BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
Member of WWPDB

BMRB Entry 15053

Title: HPRP-173-195 SOLUTION STRUCTURE   PubMed: 18563793

Authors: Saviano, Gabriella; Tancredi, Teodorico

Citation: Ronga, Luisa; Palladino, Pasquale; Saviano, Gabriella; Tancredi, Teodorico; Benedetti, Ettore; Ragone, Raffaele; Rossi, Filomena. "Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein alpha2-helical 180-195 segment, and comparison with full-length alpha2-helix-derived peptides"  J. Pept. Sci. 14, 1096-1102 (2008).

Assembly members:
HPRP173195, polymer, 23 residues, Formula weight is not available

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):
HPRP173195: NNFVHDCVNITIKQHTVTTT TKG

Data sets:
Data typeCount
1H chemical shifts133

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1prion protein fragment, alpha-2 helix1

Entities:

Entity 1, prion protein fragment, alpha-2 helix 23 residues - Formula weight is not available

1   ASNASNPHEVALHISASPCYSVALASNILE
2   THRILELYSGLNHISTHRVALTHRTHRTHR
3   THRLYSGLY

Samples:

sample: HPRP1731951 – 2 mM; TRIFLUOROETHANOL-D2, [U-2H], 100%

sample_conditions_1: pH: 5.0; pressure: 1.0 atm; temperature: 300.0 K

Experiments:

NameSampleSample stateSample conditions
NOESYsampleisotropicsample_conditions_1
COSYsampleisotropicsample_conditions_1
TOCSYsampleisotropicsample_conditions_1
15N-HSQCsampleisotropicsample_conditions_1

Software:

DYANA, P.GUNTERT - refinement

NMRView, B Johnson, One Moon Scientific - structure solution

NMR spectrometers:

  • Bruker AVANCE 600 MHz

Related Database Links:

BMRB 15824 15845 16071 16075 16076 16077 16078 16079 16080 16184 16185 16722 16723 16743 17034 17081 17084 17087 17174 17213 17714 17756 17758 17780 17834 18426 18550 19268 4307 4379 4402 4434 4620 4641 4736
PDB
DBJ BAA00011 BAA08790 BAD51981 BAE28320 BAE28693
EMBL CAA58442 CAG46836 CAG46869 CAH92912 CAJ18553
GB AAA19664 AAA37013 AAA37014 AAA37090 AAA37091
PIR B34759
REF NP_000302 NP_001009093 NP_001040617 NP_001073590 NP_001073591
SP P04156 P04273 P04925 P13852 P40245
TPE CAJ43808