Biological Magnetic Resonance Data Bank

A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
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BMRB Entry 25491

Title: Structure of Conantokin Rl-B   PubMed: 26048991

Authors: Castellino, Francis; Yuan, Yue; Kunda, Shailaja; Zajicek, Jaroslav

Citation: Castellino, Francis; Yuan, Yue; Kunda, Shailaja; Zajicek, Jaroslav. "Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities Toward Ion Channels of NMDA Receptors"  J. Biol. Chem. 290, 18156-18172 (2015).

Assembly members:
Conantokin_GNQO, polymer, 19 residues, 2323.415 Da.

Natural source:   Common Name: not available   Taxonomy ID: 745791   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Conus rolani

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Data sets:
Data typeCount
13C chemical shifts73
15N chemical shifts17
1H chemical shifts118

Additional metadata:

  • Assembly
  • Samples and Experiments
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  • Spectrometers
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Entity Assembly IDEntity NameEntity ID
1Conantokin Rl-B1


Entity 1, Conantokin Rl-B 19 residues - 2323.415 Da.



sample_1: Conantokin GNQO 2 mM; HEPES, [U-100% 2H], 10 mM; DSS 0.01 mg/mL; sodium chloride 10 mM; magnesium chloride 40 mM; D2O, [U-100% 2H], 5%

sample_conditions_1: ionic strength: 10 mM; pH: 7; pressure: 1 atm; temperature: 298 K


NameSampleSample stateSample conditions
2D 1H-1H TOCSYsample_1isotropicsample_conditions_1
2D DQF-COSYsample_1isotropicsample_conditions_1
2D 1H-1H NOESYsample_1isotropicsample_conditions_1
2D 1H-15N HSQCsample_1isotropicsample_conditions_1
2D 1H-13C HSQCsample_1isotropicsample_conditions_1


X-PLOR_NIH, Schwieters, Kuszewski, Tjandra and Clore - structure solution

TOPSPIN, Bruker Biospin - chemical shift assignment

SPARKY, Goddard - peak picking

TALOS, Cornilescu, Delaglio and Bax - structure solution

NMR spectrometers:

  • Bruker Avance 800 MHz

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