BMRB Entry 18148

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR18148

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Title:
VEGFR2-Integrin B3 interaction
Deposition date:
2011-12-18
Original release date:
2012-03-02
Authors:
Deshmukh, Lalit; Vinogradova, Olga
Citation:

Citation: West, Xiaoxia; Meller, Nahum; Malinin, Nikolay; Deshmukh, Lalit; Meller, Julia; Mahabeleshwar, Ganapati; Weber, Malory; Kerr, Bethany; Vinogradova, Olga; Byzova, Tatiana. "Integrin (3) Crosstalk with VEGFR Accommodating Tyrosine Phosphorylation as a Regulatory Switch."  PLoS ONE 7, .-. (2012).
PubMed: 22363548

Assembly members:

Assembly members:
cytoplasmic_tail_of_VEGFR-2, polymer, 20 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
cytoplasmic_tail_of_VEGFR-2: LRTVKRANGGELKTGYLSIV

Data sets:
Data typeCount
1H chemical shifts58

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1VEGFR-21

Entities:

Entity 1, VEGFR-2 20 residues - Formula weight is not available

1   LEUARGTHRVALLYSARGALAASNGLYGLY
2   GLULEULYSTHRGLYTYRLEUSERILEVAL

Samples:

sample_1: cytoplasmic tail of VEGFR-2 1 mM; D2O 5%; H20 95%; DSS 1 mM; sodium chloride 50 mM; sodium phosphate 25 mM; GST-tagged B3 integrin tail 20 uM

sample_conditions_1: pH: 6.1; pressure: 1 atm; temperature: 273 K

Experiments:

NameSampleSample stateSample conditions
2D 1H-1H TOCSYsample_1isotropicsample_conditions_1
2D 1H-1H NOESYsample_1isotropicsample_conditions_1

Software:

X-PLOR NIH v2.24, Schwieters, Kuszewski, Tjandra and Clore - structure solution

NMR spectrometers:

  • Varian INOVA 600 MHz

Related Database Links:

PDB
DBJ BAD93138
EMBL CAO79613
GB AAB88005 AAC16450 AAI31823 ABB82619 ACF37106
REF NP_001041489 NP_001103470 NP_001182599 NP_001265494 NP_002244
SP P35968
TPG DAA28658
AlphaFold P35968