BMRB Entry 18129

Title:
Structural Model for a 40-residue Beta-Amyloid Fibril with Three-Fold Symmetry, Positive Stagger
Deposition date:
2011-12-08
Original release date:
2012-01-05
Authors:
Tycko, Robert; Paravastu, Anant
Citation:

Citation: Paravastu, Anant; Leapman, Richard; Yau, Wai-Ming; Tycko, Robert. "Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils"  Proc. Natl. Acad. Sci. U.S.A. 105, 18349-18354 (2008).
PubMed: 16401079

Assembly members:

Assembly members:
beta-amyloid, polymer, 40 residues, 3375.924 Da.

Natural source:

Natural source:   Common Name: human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
beta-amyloid: DAEFRHDSGYEVHHQKLVFF AEDVGSNKGAIIGLMVGGVV

Data sets:
Data typeCount
13C chemical shifts90

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1entity_11
2entity_21
3entity_31
4entity_41
5entity_51
6entity_61
7entity_71
8entity_81
9entity_91
10entity_101
11entity_111
12entity_121
13entity_131
14entity_141
15entity_151
16entity_161
17entity_171
18entity_181

Entities:

Entity 1, entity_1 40 residues - 3375.924 Da.

1   ASPALAGLUPHEARGHISASPSERGLYTYR
2   GLUVALHISHISGLNLYSLEUVALPHEPHE
3   ALAGLUASPVALGLYSERASNLYSGLYALA
4   ILEILEGLYLEUMETVALGLYGLYVALVAL

Samples:

sample_1: beta-amyloid, selective 13C and 15N, 1 mg/mL; phosphate buffer 10 mM

sample_conditions_1: ionic strength: 10 mM; pH: 7.4; pressure: 1 atm; temperature: 300 K

Experiments:

NameSampleSample stateSample conditions
2D fpRFDRsample_1solidsample_conditions_1
2D RADsample_1solidsample_conditions_1
2D TEDORsample_1solidsample_conditions_1
fsREDORsample_1solidsample_conditions_1
15N-BAREsample_1solidsample_conditions_1
13C-BAREsample_1solidsample_conditions_1
PITHIRDS-CTsample_1solidsample_conditions_1
2D NCACXsample_1solidsample_conditions_1

Software:

X-PLOR NIH, Schwieters, Kuszewski, Tjandra and Clore - structure solution

NMR spectrometers:

  • Varian Infinity 400 MHz
  • Varian Infinity 600 MHz

Related Database Links:

BMRB 11435 15775 17159 17186 17764 17793 17794 17795 17796 18052 18127 18128 18131 19009 19309 19393 25218 25289 25429 26508 26516
PDB
DBJ BAA22264 BAA84580 BAB71958 BAD51938 BAE01907
EMBL CAA30050 CAA31830 CAA39589 CAA39590 CAA39591
GB AAA35540 AAA36829 AAA51564 AAA51722 AAA51726
PIR A60045 D60045 E60045 G60045 PQ0438
PRF 1303338A 1403400A 1405204A 1507304A 1507304B
REF NP_000475 NP_001006601 NP_001013036 NP_001070264 NP_001127014
SP P05067 P53601 P79307 P86906 Q28053
TPG DAA33655
AlphaFold P86906 Q28053 P05067 P53601 P79307