 . . 247 488 71 ILE H H 8.694 . . 248 488 71 ILE C C 175.77 . . 249 488 71 ILE CA C 60.021 . . 250 488 71 ILE N N 125.69 . . 251 489 72 SER H H 8.160 . . 252 489 72 SER C C 172.36 . . 253 489 72 SER CA C 55.480 . . 254 489 72 SER N N 119.75 . . 255 490 73 PHE H H 8.949 . . 256 490 73 PHE C C 173.63 . . 257 490 73 PHE CA C 54.618 . . 258 490 73 PHE N N 130.08 . . 259 491 74 CYS H H 8.869 . . 260 491 74 CYS C C 170.70 . . 261 491 74 CYS CA C 56.528 . . 262 491 74 CYS N N 130.63 . . 263 492 75 SER H H 8.011 . . 264 492 75 SER CA C 57.018 . . 265 492 75 SER N N 120.98 . . 266 499 82 PRO C C 176.47 . . 267 499 82 PRO CA C 62.956 . . 268 500 83 GLY H H 7.930 . . 269 500 83 GLY C C 172.79 . . 270 500 83 GLY CA C 43.471 . . 271 500 83 GLY N N 112.41 . . 272 501 84 THR H H 9.010 . . 273 501 84 THR N N 111.15 . . 274 503 86 LYS C C 178.56 . . 275 503 86 LYS CA C 60.375 . . 276 504 87 GLU C C 178.95 . . 277 504 87 GLU CA C 58.933 . . 278 505 88 ASN H H 8.013 . . 279 505 88 ASN C C 175.74 . . 280 505 88 ASN CA C 56.935 . . 281 505 88 ASN N N 116.64 . . 282 506 89 ILE H H 7.561 . . 283 506 89 ILE C C 175.48 . . 284 506 89 ILE CA C 64.515 . . 285 506 89 ILE N N 117.86 . . 286 507 90 ILE H H 8.016 . . 287 507 90 ILE C C 177.30 . . 288 507 90 ILE CA C 61.645 . . 289 507 90 ILE N N 110.26 . . 290 508 91 GLY H H 7.801 . . 291 508 91 GLY C C 174.56 . . 292 508 91 GLY CA C 46.564 . . 293 508 91 GLY N N 110.89 . . 294 509 92 VAL H H 8.445 . . 295 509 92 VAL C C 175.79 . . 296 509 92 VAL CA C 61.974 . . 297 509 92 VAL N N 120.37 . . 298 510 93 SER H H 7.773 . . 299 510 93 SER CA C 56.876 . . 300 510 93 SER N N 115.55 . . 301 511 94 TYR C C 172.72 . . 302 511 94 TYR CA C 57.625 . . 303 512 95 ASP H H 7.493 . . 304 512 95 ASP C C 174.52 . . 305 512 95 ASP CA C 52.709 . . 306 512 95 ASP N N 131.23 . . 307 513 96 GLU H H 8.617 . . 308 513 96 GLU C C 176.83 . . 309 513 96 GLU CA C 59.791 . . 310 513 96 GLU N N 126.78 . . 311 514 97 TYR H H 8.139 . . 312 514 97 TYR C C 179.02 . . 313 514 97 TYR CA C 61.128 . . 314 514 97 TYR N N 118.90 . . 315 515 98 ARG H H 8.465 . . 316 515 98 ARG C C 178.50 . . 317 515 98 ARG CA C 59.172 . . 318 515 98 ARG N N 123.06 . . 319 516 99 TYR H H 9.025 . . 320 516 99 TYR C C 176.37 . . 321 516 99 TYR CA C 61.810 . . 322 516 99 TYR N N 119.99 . . 323 517 100 ARG H H 8.519 . . 324 517 100 ARG C C 179.26 . . 325 517 100 ARG CA C 58.910 . . 326 517 100 ARG N N 116.83 . . 327 518 101 SER H H 7.938 . . 328 518 101 SER C C 176.65 . . 329 518 101 SER CA C 61.788 . . 330 518 101 SER N N 114.55 . . 331 519 102 VAL H H 8.222 . . 