BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
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BMRB Entry 19157

Title: ATOMIC-RESOLUTION STRUCTURE OF A CROSS-BETA QUADRUPLET AMYLOID FIBRIL DETERMINED BY SOLID-STATE MAGIC ANGLE SPINNING NMR AND CRYO-EM   PubMed: 23513222

Authors: Fitzpatrick, Anthony; Debelouchina, G.; Bayro, M.; Clare, D.; Caporini, M.; Bajaj, V.; Jaroniec, C.; Wang, L.; Ladizhansky, V.; Muller, S.; Macphee, C.; Waudby, C.; Mott, H.; De simone, A.; Knowles, T.; Saibil, H.; Vendruscolo, M.; Orlova, E.; Griffin, R.; Dobson, C.; Bajaj, M.; De-simone, A.

Citation: Fitzpatrick, Anthony; Debelouchina, G.; Bayro, M.; Clare, D.; Caporini, M.; Bajaj, V.; Jaroniec, C.; Wang, L.; Ladizhansky, V.; Muller, S.; Macphee, C.; Waudby, C.; Mott, H.; De simone, A.; Knowles, T.; Saibil, H.; Vendruscolo, M.; Orlova, E.; Griffin, R.; Dobson, C.. "ATOMIC STRUCTURE AND HIERARCHICAL ASSEMBLY OF A CROSS-BETA AMYLOID FIBRIL."  Proc. Natl. Acad. Sci. U. S. A. 110, 5468-5473 (2013).

Assembly members:
TRANSTHYRETIN_(chain_A), polymer, 11 residues, 1198.3778 Da.

Natural source:   Common Name: unknown   Taxonomy ID: not available   Superkingdom: not available   Kingdom: not available   Genus/species: not available not available

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):
TRANSTHYRETIN_(chain_A): YTIAALLSPYS

Data sets:
Data typeCount
13C chemical shifts52
15N chemical shifts9

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1TRANSTHYRETIN (chain A), 11
2TRANSTHYRETIN (chain A), 21
3TRANSTHYRETIN (chain A), 31
4TRANSTHYRETIN (chain A), 41
5TRANSTHYRETIN (chain A), 51
6TRANSTHYRETIN (chain A), 61
7TRANSTHYRETIN (chain A), 71
8TRANSTHYRETIN (chain A), 81
9TRANSTHYRETIN (chain A), 91
10TRANSTHYRETIN (chain A), 101
11TRANSTHYRETIN (chain A), 111
12TRANSTHYRETIN (chain A), 121
13TRANSTHYRETIN (chain A), 131
14TRANSTHYRETIN (chain A), 141
15TRANSTHYRETIN (chain A), 151
16TRANSTHYRETIN (chain A), 161
17TRANSTHYRETIN (chain A), 171
18TRANSTHYRETIN (chain A), 181
19TRANSTHYRETIN (chain A), 191
20TRANSTHYRETIN (chain A), 201
21TRANSTHYRETIN (chain A), 211
22TRANSTHYRETIN (chain A), 221
23TRANSTHYRETIN (chain A), 231
24TRANSTHYRETIN (chain A), 241
25TRANSTHYRETIN (chain A), 251
26TRANSTHYRETIN (chain A), 261
27TRANSTHYRETIN (chain A), 271
28TRANSTHYRETIN (chain A), 281
29TRANSTHYRETIN (chain A), 291
30TRANSTHYRETIN (chain A), 301
31TRANSTHYRETIN (chain A), 311
32TRANSTHYRETIN (chain A), 321
33TRANSTHYRETIN (chain A), 331
34TRANSTHYRETIN (chain A), 341
35TRANSTHYRETIN (chain A), 351
36TRANSTHYRETIN (chain A), 361
37TRANSTHYRETIN (chain A), 371
38TRANSTHYRETIN (chain A), 381
39TRANSTHYRETIN (chain A), 391
40TRANSTHYRETIN (chain A), 401
41TRANSTHYRETIN (chain A), 411
42TRANSTHYRETIN (chain A), 421
43TRANSTHYRETIN (chain A), 431
44TRANSTHYRETIN (chain A), 441
45TRANSTHYRETIN (chain A), 451
46TRANSTHYRETIN (chain A), 461
47TRANSTHYRETIN (chain A), 471
48TRANSTHYRETIN (chain A), 481

Entities:

Entity 1, TRANSTHYRETIN (chain A), 1 11 residues - 1198.3778 Da.

1   TYRTHRILEALAALALEULEUSERPROTYR
2   SER

Samples:

sample_1: TRANSTHYRETIN (chain A) na mM

sample_conditions_1: pH: .; pressure: 1.000 atm; temperature: 288.150 K

Experiments:

NameSampleSample stateSample conditions
1D DQ-DRAWSsample_1solidsample_conditions_1
REDORsample_1solidsample_conditions_1
ZF-TEDORsample_1solidsample_conditions_1
2D PDSDsample_1solidsample_conditions_1
1D DQ-DRAWSsample_1solidsample_conditions_1
REDORsample_1solidsample_conditions_1

Software:

AutoDep v4.3 -

CNSSOLVE vany, BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE- -

NMR spectrometers:

  • Bruker Custom built 750 MHz
  • VARIAN CUSTOM BUILT 500 MHz

Related Database Links:

UNP TTHY_RAT