BMRB Entry 26882

Title:
Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
Deposition date:
2016-08-28
Original release date:
2016-09-15
Authors:
Chan, Lai Yue; Craik, David; Daly, Norelle
Citation:

Citation: Chan, Lai Yue; Craik, David; Daly, Norelle. "Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy"  Sci. Rep. 6, 35347-35347 (2016).
PubMed: 27734947

Assembly members:

Assembly members:
MCoAA-02, polymer, 35 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: not available   Taxonomy ID: not available   Superkingdom: not available   Kingdom: not available   Genus/species: not available not available

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
MCoAA-02: CPKILKKCRRDSDCPGACIC RYWKVCGYHLNQPFG

Data sets:
Data typeCount
1H chemical shifts218

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1cyclic peptide1

Entities:

Entity 1, cyclic peptide 35 residues - Formula weight is not available

1   CYSPROLYSILELEULYSLYSCYSARGARG
2   ASPSERASPCYSPROGLYALACYSILECYS
3   ARGTYRTRPLYSVALCYSGLYTYRHISLEU
4   ASNGLNPROPHEGLY

Samples:

sample_1: MCoAA-02 1 mM; H2O 90%; D2O 10%

sample_conditions_1: pH: 5.5; pressure: 1 atm; temperature: 298 K

Experiments:

NameSampleSample stateSample conditions
2D 1H-1H TOCSYsample_1isotropicsample_conditions_1
2D 1H-1H NOESYsample_1isotropicsample_conditions_1

Software:

TOPSPIN, Bruker Biospin - collection, processing

NMR spectrometers:

  • Bruker Avance 600 MHz