332 519 102 VAL C C 177.16 . . 333 519 102 VAL CA C 66.517 . . 334 519 102 VAL N N 123.76 . . 335 520 103 ILE H H 8.281 . . 336 520 103 ILE C C 178.03 . . 337 520 103 ILE CA C 64.180 . . 338 520 103 ILE N N 118.96 . . 339 521 104 LYS H H 7.539 . . 340 521 104 LYS C C 180.01 . . 341 521 104 LYS CA C 59.067 . . 342 521 104 LYS N N 119.38 . . 343 522 105 ALA H H 8.018 . . 344 522 105 ALA C C 178.46 . . 345 522 105 ALA CA C 54.984 . . 346 522 105 ALA N N 121.89 . . 347 523 106 CYS H H 7.857 . . 348 523 106 CYS C C 171.25 . . 349 523 106 CYS CA C 60.222 . . 350 523 106 CYS N N 110.32 . . 351 524 107 GLN H H 7.772 . . 352 524 107 GLN C C 175.76 . . 353 524 107 GLN CA C 56.084 . . 354 524 107 GLN N N 112.57 . . 355 525 108 LEU H H 8.250 . . 356 525 108 LEU C C 177.15 . . 357 525 108 LEU CA C 54.654 . . 358 525 108 LEU N N 116.08 . . 359 526 109 GLU H H 7.850 . . 360 526 109 GLU C C 178.85 . . 361 526 109 GLU CA C 60.370 . . 362 526 109 GLU N N 121.17 . . 363 527 110 GLU H H 8.643 . . 364 527 110 GLU C C 178.53 . . 365 527 110 GLU CA C 58.136 . . 366 527 110 GLU N N 119.32 . . 367 528 111 ASP H H 7.831 . . 368 528 111 ASP C C 177.76 . . 369 528 111 ASP CA C 57.070 . . 370 528 111 ASP N N 118.49 . . 371 529 112 ILE H H 7.980 . . 372 529 112 ILE C C 176.80 . . 373 529 112 ILE CA C 64.882 . . 374 529 112 ILE N N 115.67 . . 375 530 113 SER H H 7.615 . . 376 530 113 SER C C 175.01 . . 377 530 113 SER CA C 60.493 . . 378 530 113 SER N N 112.16 . . 379 531 114 LYS H H 7.096 . . 380 531 114 LYS C C 176.95 . . 381 531 114 LYS CA C 56.655 . . 382 531 114 LYS N N 119.27 . . 383 532 115 PHE H H 7.420 . . 384 532 115 PHE N N 118.74 . . 385 535 118 LYS C C 174.97 . . 386 536 119 ASP H H 8.746 . . 387 536 119 ASP C C 174.57 . . 388 536 119 ASP CA C 53.697 . . 389 536 119 ASP N N 116.71 . . 390 537 120 ASN H H 8.267 . . 391 537 120 ASN C C 174.02 . . 392 537 120 ASN CA C 52.335 . . 393 537 120 ASN N N 115.20 . . 394 538 121 ILE H H 7.240 . . 395 538 121 ILE C C 172.96 . . 396 538 121 ILE CA C 60.594 . . 397 538 121 ILE N N 120.77 . . 398 539 122 VAL H H 7.800 . . 399 539 122 VAL C C 175.02 . . 400 539 122 VAL CA C 62.985 . . 401 539 122 VAL N N 125.15 . . 402 540 123 LEU H H 8.508 . . 403 540 123 LEU C C 177.21 . . 404 540 123 LEU CA C 53.044 . . 405 540 123 LEU N N 126.85 . . 406 541 124 GLY H H 8.325 . . 407 541 124 GLY C C 173.80 . . 408 541 124 GLY CA C 43.799 . . 409 541 124 GLY N N 108.24 . . 410 542 125 GLU H H 8.572 . . 411 542 125 GLU C C 177.70 . . 412 542 125 GLU CA C 57.630 . . 413 542 125 GLU N N 121.61 . . 414 543 126 GLY H H 8.777 . . 