BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
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BMRB Entry 18972

Title: SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU-CONOTOXIN CnVA   PubMed: 23567999

Authors: Petrel, C.; Hocking, Henry; Reynaud, M.; Favreau, P.; Paolini-bertrand, M.; Peigneur, S.; Upert, G.; Tytgat, J.; Gilles, N.; Hartley, O.; Boelens, R.; Stocklin, R.; Servent, D.; Servent, R.

Citation: Petrel, C.; Hocking, Henry; Reynaud, M.; Favreau, P.; Paolini-bertrand, M.; Peigneur, S.; Upert, G.; Tytgat, J.; Gilles, N.; Hartley, O.; Boelens, R.; Stocklin, R.; Servent, D.. "Identification, structural and pharmacological characterization of tau-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor"  Biochem. Pharmacol. 85, 1663-1671 (2013).

Assembly members:
TAU-CNVA, polymer, 15 residues, 1717.068 Da.

Natural source:   Common Name: Conus consors   Taxonomy ID: 101297   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Conus consors

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):
TAU-CNVA: ECCHRQLLCCLRFVX

Data sets:
Data typeCount
13C chemical shifts51
1H chemical shifts103

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1TAU-CNVA1

Entities:

Entity 1, TAU-CNVA 15 residues - 1717.068 Da.

1   GLUCYSCYSHISARGGLNLEULEUCYSCYS
2   LEUARGPHEVALNH2

Samples:

sample_1: TAU-CNVA, [U-13C; U-15N], 2.3 mM

sample_conditions_1: ionic strength: 0.0 mM; pH: 3.000; pressure: 1 atm; temperature: 295.000 K

Experiments:

NameSampleSample stateSample conditions
NOESYsample_1solutionsample_conditions_1
DQF-COSYsample_1solutionsample_conditions_1
e-COSYsample_1solutionsample_conditions_1
TOCSYsample_1solutionsample_conditions_1

Software:

AutoDep v4.3, PDBe - collection

CCPN_Analysis vany, CCPN - data analysis

CNS vany, BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE- - chemical shift assignment

NMR spectrometers:

  • Bruker Avance 500 MHz

Related Database Links:

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