data_15065 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; 2-PGA-bound WT chicken Triosephosphate Isomerase (TIM) ; _BMRB_accession_number 15065 _BMRB_flat_file_name bmr15065.str _Entry_type original _Submission_date 2006-12-05 _Accession_date 2006-12-05 _Entry_origination author _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details '2-PGA-bound WT chicken Triosephosphate Isomerase (TIM)' loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Kempf James G . 2 Jung Ju-yeon . . 3 Ragain Christina . . 4 Sampson Nicole S . 5 Loria Pat . . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 1 heteronucl_NOE 2 T1_relaxation 2 T2_relaxation 2 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 218 "13C chemical shifts" 449 "15N chemical shifts" 218 "T1 relaxation values" 432 "T2 relaxation values" 431 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 2010-05-25 update BMRB 'update entity name' 2007-05-18 update author 'complete entry citation' 2007-02-23 original author 'original release' stop_ loop_ _Related_BMRB_accession_number _Relationship 15064 'apo WT cTIM' 15066 'apo PGG/GGG cTIM' 15067 '2-PGA-bound PGG/GGG cTIM' stop_ save_ ############################# # Citation for this entry # ############################# save_entry_citation _Saveframe_category entry_citation _Citation_full . _Citation_title 'Dynamic Requirements for a Functional Protein Hinge' _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID 17336327 loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Kempf James G. . 2 Jung Ju-yeon . . 3 Ragain Christina . . 4 Sampson Nicole S. . 5 Loria J. Patrick . stop_ _Journal_abbreviation 'J. Mol. Biol.' _Journal_volume 368 _Journal_issue 1 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 131 _Page_last 149 _Year 2007 _Details . loop_ _Keyword 'Enzyme catalysis' 'Loop motion' 'NMR spectroscopy' 'Protein dynamics' 'Protein hinge' 'Triosephosphate isomerase' stop_ save_ ################################## # Molecular system description # ################################## save_assembly _Saveframe_category molecular_system _Mol_system_name '2-PGA bound WT cTIM homodimer' _Enzyme_commission_number 5.3.1.1 loop_ _Mol_system_component_name _Mol_label 'WT cTIM chain 1' $triosephosphate_isomerase 'WT cTIM chain 2' $triosephosphate_isomerase 2-PGA $PGA stop_ _System_molecular_weight 53200 _System_physical_state native _System_oligomer_state ? _System_paramagnetic ? _System_thiol_state . _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_triosephosphate_isomerase _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common triosephosphate_isomerase _Molecular_mass 26620 _Mol_thiol_state 'all free' _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 248 _Mol_residue_sequence ; MAPRKFFVGGNWKMNGDKKS LGELIHTLNGAKLSADTEVV CGAPSIYLDFARQKLDAKIG VAAQNCYKVPKGAFTGEISP AMIKDIGAAWVILGHSERRH VFGESDELIGQKVAHALAEG LGVIACIGEKLDEREAGITE KVVFEQTKAIADNVKDWSKV VLAYEPVWAIGTGKTATPQQ AQEVHEKLRGWLKSHVSDAV AQSTRIIYGGSVTGGNCKEL ASQHDVDGFLVGGASLKPEF VDIINAKH ; loop_ _Residue_seq_code _Residue_label 1 MET 2 ALA 3 PRO 4 ARG 5 LYS 6 PHE 7 PHE 8 VAL 9 GLY 10 GLY 11 ASN 12 TRP 13 LYS 14 MET 15 ASN 16 GLY 17 ASP 18 LYS 19 LYS 20 SER 21 LEU 22 GLY 23 GLU 24 LEU 25 ILE 26 HIS 27 THR 28 LEU 29 ASN 30 GLY 31 ALA 32 LYS 33 LEU 34 SER 35 ALA 36 ASP 37 THR 38 GLU 39 VAL 40 VAL 41 CYS 42 GLY 43 ALA 44 PRO 45 SER 46 ILE 47 TYR 48 LEU 49 ASP 50 PHE 51 ALA 52 ARG 53 GLN 54 LYS 55 LEU 56 ASP 57 ALA 58 LYS 59 ILE 60 GLY 61 VAL 62 ALA 63 ALA 64 GLN 65 ASN 66 CYS 67 TYR 68 LYS 69 VAL 70 PRO 71 LYS 72 GLY 73 ALA 74 PHE 75 THR 76 GLY 77 GLU 78 ILE 79 SER 80 PRO 81 ALA 82 MET 83 ILE 84 LYS 85 ASP 86 ILE 87 GLY 88 ALA 89 ALA 90 TRP 91 VAL 92 ILE 93 LEU 94 GLY 95 HIS 96 SER 97 GLU 98 ARG 99 ARG 100 HIS 101 VAL 102 PHE 103 GLY 104 GLU 105 SER 106 ASP 107 GLU 108 LEU 109 ILE 110 GLY 111 GLN 112 LYS 113 VAL 114 ALA 115 HIS 116 ALA 117 LEU 118 ALA 119 GLU 120 GLY 121 LEU 122 GLY 123 VAL 124 ILE 125 ALA 126 CYS 127 ILE 128 GLY 129 GLU 130 LYS 131 LEU 132 ASP 133 GLU 134 ARG 135 GLU 136 ALA 137 GLY 138 ILE 139 THR 140 GLU 141 LYS 142 VAL 143 VAL 144 PHE 145 GLU 146 GLN 147 THR 148 LYS 149 ALA 150 ILE 151 ALA 152 ASP 153 ASN 154 VAL 155 LYS 156 ASP 157 TRP 158 SER 159 LYS 160 VAL 161 VAL 162 LEU 163 ALA 164 TYR 165 GLU 166 PRO 167 VAL 168 TRP 169 ALA 170 ILE 171 GLY 172 THR 173 GLY 174 LYS 175 THR 176 ALA 177 THR 178 PRO 179 GLN 180 GLN 181 ALA 182 GLN 183 GLU 184 VAL 185 HIS 186 GLU 187 LYS 188 LEU 189 ARG 190 GLY 191 TRP 192 LEU 193 LYS 194 SER 195 HIS 196 VAL 197 SER 198 ASP 199 ALA 200 VAL 201 ALA 202 GLN 203 SER 204 THR 205 ARG 206 ILE 207 ILE 208 TYR 209 GLY 210 GLY 211 SER 212 VAL 213 THR 214 GLY 215 GLY 216 ASN 217 CYS 218 LYS 219 GLU 220 LEU 221 ALA 222 SER 223 GLN 224 HIS 225 ASP 226 VAL 227 ASP 228 GLY 229 PHE 230 LEU 231 VAL 232 GLY 233 GLY 234 ALA 235 SER 236 LEU 237 LYS 238 PRO 239 GLU 240 PHE 241 VAL 242 ASP 243 ILE 244 ILE 245 ASN 246 ALA 247 LYS 248 HIS stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date 2015-10-07 loop_ _Database_name _Database_accession_code _Database_entry_mol_name _Sequence_query_to_submitted_percentage _Sequence_subject_length _Sequence_identity _Sequence_positive _Sequence_homology_expectation_value BMRB 15064 triosephosphate_isomerase 100.00 248 100.00 100.00 1.89e-179 BMRB 15066 PGG/GGG_mono 100.00 248 97.98 97.98 6.77e-174 BMRB 15067 PGG/GGG 100.00 248 97.98 97.98 6.77e-174 PDB 1SPQ "Understanding Protein Lids: Structural Analysis Of Active Hinge Mutants In Triosephosphate Isomerase" 99.60 247 99.60 99.60 8.85e-178 PDB 1SQ7 "Understanding Protein Lids: Structural Analysis Of Active Hinge Mutants In Triosephosphate Isomerase" 99.60 247 99.19 99.19 8.49e-176 PDB 1SSD "Understanding Protein Lids: Structural Analysis Of Active Hinge Mutants In Triosephosphate Isomerase" 99.60 247 98.79 99.19 3.86e-176 PDB 1SSG "Understanding Protein Lids: Structural Analysis Of Active Hinge Mutants In Triosephosphate Isomerase" 99.60 247 98.79 99.19 3.86e-176 PDB 1SU5 "Understanding Protein Lids: Structural Analysis Of Active Hinge Mutants In Triosephosphate Isomerase" 99.60 247 98.79 98.79 8.39e-176 PDB 1SW0 "Triosephosphate Isomerase From Gallus Gallus, Loop 6 Hinge Mutant K174l, T175w" 100.00 248 99.19 99.19 6.37e-177 PDB 1SW3 "Triosephosphate Isomerase From Gallus Gallus, Loop 6 Mutant T175v" 100.00 248 99.60 99.60 1.16e-178 PDB 1SW7 "Triosephosphate Isomerase From Gallus Gallus, Loop 6 Mutant K174n, T175s, A176s" 100.00 248 98.79 99.60 5.49e-178 PDB 1TPB "Offset Of A Catalytic Lesion By A Bound Water Soluble" 99.60 247 99.19 100.00 1.90e-177 PDB 1TPC "Offset Of A Catalytic Lesion By A Bound Water Soluble" 99.60 247 98.79 99.60 1.26e-176 PDB 1TPH "1.8 Angstroms Crystal Structure Of Wild Type Chicken Triosephosphate Isomerase-Phosphoglycolohydroxamate Complex" 99.60 247 99.60 100.00 5.07e-178 PDB 1TPU "S96p Change Is A Second-Site Suppressor For H95n Sluggish Mutant Triosephosphate Isomerase" 99.60 247 99.19 100.00 3.96e-177 PDB 1TPV "S96p Change Is A Second-Site Suppressor For H95n Sluggish Mutant Triosephosphate Isomerase" 99.60 247 98.79 99.60 2.78e-176 PDB 1TPW "Triosephosphate Isomerase Drinks Water To Keep Healthy" 99.60 247 99.19 99.60 3.59e-177 PDB 4P61 "Chicken Triosephosphate Isomerase With Loop6 Mutations, V167p And W168e" 100.00 248 99.19 99.19 6.51e-177 PDB 8TIM "Triose Phosphate Isomerase" 99.60 247 99.60 100.00 5.07e-178 EMBL CAE45562 "triosephosphate isomerase, partial [Anser anser]" 85.08 211 99.53 99.53 3.04e-148 EMBL CAE45563 "triosephosphate isomerase, partial [Meleagris gallopavo]" 85.08 211 99.53 99.53 6.61e-148 EMBL CAE45564 "triosephosphate isomerase, partial [Phasianus colchicus]" 85.08 211 99.53 99.53 2.56e-148 GB AAA49094 "TIM [Gallus gallus]" 100.00 248 100.00 100.00 1.89e-179 GB AAA49095 "triosephosphate isomerase (EC 5.3.1.1) [Gallus gallus]" 100.00 248 100.00 100.00 1.89e-179 GB ACH45461 "putative triosephosphate isomerase [Taeniopygia guttata]" 100.00 248 98.79 99.19 1.54e-177 GB ACH45462 "putative triosephosphate isomerase [Taeniopygia guttata]" 100.00 248 98.79 99.19 1.54e-177 GB ACH45463 "putative triosephosphate isomerase [Taeniopygia guttata]" 100.00 248 98.39 98.79 5.34e-177 REF NP_001232159 "putative triosephosphate isomerase [Taeniopygia guttata]" 87.10 216 98.15 99.07 4.70e-152 REF NP_990782 "triosephosphate isomerase [Gallus gallus]" 100.00 248 100.00 100.00 1.89e-179 REF XP_005016819 "PREDICTED: triosephosphate isomerase [Anas platyrhynchos]" 67.34 167 99.40 99.40 1.28e-113 REF XP_005235418 "PREDICTED: triosephosphate isomerase [Falco peregrinus]" 67.34 167 99.40 99.40 1.28e-113 REF XP_005434378 "PREDICTED: triosephosphate isomerase [Falco cherrug]" 67.34 167 99.40 99.40 1.28e-113 SP P00940 "RecName: Full=Triosephosphate isomerase; Short=TIM; AltName: Full=Triose-phosphate isomerase" 100.00 248 100.00 100.00 1.89e-179 stop_ save_ ############# # Ligands # ############# save_PGA _Saveframe_category ligand _Mol_type non-polymer _Name_common "PGA (2-PHOSPHOGLYCOLIC ACID)" _BMRB_code . _PDB_code PGA _Molecular_mass 156.031 _Mol_charge 0 _Mol_paramagnetic . _Mol_aromatic no _Details ; Information obtained from PDB's Chemical Component Dictionary at http://wwpdb-remediation.rutgers.edu/downloads.html Downloaded on Tue Oct 4 22:51:28 2011 ; loop_ _Atom_name _PDB_atom_name _Atom_type _Atom_chirality _Atom_charge _Atom_oxidation_number _Atom_unpaired_electrons P P P . 0 . ? O1P O1P O . 0 . ? O2P O2P O . 0 . ? O3P O3P O . 0 . ? O4P O4P O . 0 . ? C2 C2 C . 0 . ? C1 C1 C . 0 . ? O1 O1 O . 0 . ? O2 O2 O . 0 . ? HOP3 HOP3 H . 0 . ? HOP4 HOP4 H . 0 . ? H21 H21 H . 0 . ? H22 H22 H . 0 . ? HO2 HO2 H . 