415 543 126 GLY C C 174.36 . . 416 543 126 GLY CA C 45.052 . . 417 543 126 GLY N N 113.65 . . 418 544 127 GLY H H 8.256 . . 419 544 127 GLY N N 110.13 . . 420 547 130 LEU C C 176.86 . . 421 547 130 LEU CA C 53.143 . . 422 548 131 SER H H 9.039 . . 423 548 131 SER CA C 56.796 . . 424 548 131 SER N N 117.30 . . 425 550 133 GLY C C 176.85 . . 426 551 134 GLN H H 7.758 . . 427 551 134 GLN C C 178.24 . . 428 551 134 GLN CA C 59.526 . . 429 551 134 GLN N N 122.21 . . 430 552 135 ARG H H 8.465 . . 431 552 135 ARG C C 178.56 . . 432 552 135 ARG CA C 60.380 . . 433 552 135 ARG N N 117.88 . . 434 553 136 ALA H H 8.246 . . 435 553 136 ALA CA C 55.021 . . 436 553 136 ALA N N 121.93 . . 437 554 137 ARG C C 177.79 . . 438 554 137 ARG CA C 61.084 . . 439 555 138 ILE H H 8.301 . . 440 555 138 ILE C C 176.06 . . 441 555 138 ILE CA C 65.366 . . 442 555 138 ILE N N 120.07 . . 443 556 139 SER H H 7.982 . . 444 556 139 SER N N 114.67 . . 445 559 142 ARG C C 178.78 . . 446 559 142 ARG CA C 58.414 . . 447 560 143 ALA H H 7.380 . . 448 560 143 ALA C C 180.34 . . 449 560 143 ALA CA C 54.036 . . 450 560 143 ALA N N 119.88 . . 451 561 144 VAL H H 8.515 . . 452 561 144 VAL C C 175.70 . . 453 561 144 VAL CA C 64.113 . . 454 561 144 VAL N N 115.61 . . 455 562 145 TYR H H 8.764 . . 456 562 145 TYR C C 176.77 . . 457 562 145 TYR CA C 61.351 . . 458 562 145 TYR N N 119.81 . . 459 563 146 LYS H H 6.959 . . 460 563 146 LYS CA C 56.948 . . 461 563 146 LYS N N 118.65 . . 462 564 147 ASP C C 173.38 . . 463 564 147 ASP CA C 54.719 . . 464 565 148 ALA H H 7.787 . . 465 565 148 ALA N N 127.91 . . 466 566 149 ASP C C 174.75 . . 467 566 149 ASP CA C 55.268 . . 468 567 150 LEU H H 7.563 . . 469 567 150 LEU C C 172.79 . . 470 567 150 LEU CA C 53.535 . . 471 567 150 LEU N N 121.03 . . 472 568 151 TYR H H 8.545 . . 473 568 151 TYR C C 173.54 . . 474 568 151 TYR CA C 56.873 . . 475 568 151 TYR N N 124.92 . . 476 569 152 LEU H H 9.215 . . 477 569 152 LEU C C 173.69 . . 478 569 152 LEU CA C 52.519 . . 479 569 152 LEU N N 123.54 . . 480 570 153 LEU H H 9.472 . . 481 570 153 LEU N N 124.52 . . 482 576 159 TYR C C 175.31 . . 483 576 159 TYR CA C 59.576 . . 484 577 160 LEU H H 7.652 . . 485 577 160 LEU C C 176.64 . . 486 577 160 LEU CA C 53.619 . . 487 577 160 LEU N N 118.50 . . 488 578 161 ASP H H 8.273 . . 489 578 161 ASP N N 120.74 . . 490 579 162 VAL C C 178.01 . . 491 579 162 VAL CA C 65.451 . . 492 580 163 LEU H H 8.102 . . 493 580 163 LEU N N 121.97 . . 494 581 164 THR C C 175.90 . . 495 581 164 THR CA C 66.409 . . 496 582 165 GLU H H 8.502 . . 497 582 165 GLU C C 176.00 . . 