BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
Member of WWPDB

BMRB Entry 17458

Title: NMR STRUCTURE OF THYMOSIN ALPHA-1   PubMed: 22115779

Authors: Elizondo-Riojas, Miguel; Gorenstein, David; Volk, David

Citation: Elizondo-Riojas, Miguel-Angel; Chamow, Steven; Tuthill, Cynthia; Gorenstein, David; Volk, David. "NMR structure of human thymosin alpha-1."  Biochem. Biophys. Res. Commun. 416, 356-361 (2011).

Assembly members:
Thymosin-Alpha1, polymer, 28 residues, 3070.300 Da.
ACE, non-polymer, 44.053 Da.

Natural source:   Common Name: human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo Sapiens

Experimental source:   Production method: obtained from a vendor

Entity Sequences (FASTA):
Thymosin-Alpha1: SDAAVDTSSEITTKDLKEKK EVVEEAEN

Data sets:
Data typeCount
1H chemical shifts188

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1Thymosin-Alpha11
2ACE2

Entities:

Entity 1, Thymosin-Alpha1 28 residues - 3070.300 Da.

1   SERASPALAALAVALASPTHRSERSERGLU
2   ILETHRTHRLYSASPLEULYSGLULYSLYS
3   GLUVALVALGLUGLUALAGLUASN

Entity 2, ACE - C2 H4 O - 44.053 Da.

1   ACE

Samples:

sample_1: Thymosin-Alpha1 28.8 mg; TFE 40%; D2O 10%; H2O 50%

sample_conditions_1: pH: 4.9; pressure: 1 atm; temperature: 298 K

Experiments:

NameSampleSample stateSample conditions
2D 1H-1H NOESYsample_1isotropicsample_conditions_1
2D 1H-1H TOCSYsample_1isotropicsample_conditions_1

Software:

AMBER v9.0, Case, Darden, Cheatham, III, Simmerling, Wang, Duke, Luo, ... and Kollm - data analysis, minimization, molecular dynamics

NMR spectrometers:

  • Varian UnityPlus 800 MHz

Related Database Links:

BMRB 19901
PDB
DBJ BAC29913 BAC39141 BAC40090 BAD97325 BAE20932
EMBL CAA39028 CAA39601 CAH92370
GB AAA40758 AAA41931 AAA41941 AAA41942 AAA42241
PRF 770552A
REF NP_001092755 NP_001126395 NP_001153558 NP_001291804 NP_002814
SP P01252 P06302 P06454 P26350 Q5R790
TPG DAA32328