0 . ? stop_ loop_ _Bond_order _Bond_atom_one_atom_name _Bond_atom_two_atom_name _PDB_bond_atom_one_atom_name _PDB_bond_atom_two_atom_name SING P O1P ? ? DOUB P O2P ? ? SING P O3P ? ? SING P O4P ? ? SING O1P C2 ? ? SING O3P HOP3 ? ? SING O4P HOP4 ? ? SING C2 C1 ? ? SING C2 H21 ? ? SING C2 H22 ? ? DOUB C1 O1 ? ? SING C1 O2 ? ? SING O2 HO2 ? ? stop_ _Mol_thiol_state . _Sequence_homology_query_date . save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species $triosephosphate_isomerase chicken 9031 Eukaryota Metazoa Gallus gallus stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $triosephosphate_isomerase 'recombinant technology' . Escherichia coli . pET15b/cTIM stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_2H_15N_sample _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $triosephosphate_isomerase 0.9 mM '[U-99% 15N; U-99%2H]' D2O 7.5 % 'natural abundance' 'sodium azide' 0.02 % 'natural abundance' 'sodium chloride' 10 mM 'natural abundance' MES 10 mM [U-2H] $PGA 2 mM 'natural abundance' stop_ save_ save_2H_13C_15N_sample _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $triosephosphate_isomerase 0.9 mM '[U-99% 13C; U-99% 15N; 70% 2H]' D2O 7.5 % 'natural abundance' 'sodium azide' 0.02 % 'natural abundance' 'sodium chloride' 10 mM 'natural abundance' MES 10 mM [U-2H] $PGA 2 mM 'natural abundance' stop_ save_ ############################ # Computer software used # ############################ save_SPARKY _Saveframe_category software _Name SPARKY _Version . loop_ _Vendor _Address _Electronic_address Goddard . . stop_ loop_ _Task 'data analysis' stop_ _Details . save_ save_PISTACHIO _Saveframe_category software _Name PISTACHIO _Version . loop_ _Vendor _Address _Electronic_address Eghbalnia . . stop_ loop_ _Task 'chemical shift assignment' stop_ _Details . save_ save_NMRPipe _Saveframe_category software _Name NMRPipe _Version . loop_ _Vendor _Address _Electronic_address 'Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax' . . stop_ loop_ _Task processing stop_ _Details . save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_1 _Saveframe_category NMR_spectrometer _Manufacturer Varian _Model INOVA _Field_strength 600 _Details . save_ save_spectrometer_2 _Saveframe_category NMR_spectrometer _Manufacturer Varian _Model INOVA _Field_strength 800 _Details . save_ save_spectrometer_3 _Saveframe_category NMR_spectrometer _Manufacturer Bruker _Model Avance _Field_strength 800 _Details . save_ ############################# # NMR applied experiments # ############################# save_3D_HNCA_1 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCA' _Sample_label $2H_13C_15N_sample save_ save_3D_HN(CO)CA_2 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HN(CO)CA' _Sample_label $2H_13C_15N_sample save_ save_3D_HNCACB_3 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCACB' _Sample_label $2H_13C_15N_sample save_ save_3D_HN(CO)CACB_4 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HN(CO)CACB' _Sample_label $2H_13C_15N_sample save_ save_3D_HN(CA)CO_5 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HN(CA)CO' _Sample_label $2H_13C_15N_sample save_ save_3D_HNCO_6 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCO' _Sample_label $2H_13C_15N_sample save_ save_1H-15N_ssNOE_7 _Saveframe_category NMR_applied_experiment _Experiment_name '1H-15N ssNOE' _Sample_label $2H_15N_sample save_ save_1H-15N_T1_8 _Saveframe_category NMR_applied_experiment _Experiment_name '1H-15N T1' _Sample_label $2H_15N_sample save_ save_1H-15N_T2_9 _Saveframe_category NMR_applied_experiment _Experiment_name '1H-15N T2' _Sample_label $2H_15N_sample save_ ####################### # Sample conditions # ####################### save_standard_conditions _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units 'ionic strength' . . M pH 6.5 . pH pressure 1 . atm temperature 293 . K stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chemical_shift_reference_1 _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis _Indirect_shift_ratio water C 13 protons ppm 4.821 internal indirect . . . 0.25144952 water H 1 protons ppm 4.821 internal direct . . . 1.0 water N 15 protons ppm 4.821 internal indirect . . . 0.10132905 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_assigned_chem_shift_list_1 _Saveframe_category assigned_chemical_shifts _Details . loop_ _Experiment_label '3D HNCA' '3D HN(CO)CA' '3D HNCACB' '3D HN(CO)CACB' '3D HN(CA)CO' '3D HNCO' stop_ loop_ _Sample_label $2H_13C_15N_sample stop_ _Sample_conditions_label $standard_conditions _Chem_shift_reference_set_label $chemical_shift_reference_1 _Mol_system_component_name 'WT cTIM chain 1' _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 3 3 PRO C C 176.62 0.10 1 2 3 3 PRO CB C 31.36 0.10 1 3 4 4 ARG H H 8.424 0.010 1 4 4 4 ARG C C 175.90 0.10 1 5 4 4 ARG CB C 31.36 0.10 1 6 4 4 ARG N N 122.24 0.10 1 7 5 5 LYS H H 8.975 0.010 1 8 5 5 LYS C C 175.27 0.10 1 9 5 5 LYS CB C 32.05 0.10 1 10 5 5 LYS N N 128.63 0.10 1 11 6 6 PHE H H 8.473 0.010 1 12 6 6 PHE C C 173.68 0.10 1 13 6 6 PHE CB C 39.70 0.10 1 14 6 6 PHE N N 131.95 0.10 1 15 7 7 PHE H H 8.259 0.010 1 16 7 7 PHE C C 173.78 0.10 1 17 7 7 PHE CB C 41.14 0.10 1 18 7 7 PHE N N 130.31 0.10 1 19 8 8 VAL H H 8.504 0.010 1 20 8 8 VAL C C 173.03 0.10 1 21 8 8 VAL CB C 34.35 0.10 1 22 8 8 VAL N N 126.88 0.10 1 23 9 9 GLY H H 9.143 0.010 1 24 9 9 GLY C C 173.20 0.10 1 25 9 9 GLY CA C 42.05 0.10 1 26 9 9 GLY N N 112.34 0.10 1 27 10 10 GLY H H 9.275 0.010 1 28 10 10 GLY C C 171.35 0.10 1 29 10 10 GLY CA C 44.94 0.10 1 30 10 10 GLY N N 112.96 0.10 1 31 11 11 ASN H H 9.408 0.010 1 32 11 11 ASN C C 173.69 0.10 1 33 11 11 ASN CB C 37.51 0.10 1 34 11 11 ASN N N 123.85 0.10 1 35 12 12 TRP H H 7.781 0.010 1 36 12 12 TRP C C 174.41 0.10 1 37 12 12 TRP CB C 29.20 0.10 1 38 12 12 TRP N N 124.87 0.10 1 39 13 13 LYS H H 8.002 0.010 1 40 13 13 LYS C C 174.08 0.10 1 41 13 13 LYS CB C 30.13 0.10 1 42 13 13 LYS N N 115.45 0.10 1 43 14 14 MET H H 7.479 0.010 1 44 14 14 MET C C 173.20 0.10 1 45 14 14 MET CB C 31.78 0.10 1 46 14 14 MET N N 125.23 0.10 1 47 15 15 ASN H H 7.133 0.010 1 48 15 15 ASN C C 172.23 0.10 1 49 15 15 ASN CB C 44.17 0.10 1 50 15 15 ASN N N 118.64 0.10 1 51 16 16 GLY H H 8.173 0.010 1 52 16 16 GLY C C 171.52 0.10 1 53 16 16 GLY CA C 42.95 0.10 1 54 16 16 GLY N N 104.70 0.10 1 55 17 17 ASP H H 7.060 0.010 1 56 17 17 ASP C C 175.43 0.10 1 57 17 17 ASP CB C 42.08 0.10 1 58 17 17 ASP N N 114.85 0.10 1 59 18 18 LYS H H 9.527 0.010 1 60 18 18 LYS C C 180.14 0.10 1 61 18 18 LYS CB C 31.03 0.10 1 62 18 18 LYS N N 120.97 0.10 1 63 19 19 LYS H H 8.351 0.010 1 64 19 19 LYS C C 179.35 0.10 1 65 19 19 LYS CB C 31.14 0.10 1 66 19 19 LYS N N 121.06 0.10 1 67 20 20 SER H H 8.992 0.010 1 68 20 20 SER C C 178.99 0.10 1 69 20 20 SER CB C 62.21 0.10 1 70 20 20 SER N N 118.82 0.10 1 71 21 21 LEU H H 9.208 0.010 1 72 21 21 LEU C C 179.41 0.10 1 73 21 21 LEU CB C 39.57 0.10 1 74 21 21 LEU N N 125.53 0.10 1 75 22 22 GLY H H 8.256 0.010 1 76 22 22 GLY C C 176.37 0.10 1 77 22 22 GLY CA C 46.82 0.10 1 78 22 22 GLY N N 108.52 0.10 1 79 23 23 GLU H H 7.527 0.010 1 80 23 23 GLU C C 178.56 0.10 1 81 23 23 GLU CB C 28.55 0.10 1 82 23 23 GLU N N 122.50 0.10 1 83 24 24 LEU H H 7.511 0.010 1 84 24 24 LEU C C 179.27 0.10 1 85 24 24 LEU CB C 41.35 0.10 1 86 24 24 LEU N N 123.79 0.10 1 87 25 25 ILE H H 8.779 0.010 1 88 25 25 ILE C C 176.74 0.10 1 89 25 25 ILE CB C 37.45 0.10 1 90 25 25 ILE N N 120.66 0.10 1 91 26 26 HIS H H 8.154 0.010 1 92 26 26 HIS C C 179.06 0.10 1 93 26 26 HIS CB C 29.24 0.10 1 94 26 26 HIS N N 119.76 0.10 1 95 27 27 THR H H 8.021 0.010 1 96 27 27 THR C C 176.72 0.10 1 97 27 27 THR CB C 67.97 0.10 1 98 27 27 THR N N 117.62 0.10 1 99 28 28 LEU H H 8.113 0.010 1 100 28 28 LEU C C 178.45 0.10 1 101 28 28 LEU CB C 40.70 0.10 1 102 28 28 LEU N N 123.08 0.10 1 103 29 29 ASN H H 8.812 0.010 1 104 29 29 ASN C C 178.02 0.10 1 105 29 29 ASN CB C 37.31 0.10 1 106 29 29 ASN N N 117.42 0.10 1 107 30 30 GLY H H 7.396 0.010 1 108 30 30 GLY C C 173.85 0.10 1 109 30 30 GLY CA C 43.54 0.10 1 110 30 30 GLY N N 105.14 0.10 1 111 31 31 ALA H H 7.152 0.010 1 112 31 31 ALA C C 176.72 0.10 1 113 31 31 ALA CB C 20.45 0.10 1 114 31 31 ALA N N 124.53 0.10 1 115 32 32 LYS H H 8.522 0.010 1 116 32 32 LYS C C 175.12 0.10 1 117 32 32 LYS CB C 29.57 0.10 1 118 32 32 LYS N N 122.59 0.10 1 119 33 33 LEU H H 8.185 0.010 1 120 33 33 LEU C C 177.40 0.10 1 121 33 33 LEU CB C 41.13 0.10 1 122 33 33 LEU N N 126.13 0.10 1 123 34 34 SER H H 8.684 0.010 1 124 34 34 SER C C 176.16 0.10 1 125 34 34 SER CB C 63.89 0.10 1 126 34 34 SER N N 119.23 0.10 1 127 35 35 ALA H H 8.830 0.010 1 128 35 35 ALA C C 177.76 0.10 1 129 35 35 ALA CB C 18.39 0.10 1 130 35 35 ALA N N 130.30 0.10 1 131 36 36 ASP H H 8.028 0.010 1 132 36 36 ASP C C 174.68 0.10 1 133 36 36 ASP CB C 40.37 0.10 1 134 36 36 ASP N N 115.33 0.10 1 135 37 37 THR H H 7.246 0.010 1 136 37 37 THR C C 172.95 0.10 1 137 37 37 THR CB C 70.10 0.10 1 138 37 37 THR N N 115.72 0.10 1 139 38 38 GLU H H 9.627 0.010 1 140 38 38 GLU C C 172.42 0.10 1 141 38 38 GLU CB C 30.34 0.10 1 142 38 38 GLU N N 133.27 0.10 1 143 39 39 VAL H H 8.605 0.010 1 144 39 39 VAL C C 176.03 0.10 1 145 39 39 VAL CB C 32.86 0.10 1 146 39 39 VAL N N 126.97 0.10 1 147 40 40 VAL H H 8.069 0.010 1 148 40 40 VAL C C 172.87 0.10 1 149 40 40 VAL CB C 35.35 0.10 1 150 40 40 VAL N N 126.00 0.10 1 151 41 41 CYS H H 8.181 0.010 1 152 41 41 CYS C C 173.22 0.10 1 153 41 41 CYS CB C 30.16 0.10 1 154 41 41 CYS N N 123.27 0.10 1 155 42 42 GLY H H 9.239 0.010 1 156 42 42 GLY C C 172.61 0.10 1 157 42 42 GLY CA C 42.11 0.10 1 158 42 42 GLY N N 112.27 0.10 1 159 43 43 ALA H H 7.110 0.010 1 160 43 43 ALA CB C 18.64 0.10 1 161 43 43 ALA N N 129.55 0.10 1 162 45 45 SER C C 176.10 0.10 1 163 46 46 ILE H H 5.974 0.010 1 164 46 46 ILE C C 174.06 0.10 1 165 46 46 ILE CB C 39.91 0.10 1 166 46 46 ILE N N 119.09 0.10 1 167 47 47 TYR H H 7.772 0.010 1 168 47 47 TYR C C 174.55 0.10 1 169 47 47 TYR CB C 39.91 0.10 1 170 47 47 TYR N N 118.64 0.10 1 171 48 48 LEU H H 7.205 0.010 1 172 48 48 LEU C C 176.60 0.10 1 173 48 48 LEU CB C 42.04 0.10 1 174 48 48 LEU N N 