BMRB Entry 10092

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PDB ID: 1wh4
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR10092
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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Solution structure of the DEATH domain of Interleukin-1 receptor-associated kinase4 (IRAK4) from Mus musculus

Deposition date:

2007-01-24

Original release date:

2008-08-14

Authors:

Nameki, N.; Tomizawa, T.; Koshiba, S.; Kigawa, T.; Yokoyama, S.

Citation:

Citation: Nameki, N.; Tomizawa, T.; Koshiba, S.; Kigawa, T.; Yokoyama, S.. "Solution structure of the DEATH domain of Interleukin-1 receptor-associated kinase4 (IRAK4) from Mus musculus" .

Assembly members:

Assembly members:
DEATH domain, polymer, 127 residues, Formula weight is not available

Natural source:

Natural source: Common Name: mouse Taxonomy ID: 10090 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Mus musculus

Experimental source:

Experimental source: Production method: cell free synthesis Vector: P021209-23

Entity Sequences (FASTA):

Entity Sequences (FASTA):
DEATH domain: GSSGSSGMNKPLTPSTYIRN LNVGILRKLSDFIDPQEGWK KLAVAIKKPSGDDRYNQFHI RRFEALLQTGKSPTCELLFD WGTTNCTVGDLVDLLVQIEL FAPATLLLPDAVPQTVKSLP PSGPSSG

Data sets:

assigned_chemical_shifts
- chemical_shift_1

Data type	Count
13C chemical shifts	531
15N chemical shifts	112
1H chemical shifts	857

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	interleukin-1 receptor-associated kinase 4	1

Entities:

Entity 1, interleukin-1 receptor-associated kinase 4 127 residues - Formula weight is not available

1

GLY

SER

GLY

SER

GLY

MET

ASN

LYS

2

PRO

LEU

THR

PRO

SER

THR

TYR

ILE

ARG

ASN

3

LEU

ASN

VAL

GLY

ILE

LEU

ARG

LYS

LEU

SER

4

ASP

PHE

ILE

ASP

PRO

GLN

GLU

GLY

TRP

LYS

5

LYS

LEU

ALA

VAL

ALA

ILE

LYS

PRO

SER

6

GLY

ASP

ARG

TYR

ASN

GLN

PHE

HIS

ILE

7

ARG

PHE

GLU

ALA

LEU

GLN

THR

GLY

8

LYS

SER

PRO

THR

CYS

GLU

LEU

PHE

ASP

9

TRP

GLY

THR

ASN

CYS

THR

VAL

GLY

ASP

10

LEU

VAL

ASP

LEU

VAL

GLN

ILE

GLU

LEU

11

PHE

ALA

PRO

ALA

THR

LEU

PRO

ASP

12

ALA

VAL

PRO

GLN

THR

VAL

LYS

SER

LEU

PRO

13

PRO

SER

GLY

PRO

SER

GLY

Samples:

sample_1: DEATH domain, [U-13C; U-15N], 0.7 mM; d-Tris-HCl 20 mM; NaCl 100 mM; d-DTT 1 mM; NaN3 0.02%; H2O 90%; D2O 10%

condition_1: ionic strength: 120 mM; pH: 7.5; pressure: 1 atm; temperature: 296 K

Experiments:

Name	Sample	Sample state	Sample conditions
3D 15N-separated NOESY	sample_1	not available	condition_1
3D 13C-separated NOESY	sample_1	not available	condition_1

Software:

xwinnmr v2.6, Bruker - collection

NMRPipe v20020425, Delaglio, F. - processing

NMRView v5.0.4, Johnson, B.A. - data analysis

Kujira v0.901, Kobayashi, N. - data analysis

CYANA v1.0.7, Guntert, P. - structure solution

OPALp, Billeter, M., Guntert, P., Koradi, R. - refinement

NMR spectrometers:

Bruker AVANCE 800 MHz

PDB	1WH4 2A9I
DBJ	BAB32090 BAC26146 BAE24205
GB	AAH51676 AAM15773 ABK42447 EDL04264 EDL04265
REF	NP_084202 XP_011243947
SP	Q8R4K2
AlphaFold	Q8R4K2