498 582 165 GLU CA C 59.922 . . 499 582 165 GLU N N 121.25 . . 500 583 166 LYS H H 7.607 . . 501 583 166 LYS C C 178.69 . . 502 583 166 LYS CA C 59.535 . . 503 583 166 LYS N N 119.39 . . 504 584 167 GLU H H 8.035 . . 505 584 167 GLU C C 179.48 . . 506 584 167 GLU CA C 58.830 . . 507 584 167 GLU N N 118.14 . . 508 585 168 ILE H H 8.528 . . 509 585 168 ILE C C 179.05 . . 510 585 168 ILE CA C 64.615 . . 511 585 168 ILE N N 119.60 . . 512 586 169 PHE H H 9.194 . . 513 586 169 PHE C C 176.70 . . 514 586 169 PHE CA C 62.723 . . 515 586 169 PHE N N 124.74 . . 516 587 170 GLU H H 8.158 . . 517 587 170 GLU C C 171.85 . . 518 587 170 GLU CA C 59.624 . . 519 587 170 GLU N N 117.14 . . 520 588 171 SER H H 8.970 . . 521 588 171 SER C C 175.90 . . 522 588 171 SER CA C 61.821 . . 523 588 171 SER N N 112.90 . . 524 589 172 CYS H H 9.199 . . 525 589 172 CYS C C 173.76 . . 526 589 172 CYS CA C 60.581 . . 527 589 172 CYS N N 121.45 . . 528 590 173 VAL H H 7.146 . . 529 590 173 VAL C C 176.12 . . 530 590 173 VAL CA C 66.461 . . 531 590 173 VAL N N 115.73 . . 532 591 174 CYS H H 7.299 . . 533 591 174 CYS C C 175.01 . . 534 591 174 CYS CA C 61.118 . . 535 591 174 CYS N N 112.60 . . 536 592 175 LYS H H 6.834 . . 537 592 175 LYS C C 177.40 . . 538 592 175 LYS CA C 58.306 . . 539 592 175 LYS N N 117.09 . . 540 593 176 LEU H H 7.936 . . 541 593 176 LEU C C 178.61 . . 542 593 176 LEU CA C 58.708 . . 543 593 176 LEU N N 122.20 . . 544 594 177 MET H H 7.125 . . 545 594 177 MET C C 174.06 . . 546 594 177 MET CA C 54.222 . . 547 594 177 MET N N 111.61 . . 548 595 178 ALA H H 6.757 . . 549 595 178 ALA C C 177.14 . . 550 595 178 ALA CA C 54.624 . . 551 595 178 ALA N N 118.93 . . 552 596 179 ASN H H 8.520 . . 553 596 179 ASN C C 174.62 . . 554 596 179 ASN CA C 52.883 . . 555 596 179 ASN N N 110.93 . . 556 597 180 LYS H H 7.805 . . 557 597 180 LYS C C 175.69 . . 558 597 180 LYS CA C 52.624 . . 559 597 180 LYS N N 118.07 . . 560 598 181 THR H H 8.804 . . 561 598 181 THR C C 174.09 . . 562 598 181 THR CA C 63.681 . . 563 598 181 THR N N 122.92 . . 564 599 182 ARG H H 9.303 . . 565 599 182 ARG C C 173.33 . . 566 599 182 ARG CA C 53.995 . . 567 599 182 ARG N N 126.91 . . 568 600 183 ILE H H 8.993 . . 569 600 183 ILE C C 173.01 . . 570 600 183 ILE CA C 60.449 . . 571 600 183 ILE N N 120.61 . . 572 601 184 LEU H H 9.182 . . 573 601 184 LEU C C 174.64 . . 574 601 184 LEU CA C 51.946 . . 575 601 184 LEU N N 129.29 . . 576 602 185 VAL H H 8.963 . . 577 602 185 VAL C C 175.06 . . 578 602 185 VAL CA C 61.520 . . 579 602 185 VAL N N 129.46 . . 580 603 186 THR H H 8.587 . . 