124.10 0.10 1 175 49 49 ASP H H 9.116 0.010 1 176 49 49 ASP C C 177.01 0.10 1 177 49 49 ASP CB C 40.54 0.10 1 178 49 49 ASP N N 119.47 0.10 1 179 50 50 PHE H H 8.651 0.010 1 180 50 50 PHE C C 176.26 0.10 1 181 50 50 PHE CB C 39.51 0.10 1 182 50 50 PHE N N 120.38 0.10 1 183 51 51 ALA H H 9.173 0.010 1 184 51 51 ALA C C 178.87 0.10 1 185 51 51 ALA CB C 16.73 0.10 1 186 51 51 ALA N N 119.17 0.10 1 187 52 52 ARG H H 8.551 0.010 1 188 52 52 ARG C C 179.16 0.10 1 189 52 52 ARG CB C 31.53 0.10 1 190 52 52 ARG N N 118.09 0.10 1 191 53 53 GLN H H 8.522 0.010 1 192 53 53 GLN C C 178.46 0.10 1 193 53 53 GLN CB C 28.45 0.10 1 194 53 53 GLN N N 119.07 0.10 1 195 54 54 LYS H H 7.595 0.010 1 196 54 54 LYS C C 178.60 0.10 1 197 54 54 LYS CB C 32.54 0.10 1 198 54 54 LYS N N 115.99 0.10 1 199 55 55 LEU H H 8.443 0.010 1 200 55 55 LEU C C 176.96 0.10 1 201 55 55 LEU CB C 42.30 0.10 1 202 55 55 LEU N N 123.80 0.10 1 203 56 56 ASP H H 8.969 0.010 1 204 56 56 ASP C C 176.95 0.10 1 205 56 56 ASP CB C 42.52 0.10 1 206 56 56 ASP N N 124.96 0.10 1 207 57 57 ALA H H 8.522 0.010 1 208 57 57 ALA C C 178.36 0.10 1 209 57 57 ALA CB C 18.44 0.10 1 210 57 57 ALA N N 128.17 0.10 1 211 58 58 LYS H H 8.930 0.010 1 212 58 58 LYS C C 176.09 0.10 1 213 58 58 LYS CB C 30.79 0.10 1 214 58 58 LYS N N 116.99 0.10 1 215 59 59 ILE H H 8.388 0.010 1 216 59 59 ILE C C 175.58 0.10 1 217 59 59 ILE CB C 37.89 0.10 1 218 59 59 ILE N N 123.86 0.10 1 219 60 60 GLY H H 8.912 0.010 1 220 60 60 GLY C C 171.77 0.10 1 221 60 60 GLY CA C 44.80 0.10 1 222 60 60 GLY N N 114.70 0.10 1 223 61 61 VAL H H 8.468 0.010 1 224 61 61 VAL C C 173.30 0.10 1 225 61 61 VAL CB C 34.47 0.10 1 226 61 61 VAL N N 120.66 0.10 1 227 62 62 ALA H H 8.604 0.010 1 228 62 62 ALA C C 176.27 0.10 1 229 62 62 ALA CB C 21.76 0.10 1 230 62 62 ALA N N 127.68 0.10 1 231 63 63 ALA H H 8.206 0.010 1 232 63 63 ALA C C 177.80 0.10 1 233 63 63 ALA CB C 21.10 0.10 1 234 63 63 ALA N N 120.36 0.10 1 235 64 64 GLN H H 10.05 0.010 1 236 64 64 GLN C C 172.23 0.10 1 237 64 64 GLN CB C 28.12 0.10 1 238 64 64 GLN N N 120.25 0.10 1 239 65 65 ASN H H 6.966 0.010 1 240 65 65 ASN C C 173.26 0.10 1 241 65 65 ASN CB C 38.18 0.10 1 242 65 65 ASN N N 105.90 0.10 1 243 66 66 CYS H H 7.575 0.010 1 244 66 66 CYS C C 171.58 0.10 1 245 66 66 CYS CB C 30.35 0.10 1 246 66 66 CYS N N 113.78 0.10 1 247 67 67 TYR H H 8.846 0.010 1 248 67 67 TYR N N 117.34 0.10 1 249 70 70 PRO C C 178.75 0.10 1 250 71 71 LYS H H 7.256 0.010 1 251 71 71 LYS C C 174.47 0.10 1 252 71 71 LYS CB C 33.26 0.10 1 253 71 71 LYS N N 111.35 0.10 1 254 72 72 GLY H H 8.267 0.010 1 255 72 72 GLY C C 172.81 0.10 1 256 72 72 GLY CA C 43.45 0.10 1 257 72 72 GLY N N 105.80 0.10 1 258 73 73 ALA H H 8.299 0.010 1 259 73 73 ALA C C 173.32 0.10 1 260 73 73 ALA CB C 14.86 0.10 1 261 73 73 ALA N N 128.29 0.10 1 262 74 74 PHE H H 7.131 0.010 1 263 74 74 PHE C C 173.72 0.10 1 264 74 74 PHE CB C 38.98 0.10 1 265 74 74 PHE N N 120.45 0.10 1 266 75 75 THR H H 9.173 0.010 1 267 75 75 THR C C 174.73 0.10 1 268 75 75 THR CB C 69.38 0.10 1 269 75 75 THR N N 121.13 0.10 1 270 76 76 GLY H H 9.060 0.010 1 271 76 76 GLY C C 174.50 0.10 1 272 76 76 GLY CA C 44.80 0.10 1 273 76 76 GLY N N 112.25 0.10 1 274 77 77 GLU H H 8.016 0.010 1 275 77 77 GLU C C 175.81 0.10 1 276 77 77 GLU CB C 32.66 0.10 1 277 77 77 GLU N N 122.42 0.10 1 278 78 78 ILE H H 8.816 0.010 1 279 78 78 ILE C C 173.77 0.10 1 280 78 78 ILE CB C 42.24 0.10 1 281 78 78 ILE N N 113.03 0.10 1 282 79 79 SER H H 7.632 0.010 1 283 79 79 SER CB C 65.74 0.10 1 284 79 79 SER N N 115.46 0.10 1 285 80 80 PRO C C 176.46 0.10 1 286 81 81 ALA H H 8.971 0.010 1 287 81 81 ALA C C 180.54 0.10 1 288 81 81 ALA CB C 17.74 0.10 1 289 81 81 ALA N N 120.30 0.10 1 290 82 82 MET H H 7.516 0.010 1 291 82 82 MET CB C 32.24 0.10 1 292 82 82 MET N N 119.65 0.10 1 293 83 83 ILE C C 177.66 0.10 1 294 83 83 ILE CB C 37.91 0.10 1 295 84 84 LYS H H 8.549 0.010 1 296 84 84 LYS C C 180.73 0.10 1 297 84 84 LYS CB C 32.10 0.10 1 298 84 84 LYS N N 118.41 0.10 1 299 85 85 ASP H H 7.725 0.010 1 300 85 85 ASP CB C 41.52 0.10 1 301 85 85 ASP N N 122.07 0.10 1 302 86 86 ILE C C 175.88 0.10 1 303 86 86 ILE CB C 37.84 0.10 1 304 87 87 GLY H H 7.825 0.010 1 305 87 87 GLY C C 175.36 0.10 1 306 87 87 GLY CA C 44.51 0.10 1 307 87 87 GLY N N 106.64 0.10 1 308 88 88 ALA H H 7.616 0.010 1 309 88 88 ALA C C 175.40 0.10 1 310 88 88 ALA CB C 19.43 0.10 1 311 88 88 ALA N N 125.51 0.10 1 312 89 89 ALA H H 7.745 0.010 1 313 89 89 ALA C C 176.17 0.10 1 314 89 89 ALA CB C 21.80 0.10 1 315 89 89 ALA N N 121.49 0.10 1 316 90 90 TRP H H 7.677 0.010 1 317 90 90 TRP C C 174.99 0.10 1 318 90 90 TRP CB C 35.87 0.10 1 319 90 90 TRP N N 118.44 0.10 1 320 91 91 VAL H H 8.711 0.010 1 321 91 91 VAL C C 171.96 0.10 1 322 91 91 VAL CB C 34.61 0.10 1 323 91 91 VAL N N 118.29 0.10 1 324 92 92 ILE H H 8.075 0.010 1 325 92 92 ILE C C 174.44 0.10 1 326 92 92 ILE CB C 38.59 0.10 1 327 92 92 ILE N N 129.22 0.10 1 328 93 93 LEU H H 9.173 0.010 1 329 93 93 LEU C C 176.42 0.10 1 330 93 93 LEU CB C 46.72 0.10 1 331 93 93 LEU N N 125.48 0.10 1 332 94 94 GLY H H 9.129 0.010 1 333 94 94 GLY C C 172.67 0.10 1 334 94 94 GLY CA C 45.16 0.10 1 335 94 94 GLY N N 107.01 0.10 1 336 95 95 HIS H H 7.464 0.010 1 337 95 95 HIS CB C 31.74 0.10 1 338 95 95 HIS N N 118.20 0.10 1 339 96 96 SER C C 177.35 0.10 1 340 97 97 GLU H H 11.37 0.010 1 341 97 97 GLU C C 181.19 0.10 1 342 97 97 GLU CB C 27.55 0.10 1 343 97 97 GLU N N 121.78 0.10 1 344 98 98 ARG H H 7.768 0.010 1 345 98 98 ARG C C 178.48 0.10 1 346 98 98 ARG CB C 25.74 0.10 1 347 98 98 ARG N N 115.39 0.10 1 348 99 99 ARG H H 7.826 0.010 1 349 99 99 ARG C C 178.86 0.10 1 350 99 99 ARG CB C 29.48 0.10 1 351 99 99 ARG N N 117.85 0.10 1 352 100 100 HIS H H 8.766 0.010 1 353 100 100 HIS C C 177.14 0.10 1 354 100 100 HIS CB C 30.30 0.10 1 355 100 100 HIS N N 114.03 0.10 1 356 101 101 VAL H H 7.679 0.010 1 357 101 101 VAL C C 177.60 0.10 1 358 101 101 VAL CB C 30.52 0.10 1 359 101 101 VAL N N 119.63 0.10 1 360 102 102 PHE H H 6.630 0.010 1 361 102 102 PHE C C 176.07 0.10 1 362 102 102 PHE CB C 38.81 0.10 1 363 102 102 PHE N N 114.22 0.10 1 364 103 103 GLY H H 6.766 0.010 1 365 103 103 GLY C C 175.29 0.10 1 366 103 103 GLY CA C 46.89 0.10 1 367 103 103 GLY N N 108.47 0.10 1 368 104 104 GLU H H 8.198 0.010 1 369 104 104 GLU C C 175.77 0.10 1 370 104 104 GLU CB C 27.99 0.10 1 371 104 104 GLU N N 121.66 0.10 1 372 105 105 SER H H 8.173 0.010 1 373 105 105 SER C C 174.43 0.10 1 374 105 105 SER CB C 65.50 0.10 1 375 105 105 SER N N 120.49 0.10 1 376 106 106 ASP H H 8.651 0.010 1 377 106 106 ASP C C 178.12 0.10 1 378 106 106 ASP CB C 41.01 0.10 1 379 106 106 ASP N N 120.36 0.10 1 380 107 107 GLU H H 8.330 0.010 1 381 107 107 GLU C C 178.69 0.10 1 382 107 107 GLU CB C 29.07 0.10 1 383 107 107 GLU N N 119.37 0.10 1 384 108 108 LEU H H 7.801 0.010 1 385 108 108 LEU C C 178.88 0.10 1 386 108 108 LEU CB C 40.02 0.10 1 387 108 108 LEU N N 122.77 0.10 1 388 109 109 ILE H H 8.734 0.010 1 389 109 109 ILE C C 178.07 0.10 1 390 109 109 ILE CB C 37.01 0.10 1 391 109 109 ILE N N 120.62 0.10 1 392 110 110 GLY H H 8.551 0.010 1 393 110 110 GLY C C 175.05 0.10 1 394 110 110 GLY CA C 47.56 0.10 1 395 110 110 GLY N N 107.09 0.10 1 396 111 111 GLN H H 7.557 0.010 1 397 111 111 GLN C C 180.75 0.10 1 398 111 111 GLN CB C 27.44 0.10 1 399 111 111 GLN N N 119.68 0.10 1 400 112 112 LYS H H 8.494 0.010 1 401 112 112 LYS C C 177.13 0.10 1 402 112 112 LYS CB C 33.26 0.10 1 403 112 112 LYS N N 121.80 0.10 1 404 113 113 VAL H H 8.579 0.010 1 405 113 113 VAL C C 176.82 0.10 1 406 113 113 VAL CB C 30.90 0.10 1 407 113 113 VAL N N 120.86 0.10 1 408 114 114 ALA H H 7.867 0.010 1 409 114 114 ALA C C 181.04 0.10 1 410 114 114 ALA CB C 18.44 0.10 1 411 114 114 ALA N N 118.62 0.10 1 412 115 115 HIS H H 7.629 0.010 1 413 115 115 HIS C C 175.93 0.10 1 414 115 115 HIS CB C 28.66 0.10 1 415 115 115 HIS N N 117.36 0.10 1 416 116 116 ALA H H 8.654 0.010 1 417 116 116 ALA C C 179.38 0.10 1 418 116 116 ALA CB C 17.07 0.10 1 419 116 116 ALA N N 120.48 0.10 1 420 117 117 LEU H H 8.017 0.010 1 421 117 117 LEU C C 182.53 0.10 1 422 117 117 LEU CB C 41.05 0.10 1 423 117 117 LEU N N 115.06 0.10 1 424 118 118 ALA H H 7.884 0.010 1 425 118 118 ALA C C 179.92 0.10 1 426 118 118 ALA CB C 17.66 0.10 1 427 118 118 ALA N N 125.42 0.10 1 428 119 119 GLU H H 7.376 0.010 1 429 119 119 GLU C C 176.08 0.10 1 430 119 119 GLU CB C 30.33 0.10 1 431 119 119 GLU N N 116.20 0.10 1 432 120 120 GLY H H 7.474 0.010 1 433 120 120 GLY C C 175.24 0.10 1 434 120 120 GLY CA C 44.91 0.10 1 435 120 120 GLY N N 105.71 0.10 1 436 121 121 LEU H H 7.642 0.010 1 437 121 121 LEU C C 176.36 0.10 1 438 121 121 LEU CB C 42.02 0.10 1 439 121 121 LEU N N 120.88 0.10 1 440 122 122 GLY H H 7.698 0.010 1 441 122 122 GLY C C 173.80 0.10 1 442 122 122 GLY CA C 44.46 0.10 1 443 122 122 GLY N N 106.61 0.10 1 444 123 123 VAL H H 8.713 0.010 1 445 123 123 VAL C C 174.44 0.10 1 446 123 123 VAL CB C 36.42 0.10 1 447 123 123 VAL N N 121.30 0.10 1 448 124 124 ILE H H 8.591 0.010 1 449 124 124 ILE C C 173.71 0.10 1 450 124 124 ILE CB C 38.25 0.10 1 451 124 124 ILE N N 128.24 0.10 1 452 125 125 ALA H H 8.963 0.010 1 453 125 125 ALA CB C 19.46 0.10 1 454 125 125 ALA N N 130.81 0.10 1 455 126 126 CYS C C 172.48 0.10 1 456 126 126 CYS CB C 28.46 0.10 1 457 127 127 ILE H H 8.546 0.010 1 458 127 127 ILE C C 175.85 0.10 1 459 127 127 ILE CB C 40.30 0.10 1 460 127 127 ILE N N 124.25 0.10 1 461 128 128 GLY H H 9.738 0.010 1 462 128 128 GLY C C 171.54 0.10 1 463 128 128 GLY CA C 46.32 0.10 1 464 128 128 GLY N N 109.14 0.10 1 465 129 129 GLU H H 9.967 0.010 1 466 129 129 GLU C C 174.80 0.10 1 467 129 129 GLU CB C 29.17 0.10 1 468 129 129 GLU N N 128.86 0.10 1 469 130 130 LYS H H 9.573 0.010 1 470 130 130 LYS C C 178.69 0.10 1 471 130 130 LYS CB C 33.86 0.10 1 472 130 130 LYS N N 121.54 0.10 1 473 131 131 LEU H H 9.744 0.010 1 474 131 131 LEU C C 