BMRB Entry 25517

Title:
Short hydrophobic peptide, 11mer
Deposition date:
2015-03-04
Original release date:
2016-07-13
Authors:
Hoang, Huy
Citation:

Citation: Hoang, Huy; Song, Kun; Hill, Timothy; Derksen, David; Edmonds, David; Kok, W. Mei; Limberakis, Chris; Liras, Spiros; Loria, Paula; Mascitti, Vincent; Mathiowetz, Alan; Mitchell, Justin; Piotrowski, David; Price, David; Stanton, Robert; Suen, Jacky; Withka, Jane; Griffith, David; Fairlie, David. "Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists"  J. Med. Chem. 58, 4080-4085 (2015).
PubMed: 25839426

Assembly members:

Assembly members:
entity, polymer, 12 residues, 1259.314 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity: HAEGTFTSDFFX

Data sets:
Data typeCount
1H chemical shifts20

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1entity1

Entities:

Entity 1, entity 12 residues - 1259.314 Da.

1   HISALAGLUGLYTHRPHETHRSERASPPHE
2   PHENH2

Samples:

sample_1: entity 1 mM

sample_conditions_1: ionic strength: 0.01 M; pH: 7; pressure: 1 atm; temperature: 298 K

Experiments:

NameSampleSample stateSample conditions
NOESYsample_1isotropicsample_conditions_1

Software:

xplor, Brunger - structure solution

NMR spectrometers:

  • Bruker Avance 600 MHz