581 603 186 THR C C 170.67 . . 582 603 186 THR CA C 59.177 . . 583 603 186 THR N N 122.05 . . 584 604 187 SER H H 8.119 . . 585 604 187 SER C C 173.62 . . 586 604 187 SER CA C 56.633 . . 587 604 187 SER N N 117.77 . . 588 605 188 LYS H H 7.853 . . 589 605 188 LYS C C 177.30 . . 590 605 188 LYS CA C 54.557 . . 591 605 188 LYS N N 121.17 . . 592 606 189 MET H H 9.035 . . 593 606 189 MET C C 177.37 . . 594 606 189 MET CA C 58.105 . . 595 606 189 MET N N 127.74 . . 596 607 190 GLU H H 9.043 . . 597 607 190 GLU C C 177.61 . . 598 607 190 GLU CA C 58.976 . . 599 607 190 GLU N N 115.92 . . 600 608 191 HIS H H 6.823 . . 601 608 191 HIS C C 177.37 . . 602 608 191 HIS CA C 55.300 . . 603 608 191 HIS N N 116.68 . . 604 609 192 LEU H H 7.414 . . 605 609 192 LEU C C 177.72 . . 606 609 192 LEU CA C 58.172 . . 607 609 192 LEU N N 117.99 . . 608 610 193 LYS H H 7.371 . . 609 610 193 LYS C C 177.22 . . 610 610 193 LYS CA C 58.239 . . 611 610 193 LYS N N 114.15 . . 612 611 194 LYS H H 6.967 . . 613 611 194 LYS C C 175.54 . . 614 611 194 LYS CA C 54.624 . . 615 611 194 LYS N N 115.75 . . 616 612 195 ALA H H 7.365 . . 617 612 195 ALA C C 176.51 . . 618 612 195 ALA CA C 52.147 . . 619 612 195 ALA N N 122.24 . . 620 613 196 ASP H H 9.026 . . 621 613 196 ASP C C 176.85 . . 622 613 196 ASP CA C 57.570 . . 623 613 196 ASP N N 120.94 . . 624 614 197 LYS H H 7.984 . . 625 614 197 LYS C C 173.09 . . 626 614 197 LYS CA C 53.486 . . 627 614 197 LYS N N 114.64 . . 628 615 198 ILE H H 9.223 . . 629 615 198 ILE C C 172.70 . . 630 615 198 ILE CA C 59.578 . . 631 615 198 ILE N N 120.04 . . 632 616 199 LEU H H 9.095 . . 633 616 199 LEU C C 174.33 . . 634 616 199 LEU CA C 52.950 . . 635 616 199 LEU N N 126.68 . . 636 617 200 ILE H H 9.570 . . 637 617 200 ILE C C 175.61 . . 638 617 200 ILE CA C 59.244 . . 639 617 200 ILE N N 124.79 . . 640 618 201 LEU H H 8.954 . . 641 618 201 LEU C C 176.35 . . 642 618 201 LEU CA C 52.683 . . 643 618 201 LEU N N 127.70 . . 644 619 202 HIS H H 9.237 . . 645 619 202 HIS C C 174.80 . . 646 619 202 HIS CA C 56.700 . . 647 619 202 HIS N N 119.04 . . 648 620 203 GLU H H 9.575 . . 649 620 203 GLU C C 176.06 . . 650 620 203 GLU CA C 56.833 . . 651 620 203 GLU N N 126.88 . . 652 621 204 GLY H H 7.886 . . 653 621 204 GLY C C 172.33 . . 654 621 204 GLY CA C 46.858 . . 655 621 204 GLY N N 105.28 . . 656 622 205 SER H H 7.981 . . 657 622 205 SER C C 173.38 . . 658 622 205 SER CA C 56.900 . . 659 622 205 SER N N 113.99 . . 660 623 206 SER H H 9.278 . . 661 623 206 SER C C 174.04 . . 662 623 206 SER CA C 57.217 . . 663 623 206 SER N N 116.38 . . 