177.88 0.10 1 475 131 131 LEU CB C 40.79 0.10 1 476 131 131 LEU N N 124.58 0.10 1 477 132 132 ASP H H 8.742 0.010 1 478 132 132 ASP C C 179.01 0.10 1 479 132 132 ASP CB C 38.46 0.10 1 480 132 132 ASP N N 114.92 0.10 1 481 133 133 GLU H H 6.873 0.010 1 482 133 133 GLU CB C 29.36 0.10 1 483 133 133 GLU N N 122.49 0.10 1 484 134 134 ARG C C 181.37 0.10 1 485 135 135 GLU H H 8.887 0.010 1 486 135 135 GLU C C 177.71 0.10 1 487 135 135 GLU CB C 28.57 0.10 1 488 135 135 GLU N N 121.12 0.10 1 489 136 136 ALA H H 7.446 0.010 1 490 136 136 ALA C C 177.71 0.10 1 491 136 136 ALA CB C 18.89 0.10 1 492 136 136 ALA N N 119.47 0.10 1 493 137 137 GLY H H 7.768 0.010 1 494 137 137 GLY C C 176.62 0.10 1 495 137 137 GLY CA C 45.59 0.10 1 496 137 137 GLY N N 106.36 0.10 1 497 138 138 ILE H H 7.713 0.010 1 498 138 138 ILE C C 174.37 0.10 1 499 138 138 ILE CB C 37.29 0.10 1 500 138 138 ILE N N 112.03 0.10 1 501 139 139 THR H H 7.453 0.010 1 502 139 139 THR C C 174.88 0.10 1 503 139 139 THR N N 118.53 0.10 1 504 140 140 GLU H H 8.489 0.010 1 505 140 140 GLU C C 175.55 0.10 1 506 140 140 GLU CB C 28.19 0.10 1 507 140 140 GLU N N 117.60 0.10 1 508 141 141 LYS H H 7.064 0.010 1 509 141 141 LYS C C 179.48 0.10 1 510 141 141 LYS CB C 31.76 0.10 1 511 141 141 LYS N N 118.21 0.10 1 512 142 142 VAL H H 7.827 0.010 1 513 142 142 VAL C C 178.86 0.10 1 514 142 142 VAL CB C 31.66 0.10 1 515 142 142 VAL N N 118.36 0.10 1 516 143 143 VAL H H 8.527 0.010 1 517 143 143 VAL C C 180.45 0.10 1 518 143 143 VAL CB C 30.76 0.10 1 519 143 143 VAL N N 114.41 0.10 1 520 144 144 PHE H H 8.875 0.010 1 521 144 144 PHE C C 177.98 0.10 1 522 144 144 PHE CB C 35.10 0.10 1 523 144 144 PHE N N 124.24 0.10 1 524 145 145 GLU H H 7.934 0.010 1 525 145 145 GLU C C 180.04 0.10 1 526 145 145 GLU CB C 28.36 0.10 1 527 145 145 GLU N N 122.79 0.10 1 528 146 146 GLN H H 8.112 0.010 1 529 146 146 GLN C C 180.08 0.10 1 530 146 146 GLN CB C 28.50 0.10 1 531 146 146 GLN N N 119.60 0.10 1 532 147 147 THR H H 8.079 0.010 1 533 147 147 THR C C 175.51 0.10 1 534 147 147 THR CB C 66.61 0.10 1 535 147 147 THR N N 118.13 0.10 1 536 148 148 LYS H H 8.086 0.010 1 537 148 148 LYS C C 176.76 0.10 1 538 148 148 LYS CB C 31.53 0.10 1 539 148 148 LYS N N 124.37 0.10 1 540 149 149 ALA H H 7.095 0.010 1 541 149 149 ALA C C 179.80 0.10 1 542 149 149 ALA CB C 17.81 0.10 1 543 149 149 ALA N N 118.40 0.10 1 544 150 150 ILE H H 6.939 0.010 1 545 150 150 ILE C C 177.08 0.10 1 546 150 150 ILE CB C 38.15 0.10 1 547 150 150 ILE N N 117.38 0.10 1 548 151 151 ALA H H 9.466 0.010 1 549 151 151 ALA C C 180.14 0.10 1 550 151 151 ALA CB C 19.57 0.10 1 551 151 151 ALA N N 122.55 0.10 1 552 152 152 ASP H H 8.760 0.010 1 553 152 152 ASP C C 176.47 0.10 1 554 152 152 ASP CB C 39.98 0.10 1 555 152 152 ASP N N 117.75 0.10 1 556 153 153 ASN H H 8.195 0.010 1 557 153 153 ASN C C 172.95 0.10 1 558 153 153 ASN CB C 42.03 0.10 1 559 153 153 ASN N N 117.75 0.10 1 560 154 154 VAL H H 7.289 0.010 1 561 154 154 VAL C C 175.31 0.10 1 562 154 154 VAL CB C 33.46 0.10 1 563 154 154 VAL N N 121.31 0.10 1 564 155 155 LYS H H 7.970 0.010 1 565 155 155 LYS C C 175.96 0.10 1 566 155 155 LYS CB C 32.07 0.10 1 567 155 155 LYS N N 125.77 0.10 1 568 156 156 ASP H H 7.386 0.010 1 569 156 156 ASP C C 175.62 0.10 1 570 156 156 ASP CB C 40.83 0.10 1 571 156 156 ASP N N 120.02 0.10 1 572 157 157 TRP H H 8.885 0.010 1 573 157 157 TRP C C 177.93 0.10 1 574 157 157 TRP CB C 28.63 0.10 1 575 157 157 TRP N N 126.28 0.10 1 576 158 158 SER H H 8.621 0.010 1 577 158 158 SER C C 175.73 0.10 1 578 158 158 SER CB C 62.98 0.10 1 579 158 158 SER N N 118.74 0.10 1 580 159 159 LYS H H 8.061 0.010 1 581 159 159 LYS C C 172.73 0.10 1 582 159 159 LYS CB C 31.34 0.10 1 583 159 159 LYS N N 122.36 0.10 1 584 160 160 VAL H H 7.155 0.010 1 585 160 160 VAL C C 174.67 0.10 1 586 160 160 VAL CB C 33.50 0.10 1 587 160 160 VAL N N 118.04 0.10 1 588 161 161 VAL H H 9.019 0.010 1 589 161 161 VAL CB C 34.27 0.10 1 590 161 161 VAL N N 129.03 0.10 1 591 162 162 LEU C C 173.79 0.10 1 592 163 163 ALA H H 9.025 0.010 1 593 163 163 ALA CB C 21.00 0.10 1 594 163 163 ALA N N 127.53 0.10 1 595 166 166 PRO C C 179.50 0.10 1 596 166 166 PRO CB C 28.70 0.10 1 597 167 167 VAL CB C 31.62 0.10 1 598 168 168 TRP C C 175.97 0.10 1 599 169 169 ALA H H 7.267 0.010 1 600 169 169 ALA C C 176.79 0.10 1 601 169 169 ALA CB C 21.25 0.10 1 602 169 169 ALA N N 125.89 0.10 1 603 170 170 ILE H H 6.905 0.010 1 604 170 170 ILE C C 177.99 0.10 1 605 170 170 ILE CB C 37.07 0.10 1 606 170 170 ILE N N 121.40 0.10 1 607 171 171 GLY H H 11.32 0.010 1 608 171 171 GLY C C 174.93 0.10 1 609 171 171 GLY CA C 45.63 0.10 1 610 171 171 GLY N N 123.23 0.10 1 611 172 172 THR H H 6.609 0.010 1 612 172 172 THR C C 176.16 0.10 1 613 172 172 THR CB C 71.14 0.10 1 614 172 172 THR N N 106.43 0.10 1 615 173 173 GLY H H 8.221 0.010 1 616 173 173 GLY C C 178.89 0.10 1 617 173 173 GLY CA C 44.87 0.10 1 618 173 173 GLY N N 112.41 0.10 1 619 174 174 LYS H H 8.042 0.010 1 620 174 174 LYS C C 172.40 0.10 1 621 174 174 LYS CB C 29.40 0.10 1 622 174 174 LYS N N 120.73 0.10 1 623 175 175 THR H H 7.299 0.010 1 624 175 175 THR C C 176.50 0.10 1 625 175 175 THR CB C 69.89 0.10 1 626 175 175 THR N N 114.25 0.10 1 627 176 176 ALA H H 8.219 0.010 1 628 176 176 ALA C C 177.40 0.10 1 629 176 176 ALA CB C 18.65 0.10 1 630 176 176 ALA N N 130.31 0.10 1 631 177 177 THR H H 8.874 0.010 1 632 177 177 THR CB C 67.28 0.10 1 633 177 177 THR N N 112.89 0.10 1 634 178 178 PRO C C 177.49 0.10 1 635 178 178 PRO CB C 30.85 0.10 1 636 179 179 GLN H H 7.824 0.010 1 637 179 179 GLN C C 175.44 0.10 1 638 179 179 GLN CB C 27.07 0.10 1 639 179 179 GLN N N 113.67 0.10 1 640 180 180 GLN H H 7.915 0.010 1 641 180 180 GLN C C 180.40 0.10 1 642 180 180 GLN CB C 29.15 0.10 1 643 180 180 GLN N N 121.92 0.10 1 644 181 181 ALA H H 8.298 0.010 1 645 181 181 ALA C C 177.43 0.10 1 646 181 181 ALA CB C 16.72 0.10 1 647 181 181 ALA N N 121.73 0.10 1 648 182 182 GLN H H 8.317 0.010 1 649 182 182 GLN C C 177.48 0.10 1 650 182 182 GLN CB C 26.61 0.10 1 651 182 182 GLN N N 117.46 0.10 1 652 183 183 GLU H H 7.923 0.010 1 653 183 183 GLU C C 179.13 0.10 1 654 183 183 GLU CB C 29.15 0.10 1 655 183 183 GLU N N 116.44 0.10 1 656 184 184 VAL H H 7.137 0.010 1 657 184 184 VAL C C 178.00 0.10 1 658 184 184 VAL CB C 31.79 0.10 1 659 184 184 VAL N N 118.04 0.10 1 660 185 185 HIS H H 9.216 0.010 1 661 185 185 HIS C C 177.78 0.10 1 662 185 185 HIS CB C 28.00 0.10 1 663 185 185 HIS N N 121.42 0.10 1 664 186 186 GLU H H 8.979 0.010 1 665 186 186 GLU C C 180.23 0.10 1 666 186 186 GLU CB C 28.63 0.10 1 667 186 186 GLU N N 118.88 0.10 1 668 187 187 LYS H H 7.564 0.010 1 669 187 187 LYS C C 180.46 0.10 1 670 187 187 LYS CB C 31.60 0.10 1 671 187 187 LYS N N 121.99 0.10 1 672 188 188 LEU H H 9.093 0.010 1 673 188 188 LEU C C 178.32 0.10 1 674 188 188 LEU CB C 41.91 0.10 1 675 188 188 LEU N N 123.69 0.10 1 676 189 189 ARG H H 8.703 0.010 1 677 189 189 ARG C C 179.43 0.10 1 678 189 189 ARG CB C 27.92 0.10 1 679 189 189 ARG N N 122.64 0.10 1 680 190 190 GLY H H 8.156 0.010 1 681 190 190 GLY C C 176.28 0.10 1 682 190 190 GLY CA C 46.38 0.10 1 683 190 190 GLY N N 106.03 0.10 1 684 191 191 TRP H H 8.355 0.010 1 685 191 191 TRP C C 177.97 0.10 1 686 191 191 TRP CB C 28.63 0.10 1 687 191 191 TRP N N 127.46 0.10 1 688 192 192 LEU C C 178.50 0.10 1 689 193 193 LYS H H 8.002 0.010 1 690 193 193 LYS C C 176.81 0.10 1 691 193 193 LYS CB C 31.50 0.10 1 692 193 193 LYS N N 121.08 0.10 1 693 194 194 SER H H 7.516 0.010 1 694 194 194 SER C C 175.66 0.10 1 695 194 194 SER CB C 63.63 0.10 1 696 194 194 SER N N 110.40 0.10 1 697 195 195 HIS H H 7.935 0.010 1 698 195 195 HIS C C 174.54 0.10 1 699 195 195 HIS CB C 27.31 0.10 1 700 195 195 HIS N N 115.74 0.10 1 701 196 196 VAL H H 7.710 0.010 1 702 196 196 VAL C C 174.47 0.10 1 703 196 196 VAL CB C 31.57 0.10 1 704 196 196 VAL N N 121.65 0.10 1 705 197 197 SER H H 7.579 0.010 1 706 197 197 SER C C 174.04 0.10 1 707 197 197 SER CB C 63.75 0.10 1 708 197 197 SER N N 112.56 0.10 1 709 198 198 ASP H H 8.944 0.010 1 710 198 198 ASP C C 177.73 0.10 1 711 198 198 ASP CB C 40.84 0.10 1 712 198 198 ASP N N 122.47 0.10 1 713 199 199 ALA H H 8.289 0.010 1 714 199 199 ALA C C 181.18 0.10 1 715 199 199 ALA CB C 17.56 0.10 1 716 199 199 ALA N N 121.42 0.10 1 717 200 200 VAL H H 7.760 0.010 1 718 200 200 VAL C C 179.24 0.10 1 719 200 200 VAL CB C 30.75 0.10 1 720 200 200 VAL N N 120.64 0.10 1 721 201 201 ALA H H 7.888 0.010 1 722 201 201 ALA C C 177.74 0.10 1 723 201 201 ALA CB C 18.39 0.10 1 724 201 201 ALA N N 125.87 0.10 1 725 202 202 GLN H H 7.984 0.010 1 726 202 202 GLN C C 178.27 0.10 1 727 202 202 GLN CB C 27.96 0.10 1 728 202 202 GLN N N 111.15 0.10 1 729 203 203 SER H H 7.684 0.010 1 730 203 203 SER C C 174.82 0.10 1 731 203 203 SER CB C 65.11 0.10 1 732 203 203 SER N N 112.03 0.10 1 733 204 204 THR H H 7.299 0.010 1 734 204 204 THR C C 172.63 0.10 1 735 204 204 THR CB C 69.12 0.10 1 736 204 204 THR N N 122.00 0.10 1 737 205 205 ARG H H 9.309 0.010 1 738 205 205 ARG C C 174.19 0.10 1 739 205 205 ARG CB C 27.74 0.10 1 740 205 205 ARG N N 129.02 0.10 1 741 206 206 ILE H H 9.876 0.010 1 742 206 206 ILE CB C 37.73 0.10 1 743 206 206 ILE N N 124.79 0.10 1 744 208 208 TYR C C 175.22 0.10 1 745 208 208 TYR CB C 41.08 0.10 1 746 209 209 GLY H H 8.002 0.010 1 747 209 209 GLY CA C 45.62 0.10 1 748 209 209 GLY N N 116.48 0.10 1 749 211 211 SER C C 179.89 0.10 1 750 211 211 SER CB C 62.86 0.10 1 751 212 212 VAL H H 8.535 0.010 1 752 212 212 VAL C C 174.98 0.10 1 753 212 212 VAL CB C 30.55 0.10 1 754 212 212 VAL N N 119.35 0.10 1 755 213 213 THR H H 9.388 0.010 1 756 213 213 THR C C 175.39 0.10 1 757 213 213 THR CB C 72.55 0.10 1 758 213 213 THR N N 118.21 0.10 1 759 214 214 GLY H H 9.980 0.010 1 760 214 214 GLY C C 175.69 0.10 1 761 214 214 GLY CA C 46.35 0.10 1 762 214 214 GLY N N 108.06 0.10 1 763 215 215 GLY H H 8.154 0.010 1 764 215 