BMRB Entry 5869

Title:
Solution Conformation of alphaA-Conotoxin EIVA
Deposition date:
2003-07-14
Original release date:
2008-07-17
Authors:
Chi, S.-W.; Park, K.-H.; Suk, J.-E.; Olivera, B.; McIntosh, J.; Han, K.-H.
Citation:

Citation: Chi, S.-W.; Park, K.-H.; Suk, J.-E.; Olivera, B.; McIntosh, J.; Han, K.-H.. "Solution Conformation of alphaA-conotoxin EIVA, a Potent Neuromuscular Nicotinic Acetylcholine Receptor Antagonist from Conus ermineus"  J. Biol. Chem. 278, 42208-42213 (2003).
PubMed: 12900418

Assembly members:

Assembly members:
Alpha-A-conotoxin EIVA., polymer, 31 residues, 3095.2 Da.

Natural source:

Natural source:   Common Name: Atlantic fish-hunting cone   Taxonomy ID: 55423   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Conus ermineus

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
Alpha-A-conotoxin EIVA.: GCCGPYXNAACHXCGCKVGR XXYCDRXSGGX

Data sets:
Data typeCount
1H chemical shifts154
coupling constants16

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1Alpha-A-conotoxin EIVA1

Entities:

Entity 1, Alpha-A-conotoxin EIVA 31 residues - 3095.2 Da.

1   GLYCYSCYSGLYPROTYRHYPASNALAALA
2   CYSHISHYPCYSGLYCYSLYSVALGLYARG
3   HYPHYPTYRCYSASPARGHYPSERGLYGLY
4   NH2

Samples:

sample_1: Alpha-A-conotoxin EIVA. 5 mM

sample_cond_1: ionic strength: 0.0 M; pH: 3.6; pressure: 1 atm; temperature: 288 K

Experiments:

NameSampleSample stateSample conditions
2D NOESYsample_1not availablesample_cond_1
2D TOCSYsample_1not availablesample_cond_1
DQF-COSYsample_1not availablesample_cond_1
PE-COSYsample_1not availablesample_cond_1

Software:

VNMR v6.1B - data collection

FELIX v98.0 - data processing

DISCOVER v2.98 - refinement

NMR spectrometers:

  • Varian INOVA 600 MHz

Related Database Links:

PDB