664 624 207 TYR H H 9.408 . . 665 624 207 TYR C C 175.48 . . 666 624 207 TYR CA C 59.110 . . 667 624 207 TYR N N 133.26 . . 668 625 208 PHE H H 7.896 . . 669 625 208 PHE C C 171.38 . . 670 625 208 PHE CA C 58.440 . . 671 625 208 PHE N N 116.70 . . 672 626 209 TYR H H 7.236 . . 673 626 209 TYR C C 173.51 . . 674 626 209 TYR CA C 54.959 . . 675 626 209 TYR N N 127.73 . . 676 627 210 GLY H H 7.982 . . 677 627 210 GLY C C 171.57 . . 678 627 210 GLY CA C 45.452 . . 679 627 210 GLY N N 115.67 . . 680 628 211 THR H H 8.888 . . 681 628 211 THR C C 175.32 . . 682 628 211 THR CA C 60.248 . . 683 628 211 THR N N 113.00 . . 684 629 212 PHE H H 9.439 . . 685 629 212 PHE C C 176.64 . . 686 629 212 PHE CA C 62.390 . . 687 629 212 PHE N N 121.91 . . 688 630 213 SER H H 8.626 . . 689 630 213 SER C C 177.01 . . 690 630 213 SER CA C 61.252 . . 691 630 213 SER N N 112.80 . . 692 631 214 GLU H H 7.443 . . 693 631 214 GLU C C 178.22 . . 694 631 214 GLU CA C 58.507 . . 695 631 214 GLU N N 121.13 . . 696 632 215 LEU H H 7.910 . . 697 632 215 LEU C C 177.53 . . 698 632 215 LEU CA C 57.465 . . 699 632 215 LEU N N 123.62 . . 700 633 216 GLN H H 7.673 . . 701 633 216 GLN C C 176.76 . . 702 633 216 GLN CA C 57.803 . . 703 633 216 GLN N N 114.58 . . 704 634 217 ASN H H 7.260 . . 705 634 217 ASN C C 175.83 . . 706 634 217 ASN CA C 54.360 . . 707 634 217 ASN N N 114.57 . . 708 635 218 LEU H H 7.825 . . 709 635 218 LEU C C 177.26 . . 710 635 218 LEU CA C 55.819 . . 711 635 218 LEU N N 119.74 . . 712 636 219 GLN H H 8.268 . . 713 636 219 GLN N N 117.58 . . 714 637 220 PRO C C 177.06 . . 715 637 220 PRO CA C 64.340 . . 716 638 221 ASP H H 8.363 . . 717 638 221 ASP C C 176.69 . . 718 638 221 ASP CA C 53.543 . . 719 638 221 ASP N N 117.22 . . 720 639 222 PHE H H 7.986 . . 721 639 222 PHE C C 175.49 . . 722 639 222 PHE CA C 59.788 . . 723 639 222 PHE N N 120.67 . . 724 640 223 SER H H 7.805 . . 725 640 223 SER C C 175.49 . . 726 640 223 SER CA C 59.846 . . 727 640 223 SER N N 116.50 . . 728 641 224 SER H H 8.032 . . 729 641 224 SER C C 175.37 . . 730 641 224 SER CA C 60.080 . . 731 641 224 SER N N 117.18 . . 732 642 225 LYS H H 7.789 . . 733 642 225 LYS C C 176.53 . . 734 642 225 LYS CA C 56.519 . . 735 642 225 LYS N N 121.06 . . 736 643 226 LEU H H 7.514 . . 737 643 226 LEU C C 176.47 . . 738 643 226 LEU CA C 55.012 . . 739 643 226 LEU N N 118.50 . . 740 644 227 MET H H 7.731 . . 741 644 227 MET C C 175.26 . . 742 644 227 MET CA C 55.060 . . 743 644 227 MET N N 117.11 . . 744 645 228 GLY H H 7.843 . . 745 645 228 GLY CA C 46.031 . . 746 645 228 GLY N N 115.09 . . stop_ save_