215 GLY C C 174.99 0.10 1 765 215 215 GLY CA C 45.21 0.10 1 766 215 215 GLY N N 106.95 0.10 1 767 216 216 ASN H H 7.327 0.010 1 768 216 216 ASN C C 179.18 0.10 1 769 216 216 ASN CB C 38.81 0.10 1 770 216 216 ASN N N 117.24 0.10 1 771 217 217 CYS H H 7.386 0.010 1 772 217 217 CYS C C 176.32 0.10 1 773 217 217 CYS CB C 27.04 0.10 1 774 217 217 CYS N N 117.29 0.10 1 775 218 218 LYS H H 8.509 0.010 1 776 218 218 LYS CB C 30.57 0.10 1 777 218 218 LYS N N 126.03 0.10 1 778 219 219 GLU C C 180.56 0.10 1 779 219 219 GLU CB C 28.48 0.10 1 780 220 220 LEU H H 7.078 0.010 1 781 220 220 LEU C C 177.51 0.10 1 782 220 220 LEU CB C 43.24 0.10 1 783 220 220 LEU N N 120.41 0.10 1 784 221 221 ALA H H 8.406 0.010 1 785 221 221 ALA C C 176.85 0.10 1 786 221 221 ALA CB C 18.64 0.10 1 787 221 221 ALA N N 117.40 0.10 1 788 222 222 SER H H 7.279 0.010 1 789 222 222 SER C C 174.97 0.10 1 790 222 222 SER CB C 63.88 0.10 1 791 222 222 SER N N 110.46 0.10 1 792 223 223 GLN H H 7.360 0.010 1 793 223 223 GLN C C 177.28 0.10 1 794 223 223 GLN CB C 26.77 0.10 1 795 223 223 GLN N N 121.70 0.10 1 796 224 224 HIS H H 8.615 0.010 1 797 224 224 HIS C C 176.53 0.10 1 798 224 224 HIS CB C 29.15 0.10 1 799 224 224 HIS N N 121.14 0.10 1 800 225 225 ASP H H 10.05 0.010 1 801 225 225 ASP C C 174.30 0.10 1 802 225 225 ASP CB C 41.29 0.10 1 803 225 225 ASP N N 116.17 0.10 1 804 226 226 VAL H H 7.034 0.010 1 805 226 226 VAL C C 174.80 0.10 1 806 226 226 VAL CB C 31.29 0.10 1 807 226 226 VAL N N 120.75 0.10 1 808 227 227 ASP H H 8.609 0.010 1 809 227 227 ASP C C 172.05 0.10 1 810 227 227 ASP CB C 41.57 0.10 1 811 227 227 ASP N N 124.93 0.10 1 812 228 228 GLY H H 6.923 0.010 1 813 228 228 GLY C C 172.82 0.10 1 814 228 228 GLY CA C 42.78 0.10 1 815 228 228 GLY N N 104.24 0.10 1 816 229 229 PHE H H 8.165 0.010 1 817 229 229 PHE C C 174.17 0.10 1 818 229 229 PHE CB C 45.82 0.10 1 819 229 229 PHE N N 112.99 0.10 1 820 230 230 LEU H H 8.510 0.010 1 821 230 230 LEU C C 174.81 0.10 1 822 230 230 LEU CB C 41.63 0.10 1 823 230 230 LEU N N 124.96 0.10 1 824 231 231 VAL H H 8.975 0.010 1 825 231 231 VAL CB C 33.63 0.10 1 826 231 231 VAL N N 125.17 0.10 1 827 232 232 GLY C C 176.61 0.10 1 828 232 232 GLY CA C 43.50 0.10 1 829 233 233 GLY H H 11.06 0.010 1 830 233 233 GLY C C 176.68 0.10 1 831 233 233 GLY CA C 48.27 0.10 1 832 233 233 GLY N N 122.83 0.10 1 833 234 234 ALA H H 9.071 0.010 1 834 234 234 ALA C C 177.51 0.10 1 835 234 234 ALA CB C 17.20 0.10 1 836 234 234 ALA N N 120.91 0.10 1 837 235 235 SER H H 8.156 0.010 1 838 235 235 SER C C 174.56 0.10 1 839 235 235 SER CB C 63.06 0.10 1 840 235 235 SER N N 114.86 0.10 1 841 236 236 LEU H H 6.607 0.010 1 842 236 236 LEU C C 175.82 0.10 1 843 236 236 LEU CB C 41.32 0.10 1 844 236 236 LEU N N 120.19 0.10 1 845 237 237 LYS H H 7.181 0.010 1 846 237 237 LYS CB C 33.58 0.10 1 847 237 237 LYS N N 119.14 0.10 1 848 238 238 PRO C C 178.54 0.10 1 849 238 238 PRO CB C 30.35 0.10 1 850 239 239 GLU H H 7.889 0.010 1 851 239 239 GLU C C 175.91 0.10 1 852 239 239 GLU CB C 29.35 0.10 1 853 239 239 GLU N N 114.49 0.10 1 854 240 240 PHE H H 8.275 0.010 1 855 240 240 PHE C C 177.26 0.10 1 856 240 240 PHE CB C 38.97 0.10 1 857 240 240 PHE N N 123.65 0.10 1 858 241 241 VAL H H 7.588 0.010 1 859 241 241 VAL C C 176.23 0.10 1 860 241 241 VAL CB C 31.64 0.10 1 861 241 241 VAL N N 115.15 0.10 1 862 242 242 ASP H H 6.852 0.010 1 863 242 242 ASP C C 178.28 0.10 1 864 242 242 ASP CB C 39.44 0.10 1 865 242 242 ASP N N 118.27 0.10 1 866 243 243 ILE H H 7.403 0.010 1 867 243 243 ILE CB C 37.69 0.10 1 868 243 243 ILE N N 120.94 0.10 1 869 244 244 ILE C C 177.09 0.10 1 870 244 244 ILE CB C 36.63 0.10 1 871 245 245 ASN H H 7.276 0.010 1 872 245 245 ASN C C 176.55 0.10 1 873 245 245 ASN CB C 37.55 0.10 1 874 245 245 ASN N N 117.19 0.10 1 875 246 246 ALA H H 7.410 0.010 1 876 246 246 ALA C C 178.37 0.10 1 877 246 246 ALA CB C 20.60 0.10 1 878 246 246 ALA N N 121.92 0.10 1 879 247 247 LYS H H 8.587 0.010 1 880 247 247 LYS C C 175.78 0.10 1 881 247 247 LYS CB C 29.95 0.10 1 882 247 247 LYS N N 115.74 0.10 1 883 248 248 HIS H H 7.687 0.010 1 884 248 248 HIS CB C 30.12 0.10 1 885 248 248 HIS N N 125.13 0.10 1 stop_ save_ save_15N_T1_600MHz _Saveframe_category T1_relaxation _Details . loop_ _Sample_label $2H_15N_sample stop_ _Sample_conditions_label $standard_conditions _Spectrometer_frequency_1H 600 _T1_coherence_type Nz _T1_value_units s _Mol_system_component_name 'WT cTIM chain 1' _Text_data_format . _Text_data . loop_ _T1_ID _Residue_seq_code _Residue_label _Atom_name _T1_value _T1_value_error 1 4 ARG N 1.739 0.0270 2 5 LYS N 2.362 0.0730 3 6 PHE N 2.478 0.0650 4 7 PHE N 2.450 0.119 5 8 VAL N 2.125 0.180 6 9 GLY N 2.201 0.175 7 10 GLY N 2.400 0.267 8 11 ASN N 2.717 0.128 9 12 TRP N 2.315 0.260 10 13 LYS N 2.278 0.0810 11 14 MET N 2.384 0.0560 12 15 ASN N 2.486 0.0550 13 16 GLY N 2.541 0.0890 14 17 ASP N 2.918 0.0700 15 18 LYS N 2.982 0.0850 16 19 LYS N 2.642 0.0710 17 20 SER N 2.769 0.0800 18 21 LEU N 3.032 0.0970 19 22 GLY N 2.968 0.0550 20 23 GLU N 2.708 0.0580 21 24 LEU N 2.955 0.0720 22 25 ILE N 2.366 0.0470 23 26 HIS N 2.596 0.0790 24 27 THR N 2.755 0.0730 25 28 LEU N 2.940 0.0630 26 29 ASN N 2.814 0.0600 27 30 GLY N 2.453 0.0550 28 31 ALA N 2.584 0.0700 29 32 LYS N 2.348 0.0500 30 33 LEU N 2.412 0.0630 31 34 SER N 2.226 0.0460 32 35 ALA N 2.296 0.130 33 36 ASP N 1.949 0.0420 34 37 THR N 2.156 0.0410 35 38 GLU N 2.426 0.0640 36 39 VAL N 2.442 0.0470 37 40 VAL N 2.327 0.260 38 41 CYS N 1.799 0.197 39 42 GLY N 1.917 0.243 40 43 ALA N 2.380 0.175 41 46 ILE N 2.297 0.0240 42 47 TYR N 2.598 0.253 43 48 LEU N 2.747 0.124 44 49 ASP N 2.577 0.0570 45 50 PHE N 2.435 0.0690 46 51 ALA N 2.077 0.248 47 52 ARG N 2.479 0.142 48 53 GLN N 2.643 0.0480 49 54 LYS N 2.478 0.0690 50 55 LEU N 2.294 0.0890 51 56 ASP N 2.430 0.0500 52 57 ALA N 2.346 0.0300 53 58 LYS N 2.219 0.0290 54 59 ILE N 2.479 0.0410 55 60 GLY N 2.687 0.0660 56 61 VAL N 2.326 0.0810 57 62 ALA N 2.029 0.167 58 63 ALA N 2.333 0.170 59 64 GLN N 2.989 0.0930 60 65 ASN N 2.407 0.0440 61 66 CYS N 2.476 0.0320 62 67 TYR N 2.578 0.0590 63 71 LYS N 2.377 0.0330 64 72 GLY N 2.375 0.0820 65 73 ALA N 2.338 0.0420 66 74 PHE N 2.538 0.0510 67 75 THR N 2.563 0.108 68 76 GLY N 2.498 0.0570 69 77 GLU N 2.552 0.0340 70 78 ILE N 2.681 0.0540 71 79 SER N 2.553 0.0640 72 81 ALA N 2.491 0.0640 73 82 MET N 2.385 0.0210 74 84 LYS N 2.391 0.0710 75 85 ASP N 2.430 0.0360 76 87 GLY N 2.457 0.0310 77 88 ALA N 2.993 0.0670 78 89 ALA N 2.520 0.0940 79 90 TRP N 2.543 0.0900 80 91 VAL N 1.849 0.448 81 92 ILE N 1.690 0.395 82 93 LEU N 2.801 0.0890 83 94 GLY N 3.184 0.142 84 95 HIS N 2.415 0.0430 85 97 GLU N 2.507 0.110 86 98 ARG N 2.854 0.0780 87 99 ARG N 2.474 0.182 88 100 HIS N 2.608 0.0910 89 101 VAL N 2.301 0.0510 90 102 PHE N 2.994 0.101 91 103 GLY N 2.659 0.0600 92 104 GLU N 2.419 0.0490 93 105 SER N 2.926 0.0490 94 106 ASP N 2.435 0.0740 95 107 GLU N 2.272 0.0400 96 108 LEU N 2.399 0.0300 97 109 ILE N 2.032 0.0860 98 110 GLY N 2.342 0.0320 99 111 GLN N 2.361 0.0350 100 112 LYS N 1.800 0.244 101 113 VAL N 1.710 0.273 102 114 ALA N 2.286 0.209 103 115 HIS N 2.320 0.0350 104 116 ALA N 2.546 0.0480 105 117 LEU N 1.748 0.116 106 118 ALA N 2.384 0.0330 107 119 GLU N 2.493 0.0400 108 120 GLY N 2.459 0.0380 109 121 LEU N 2.430 0.0420 110 122 GLY N 2.414 0.164 111 123 VAL N 2.198 0.336 112 124 ILE N 2.487 0.632 113 125 ALA N 3.643 0.932 114 127 ILE N 2.769 0.822 115 128 GLY N 2.549 0.0350 116 129 GLU N 2.856 0.0760 117 130 LYS N 2.348 0.0550 118 131 LEU N 2.633 0.102 119 132 ASP N 2.580 0.0880 120 133 GLU N 2.533 0.0700 121 135 GLU N 2.778 0.101 122 136 ALA N 2.627 0.0790 123 137 GLY N 2.391 0.0800 124 138 ILE N 2.398 0.0720 125 139 THR N 2.415 0.0670 126 140 GLU N 2.488 0.0570 127 141 LYS N 2.339 0.0850 128 142 VAL N 2.403 0.119 129 143 VAL N 2.454 0.0790 130 144 PHE N 2.193 0.0840 131 145 GLU N 2.251 0.0750 132 146 GLN N 2.370 0.0710 133 147 THR N 2.387 0.0830 134 148 LYS N 2.120 0.0910 135 149 ALA N 2.397 0.0440 136 150 ILE N 2.466 0.324 137 151 ALA N 1.643 0.182 138 152 ASP N 2.234 0.0440 139 153 ASN N 2.365 0.0430 140 154 VAL N 2.585 0.0480 141 155 LYS N 2.402 0.162 142 156 ASP N 2.555 0.119 143 157 TRP N 2.249 0.0280 144 158 SER N 2.247 0.0430 145 159 LYS N 1.911 0.0290 146 160 VAL N 2.839 0.0520 147 161 VAL N 3.271 1.07 148 163 ALA N 3.130 0.660 149 167 VAL N 2.284 0.0720 150 169 ALA N 2.161 0.0460 151 170 ILE N 2.395 0.0610 152 171 GLY N 2.559 0.0570 153 172 THR N 2.383 0.0520 154 173 GLY N 2.428 0.0700 155 174 LYS N 2.299 0.0420 156 175 THR N 2.190 0.0470 157 176 ALA N 2.425 0.0510 158 177 THR N 2.371 0.0470 159 179 GLN N 2.269 0.0560 160 181 ALA N 2.212 0.0500 161 182 GLN N 2.382 0.0620 162 183 GLU N 2.214 0.0470 163 184 VAL N 2.395 0.0400 164 185 HIS N 2.256 0.0800 165 186 GLU N 2.437 0.100 166 187 LYS N 2.090 0.0870 167 188 LEU N 2.066 0.378 168 190 GLY N 2.251 0.0640 169 191 TRP N 2.554 0.0880 170 193 LYS N 2.291 0.130 171 194 SER N 2.356 0.0310 172 195 HIS N 2.382 0.0360 173 196 VAL N 2.771 0.0440 174 197 SER N 2.484 0.0350 175 198 ASP N 2.324 0.117 176 199 ALA N 2.170 0.0530 177 200 VAL N 2.420 0.0660 178 201 ALA N 2.290 0.0450 179 202 GLN N 2.308 0.0470 180 203 SER N 2.264 0.0460 181 204 THR N 2.559 0.0400 182 205 ARG N 2.701 0.0660 183 206 ILE N 1.905 1.30 184 212 VAL N 2.318 0.0730 185 213 THR N 2.870 0.0760 186 214 GLY N 2.730 0.0990 187 215 GLY N 2.788 0.134 188 216 ASN N 2.698 0.140 189 217 CYS N 2.365 0.0570 190 218 LYS N 2.345 0.0250 191 220 LEU N 2.486 0.0580 192 221 ALA N 2.310 0.0470 193 222 SER N 2.448 0.0360 194 223 GLN N 2.733 0.0520 195 224 HIS N 2.350 0.0470 196 225 ASP N 2.459 0.0580 197 226 VAL N 2.917 0.0410 198 227 ASP N 2.713 0.0370 199 228 GLY N 2.567 0.751 200 229 PHE N 2.280 0.369 201 230 LEU N 2.715 0.287 202 231 VAL N 2.376 0.100 203 233 GLY N 2.218 0.0690 204 234 ALA N 2.426 0.0570 205 235 SER N 2.441 0.119 206 236 LEU N 2.173 0.0890 207 237 LYS