BMRB Entry 25204

Title:
Shifting the Polarity of some Critical Residues in Malarial Peptides Binding to Host Cells is a Key Factor in Breaking Conserved Antigens
Deposition date:
2014-09-05
Original release date:
2015-09-14
Authors:
Cifuentes, Gladys; Bermudez, Adriana; Rodriguez, Raul; Patarroyo, Manuel Alfonso; Patarroyo, Manuel Elkin
Citation:

Citation: Cifuentes, Gladys; Bermudez, Adriana; Rodriguez, Raul; Patarroyo, Manuel Alfonso; Patarroyo, Manuel Elkin. "Shifting the Polarity of some Critical Residues in Malarial Peptides Binding to Host Cells is a Key Factor in Breaking Conserved Antigens"  Med. Chem. 4, 278-292 (2008).
PubMed: 18473921

Assembly members:

Assembly members:
entity, polymer, 21 residues, 2457.902 Da.

Natural source:

Natural source:   Common Name: not available   Taxonomy ID: not available   Superkingdom: not available   Kingdom: not available   Genus/species: not available not available

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity: YLGRSGGDIIKKMQTLWDEI M

Data sets:
Data typeCount
1H chemical shifts161

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1entity1

Entities:

Entity 1, entity 21 residues - 2457.902 Da.

1   TYRLEUGLYARGSERGLYGLYASPILEILE
2   LYSLYSMETGLNTHRLEUTRPASPGLUILE
3   MET

Samples:

sample_1: entity10 – 12 mM; H2O 70%; trifluoroethanol 30%

sample_conditions_1: pH: 3.7; pressure: 1 atm; temperature: 295 K

Experiments:

NameSampleSample stateSample conditions
2D DQF-COSYsample_1isotropicsample_conditions_1
2D 1H-1H TOCSYsample_1isotropicsample_conditions_1
2D 1H-1H NOESYsample_1isotropicsample_conditions_1

Software:

InsightII, Accelrys Software Inc. - geometry optimization, refinement

NMR spectrometers:

  • Bruker DRX 500 MHz

Related Database Links:

PDB
EMBL CAA28241 CAD48982
GB AAN36078 ETW17862 ETW21002 ETW28257 ETW30242
REF XP_001348165 XP_001350954
SP P13830
AlphaFold P13830