N 2.374 0.106 208 239 GLU N 2.282 0.0680 209 240 PHE N 2.423 0.115 210 241 VAL N 2.306 0.0900 211 242 ASP N 2.816 0.0730 212 243 ILE N 2.806 0.137 213 245 ASN N 2.643 0.0370 214 246 ALA N 2.706 0.0510 215 247 LYS N 2.530 0.0540 216 248 HIS N 1.314 0.0130 stop_ save_ save_15N_T1_800MHz _Saveframe_category T1_relaxation _Details . loop_ _Sample_label $2H_15N_sample stop_ _Sample_conditions_label $standard_conditions _Spectrometer_frequency_1H 800 _T1_coherence_type Nz _T1_value_units s _Mol_system_component_name 'WT cTIM chain 1' _Text_data_format . _Text_data . loop_ _T1_ID _Residue_seq_code _Residue_label _Atom_name _T1_value _T1_value_error 1 4 ARG N 1.889 0.0320 2 5 LYS N 2.987 0.0490 3 6 PHE N 3.067 0.0800 4 7 PHE N 2.535 0.206 5 8 VAL N 3.271 0.108 6 9 GLY N 2.899 0.132 7 10 GLY N 2.938 0.242 8 11 ASN N 3.445 0.146 9 12 TRP N 3.043 0.189 10 13 LYS N 2.909 0.109 11 14 MET N 3.158 0.171 12 15 ASN N 2.771 0.116 13 16 GLY N 3.352 0.0850 14 17 ASP N 3.352 0.126 15 18 LYS N 3.283 0.146 16 19 LYS N 2.982 0.123 17 20 SER N 3.567 0.149 18 21 LEU N 2.774 0.0860 19 22 GLY N 3.100 0.125 20 23 GLU N 3.222 0.114 21 24 LEU N 3.567 0.109 22 25 ILE N 2.656 0.0680 23 26 HIS N 3.066 0.112 24 27 THR N 3.536 0.137 25 28 LEU N 2.741 0.116 26 29 ASN N 3.605 0.103 27 30 GLY N 2.806 0.0740 28 31 ALA N 2.656 0.0770 29 32 LYS N 2.981 0.102 30 33 LEU N 2.830 0.0560 31 34 SER N 2.681 0.0740 32 35 ALA N 2.806 0.0860 33 36 ASP N 2.253 0.0640 34 37 THR N 2.419 0.0660 35 38 GLU N 2.854 0.0780 36 39 VAL N 3.321 0.0420 37 40 VAL N 2.804 0.207 38 41 CYS N 1.944 0.235 39 42 GLY N 2.476 0.199 40 43 ALA N 2.485 0.109 41 46 ILE N 2.616 0.0950 42 47 TYR N 2.584 0.134 43 48 LEU N 2.795 0.0580 44 49 ASP N 2.861 0.123 45 50 PHE N 3.128 0.0860 46 51 ALA N 3.330 0.582 47 52 ARG N 2.778 0.162 48 53 GLN N 3.152 0.0700 49 54 LYS N 2.901 0.0860 50 55 LEU N 2.747 0.0520 51 56 ASP N 2.892 0.0690 52 57 ALA N 2.951 0.0590 53 58 LYS N 2.858 0.0440 54 59 ILE N 2.943 0.0680 55 60 GLY N 3.048 0.0690 56 61 VAL N 3.138 0.0770 57 62 ALA N 2.732 0.159 58 63 ALA N 2.392 0.112 59 64 GLN N 3.457 0.188 60 65 ASN N 2.459 0.0850 61 66 CYS N 2.980 0.0970 62 67 TYR N 2.822 0.153 63 71 LYS N 2.635 0.0760 64 72 GLY N 3.020 0.100 65 73 ALA N 2.700 0.113 66 74 PHE N 2.940 0.105 67 75 THR N 3.327 0.139 68 76 GLY N 2.962 0.101 69 77 GLU N 2.731 0.0790 70 78 ILE N 3.240 0.115 71 79 SER N 2.750 0.103 72 81 ALA N 2.692 0.0780 73 82 MET N 2.649 0.0750 74 84 LYS N 3.010 0.231 75 85 ASP N 2.739 0.0680 76 87 GLY N 3.019 0.0530 77 88 ALA N 3.232 0.103 78 89 ALA N 3.293 0.0900 79 90 TRP N 3.341 0.0720 80 91 VAL N 2.726 0.220 81 92 ILE N 3.795 2.16 82 93 LEU N 3.614 0.125 83 94 GLY N 3.795 0.205 84 95 HIS N 2.896 0.112 85 97 GLU N 2.956 0.0840 86 98 ARG N 3.255 0.169 87 99 ARG N 3.058 0.160 88 100 HIS N 3.006 0.108 89 101 VAL N 2.573 0.0670 90 102 PHE N 3.251 0.175 91 103 GLY N 3.064 0.0750 92 104 GLU N 2.879 0.0990 93 105 SER N 3.479 0.161 94 106 ASP N 2.894 0.0780 95 107 GLU N 2.549 0.0980 96 108 LEU N 2.775 0.113 97 109 ILE N 2.475 0.112 98 110 GLY N 2.425 0.0720 99 111 GLN N 2.668 0.0760 100 112 LYS N 2.276 0.162 101 113 VAL N 2.604 0.845 102 114 ALA N 1.798 0.343 103 115 HIS N 2.461 0.0540 104 116 ALA N 3.182 0.119 105 117 LEU N 1.979 0.348 106 118 ALA N 2.836 0.0620 107 119 GLU N 3.139 0.0670 108 120 GLY N 2.515 0.0610 109 121 LEU N 2.621 0.0590 110 122 GLY N 3.741 0.399 111 123 VAL N 3.408 0.820 112 124 ILE N 4.150 0.947 113 125 ALA N 3.027 0.548 114 127 ILE N 3.055 1.23 115 128 GLY N 2.876 0.0820 116 129 GLU N 3.286 0.169 117 130 LYS N 2.972 0.0840 118 131 LEU N 3.308 0.164 119 132 ASP N 3.142 0.0910 120 133 GLU N 3.122 0.0940 121 135 GLU N 3.396 0.127 122 136 ALA N 3.492 0.0700 123 137 GLY N 2.796 0.0770 124 138 ILE N 2.796 0.0880 125 139 THR N 3.087 0.0880 126 140 GLU N 2.731 0.0870 127 141 LYS N 3.177 0.0960 128 142 VAL N 3.262 0.128 129 143 VAL N 3.226 0.121 130 144 PHE N 2.809 0.0930 131 145 GLU N 2.765 0.106 132 146 GLN N 3.282 0.0970 133 147 THR N 2.942 0.141 134 148 LYS N 2.829 0.0880 135 149 ALA N 2.870 0.0720 136 150 ILE N 2.824 0.285 137 151 ALA N 2.159 0.298 138 152 ASP N 2.922 0.0540 139 153 ASN N 3.078 0.0730 140 154 VAL N 2.919 0.0780 141 155 LYS N 2.961 0.0830 142 156 ASP N 3.088 0.112 143 157 TRP N 2.748 0.0710 144 158 SER N 2.622 0.0560 145 159 LYS N 2.241 0.0830 146 160 VAL N 3.497 0.0900 147 161 VAL N 2.512 0.377 148 163 ALA N 5.350 2.59 149 167 VAL N 2.758 0.105 150 169 ALA N 2.418 0.0810 151 170 ILE N 3.025 0.140 152 171 GLY N 2.588 0.130 153 172 THR N 2.400 0.0840 154 173 GLY N 2.448 0.103 155 174 LYS N 2.945 0.0670 156 175 THR N 2.307 0.0620 157 176 ALA N 2.973 0.0900 158 177 THR N 2.925 0.0580 159 179 GLN N 2.895 0.0720 160 181 ALA N 2.743 0.0780 161 182 GLN N 3.116 0.0900 162 183 GLU N 2.703 0.0720 163 184 VAL N 2.789 0.0820 164 185 HIS N 2.752 0.118 165 186 GLU N 2.775 0.128 166 187 LYS N 2.527 0.0650 167 188 LEU N 3.027 0.206 168 190 GLY N 2.939 0.0620 169 191 TRP N 2.783 0.0940 170 193 LYS N 2.887 0.149 171 194 SER N 2.559 0.0810 172 195 HIS N 2.679 0.0700 173 196 VAL N 3.105 0.122 174 197 SER N 2.977 0.0990 175 198 ASP N 2.729 0.132 176 199 ALA N 2.844 0.110 177 200 VAL N 2.982 0.0740 178 201 ALA N 2.693 0.0860 179 202 GLN N 2.838 0.0830 180 203 SER N 2.713 0.123 181 204 THR N 2.723 0.0840 182 205 ARG N 3.335 0.0540 183 206 ILE N 7.099 4.90 184 212 VAL N 2.876 0.0900 185 213 THR N 3.393 0.157 186 214 GLY N 2.940 0.138 187 215 GLY N 3.196 0.119 188 216 ASN N 3.384 0.163 189 217 CYS N 2.912 0.111 190 218 LYS N 2.778 0.0770 191 220 LEU N 2.568 0.0810 192 221 ALA N 2.696 0.0890 193 222 SER N 2.798 0.109 194 223 GLN N 3.068 0.100 195 224 HIS N 2.925 0.0890 196 225 ASP N 3.152 0.121 197 226 VAL N 2.977 0.0990 198 227 ASP N 2.928 0.106 199 228 GLY N 1.876 0.316 200 229 PHE N 3.636 0.734 201 230 LEU N 4.094 0.790 202 231 VAL N 2.796 0.470 203 233 GLY N 2.875 0.144 204 234 ALA N 2.544 0.0760 205 235 SER N 2.574 0.0990 206 236 LEU N 2.602 0.108 207 237 LYS N 2.662 0.109 208 239 GLU N 2.906 0.0920 209 240 PHE N 2.473 0.103 210 241 VAL N 2.688 0.132 211 242 ASP N 2.995 0.0900 212 243 ILE N 3.319 0.190 213 245 ASN N 3.057 0.103 214 246 ALA N 2.903 0.0680 215 247 LYS N 2.952 0.0980 216 248 HIS N 1.440 0.0240 stop_ save_ save_15N_T2_600MHz _Saveframe_category T2_relaxation _Details . loop_ _Sample_label $2H_15N_sample stop_ _Sample_conditions_label $standard_conditions _Spectrometer_frequency_1H 600 _T2_coherence_type Nx _T2_value_units s _Mol_system_component_name 'WT cTIM chain 1' _Text_data_format . _Text_data . loop_ _T2_ID _Residue_seq_code _Residue_label _Atom_name _T2_value _T2_value_error _Rex_value _Rex_error 1 4 ARG N 0.03923 0 . . 2 5 LYS N 0.02692 0 . . 3 6 PHE N 0.02300 0 . . 4 7 PHE N 0.02458 0.000020 . . 5 8 VAL N 0.02554 0.000040 . . 6 9 GLY N 0.02771 0.000060 . . 7 10 GLY N 0.02599 0.000030 . . 8 11 ASN N 0.02573 0 . . 9 12 TRP N 0.02748 0.000040 . . 10 13 LYS N 0.02373 0 . . 11 14 MET N 0.02468 0 . . 12 15 ASN N 0.02557 0 . . 13 16 GLY N 0.02896 0 . . 14 17 ASP N 0.02399 0 . . 15 18 LYS N 0.02106 0 . . 16 19 LYS N 0.02385 0 . . 17 20 SER N 0.02143 0 . . 18 21 LEU N 0.01925 0.000010 . . 19 22 GLY N 0.02034 0 . . 20 23 GLU N 0.02263 0 . . 21 24 LEU N 0.02015 0 . . 22 25 ILE N 0.02571 0 . . 23 26 HIS N 0.02154 0 . . 24 27 THR N 0.02153 0 . . 25 28 LEU N 0.02149 0.000010 . . 26 29 ASN N 0.02112 0 . . 27 30 GLY N 0.02421 0 . . 28 31 ALA N 0.02279 0 . . 29 32 LYS N 0.02925 0 . . 30 33 LEU N 0.03184 0 . . 31 34 SER N 0.02890 0 . . 32 35 ALA N 0.02494 0 . . 33 36 ASP N 0.02769 0 . . 34 37 THR N 0.02909 0 . . 35 38 GLU N 0.02446 0 . . 36 39 VAL N 0.02885 0 . . 37 40 VAL N 0.02286 0.000060 . . 38 41 CYS N 0.03602 0.00014 . . 39 42 GLY N 0.02942 0.000070 . . 40 43 ALA N 0.02546 0.000040 . . 41 46 ILE N 0.02514 0 . . 42 47 TYR N 0.02383 0.000090 . . 43 48 LEU N 0.02179 0.000020 . . 44 49 ASP N 0.02200 0 . . 45 50 PHE N 0.02555 0 . . 46 51 ALA N 0.02302 0.000090 . . 47 52 ARG N 0.02677 0.000070 . . 48 53 GLN N 0.02296 0 . . 49 54 LYS N 0.02434 0 . . 50 55 LEU N 0.02589 0.000020 . . 51 56 ASP N 0.02549 0 . . 52 57 ALA N 0.02829 0 . . 53 58 LYS N 0.02548 0 . . 54 59 ILE N 0.02369 0 . . 55 60 GLY N 0.02240 0 . . 56 61 VAL N 0.02579 0 . . 57 62 ALA N 0.03518 0.000040 . . 58 63 ALA N 0.02732 0.000020 . . 59 64 GLN N 0.02338 0.000010 . . 60 65 ASN N 0.02553 0 . . 61 66 CYS N 0.02688 0 . . 62 67 TYR N 0.02478 0 . . 63 71 LYS N 0.02564 0 . . 64 72 GLY N 0.02551 0 . . 65 73 ALA N 0.02743 0 . . 66 74 PHE N 0.02632 0 . . 67 75 THR N 0.02257 0.000010 . . 68 76 GLY N 0.02476 0 . . 69 77 GLU N 0.02154 0 . . 70 78 ILE N 0.02507 0 . . 71 79 SER N 0.02141 0.000010 . . 72 81 ALA N 0.02517 0 . . 73 82 MET N 0.02571 0 . . 74 84 LYS N 0.02658 0.000050 . . 75 85 ASP N 0.02371 0 . . 76 87 GLY N 0.02548 0 . . 77 88 ALA N 0.02077 0 . . 78 89 ALA N 0.02626 0 . . 79 90 TRP N 0.02566 0 . . 80 91 VAL N 0.02684 0.00092 . . 81 92 ILE N 0.02177 0.00040 . . 82 93 LEU N 0.02053 0 . . 83 94 GLY N 0.02202 0.000010 . . 84 95 HIS N 0.02328 0 . . 85 97 GLU N 0.02370 0.000010 . . 86 98 ARG N 0.02050 0 . . 87 99 ARG N 0.02374 0.000040 . . 88 100 HIS N 0.02481 0 . . 89 101 VAL N 0.02517 0.000010 . . 90 102 PHE N 0.02356 0.000010 . . 91 103 GLY N 0.02581 0 . . 92 104 GLU N 0.02421 0 . . 93 105 SER N 0.02218 0 . . 94 106 ASP N 0.02555 0 . . 95 107 GLU N 0.02711 0 . . 96 108 LEU N 0.02544 0 . . 97 109 ILE N 0.02257 0.000030 . . 98 110 GLY N 0.02440 0 . . 99 111 GLN N 0.02400 0 . . 100 112 LYS N 0.02545 0.00021 . . 101 113 VAL N 0.02079 0.00035 . . 102 114 ALA N 0.02229 0.00010 . . 103 115 HIS N 0.02464 0 . . 104 116 ALA N 0.02291 0 . . 105 117 LEU N 0.05307 0.00013 . . 106 118 ALA N 0.02592 0 . . 107 119 GLU N 0.02759 0 . . 108 120 GLY N 0.02629 0 . . 109 121 LEU N 0.02390 0 . . 110 122 GLY N 0.02611 0.00011 . . 111 123 VAL N 0.02058 0.00023 . . 112 124 ILE N 0.04917 0.00099 . . 113 125 ALA N 0.01876 0.00041 . . 114 127 ILE N 0.01911 0.00031 . . 115 128 GLY N 0.02714 0 . . 116 129 GLU N 0.02128 0 . . 117 130 LYS N 0.02630 0 . . 118 131 LEU N 0.02325 0 . . 119 132 ASP N 0.02282 0 . . 120 133 GLU N 0.02519 0 . . 121 135 GLU N 0.02125 0 . . 122 136 ALA N 0.02359 0 . . 123 137 GLY N 0.02599 0 . . 124 138 ILE N 0.02520 0 . . 125 139 THR N 0.02441 0 . . 126 140 GLU N 0.02441 0 . . 127 141 LYS N 0.02592 0 . . 128 142 VAL N 0.02371 0 . . 129 143 VAL N 0.02337 0 . . 130 144 PHE N 0.02513 0 . . 131 145 GLU N 0.02482 0 . . 132 146 GLN N 0.02398 0 . . 133 147 THR N 0.02460 0.000010 . . 134 148 LYS N 0.02574 0 . . 135 149 ALA N 0.02507 0 . . 136 150 ILE N 0.02680 0.00016 . . 137 151 ALA N 0.02480 0.00028 . . 138 152 ASP N 0.02604 0 . . 139 153 ASN N 0.02623 0 . . 140 154 VAL N 0.02509 0 . . 141 155 LYS N 0.02639 0 . . 142 156 ASP N 0.02962 0 . . 143 157 TRP N 0.02865 0 . . 144 158 SER N 0.02563 0 . . 145 159 LYS N 0.02746 0 . . 146 160 VAL N 0.02429 0 . . 147 161 VAL N 0.02403 0.00058 . . 148 163 ALA N 0.02421 0.00038 . . 149 167 VAL N 0.02504 0 . . 150 169 ALA N 0.02438 0 . . 151 170 ILE N 0.02404 0 . . 152 171 GLY N 0.02498 0 . . 153 172 THR N 0.02547 0.000010 . . 154 173 GLY N 0.02652 0.000010 . . 155 174 LYS N 0.02598 0 . . 156 175 THR N 0.03373 0 . . 157 176 ALA N 0.02289 0 . . 158 177 THR N 0.02525 0 . . 159 179 GLN N 0.02836 0 . . 160 181 ALA N 0.02498 0 . . 161 182 GLN N 0.02563 0 . . 162 183 GLU N 0.02609 0 . . 163 184 VAL N 0.02476 0 . . 164 185 HIS N 0.02453 0 . . 165 186 GLU N 0.02351 0.000010 . . 166 187 LYS N 0.02562 0 . . 167 188 LEU N 0.02368 0.00020 . . 168 190 GLY N 0.02599 0 . . 169 191 TRP N 0.02502 0.000010 . . 170 193 LYS N 0.02255 0.000020 . . 171 194 SER N 0.02818 0 . . 172 195 HIS N 0.02745 0 . . 173 196 VAL N 0.02426 0 . . 174 197 SER N 0.02922 0 . . 175 198 ASP N 0.02376 0.000010 . . 176 199 ALA N 0.02945 0 . . 177 200 VAL N 0.02579 0 . . 178 201 ALA N 0.02398 0 . . 179 202 GLN N 0.02704 0 . . 180 203 SER N 0.02680 0.000010 . . 181 204 THR N 0.02146 0 . . 182 205 ARG N 0.02314 0 . . 183 206 ILE N 0.01615 0.00084 . . 184 212 VAL N 0.02438 0 . . 185 213 THR N 0.02170 0 . . 186 214 GLY N 0.02301 0 . . 187 215 GLY N 0.01968 0 . . 188 216 ASN N 0.02175 0.000010 . . 189 217 CYS N 0.02371 0.000010 . . 190 218 LYS N 0.02544 0 . . 191 220 LEU N 0.02349 0 . . 192 221 ALA N 0.02508 0 . . 193 222 SER N 0.02644 0 . . 194 223 GLN N 0.02149 0 . . 195 224 HIS N 0.02581 0 . . 196 225 ASP N 0.02834 0 . . 197 226 VAL N 0.02003 0 . . 198 227 ASP N 0.02418 0 . . 199 228 GLY N 0.02214 0.00071 . . 200 229 PHE N 0.02151 0.00039 . . 201 230 LEU N 0.02309 0.00023 . . 202 231 VAL N 0.01838 0.000010 . . 203 233 GLY N 0.02560 0 . . 204 234 ALA N 0.02333 0 . . 205 235 SER N 0.02429 0.000010 . . 206 236 LEU N 0.02531 0 . . 207 237 LYS N 0.02543 0 . . 208 239 GLU N 0.02524 0 . . 209 240 PHE N 0.02034 0 . . 210 241 VAL N 0.02330 0 . . 211 242 ASP N 0.02451 0 . . 212 243 ILE N 0.02323 0.000020 . . 213 245 ASN N 0.02405 0 . . 214 246 ALA N 0.02046 0 . . 215 247 LYS N 0.02490 0 . . 216 248 HIS N 0.03280 0 . . stop_ save_ save_15N_T2_800MHz _Saveframe_category T2_relaxation _Details . loop_ _Sample_label $2H_15N_sample stop_ _Sample_conditions_label $standard_conditions _Spectrometer_frequency_1H 800 _T2_coherence_type Nz _T2_value_units s _Mol_system_component_name 'WT cTIM chain 1' _Text_data_format . _Text_data . loop_ _T2_ID _Residue_seq_code _Residue_label _Atom_name _T2_value _T2_value_error _Rex_value _Rex_error 1 4 ARG N 0.03159 0 . . 2 5 LYS N 0.02134 0 . . 3 6 PHE N 0.01916 0 . . 4 7 PHE N 0.01995 0.0014 . . 5 8 VAL N 0.02569 0.0015 . . 6 9 GLY N 0.01793 0.00088 . . 7 10 GLY N 0.01797 0.00068 . . 8 11 ASN N 0.02065 0 . . 9 12 TRP N 0.02294 0.000030 . . 10 13 LYS N 0.01779 0 . . 11 14 MET N 0.02139 0 . . 12 15 ASN N 0.02090 0 . . 13 16 GLY N 0.02447 0 . . 14 17 ASP N 0.02010 0 . . 15 18 LYS N 0.01680 0 . . 16 19 LYS N 0.01892 0 . . 17 20 SER N 0.01576 0 . . 18 21 LEU N 0.01633 0.000020 . . 19 22 GLY N 0.01664 0 . . 20 23 GLU N 0.01720 0 . . 21 24 LEU N 0.01671 0 . . 22 25 ILE N 0.01900 0 . . 23 26 HIS N 0.01697 0 . . 24 27 THR N 0.01694 0 . . 25 28 LEU N 0.01632 0.000010 . . 26 29 ASN N 0.01671 0 . . 27 30 GLY N 0.01951 0 . . 28 31 ALA N 0.01808 0 . . 29 32 LYS N 0.02421 0 . . 30 33 LEU N 0.02534 0 . . 31 34 SER N 0.02297 0 . . 32 35 ALA N 0.02021 0 . . 33 36 ASP N 0.02354 0 . . 34 37 THR N 0.02293 0 . . 35 38 GLU N 0.01893 0 . . 36 39 VAL N 0.02231 0 . . 37 40 VAL N 0.01977 0.0029 . . 38 41 CYS N 0.01875 0.0015 . . 39 42 GLY N 0.01473 0.0022 . . 40 43 ALA N 0.01918 0.0011 . . 41 46 ILE N 0.01959 0 . . 42 47 TYR N 0.01786 0.00099 . . 43 48 LEU N 0.01803 0.000010 . . 44 49 ASP N 0.01783 0 . . 45 50 PHE N 0.01953 0 . . 46 51 ALA N 0.01562 0.00047 . . 47 52 ARG N 0.01771 0.00090 . . 48 53 GLN N 0.01756 0 . . 49 54 LYS N 0.02023 0 . . 50 55 LEU N 0.01739 0.000020 . . 51 56 ASP N 0.02123 0 . . 52 57 ALA N 0.02183 0 . . 53 58 LYS N 0.02220 0 . . 54 59 ILE N 0.02019 0 . . 55 60 GLY N 0.01950 0 . . 56 61 VAL N 0.02114 0 . . 57 62 ALA N 0.02277 0.0013 . . 58 63 ALA N 0.01860 0.00037 . . 59 64 GLN N 0.01947 0.000010 . . 60 65 ASN N 0.02048 0 . . 61 66 CYS N 0.01953 0 . . 62 67 TYR N 0.01967 0 . . 63 71 LYS N 0.01859 0 . . 64 72 GLY N 0.02053 0 . . 65 73 ALA N 0.02153 0 . . 66 74 PHE N 0.02218 0 . . 67 75 THR N 0.01903 0.000020 . . 68 76 GLY N 0.01893 0 . . 69 77 GLU N 0.01601 0 . . 70 78 ILE N 0.01998 0 . . 71 79 SER N 0.01547 0 . . 72 81 ALA N 0.01985 0.000010 . . 73 82 MET N 0.02048 0 . . 74 84 LYS N 0.01905 0.00046 . . 75 85 ASP N 0.01908 0 . . 76 87 GLY N 0.01911 0 . . 77 88 ALA N 0.01649 0 . . 78 89 ALA N 0.02180 0 . . 79 90 TRP N 0.01862 0.00031 . . 80 91 VAL N 0.01754 0.0034 . . 81 92 ILE N 0.02176 0.016 . . 82 93 LEU N 0.01599 0 . . 83 94 GLY N 0.01535 0.000010 . . 84 95 HIS N 0.01810 0 . . 85 97 GLU N 0.01811 0.000010 . . 86 98 ARG N 0.01618 0 . . 87 99 ARG N 0.01888 0.00061 . . 88 100 HIS N 0.01904 0 . . 89 101 VAL N 0.01975 0.000010 . . 90 102 PHE N 0.01823 0.000010 . . 91 103 GLY N 0.01908 0 . . 92 104 GLU N 0.01887 0 . . 93 105 SER N 0.01776 0 . . 94 106 ASP N 0.01953 0 . . 95 107 GLU N 0.02096 0 . . 96 108 LEU N 0.02045 0 . . 97 109 ILE N 0.01900 0.000030 . . 98 110 GLY N 0.01770 0 . . 99 111 GLN N 0.01934 0 . . 100 112 LYS N 0.01445 0.0012 . . 101 114 ALA N 0.01687 0.0034 . . 102 115 HIS N 0.01930 0 . . 103 116 ALA N 0.01922 0 . . 104 117 LEU N 0.07599 0.0042 . . 105 118 ALA N 0.02037 0 . . 106 119 GLU N 0.02219 0 . . 107 120 GLY N 0.02085 0 . . 108 121 LEU N 0.01862 0 . . 109 122 GLY N 0.01684 0.0011 . . 110 123 VAL N 0.01547 0.00052 . . 111 124 ILE N 0.01583 0.0031 . . 112 125 ALA N 0.01506 0.0025 . . 113 127 ILE N 0.02809 0.0049 . . 114 128 GLY N 0.02031 0 . . 115 129 GLU N 0.01650 0 . . 116 130 LYS N 0.02064 0 . . 117 131 LEU N 0.01774 0 . . 118 132 ASP N 0.01794 0 . . 119 133 GLU N 0.02075 0 . . 120 135 GLU N 0.01801 0 . . 121 136 ALA N 0.01914 0 . . 122 137 GLY N 0.01805 0 . . 123 138 ILE N 0.01958 0 . . 124 139 THR N 0.01852 0 . . 125 140 GLU N 0.01887 0 . . 126 141 LYS N 0.02114 0 . . 127 142 VAL N 0.01835 0 . . 128 143 VAL N 0.01641 0 . . 129 144 PHE N 0.01968 0 . . 130 145 GLU N 0.01976 0 . . 131 146 GLN N 0.01977 0 . . 132 147 THR N 0.02009 0.00048 . . 133 148 LYS N 0.02051 0 . . 134 149 ALA N 0.01911 0 . . 135 150 ILE N 0.01805 0.00083 . . 136 151 ALA N 0.01713 0.00040 . . 137 152 ASP N 0.02025 0 . . 138 153 ASN N 0.01992 0.00029 . . 139 154 VAL N 0.02014 0 . . 140 155 LYS N 0.02147 0 . . 141 156 ASP N 0.02445 0 . . 142 157 TRP N 0.02347 0 . . 143 158 SER N 0.02034 0.00028 . . 144 159 LYS N 0.02187 0 . . 145 160 VAL N 0.01891 0 . . 146 161 VAL N 0.01069 0.0023 . . 147 163 ALA N 0.01705 0.0021 . . 148 167 VAL N 0.02002 0 . . 149 169 ALA N 0.01901 0 . . 150 170 ILE N 0.02091 0 . . 151 171 GLY N 0.01883 0 . . 152 172 THR N 0.01932 0 . . 153 173 GLY N 0.01663 0.000010 . . 154 174 LYS N 0.02090 0 . . 155 175 THR N 0.02601 0 . . 156 176 ALA N 0.01791 0 . . 157 177 THR N 0.01886 0 . . 158 179 GLN N 0.02148 0 . . 159 181 ALA N 0.01924 0 . . 160 182 GLN N 0.02098 0 . . 161 183 GLU N 0.02105 0 . . 162 184 VAL N 0.02005 0 . . 163 185 HIS N 0.01928 0 . . 164 186 GLU N 0.01801 0.00038 . . 165 187 LYS N 0.02053 0 . . 166 188 LEU N 0.01990 0.0016 . . 167 190 GLY N 0.01929 0 . . 168 191 TRP N 0.01917 0.000010 . . 169 193 LYS N 0.02085 0.000020 . . 170 194 SER N 0.01972 0.00014 . . 171 195 HIS N 0.02044 0 . . 172 196 VAL N 0.01941 0 . . 173 197 SER N 0.02156 0 . . 174 198 ASP N 0.02079 0.00025 . . 175 199 ALA N 0.02140 0 . . 176 200 VAL N 0.02029 0 . . 177 201 ALA N 0.02092 0 . . 178 202 GLN N 0.02088 0 . . 179 203 SER N 0.01876 0.00027 . . 180 204 THR N 0.01822 0.00027 . . 181 205 ARG N 0.01751 0.00040 . . 182 206 ILE N 0.01018 0.0023 . . 183 212 VAL N 0.01983 0 . . 184 213 THR N 0.01717 0 . . 185 214 GLY N 0.01638 0 . . 186 215 GLY N 0.01587 0 . . 187 216 ASN N 0.01744 0.000010 . . 188 217 CYS N 0.01923 0.00050 . . 189 218 LYS N 0.01935 0 . . 190 220 LEU N 0.01969 0 . . 191 221 ALA N 0.02198 0 . . 192 222 SER N 0.01969 0.00034 . . 193 223 GLN N 0.01702 0 . . 194 224 HIS N 0.02051 0 . . 195 225 ASP N 0.02293 0.000010 . . 196 226 VAL N 0.01669 0 . . 197 227 ASP N 0.02043 0 . . 198 228 GLY N 0.01349 0.0040 . . 199 229 PHE N 0.02124 0.0026 . . 200 230 LEU N 0.01909 0.0014 . . 201 231 VAL N 0.03174 0.00024 . . 202 233 GLY N 0.02105 0 . . 203 234 ALA N 0.01793 0.000010 . . 204 235 SER N 0.02140 0.000010 . . 205 236 LEU N 0.01949 0 . . 206 237 LYS N 0.02057 0 . . 207 239 GLU N 0.01915 0 . . 208 240 PHE N 0.01634 0 . . 209 241 VAL N 0.01761 0 . . 210 242 ASP N 0.01798 0 . . 211 243 ILE N 0.01977 0.00071 . . 212 245 ASN N 0.01977 0 . . 213 246 ALA N 0.01624 0 . . 214 247 LYS N 0.01866 0 . . 215 248 HIS N 0.02717 0 . . stop_ save_ save_1H15N_ssNOE_600MHz _Saveframe_category heteronuclear_NOE _Details . loop_ _Experiment_label '1H-15N ssNOE' stop_ loop_ _Sample_label . stop_ _Sample_conditions_label $standard_conditions _Spectrometer_frequency_1H 600 _Mol_system_component_name 'WT cTIM chain 1' _Atom_one_atom_name N _Atom_two_atom_name H _Heteronuclear_NOE_value_type 'relative intensities' _NOE_reference_value 1.0 _NOE_reference_description . _Text_data_format . _Text_data . loop_ _Residue_seq_code _Residue_label _Heteronuclear_NOE_value _Heteronuclear_NOE_value_error 4 ARG -0.138 0.0140 5 LYS 0.660 0.0140 6 PHE 0.729 0.0100 7 PHE 0.951 0.0840 8 VAL 0.724 0.115 9 GLY 0.821 0.133 10 GLY 0.870 0.0930 11 ASN 0.896 0.0150 12 TRP 0.788 0.0760 13 LYS 0.912 0.0190 14 MET 0.740 0.0220 15 ASN 0.849 0.0130 16 GLY 0.878 0.0100 17 ASP 0.798 0.0220 18 LYS 0.820 0.0220 19 LYS 0.707 0.0140 20 SER 0.883 0.0280 21 LEU 0.929 0.0480 22 GLY 0.905 0.0210 23 GLU 0.756 0.0150 24 LEU 0.747 0.0130 25 ILE 0.830 0.0270 26 HIS 0.910 0.0150 27 THR 0.908 0.0220 28 LEU 0.898 0.0570 29 ASN 0.837 0.0150 30 GLY 0.712 0.0160 31 ALA 0.767 0.0120 32 LYS 0.676 0.00700 33 LEU 0.651 0.00700 34 SER 0.646 0.0110 35 ALA 0.635 0.0140 36 ASP 0.727 0.0200 37 THR 0.587 0.0100 38 GLU 0.815 0.0110 39 VAL 0.768 0.00800 40 VAL 1.21 0.333 41 CYS 1.07 0.290 42 GLY 0.857 0.140 43 ALA 0.922 0.118 46 ILE 0.497 0.00700 47 TYR 0.885 0.143 48 LEU 0.867 0.0620 49 ASP 0.830 0.0270 50 PHE 0.729 0.00900 51 ALA 0.902 0.161 52 ARG 0.844 0.108 53 GLN 0.819 0.0130 54 LYS 0.775 0.0120 55 LEU 0.727 0.0660 56 ASP 0.867 0.0140 57 ALA 0.800 0.00900 58 LYS 0.750 0.0170 59 ILE 0.820 0.0130 60 GLY 0.856 0.0110 61 VAL 0.781 0.0130 62 ALA 0.736 0.0730 63 ALA 0.715 0.0750 64 GLN 0.845 0.0320 65 ASN 1.01 0.0210 66 CYS 0.729 0.0130 67 TYR 0.849 0.0280 71 LYS 0.785 0.0110 72 GLY 0.874 0.0140 73 ALA 0.849 0.00900 74 PHE 0.848 0.0170 75 THR 0.940 0.0490 76 GLY 0.894 0.0230 77 GLU 0.907 0.0200 78 ILE 0.828 0.0130 79 SER 0.884 0.0410 81 ALA 0.840 0.0290 82 MET 0.745 0.0160 84 LYS 0.832 0.0950 85 ASP 0.857 0.0110 87 GLY 0.882 0.0150 88 ALA 0.813 0.0160 89 ALA 0.810 0.0170 90 TRP 0.832 0.0280 91 VAL 0.954 0.424 92 ILE 0.477 0.332 93 LEU 0.849 0.0270 94 GLY 0.919 0.0420 95 HIS 0.739 0.0190 97 GLU 0.848 0.0380 98 ARG 0.873 0.0270 99 ARG 0.836 0.0710 100 HIS 0.818 0.0220 101 VAL 0.766 0.0320 102 PHE 0.861 0.0450 103 GLY 1.01 0.0240 104 GLU 0.884 0.00900 105 SER 0.881 0.0180 106 ASP 0.729 0.00900 107 GLU 0.841 0.0170 108 LEU 0.890 0.0170 109 ILE 0.729 0.0700 110 GLY 0.817 0.0120 111 GLN 0.775 0.0110 112 LYS 1.10 0.277 113 VAL 0.793 0.276 114 ALA 1.10 0.261 115 HIS 0.772 0.00900 116 ALA 0.770 0.0100 117 LEU 0.613 0.0900 118 ALA 0.914 0.0130 119 GLU 0.745 0.0150 120 GLY 0.729 0.0150 121 LEU 0.785 0.00900 122 GLY 0.770 0.174 123 VAL 0.763 0.253 124 ILE 0.839 0.407 125 ALA 1.27 0.601 127 ILE 0.677 0.206 128 GLY 0.774 0.0190 129 GLU 0.882 0.0180 130 LYS 0.860 0.0120 131 LEU 0.803 0.0150 132 ASP 0.685 0.0170 133 GLU 0.916 0.0330 135 GLU 0.802 0.0170 136 ALA 0.712 0.0150 137 GLY 0.809 0.0160 138 ILE 0.791 0.0180 139 THR 0.734 0.0180 140 GLU 0.789 0.0140 141 LYS 0.789 0.0150 142 VAL 0.874 0.0190 143 VAL 0.829 0.0180 144 PHE 0.828 0.0190 145 GLU 0.871 0.0190 146 GLN 0.911 0.0210 147 THR 0.927 0.0520 148 LYS 0.890 0.0260 149 ALA 0.850 0.0150 150 ILE 0.725 0.204 151 ALA 0.899 0.402 152 ASP 0.822 0.0120 153 ASN 0.876 0.0270 154 VAL 0.722 0.0120 155 LYS 0.659 0.0290 156 ASP 0.191 0.0180 157 TRP 0.573 0.0200 158 SER 0.772 0.0280 159 LYS 0.553 0.0220 160 VAL 0.853 0.0220 161 VAL 1.07 0.368 163 ALA 1.39 0.575 167 VAL 0.842 0.0180 169 ALA 0.780 0.0230 170 ILE 1.01 0.0270 171 GLY 0.849 0.0230 172 THR 0.839 0.0310 173 GLY 0.873 0.0360 174 LYS 0.943 0.0290 175 THR 0.515 0.00900 176 ALA 0.883 0.0210 177 THR 0.836 0.0130 179 GLN 0.834 0.0160 181 ALA 0.850 0.0150 182 GLN 0.883 0.0170 183 GLU 0.914 0.0140 184 VAL 0.832 0.0150 185 HIS 0.938 0.0230 186 GLU 0.780 0.0400 187 LYS 0.727 0.00900 188 LEU 0.795 0.301 190 GLY 0.940 0.0110 191 TRP 0.797 0.0450 193 LYS 0.946 0.0820 194 SER 0.763 0.0170 195 HIS 0.843 0.0300 196 VAL 0.815 0.0190 197 SER 0.734 0.0140 198 ASP 0.833 0.0410 199 ALA 0.824 0.0180 200 VAL 0.795 0.0240 201 ALA 0.903 0.0240 202 GLN 0.897 0.0300 203 SER 0.760 0.0310 204 THR 0.703 0.0260 205 ARG 0.861 0.0290 206 ILE 2.79 3.53 212 VAL 0.698 0.0140 213 THR 0.895 0.0200 214 GLY 0.797 0.0170 215 GLY 0.847 0.0320 216 ASN 0.664 0.0310 217 CYS 0.693 0.0360 218 LYS 0.791 0.0150 220 LEU 0.826 0.0200 221 ALA 0.868 0.0220 222 SER 0.741 0.0210 223 GLN 0.709 0.0120 224 HIS 0.773 0.0120 225 ASP 0.829 0.0270 226 VAL 0.944 0.0180 227 ASP 0.796 0.0210 228 GLY 0.790 0.341 229 PHE 1.13 0.464 230 LEU 0.661 0.178 231 VAL 0.832 0.0680 233 GLY 0.797 0.0180 234 ALA 0.903 0.0320 235 SER 0.907 0.0450 236 LEU 0.842 0.0250 237 LYS 0.736 0.0130 239 GLU 0.787 0.0150 240 PHE 0.856 0.0190 241 VAL 0.767 0.0180 242 ASP 1.01 0.0260 243 ILE 0.757 0.0470 245 ASN 0.752 0.0140 246 ALA 0.667 0.0130 247 LYS 0.646 0.0180 248 HIS 0.392 0.00700 stop_ save_ save_1H15N_ssNOE_800MHz _Saveframe_category heteronuclear_NOE _Details . loop_ _Experiment_label '1H-15N ssNOE' stop_ loop_ _Sample_label . stop_ _Sample_conditions_label $standard_conditions _Spectrometer_frequency_1H 800 _Mol_system_component_name 'WT cTIM chain 1' _Atom_one_atom_name N _Atom_two_atom_name H _Heteronuclear_NOE_value_type 'relative intensities' _NOE_reference_value 1.0 _NOE_reference_description . _Text_data_format . _Text_data . loop_ _Residue_seq_code _Residue_label _Heteronuclear_NOE_value _Heteronuclear_NOE_value_error 4 ARG -0.0880 0.00600 5 LYS 0.739 0.00800 6 PHE 0.818 0.00600 7 PHE 0.916 0.0700 8 VAL 0.916 0.0430 9 GLY 0.885 0.0800 10 GLY 0.860 0.0690 11 ASN 0.896 0.00900 12 TRP 1.03 0.0480 13 LYS 0.948 0.00900 14 MET 0.919 0.0120 15 ASN 0.885 0.00700 16 GLY 0.808 0.00500 17 ASP 0.782 0.00900 18 LYS 0.889 0.0120 19 LYS 0.762 0.00700 20 SER 0.903 0.0130 21 LEU 0.904 0.0310 22 GLY 0.885 0.0100 23 GLU 0.913 0.00800 24 LEU 0.923 0.00800 25 ILE 0.905 0.0140 26 HIS 0.896 0.00700 27 THR 0.907 0.0100 28 LEU 0.903 0.0200 29 ASN 0.924 0.00800 30 GLY 0.866 0.00800 31 ALA 0.842 0.00600 32 LYS 0.734 0.00400 33 LEU 0.624 0.00300 34 SER 0.722 0.00500 35 ALA 0.731 0.00800 36 ASP 0.743 0.00700 37 THR 0.718 0.00500 38 GLU 0.893 0.00800 39 VAL 0.901 0.00500 40 VAL 1.18 0.166 41 CYS 0.755 0.104 42 GLY 0.809 0.114 43 ALA 0.855 0.0680 46 ILE 0.928 0.0110 47 TYR 0.928 0.0680 48 LEU 0.900 0.0260 49 ASP 0.894 0.0130 50 PHE 0.906 0.00600 51 ALA 0.898 0.0820 52 ARG 0.951 0.0630 53 GLN 0.933 0.00700 54 LYS 0.909 0.00600 55 LEU 0.878 0.0350 56 ASP 0.886 0.00700 57 ALA 0.907 0.00500 58 LYS 0.808 0.00800 59 ILE 0.885 0.00700 60 GLY 0.869 0.00600 61 VAL 0.823 0.00700 62 ALA 0.827 0.0500 63 ALA 0.899 0.0490 64 GLN 0.909 0.0170 65 ASN 0.893 0.00800 66 CYS 0.933 0.00700 67 TYR 0.923 0.0160 71 LYS 0.856 0.00600 72 GLY 0.908 0.00700 73 ALA 0.881 0.00600 74 PHE 0.882 0.00800 75 THR 0.960 0.0230 76 GLY 0.921 0.0110 77 GLU 0.823 0.00700 78 ILE 0.912 0.00700 79 SER 0.931 0.0190 81 ALA 0.889 0.0140 82 MET 0.917 0.00800 84 LYS 0.885 0.0440 85 ASP 0.943 0.00600 87 GLY 0.928 0.00700 88 ALA 0.898 0.00800 89 ALA 0.833 0.00800 90 TRP 0.911 0.0120 91 VAL 0.726 0.0740 92 ILE 1.03 0.322 93 LEU 0.920 0.0140 94 GLY 0.934 0.0190 95 HIS 0.924 0.0110 97 GLU 0.893 0.0230 98 ARG 0.932 0.0140 99 ARG 0.903 0.0310 100 HIS 0.930 0.0120 101 VAL 0.857 0.0160 102 PHE 0.853 0.0170 103 GLY 0.896 0.00800 104 GLU 0.885 0.00400 105 SER 0.861 0.00800 106 ASP 0.863 0.00900 107 GLU 0.879 0.00800 108 LEU 0.892 0.00800 109 ILE 0.882 0.0460 110 GLY 0.908 0.00700 111 GLN 0.929 0.00700 112 LYS 0.796 0.0820 113 VAL 0.632 0.181 114 ALA 0.949 0.196 115 HIS 0.934 0.00500 116 ALA 0.905 0.00700 117 LEU 0.843 0.172 118 ALA 0.944 0.00600 119 GLU 0.912 0.00700 120 GLY 0.856 0.00800 121 LEU 0.897 0.00500 122 GLY 0.768 0.0830 123 VAL 0.959 0.255 124 ILE 0.765 0.203 125 ALA 1.03 0.232 127 ILE 0.724 0.118 128 GLY 0.864 0.0110 129 GLU 0.913 0.0110 130 LYS 0.935 0.00800 131 LEU 0.877 0.00900 132 ASP 0.828 0.0100 133 GLU 0.830 0.0110 135 GLU 0.906 0.00900 136 ALA 0.905 0.00900 137 GLY 0.879 0.00800 138 ILE 0.874 0.00900 139 THR 0.881 0.0100 140 GLU 0.839 0.00800 141 LYS 0.791 0.00600 142 VAL 0.882 0.00800 143 VAL 0.919 0.0100 144 PHE 0.901 0.0100 145 GLU 0.874 0.00800 146 GLN 0.922 0.00900 147 THR 0.836 0.0160 148 LYS 0.883 0.0120 149 ALA 0.918 0.00800 150 ILE 0.885 0.0950 151 ALA 1.09 0.195 152 ASP 0.914 0.00700 153 ASN 0.878 0.0110 154 VAL 0.849 0.00700 155 LYS 0.640 0.0120 156 ASP 0.271 0.00800 157 TRP 0.626 0.00900 158 SER 0.845 0.0120 159 LYS 0.661 0.0120 160 VAL 0.885 0.0120 161 VAL 1.01 0.263 163 ALA 1.02 0.205 167 VAL 0.904 0.0100 169 ALA 0.924 0.0120 170 ILE 0.927 0.0100 171 GLY 0.844 0.0140 172 THR 0.873 0.0130 173 GLY 0.881 0.0150 174 LYS 0.901 0.0110 175 THR 0.700 0.00500 176 ALA 0.891 0.0110 177 THR 0.901 0.00800 179 GLN 0.904 0.00800 181 ALA 0.802 0.00700 182 GLN 0.927 0.00900 183 GLU 0.918 0.00600 184 VAL 0.862 0.00700 185 HIS 0.937 0.0110 186 GLU 0.858 0.0170 187 LYS 0.940 0.00500 188 LEU 0.918 0.129 190 GLY 0.941 0.00500 191 TRP 0.941 0.0220 193 LYS 0.893 0.0330 194 SER 0.872 0.00900 195 HIS 0.862 0.0120 196 VAL 0.894 0.0100 197 SER 0.880 0.00800 198 ASP 0.849 0.0210 199 ALA 0.877 0.00800 200 VAL 0.914 0.0120 201 ALA 0.907 0.0110 202 GLN 0.856 0.0120 203 SER 0.806 0.0150 204 THR 0.832 0.0130 205 ARG 0.925 0.0140 206 ILE 0.603 0.209 212 VAL 0.780 0.00800 213 THR 0.928 0.0100 214 GLY 0.857 0.0100 215 GLY 0.795 0.0130 216 ASN 0.813 0.0170 217 CYS 0.838 0.0180 218 LYS 0.861 0.00800 220 LEU 0.836 0.00800 221 ALA 0.866 0.0100 222 SER 0.830 0.0100 223 GLN 0.880 0.00800 224 HIS 0.862 0.00700 225 ASP 0.854 0.0130 226 VAL 0.885 0.00800 227 ASP 0.881 0.0100 228 GLY 1.26 0.288 229 PHE 0.888 0.174 230 LEU 0.967 0.0970 231 VAL 0.976 0.172 233 GLY 0.892 0.0110 234 ALA 0.878 0.0140 235 SER 0.896 0.0170 236 LEU 0.859 0.0110 237 LYS 0.820 0.00700 239 GLU 0.775 0.00700 240 PHE 0.883 0.00900 241 VAL 0.883 0.00900 242 ASP 0.896 0.00800 243 ILE 0.890 0.0230 245 ASN 0.895 0.00800 246 ALA 0.839 0.00800 247 LYS 0.718 0.00900 248 HIS 0.558 0.00300 stop_ save_